RU94012931A - Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2 - Google Patents

Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2

Info

Publication number
RU94012931A
RU94012931A RU94012931/04A RU94012931A RU94012931A RU 94012931 A RU94012931 A RU 94012931A RU 94012931/04 A RU94012931/04 A RU 94012931/04A RU 94012931 A RU94012931 A RU 94012931A RU 94012931 A RU94012931 A RU 94012931A
Authority
RU
Russia
Prior art keywords
acetic acid
hydrazides
indol
spla2 inhibitors
spla2
Prior art date
Application number
RU94012931/04A
Other languages
English (en)
Other versions
RU2127725C1 (ru
Inventor
Джеймс Бах Николас
Дилейн Диллард Роберт
Элизабет Драхайм Сюзан
Белл Херманн Роберт
Уолтер Шевиц Ричард
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU94012931A publication Critical patent/RU94012931A/ru
Application granted granted Critical
Publication of RU2127725C1 publication Critical patent/RU2127725C1/ru

Links

Claims (1)

  1. Раскрывается класс новых гидразидов IH-индол-З-уксусной кислоты, а также использование указанных индоловых соединений в целях ингибирования SPLA2 -опосредованного высвобождения жирных кислот (например арахидоновой кислоты) для лечения таких состояний, как септический шок.
RU94012931A 1993-04-16 1994-04-15 Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2 RU2127725C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4860893A 1993-04-16 1993-04-16
US08/048608 1993-04-16
US08/048.608 1993-04-16

Publications (2)

Publication Number Publication Date
RU94012931A true RU94012931A (ru) 1995-12-20
RU2127725C1 RU2127725C1 (ru) 1999-03-20

Family

ID=21955471

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94012931A RU2127725C1 (ru) 1993-04-16 1994-04-15 Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2

Country Status (27)

Country Link
US (1) US5578634A (ru)
EP (1) EP0620214B1 (ru)
JP (1) JP3621128B2 (ru)
KR (1) KR100330816B1 (ru)
CN (1) CN1067986C (ru)
AT (1) ATE177081T1 (ru)
AU (1) AU669782B2 (ru)
BR (1) BR9401484A (ru)
CA (1) CA2121321A1 (ru)
CO (1) CO4230091A1 (ru)
CZ (1) CZ289791B6 (ru)
DE (1) DE69416705T2 (ru)
DK (1) DK0620214T3 (ru)
ES (1) ES2128510T3 (ru)
FI (1) FI941766A (ru)
GR (1) GR3029689T3 (ru)
HU (1) HU220221B (ru)
IL (1) IL109309A (ru)
NO (1) NO300210B1 (ru)
NZ (1) NZ260299A (ru)
PL (1) PL179472B1 (ru)
RU (1) RU2127725C1 (ru)
SI (1) SI0620214T1 (ru)
TW (1) TW306914B (ru)
UA (1) UA40575C2 (ru)
YU (1) YU20094A (ru)
ZA (1) ZA942614B (ru)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1067054C (zh) * 1994-04-01 2001-06-13 伊莱利利公司 1H-吲哚-3-乙醛酰胺sPLA2抑制剂
US6214876B1 (en) 1994-07-21 2001-04-10 Eli Lilly And Company Indene-1-acetamide sPLA2 inhibitors
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
KR100482268B1 (ko) * 1996-08-01 2005-04-14 메르클레 게엠베하 세포질 포스포리파제 a2의 저해제로서의 아실피롤디카르복실산
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
TR199900956T2 (xx) * 1996-10-30 1999-07-21 Eli Lilly And Company S�bstit�e edilmi� trisiklik bile�imler.
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
WO1998037069A1 (fr) * 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Derives d'acide indoldicarboxylique
CN1310706A (zh) * 1998-02-25 2001-08-29 遗传研究所有限公司 磷脂酶抑制剂
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
KR20010042307A (ko) 1998-03-31 2001-05-25 시오노 요시히코 피롤로[1,2-a]피라진 sPLA2 억제제
ID23219A (id) * 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
EP1085021A4 (en) 1998-05-21 2003-01-08 Shionogi & Co DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2?
WO2000007590A1 (en) 1998-08-03 2000-02-17 Eli Lilly And Company INDOLE sPLA2 INHIBITORS
EP1100493A4 (en) * 1998-08-03 2001-10-24 Lilly Co Eli SPLA 2 INHIBITORS? OF THE INDOLTYPS
US6325991B1 (en) 1998-08-24 2001-12-04 Susan E. Draheim Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2
ATE329619T1 (de) 1998-10-14 2006-07-15 Shionogi & Co Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden
US6448284B1 (en) 1998-12-22 2002-09-10 Eli Lilly And Company Substituted tricyclics
AU2373600A (en) * 1998-12-22 2000-07-12 Eli Lilly And Company Novel spla2 inhibitors
AU6015600A (en) 1999-07-19 2001-02-05 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
AU6762400A (en) * 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
WO2001014378A1 (fr) 1999-08-23 2001-03-01 Shionogi & Co., Ltd. DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2?
AU7559600A (en) * 1999-10-15 2001-04-23 Shionogi & Co., Ltd. V type and/or x type spla2 inhibitors
WO2001036420A1 (fr) 1999-11-15 2001-05-25 Shionogi & Co., Ltd. Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2?
US6967200B2 (en) 2000-06-29 2005-11-22 Shionogi & Co., Ltd. Remedies for cirrhosis
AU2001267824A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cancer
AU2001267823A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
CN1450893A (zh) * 2000-07-14 2003-10-22 伊莱利利公司 治疗脓毒症的方法
EP1349834A2 (en) 2000-12-18 2003-10-08 Eli Lilly And Company Cycloalkyfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
TWI314457B (ru) * 2001-03-19 2009-09-11 Shionogi & Co
US7205329B2 (en) 2003-05-30 2007-04-17 Microbia, Inc. Modulators of CRTH2 activity
US7348338B2 (en) 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
KR20130023381A (ko) 2003-07-17 2013-03-07 플렉시콘, 인코퍼레이티드 Ppar 활성 화합물
GB2407318A (en) * 2003-10-23 2005-04-27 Oxagen Ltd Substituted Indol-3-yl acetic acid derivatives
US7531568B2 (en) 2004-11-30 2009-05-12 Plexxikon, Inc. PPAR active compounds
WO2006102126A2 (en) * 2005-03-18 2006-09-28 Duke University Inhibitors of isoprenylcysteine carboxyl methyltransferase
GT200600228A (es) 2005-05-27 2006-12-26 Inhibidores de la fosfolipasa a2 citosolica
MX2008005666A (es) 2005-11-03 2009-03-02 Ilypsa Inc Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2.
WO2007056275A2 (en) * 2005-11-03 2007-05-18 Ilypsa, Inc. Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
US8048880B2 (en) * 2007-05-03 2011-11-01 Anthera Pharmaceuticals, Inc. Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
EP2890677B1 (en) * 2012-08-30 2017-11-15 Chong Kun Dang Pharmaceutical Corp. N-acylhydrazone derivatives for selective t cell inhibitor and anti-lymphoid malignancy drug
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2825734A (en) * 1955-04-11 1958-03-04 Upjohn Co Reduction of carbonylic radicals in indolyl-3 compounds
US2890223A (en) * 1956-03-22 1959-06-09 Research Corp 1-benzyl, 2-methyl, 5-methoxy tryptamine
US3242193A (en) * 1961-03-13 1966-03-22 Merck & Co Inc Indolyl aliphatic acids
US3242163A (en) * 1961-03-13 1966-03-22 Merck & Co Inc Indolyl aliphatic acids
US3196162A (en) * 1961-03-13 1965-07-20 Merck & Co Inc Indolyl aliphatic acids
US3242162A (en) * 1961-03-13 1966-03-22 Merck & Co Inc Indolyl aliphatic acids
US3271416A (en) * 1961-10-24 1966-09-06 Merck & Co Inc Indolyl aliphatic acids
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US4012513A (en) * 1971-11-03 1977-03-15 Imperial Chemical Industries Limited Indole derivatives for providing analgesic and anti-inflammatory effects
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors

Similar Documents

Publication Publication Date Title
RU94012931A (ru) Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2
ATE220394T1 (de) 1h-indol-3-glyoxylamid spla2 inhibitoren
NO941360D0 (no) 1H-indol-3-eddiksyrehydrazid sPLA2 inhibitorer
RU94012930A (ru) Новые 1-н-индол-3-ацетамиды как ингибиторы spla2 и фармацевтическая композиция на их основе
DE69531864D1 (de) Indolizin spal2 inhibitoren
FI941767A (fi) 1H-indoli-3-asetamidi sPLA2 inhibiittoreita
EA199900301A2 (ru) Замещенные трициклические соединения
ES2159347T3 (es) Naftil-acetamidas como inhibidores de spla2.
EP1100492A4 (en) SPLA 2 INHIBITORS? INDOLE TYPE