ES2181052T3 - Fenilacetamidas como inhibidores de la spla2. - Google Patents
Fenilacetamidas como inhibidores de la spla2.Info
- Publication number
- ES2181052T3 ES2181052T3 ES97952228T ES97952228T ES2181052T3 ES 2181052 T3 ES2181052 T3 ES 2181052T3 ES 97952228 T ES97952228 T ES 97952228T ES 97952228 T ES97952228 T ES 97952228T ES 2181052 T3 ES2181052 T3 ES 2181052T3
- Authority
- ES
- Spain
- Prior art keywords
- phenylacetamids
- spla2
- inhibitors
- septi
- phenylacetamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UNA CLASE DE NUEVAS FENILACETAMIDAS ASI COMO AL USO DE ESTOS COMPUESTOS TRATANDOSE DE INHIBIR LA LIBERACION DE LOS ACIDOS GRASOS CON MEDIACION SPLA 2 DE FORMA QUE SE TRATEN LOS TRASTORNOS COMO, POR EJEMPLO, UN CHOQUE SEPTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3250896P | 1996-12-03 | 1996-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2181052T3 true ES2181052T3 (es) | 2003-02-16 |
Family
ID=21865299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97952228T Expired - Lifetime ES2181052T3 (es) | 1996-12-03 | 1997-11-25 | Fenilacetamidas como inhibidores de la spla2. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6353128B1 (es) |
EP (1) | EP0946495B1 (es) |
JP (1) | JP2001505575A (es) |
KR (1) | KR20000069248A (es) |
AU (1) | AU5589298A (es) |
BR (1) | BR9713987A (es) |
CA (1) | CA2273995A1 (es) |
DE (1) | DE69714289T2 (es) |
ES (1) | ES2181052T3 (es) |
HU (1) | HUP9904172A2 (es) |
IL (1) | IL130200A0 (es) |
WO (1) | WO1998024756A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-a]피라진 sPLA2 억제제 |
EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
ATE329619T1 (de) | 1998-10-14 | 2006-07-15 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
FR2793791B1 (fr) * | 1999-05-19 | 2002-01-25 | Univ Paris 7 Denis Diderot | Nouveaux composes inhibiteurs specifiques de phospholipases a2 |
AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
JP4636522B2 (ja) | 1999-08-02 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環式化合物 |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
SE0000754D0 (sv) * | 2000-03-07 | 2000-03-07 | Amersham Pharm Biotech Ab | Mass spectral peak identification |
US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
AU2001267823A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
TWI314457B (es) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
EP2424521A4 (en) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE |
WO2015026990A2 (en) * | 2013-08-20 | 2015-02-26 | University Of Washington Through Its Center For Commercialization | Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydrolase |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1584246A (en) | 1976-06-16 | 1981-02-11 | Ici Ltd | Carboxamidoesters |
US4256758A (en) | 1979-06-11 | 1981-03-17 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
EP0161529B1 (en) | 1984-05-18 | 1989-07-12 | Asahi Kasei Kogyo Kabushiki Kaisha | 2-nitro-5-(2'-chloro-4'trifluoromethylphenoxy)phenylacetic ester, thioester and amide, process for preparation therof, herbicidal composition, and method for destruction of undesirable weeds |
DE3812768A1 (de) | 1988-04-16 | 1989-10-26 | Bayer Ag | Halogensubstituierte phenoxybenzylverbindungen |
BR9612347A (pt) | 1995-12-13 | 1999-07-13 | Lilly Co Eli | Naftil acetamidas como inibidores de spla2 |
-
1997
- 1997-11-24 US US08/976,858 patent/US6353128B1/en not_active Expired - Fee Related
- 1997-11-25 CA CA002273995A patent/CA2273995A1/en not_active Abandoned
- 1997-11-25 DE DE69714289T patent/DE69714289T2/de not_active Expired - Fee Related
- 1997-11-25 EP EP97952228A patent/EP0946495B1/en not_active Expired - Lifetime
- 1997-11-25 IL IL13020097A patent/IL130200A0/xx unknown
- 1997-11-25 AU AU55892/98A patent/AU5589298A/en not_active Abandoned
- 1997-11-25 WO PCT/US1997/021622 patent/WO1998024756A1/en not_active Application Discontinuation
- 1997-11-25 JP JP52565298A patent/JP2001505575A/ja not_active Withdrawn
- 1997-11-25 HU HU9904172A patent/HUP9904172A2/hu unknown
- 1997-11-25 BR BR9713987-4A patent/BR9713987A/pt unknown
- 1997-11-25 ES ES97952228T patent/ES2181052T3/es not_active Expired - Lifetime
- 1997-11-25 KR KR1019997004847A patent/KR20000069248A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US6353128B1 (en) | 2002-03-05 |
EP0946495B1 (en) | 2002-07-24 |
CA2273995A1 (en) | 1998-06-11 |
EP0946495A1 (en) | 1999-10-06 |
EP0946495A4 (en) | 2000-04-12 |
KR20000069248A (ko) | 2000-11-25 |
DE69714289D1 (en) | 2002-08-29 |
WO1998024756A1 (en) | 1998-06-11 |
BR9713987A (pt) | 2000-02-08 |
HUP9904172A2 (hu) | 2000-05-28 |
AU5589298A (en) | 1998-06-29 |
IL130200A0 (en) | 2000-06-01 |
DE69714289T2 (de) | 2003-01-16 |
JP2001505575A (ja) | 2001-04-24 |
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