ZA952693B - 1H-indole-3-Glyoxylamide sPLA2 inhibitors - Google Patents
1H-indole-3-Glyoxylamide sPLA2 inhibitorsInfo
- Publication number
- ZA952693B ZA952693B ZA952693A ZA952693A ZA952693B ZA 952693 B ZA952693 B ZA 952693B ZA 952693 A ZA952693 A ZA 952693A ZA 952693 A ZA952693 A ZA 952693A ZA 952693 B ZA952693 B ZA 952693B
- Authority
- ZA
- South Africa
- Prior art keywords
- indole
- spla2 inhibitors
- glyoxylamide spla2
- glyoxylamide
- sub
- Prior art date
Links
- AWMLDBKLOPNOAR-UHFFFAOYSA-N indole-3-glyoxylamide Natural products C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 3
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 title 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22191694A | 1994-04-01 | 1994-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA952693B true ZA952693B (en) | 1996-09-30 |
Family
ID=22829963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA952693A ZA952693B (en) | 1994-04-01 | 1995-03-31 | 1H-indole-3-Glyoxylamide sPLA2 inhibitors |
Country Status (29)
Country | Link |
---|---|
US (6) | US5654326A (xx) |
EP (5) | EP2341045A1 (xx) |
JP (1) | JP3109974B2 (xx) |
KR (1) | KR100368707B1 (xx) |
CN (1) | CN1067054C (xx) |
AT (2) | ATE220394T1 (xx) |
AU (1) | AU688458B2 (xx) |
BR (1) | BR9501404A (xx) |
CA (1) | CA2146097C (xx) |
CO (1) | CO4370099A1 (xx) |
CZ (1) | CZ82295A3 (xx) |
DE (1) | DE69527322T2 (xx) |
DK (2) | DK0675110T3 (xx) |
ES (2) | ES2377223T3 (xx) |
FI (1) | FI114793B (xx) |
HU (1) | HUT72048A (xx) |
IL (1) | IL113210A (xx) |
MX (1) | MX9501608A (xx) |
MY (1) | MY112897A (xx) |
NO (1) | NO304186B1 (xx) |
NZ (1) | NZ270848A (xx) |
PE (1) | PE18696A1 (xx) |
PL (1) | PL180523B1 (xx) |
PT (1) | PT675110E (xx) |
RU (1) | RU2128169C1 (xx) |
SI (1) | SI0675110T1 (xx) |
TW (1) | TW383302B (xx) |
UA (1) | UA47387C2 (xx) |
ZA (1) | ZA952693B (xx) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA47387C2 (uk) * | 1994-04-01 | 2002-07-15 | Елі Ліллі Енд Компані | 1H-ІНДОЛ-3-ГЛІОКСИЛАМІДИ ЯК ІНГІБІТОРИ sPLA<sub>2</sub> ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ |
JPH08193074A (ja) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | 除草性1−シクロプロピルテトラゾリノン類 |
US6043264A (en) * | 1995-01-06 | 2000-03-28 | Toray Industries, Inc. | Benzene-condensed heterocyclic derivatives and their uses |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
EP0987250A4 (en) * | 1997-02-20 | 2000-12-06 | Shionogi & Co | INDOLDICARBONIC ACID DERIVATIVES |
US5972988A (en) * | 1997-03-26 | 1999-10-26 | Eli Lilly And Company | Method for treatment of chronic bronchitis using indole compounds |
WO1998047507A1 (en) | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
TW455581B (en) * | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
WO1999009978A1 (en) * | 1997-08-28 | 1999-03-04 | Eli Lilly And Company | Method for treatment of non-rheumatoid athritis |
ES2241178T3 (es) | 1997-10-27 | 2005-10-16 | Eli Lilly And Company | Profarmacos de ester de morlino-n-etilo de inhibidores indolicos de spla 2. |
CA2309135A1 (en) * | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
WO1999021545A1 (en) * | 1997-10-27 | 1999-05-06 | Eli Lilly And Company | ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS |
WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
JP2001522883A (ja) * | 1997-11-14 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | アルツハイマー病の処置 |
CA2310250A1 (en) * | 1997-11-14 | 1999-05-27 | August Masaru Watanabe | Treatment for alzheimer's disease |
CA2322162A1 (en) * | 1998-02-25 | 1999-09-02 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
ES2253877T3 (es) * | 1998-03-03 | 2006-06-01 | SHIONOGI & CO., LTD. | Composiciones farmaceuticas que contienen el inhibidor de fosfolipasa((3-(2-amino-1,2-dioxoetil)-2-etil-1-(fenilmetil)-1h-indol-4-il)oxi)acetato de sodio. |
AU3054399A (en) | 1998-03-31 | 1999-10-25 | Shionogi & Co., Ltd. | Pyrrolo(1,2-a)pyrazine sPLA2 inhibitor |
DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
CZ302588B6 (cs) * | 1998-04-02 | 2011-07-27 | Ziopharm Oncology, Inc. | Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva |
DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
WO1999054295A1 (en) * | 1998-04-17 | 1999-10-28 | Eli Lilly And Company | Process for preparing 4-hydroxy indole, indazole and carbazole compounds |
ES2230847T3 (es) * | 1998-05-01 | 2005-05-01 | Eli Lilly And Company | Esteres inhibidores de spla2. |
SK16342000A3 (sk) | 1998-05-01 | 2002-04-04 | Eli Lilly And Company | Liečivo na liečbu zápalového ochorenia čreva obsahujúce 1H-indol-3-glyoxylamidy |
EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
CA2338727A1 (en) * | 1998-08-03 | 2000-02-17 | Edward David Mihelich | Indole spla2 inhibitors |
EP1100492B1 (en) * | 1998-08-03 | 2006-05-24 | Eli Lilly & Company | INDOLE sPLA2 INHIBITORS |
AU6240099A (en) | 1998-08-24 | 2000-03-14 | Susan E Draheim | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 |
US6576654B1 (en) | 1998-09-23 | 2003-06-10 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
DZ2771A1 (fr) * | 1998-10-09 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
US7098237B1 (en) | 1998-10-14 | 2006-08-29 | Shionogi & Co., Ltd. | Remedies for ischemia reperfusion injury |
US20030149000A1 (en) * | 1998-11-10 | 2003-08-07 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds |
JP2002542148A (ja) * | 1998-12-21 | 2002-12-10 | イーライ・リリー・アンド・カンパニー | 敗血症の処置のための組み合わせ療法 |
AU2373600A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Novel spla2 inhibitors |
ATE247119T1 (de) * | 1998-12-22 | 2003-08-15 | Lilly Co Eli | Substituierte pyrroloindole |
US6380397B1 (en) | 1999-04-15 | 2002-04-30 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
US6274578B1 (en) | 1999-04-20 | 2001-08-14 | Eli Lilly And Company | sPLA2 inhibitor ester |
US6140327A (en) * | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
JP4636521B2 (ja) | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | sPLA2阻害作用を有する三環系化合物 |
EP1202963B1 (en) * | 1999-07-19 | 2007-01-03 | Eli Lilly And Company | Spla2 inhibitors |
US6673781B1 (en) | 1999-08-02 | 2004-01-06 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
WO2001021587A2 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors |
WO2001026653A1 (fr) * | 1999-10-15 | 2001-04-19 | Shionogi & Co., Ltd. | Inhibiteurs spla2 du type v et/ou du type x |
WO2001036420A1 (fr) | 1999-11-15 | 2001-05-25 | Shionogi & Co., Ltd. | Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2? |
AU2252201A (en) * | 1999-12-16 | 2001-06-25 | Eli Lilly And Company | Carbon monoxide-based synthesis of spla2 inhibitors |
AU2050001A (en) * | 1999-12-16 | 2001-06-25 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
EP1259260A1 (en) * | 2000-01-06 | 2002-11-27 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
US20030096854A1 (en) * | 2002-06-12 | 2003-05-22 | Ho-Shen Lin | Substituted tricyclics |
AU4599601A (en) * | 2000-01-07 | 2001-07-16 | Eli Lilly And Company | Substituted tricyclics |
WO2001066110A2 (en) * | 2000-03-09 | 2001-09-13 | Eli Lilly And Company | METHOD FOR THE TREATMENT OF RENAL DYSFUNCTION WITH sPLA2 INHIBITORS |
BR0002188A (pt) * | 2000-03-30 | 2001-11-13 | Brasil Compressores Sa | Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas |
WO2001081306A2 (en) * | 2000-04-19 | 2001-11-01 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
WO2002000255A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre le cancer |
AU2001267825A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
WO2002000621A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Composes inhibiteurs de la spla2 de type x |
WO2002000257A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes a la maladie d'alzheimer |
EP1303262A2 (en) * | 2000-07-14 | 2003-04-23 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
AU2001280461A1 (en) * | 2000-08-04 | 2002-02-18 | Eli Lilly And Company | Substituted pyrrole compounds and their use as spla2 inhibitors |
US6916840B2 (en) | 2000-12-18 | 2005-07-12 | Eli Lilly And Company | Spla2 inhibitors |
TWI314457B (xx) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
MX2008005660A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de indol que tienen sustituyentes c4-amida y uso de los mismos como inhibidores de la fosfolipasa a2. |
CA2627349A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
EP1948604A1 (en) * | 2005-11-03 | 2008-07-30 | Ilypsa, Inc. | Indole compounds having c4-acidic substituents and use thereof as phospholipase-a2 inhibitors |
EP1960356A2 (en) | 2005-11-03 | 2008-08-27 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
JP5198560B2 (ja) * | 2008-04-28 | 2013-05-15 | 旭化成ファーマ株式会社 | フェニルプロピオン酸誘導体及びその用途 |
CN102271507A (zh) * | 2009-01-08 | 2011-12-07 | 安塞拉制药有限公司 | 分泌型磷脂酶a2(spla2)抑制剂和烟酸药物组合物以及治疗心血管疾病和血脂异常的方法 |
CN106822080A (zh) | 2009-04-29 | 2017-06-13 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
CN101838232B (zh) * | 2009-07-07 | 2012-02-22 | 爱斯医药科技(南京)有限公司 | Varespladib的制备方法 |
MA40998A (fr) * | 2014-11-21 | 2017-09-26 | Ophirex Inc | Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés |
WO2017037041A1 (en) * | 2015-08-31 | 2017-03-09 | Diaccurate | Use of indole compounds to stimulate the immune system |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2825734A (en) | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
US2825743A (en) | 1955-08-30 | 1958-03-04 | Celanese Corp | Catalytic hydrogenation of unsaturated aldehydes and ketones |
US3242163A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
GB1089071A (en) | 1964-02-28 | 1967-11-01 | Merck & Co Inc | Indole derivatives |
NL287416A (xx) | 1964-04-25 | |||
US3449363A (en) | 1966-12-22 | 1969-06-10 | American Cyanamid Co | 3-substituted 4-trifluoromethyl indoles |
IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
US3691194A (en) * | 1970-07-30 | 1972-09-12 | Little Inc A | 3-indole-glyoxamides |
US3686213A (en) | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
US4397850A (en) | 1981-10-07 | 1983-08-09 | Sandoz, Inc. | Isoxazolyl indolamines |
US4552876A (en) * | 1984-07-09 | 1985-11-12 | Usv Pharmaceutical Corp. | Bisbenzoxazines and pharmaceutical use |
US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
NZ234883A (en) * | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
US5334719A (en) * | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
UA47387C2 (uk) | 1994-04-01 | 2002-07-15 | Елі Ліллі Енд Компані | 1H-ІНДОЛ-3-ГЛІОКСИЛАМІДИ ЯК ІНГІБІТОРИ sPLA<sub>2</sub> ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ |
US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
DE69620241T2 (de) * | 1995-12-14 | 2002-10-02 | Merck & Co Inc | Gonadotropin releasing hormon- antagonisten |
PL327132A1 (en) | 1995-12-14 | 1998-11-23 | Merck & Co Inc | Antagonists of the gonadotrophin liberating hormone |
CA2309135A1 (en) * | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
-
1995
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 FI FI951553A patent/FI114793B/fi not_active IP Right Cessation
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
-
1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
- 1997-12-16 US US08/991,149 patent/US5919943A/en not_active Expired - Lifetime
-
1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
-
2000
- 2000-11-16 US US09/714,364 patent/US6433001B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA952693B (en) | 1H-indole-3-Glyoxylamide sPLA2 inhibitors | |
IL130338A0 (en) | Pyrroles as sPLA2 inhibitors | |
HU9401060D0 (en) | 1-h-indole-3-acetamide spla2 inhibitors | |
EP0772596A4 (en) | INDOLIZINE SPAL2 INHIBITORS | |
MX9804751A (es) | Naftil acetamidas como inhibidores de la spla2. | |
EP1100492A4 (en) | SPLA 2 INHIBITORS? INDOLE TYPE | |
IL130201A0 (en) | Phenyl glyoxamides as spla2 inhibitors | |
MX9804750A (es) | Naftil glioxamidas como inhibidores de la spla2. | |
AU5873400A (en) | spla2 inhibitors | |
ATE247119T1 (de) | Substituierte pyrroloindole | |
AU7053700A (en) | Novel spla2 inhibitors |