RU94012931A - Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2 - Google Patents
Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2Info
- Publication number
- RU94012931A RU94012931A RU94012931/04A RU94012931A RU94012931A RU 94012931 A RU94012931 A RU 94012931A RU 94012931/04 A RU94012931/04 A RU 94012931/04A RU 94012931 A RU94012931 A RU 94012931A RU 94012931 A RU94012931 A RU 94012931A
- Authority
- RU
- Russia
- Prior art keywords
- acetic acid
- hydrazides
- indol
- spla2 inhibitors
- spla2
- Prior art date
Links
- 229940042795 Hydrazides for tuberculosis treatment Drugs 0.000 title claims 2
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940114079 Arachidonic Acid Drugs 0.000 claims 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N Arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 1
- 206010040070 Septic shock Diseases 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000003617 indole-3-acetic acid Substances 0.000 claims 1
- 150000002475 indoles Chemical class 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
Claims (1)
- Раскрывается класс новых гидразидов IH-индол-З-уксусной кислоты, а также использование указанных индоловых соединений в целях ингибирования SPLA2 -опосредованного высвобождения жирных кислот (например арахидоновой кислоты) для лечения таких состояний, как септический шок.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4860893A | 1993-04-16 | 1993-04-16 | |
US08/048608 | 1993-04-16 | ||
US08/048.608 | 1993-04-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94012931A true RU94012931A (ru) | 1995-12-20 |
RU2127725C1 RU2127725C1 (ru) | 1999-03-20 |
Family
ID=21955471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94012931A RU2127725C1 (ru) | 1993-04-16 | 1994-04-15 | Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2 |
Country Status (27)
Country | Link |
---|---|
US (1) | US5578634A (ru) |
EP (1) | EP0620214B1 (ru) |
JP (1) | JP3621128B2 (ru) |
KR (1) | KR100330816B1 (ru) |
CN (1) | CN1067986C (ru) |
AT (1) | ATE177081T1 (ru) |
AU (1) | AU669782B2 (ru) |
BR (1) | BR9401484A (ru) |
CA (1) | CA2121321A1 (ru) |
CO (1) | CO4230091A1 (ru) |
CZ (1) | CZ289791B6 (ru) |
DE (1) | DE69416705T2 (ru) |
DK (1) | DK0620214T3 (ru) |
ES (1) | ES2128510T3 (ru) |
FI (1) | FI941766A (ru) |
GR (1) | GR3029689T3 (ru) |
HU (1) | HU220221B (ru) |
IL (1) | IL109309A (ru) |
NO (1) | NO300210B1 (ru) |
NZ (1) | NZ260299A (ru) |
PL (1) | PL179472B1 (ru) |
RU (1) | RU2127725C1 (ru) |
SI (1) | SI0620214T1 (ru) |
TW (1) | TW306914B (ru) |
UA (1) | UA40575C2 (ru) |
YU (1) | YU20094A (ru) |
ZA (1) | ZA942614B (ru) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1067054C (zh) * | 1994-04-01 | 2001-06-13 | 伊莱利利公司 | 1H-吲哚-3-乙醛酰胺sPLA2抑制剂 |
US6214876B1 (en) | 1994-07-21 | 2001-04-10 | Eli Lilly And Company | Indene-1-acetamide sPLA2 inhibitors |
US5641800A (en) * | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
KR100482268B1 (ko) * | 1996-08-01 | 2005-04-14 | 메르클레 게엠베하 | 세포질 포스포리파제 a2의 저해제로서의 아실피롤디카르복실산 |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
TR199900956T2 (xx) * | 1996-10-30 | 1999-07-21 | Eli Lilly And Company | S�bstit�e edilmi� trisiklik bile�imler. |
US6177440B1 (en) | 1996-10-30 | 2001-01-23 | Eli Lilly And Company | Substituted tricyclics |
US6713645B1 (en) * | 1996-10-30 | 2004-03-30 | Eli Lilly And Company | Substituted tricyclics |
WO1998037069A1 (fr) * | 1997-02-20 | 1998-08-27 | Shionogi & Co., Ltd. | Derives d'acide indoldicarboxylique |
CN1310706A (zh) * | 1998-02-25 | 2001-08-29 | 遗传研究所有限公司 | 磷脂酶抑制剂 |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-a]피라진 sPLA2 억제제 |
ID23219A (id) * | 1998-04-17 | 2000-03-30 | Lilly Co Eli | Trisiklik tersubstitusi |
DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
WO2000007590A1 (en) | 1998-08-03 | 2000-02-17 | Eli Lilly And Company | INDOLE sPLA2 INHIBITORS |
EP1100493A4 (en) * | 1998-08-03 | 2001-10-24 | Lilly Co Eli | SPLA 2 INHIBITORS? OF THE INDOLTYPS |
US6325991B1 (en) | 1998-08-24 | 2001-12-04 | Susan E. Draheim | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 |
ATE329619T1 (de) | 1998-10-14 | 2006-07-15 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
US6448284B1 (en) | 1998-12-22 | 2002-09-10 | Eli Lilly And Company | Substituted tricyclics |
AU2373600A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Novel spla2 inhibitors |
AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
AU6762400A (en) * | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
WO2001036420A1 (fr) | 1999-11-15 | 2001-05-25 | Shionogi & Co., Ltd. | Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2? |
US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
AU2001267824A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cancer |
AU2001267823A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
CN1450893A (zh) * | 2000-07-14 | 2003-10-22 | 伊莱利利公司 | 治疗脓毒症的方法 |
EP1349834A2 (en) | 2000-12-18 | 2003-10-08 | Eli Lilly And Company | Cycloalkyfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases |
TWI314457B (ru) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US7205329B2 (en) | 2003-05-30 | 2007-04-17 | Microbia, Inc. | Modulators of CRTH2 activity |
US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
KR20130023381A (ko) | 2003-07-17 | 2013-03-07 | 플렉시콘, 인코퍼레이티드 | Ppar 활성 화합물 |
GB2407318A (en) * | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
US7531568B2 (en) | 2004-11-30 | 2009-05-12 | Plexxikon, Inc. | PPAR active compounds |
WO2006102126A2 (en) * | 2005-03-18 | 2006-09-28 | Duke University | Inhibitors of isoprenylcysteine carboxyl methyltransferase |
GT200600228A (es) | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
MX2008005666A (es) | 2005-11-03 | 2009-03-02 | Ilypsa Inc | Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2. |
WO2007056275A2 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
EP2890677B1 (en) * | 2012-08-30 | 2017-11-15 | Chong Kun Dang Pharmaceutical Corp. | N-acylhydrazone derivatives for selective t cell inhibitor and anti-lymphoid malignancy drug |
GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
Family Cites Families (11)
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US2825734A (en) * | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
US2890223A (en) * | 1956-03-22 | 1959-06-09 | Research Corp | 1-benzyl, 2-methyl, 5-methoxy tryptamine |
US3242193A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
US3242163A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
US3196162A (en) * | 1961-03-13 | 1965-07-20 | Merck & Co Inc | Indolyl aliphatic acids |
US3242162A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
US3271416A (en) * | 1961-10-24 | 1966-09-06 | Merck & Co Inc | Indolyl aliphatic acids |
IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
-
1994
- 1994-04-12 IL IL10930994A patent/IL109309A/xx not_active IP Right Cessation
- 1994-04-13 TW TW083103279A patent/TW306914B/zh active
- 1994-04-13 HU HU9401058A patent/HU220221B/hu not_active IP Right Cessation
- 1994-04-13 NZ NZ260299A patent/NZ260299A/en unknown
- 1994-04-14 CO CO94014980A patent/CO4230091A1/es unknown
- 1994-04-14 ES ES94302646T patent/ES2128510T3/es not_active Expired - Lifetime
- 1994-04-14 SI SI9430246T patent/SI0620214T1/xx unknown
- 1994-04-14 CA CA002121321A patent/CA2121321A1/en not_active Abandoned
- 1994-04-14 CZ CZ1994894A patent/CZ289791B6/cs not_active IP Right Cessation
- 1994-04-14 AT AT94302646T patent/ATE177081T1/de not_active IP Right Cessation
- 1994-04-14 BR BR9401484A patent/BR9401484A/pt not_active Application Discontinuation
- 1994-04-14 DK DK94302646T patent/DK0620214T3/da active
- 1994-04-14 DE DE69416705T patent/DE69416705T2/de not_active Expired - Fee Related
- 1994-04-14 EP EP94302646A patent/EP0620214B1/en not_active Expired - Lifetime
- 1994-04-15 ZA ZA942614A patent/ZA942614B/xx unknown
- 1994-04-15 CN CN94104433A patent/CN1067986C/zh not_active Expired - Fee Related
- 1994-04-15 RU RU94012931A patent/RU2127725C1/ru active
- 1994-04-15 PL PL94303027A patent/PL179472B1/pl unknown
- 1994-04-15 AU AU59486/94A patent/AU669782B2/en not_active Ceased
- 1994-04-15 NO NO941360A patent/NO300210B1/no not_active IP Right Cessation
- 1994-04-15 YU YU20094A patent/YU20094A/sh unknown
- 1994-04-15 KR KR1019940007934A patent/KR100330816B1/ko not_active IP Right Cessation
- 1994-04-15 UA UA94005182A patent/UA40575C2/ru unknown
- 1994-04-15 JP JP07764694A patent/JP3621128B2/ja not_active Expired - Fee Related
- 1994-04-15 FI FI941766A patent/FI941766A/fi unknown
-
1995
- 1995-05-12 US US08/440,154 patent/US5578634A/en not_active Expired - Fee Related
-
1999
- 1999-03-12 GR GR990400773T patent/GR3029689T3/el unknown
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