ES2179088T3 - Inhibidores de flsa2 1h-indol-3-glioxilamida. - Google Patents
Inhibidores de flsa2 1h-indol-3-glioxilamida.Info
- Publication number
- ES2179088T3 ES2179088T3 ES95302166T ES95302166T ES2179088T3 ES 2179088 T3 ES2179088 T3 ES 2179088T3 ES 95302166 T ES95302166 T ES 95302166T ES 95302166 T ES95302166 T ES 95302166T ES 2179088 T3 ES2179088 T3 ES 2179088T3
- Authority
- ES
- Spain
- Prior art keywords
- indol
- glioxylamide
- flsa2
- inhibitors
- glicoxilamidas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE PRESENTA UNA NUEVA CLASE DE 1H-INDOL-3-GLICOXILAMIDAS JUNTO CON EL USO DE TALES COMPUESTOS DE INDOL, PARA INHIBIR LA LIBERACION MEDIADA POR SPLA2 DE ACIDOS GRASOS PARA EL TRATAMIENTO DE ESTADOS COMO EL CHOQUE SEPTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22191694A | 1994-04-01 | 1994-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179088T3 true ES2179088T3 (es) | 2003-01-16 |
Family
ID=22829963
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08001265T Expired - Lifetime ES2377223T3 (es) | 1994-04-01 | 1995-03-31 | Éster metÃlico de ácido [[3-(2-amino-1,2-dioxoetil)-2-etil-1-(fenilmetil)-11H-indol-4-IL]oxi]acético como inhibidor de sPLA2 |
ES95302166T Expired - Lifetime ES2179088T3 (es) | 1994-04-01 | 1995-03-31 | Inhibidores de flsa2 1h-indol-3-glioxilamida. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08001265T Expired - Lifetime ES2377223T3 (es) | 1994-04-01 | 1995-03-31 | Éster metÃlico de ácido [[3-(2-amino-1,2-dioxoetil)-2-etil-1-(fenilmetil)-11H-indol-4-IL]oxi]acético como inhibidor de sPLA2 |
Country Status (29)
Country | Link |
---|---|
US (6) | US5654326A (es) |
EP (5) | EP1197484A2 (es) |
JP (1) | JP3109974B2 (es) |
KR (1) | KR100368707B1 (es) |
CN (1) | CN1067054C (es) |
AT (2) | ATE540923T1 (es) |
AU (1) | AU688458B2 (es) |
BR (1) | BR9501404A (es) |
CA (1) | CA2146097C (es) |
CO (1) | CO4370099A1 (es) |
CZ (1) | CZ82295A3 (es) |
DE (1) | DE69527322T2 (es) |
DK (2) | DK0675110T3 (es) |
ES (2) | ES2377223T3 (es) |
FI (1) | FI114793B (es) |
HU (1) | HUT72048A (es) |
IL (1) | IL113210A (es) |
MX (1) | MX9501608A (es) |
MY (1) | MY112897A (es) |
NO (1) | NO304186B1 (es) |
NZ (1) | NZ270848A (es) |
PE (1) | PE18696A1 (es) |
PL (1) | PL180523B1 (es) |
PT (1) | PT675110E (es) |
RU (1) | RU2128169C1 (es) |
SI (1) | SI0675110T1 (es) |
TW (1) | TW383302B (es) |
UA (1) | UA47387C2 (es) |
ZA (1) | ZA952693B (es) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2128169C1 (ru) * | 1994-04-01 | 1999-03-27 | Эли Лилли Энд Компани | Iн-индол-3-глиоксиламиды, ингибирующие spla2-медиируемое выделение жирных кислот, фармацевтическая композиция |
JPH08193074A (ja) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | 除草性1−シクロプロピルテトラゾリノン類 |
KR100436812B1 (ko) * | 1995-01-06 | 2004-08-31 | 도레이 가부시끼가이샤 | 벤젠축합헤테로환유도체및그유도체를유효성분으로함유하는의약조성물 |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
WO1998037069A1 (fr) * | 1997-02-20 | 1998-08-27 | Shionogi & Co., Ltd. | Derives d'acide indoldicarboxylique |
US5972988A (en) * | 1997-03-26 | 1999-10-26 | Eli Lilly And Company | Method for treatment of chronic bronchitis using indole compounds |
WO1998047507A1 (en) * | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
TW455581B (en) * | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
EP1011670A4 (en) * | 1997-08-28 | 2004-10-27 | Lilly Co Eli | PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS |
EP1030661A4 (en) * | 1997-10-27 | 2002-07-17 | Lilly Co Eli | N, N-DIETHYLGLYCOLAMIDOESTER OF INDOLS AS PRELIMINARY MEDICINE OF SPLA 2 INHIBITORS |
ATE296286T1 (de) | 1997-10-27 | 2005-06-15 | Lilly Co Eli | Morpholino-n-ethyl ester prodrogen von indol spla 2 hemmer |
AU1200799A (en) * | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Isopropyl ester prodrugs of indole spla2 inhibitors |
WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
WO1999025339A1 (en) * | 1997-11-14 | 1999-05-27 | Eli Lilly And Company | Treatment for alzheimer's disease |
AU1407399A (en) * | 1997-11-14 | 1999-06-07 | Eli Lilly And Company | Treatment for alzheimer's disease |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
TR200002447T2 (tr) * | 1998-02-25 | 2000-11-21 | Genetics Institute, Inc. | Fosfolinaz enzimlerinin inhibitörleri |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
TR200002543T2 (tr) * | 1998-03-03 | 2000-11-21 | Shionogi & Co., Ltd. | Fosfolipaz önleyici sodyum [[3-(2-amino-1,2-dioksietil-1-fenilmetil) -2-etil-1-fenilmetil)- 1H-indol-4-il]oksi] asetat içeren farmasötik kompozisyonlar |
AU3054399A (en) | 1998-03-31 | 1999-10-25 | Shionogi & Co., Ltd. | Pyrrolo(1,2-a)pyrazine sPLA2 inhibitor |
CZ302588B6 (cs) * | 1998-04-02 | 2011-07-27 | Ziopharm Oncology, Inc. | Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva |
DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
AU3563299A (en) * | 1998-04-17 | 1999-11-08 | Eli Lilly And Company | Process for preparing 4-hydroxy indole, indazole and carbazole compounds |
DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
CN1303290A (zh) * | 1998-05-01 | 2001-07-11 | 伊莱利利公司 | sPLA2抑制剂酯 |
US6340699B1 (en) * | 1998-05-01 | 2002-01-22 | Eli Lilly And Company | SPLA2 inhibitor compounds for treatment of disease |
CA2332528A1 (en) | 1998-05-21 | 1999-11-25 | Shionogi & Co., Ltd. | Pyrrolo[1,2-b]pyridazine spla2 inhibitory |
US6608099B1 (en) | 1998-08-03 | 2003-08-19 | Eli Lilly And Company | Indole sPLA2 inhibitors |
ES2263283T3 (es) | 1998-08-03 | 2006-12-01 | ELI LILLY & COMPANY | Inhibidores de spla2 indol. |
WO2000010568A1 (en) | 1998-08-24 | 2000-03-02 | Draheim Susan E | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2? |
US6576654B1 (en) | 1998-09-23 | 2003-06-10 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
DZ2771A1 (fr) * | 1998-10-09 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
CA2346334A1 (en) * | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Composition for treating or preventing ischemia reperfusion injury |
US20030149000A1 (en) * | 1998-11-10 | 2003-08-07 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds |
CA2358492A1 (en) * | 1998-12-21 | 2000-06-29 | Eli Lilly And Company | Combination therapy for the treatment of sepsis |
AU1928800A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Substituted tricyclics |
JP2002532571A (ja) * | 1998-12-22 | 2002-10-02 | イーライ・リリー・アンド・カンパニー | 新規sPLA2インヒビター |
US6380397B1 (en) | 1999-04-15 | 2002-04-30 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
US6274578B1 (en) | 1999-04-20 | 2001-08-14 | Eli Lilly And Company | sPLA2 inhibitor ester |
US6140327A (en) * | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
JP2003505372A (ja) * | 1999-07-19 | 2003-02-12 | イーライ・リリー・アンド・カンパニー | sPLA2インヒビター |
JP4636521B2 (ja) | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環系化合物 |
US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
JP4636522B2 (ja) | 1999-08-02 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環式化合物 |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
EP1220839B1 (en) * | 1999-09-20 | 2006-12-06 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors |
US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
AU1304801A (en) | 1999-11-15 | 2001-05-30 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect |
WO2001044185A1 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Carbon monoxide-based synthesis of spla2 inhibitors |
WO2001044184A1 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
WO2001049323A1 (en) * | 2000-01-06 | 2001-07-12 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
US20030096854A1 (en) * | 2002-06-12 | 2003-05-22 | Ho-Shen Lin | Substituted tricyclics |
EP1248769A2 (en) * | 2000-01-07 | 2002-10-16 | Eli Lilly And Company | Carbazole derivatives as inhibitors of spla2 |
EP1265607A2 (en) * | 2000-03-09 | 2002-12-18 | Eli Lilly And Company | METHOD FOR THE TREATMENT OF RENAL DYSFUNCTION WITH sPLA 2 INHIBITORS |
BR0002188A (pt) * | 2000-03-30 | 2001-11-13 | Brasil Compressores Sa | Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas |
AU2001252922A1 (en) * | 2000-04-19 | 2001-11-07 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
JPWO2002000621A1 (ja) * | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | X型sPLA2阻害作用を有する化合物 |
AU2001267826A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for alzheimer's disease |
AU2001267825A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
WO2002000255A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre le cancer |
CN1450893A (zh) * | 2000-07-14 | 2003-10-22 | 伊莱利利公司 | 治疗脓毒症的方法 |
WO2002012249A2 (en) * | 2000-08-04 | 2002-02-14 | Eli Lilly And Company | Substituted pyrrole compounds and their use as spla2 inhibitors |
EP1358156B1 (en) * | 2000-12-18 | 2007-02-21 | Eli Lilly And Company | Benz(g) indoles and their use as spla2 inhibitors |
TWI314457B (es) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
WO2007056184A2 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
CA2627352A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
AU2006311766A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors |
WO2007056281A2 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
KR101269393B1 (ko) * | 2008-04-28 | 2013-05-29 | 아사히 가세이 파마 가부시키가이샤 | 페닐프로피온산 유도체 및 이의 용도 |
EP2395837A1 (en) * | 2009-01-08 | 2011-12-21 | Anthera Pharmaceuticals, Inc. | Secretory phospholipase a2 (spla2) inhibitor and niacin drug compositions and methods for treating cardiovascular disease and dyslipidemia |
NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
CN101838232B (zh) * | 2009-07-07 | 2012-02-22 | 爱斯医药科技(南京)有限公司 | Varespladib的制备方法 |
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CN108463221A (zh) * | 2015-08-31 | 2018-08-28 | 迪亚库雷特公司 | 吲哚类化合物刺激免疫系统的用途 |
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-
1995
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 FI FI951553A patent/FI114793B/fi not_active IP Right Cessation
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
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1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
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1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
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2000
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