DK0675110T3 - 1H-indol-3-glyoxylamid-sPLA2-inhibitorer - Google Patents
1H-indol-3-glyoxylamid-sPLA2-inhibitorerInfo
- Publication number
- DK0675110T3 DK0675110T3 DK95302166T DK95302166T DK0675110T3 DK 0675110 T3 DK0675110 T3 DK 0675110T3 DK 95302166 T DK95302166 T DK 95302166T DK 95302166 T DK95302166 T DK 95302166T DK 0675110 T3 DK0675110 T3 DK 0675110T3
- Authority
- DK
- Denmark
- Prior art keywords
- indole
- spla2 inhibitors
- glyoxylamide spla2
- glyoxylamide
- sub
- Prior art date
Links
- AWMLDBKLOPNOAR-UHFFFAOYSA-N indole-3-glyoxylamide Natural products C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 3
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 title 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22191694A | 1994-04-01 | 1994-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0675110T3 true DK0675110T3 (da) | 2002-10-07 |
Family
ID=22829963
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95302166T DK0675110T3 (da) | 1994-04-01 | 1995-03-31 | 1H-indol-3-glyoxylamid-sPLA2-inhibitorer |
DK08001265.1T DK1950200T3 (da) | 1994-04-01 | 1995-03-31 | [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08001265.1T DK1950200T3 (da) | 1994-04-01 | 1995-03-31 | [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR |
Country Status (29)
Country | Link |
---|---|
US (6) | US5654326A (da) |
EP (5) | EP1197484A2 (da) |
JP (1) | JP3109974B2 (da) |
KR (1) | KR100368707B1 (da) |
CN (1) | CN1067054C (da) |
AT (2) | ATE540923T1 (da) |
AU (1) | AU688458B2 (da) |
BR (1) | BR9501404A (da) |
CA (1) | CA2146097C (da) |
CO (1) | CO4370099A1 (da) |
CZ (1) | CZ82295A3 (da) |
DE (1) | DE69527322T2 (da) |
DK (2) | DK0675110T3 (da) |
ES (2) | ES2377223T3 (da) |
FI (1) | FI114793B (da) |
HU (1) | HUT72048A (da) |
IL (1) | IL113210A (da) |
MX (1) | MX9501608A (da) |
MY (1) | MY112897A (da) |
NO (1) | NO304186B1 (da) |
NZ (1) | NZ270848A (da) |
PE (1) | PE18696A1 (da) |
PL (1) | PL180523B1 (da) |
PT (1) | PT675110E (da) |
RU (1) | RU2128169C1 (da) |
SI (1) | SI0675110T1 (da) |
TW (1) | TW383302B (da) |
UA (1) | UA47387C2 (da) |
ZA (1) | ZA952693B (da) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY112897A (en) * | 1994-04-01 | 2001-10-31 | Lilly Co Eli | Ih-indole-3-glyoxylamide spla2 inhibitors |
JPH08193074A (ja) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | 除草性1−シクロプロピルテトラゾリノン類 |
US6043264A (en) * | 1995-01-06 | 2000-03-28 | Toray Industries, Inc. | Benzene-condensed heterocyclic derivatives and their uses |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
AU6229298A (en) * | 1997-02-20 | 1998-09-09 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
US5972988A (en) * | 1997-03-26 | 1999-10-26 | Eli Lilly And Company | Method for treatment of chronic bronchitis using indole compounds |
WO1998047507A1 (en) * | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
TW455581B (en) * | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
US6610728B2 (en) * | 1997-08-28 | 2003-08-26 | Eli Lilly And Company | Method for treatment of non-rheumatoid arthritis |
CA2308443A1 (en) * | 1997-10-27 | 1999-05-06 | Michael Lyle Denney | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
JP2001520991A (ja) * | 1997-10-27 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | インドールsPLA2阻害剤のN,N−ジエチルグリコールアミドエステルプロドラッグ |
WO1999021545A1 (en) * | 1997-10-27 | 1999-05-06 | Eli Lilly And Company | ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS |
WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
EP1039901A1 (en) * | 1997-11-14 | 2000-10-04 | Eli Lilly And Company | Treatment for alzheimer's disease |
WO1999025340A1 (en) * | 1997-11-14 | 1999-05-27 | Eli Lilly And Company | Treatment for alzheimer's disease |
NZ506329A (en) * | 1998-02-25 | 2004-01-30 | Inst Genetics Llc | Inhibitors of phospholipase enzymes |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
EP1058547B1 (en) * | 1998-03-03 | 2005-11-23 | Shionogi & Co., Ltd. | Pharmaceutical compositions containing the phospholipase inhibitor sodium 3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-phenylmethyl)-1h-indol-4-yl]oxy]acetate |
CN1303384A (zh) | 1998-03-31 | 2001-07-11 | 盐野义制药株式会社 | 吡咯并[1,2-a]吡嗪sPLA2抑制剂 |
CZ302588B6 (cs) * | 1998-04-02 | 2011-07-27 | Ziopharm Oncology, Inc. | Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva |
DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
EP1071661A4 (en) * | 1998-04-17 | 2001-08-22 | Lilly Co Eli | METHOD FOR PRODUCING 4-HYDROXYINDOL, INDAZOL AND CARBAZOL COMPOUNDS |
DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
DE69921314T2 (de) * | 1998-05-01 | 2006-02-09 | Eli Lilly And Co., Indianapolis | INHIBITORISCHE ESTER FÜR sPLA 2 |
HUP0102243A2 (hu) * | 1998-05-01 | 2001-10-28 | Eli Lilly And Co. | sPLA2-inhibitor vegyületek betegség kezelésére |
US6472389B1 (en) | 1998-05-21 | 2002-10-29 | Shionogi & Co., Ltd. | Pyrrolo[1,2-b] pyridazine derivatives having sPLA2 inhibitory effect |
EP1100492B1 (en) * | 1998-08-03 | 2006-05-24 | Eli Lilly & Company | INDOLE sPLA2 INHIBITORS |
AU5331499A (en) * | 1998-08-03 | 2000-02-28 | Eli Lilly And Company | Indole spla2 inhibitors |
US6325991B1 (en) | 1998-08-24 | 2001-12-04 | Susan E. Draheim | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 |
US6576654B1 (en) | 1998-09-23 | 2003-06-10 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
DZ2771A1 (fr) * | 1998-10-09 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
CA2346334A1 (en) | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Composition for treating or preventing ischemia reperfusion injury |
US20030149000A1 (en) * | 1998-11-10 | 2003-08-07 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds |
WO2000037022A2 (en) * | 1998-12-21 | 2000-06-29 | Eli Lilly And Company | Combination therapy for the treatment of sepsis |
WO2000037358A1 (en) * | 1998-12-22 | 2000-06-29 | Eli Lilly And Company | NOVEL sPLA2 INHIBITORS |
AU1928800A (en) * | 1998-12-22 | 2000-07-12 | Eli Lilly And Company | Substituted tricyclics |
US6380397B1 (en) | 1999-04-15 | 2002-04-30 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
US6274578B1 (en) | 1999-04-20 | 2001-08-14 | Eli Lilly And Company | sPLA2 inhibitor ester |
US6140327A (en) * | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
CA2379208A1 (en) * | 1999-07-19 | 2001-01-25 | Eli Lilly & Company | Spla2 inhibitors |
US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
US6703385B1 (en) | 1999-07-19 | 2004-03-09 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
WO2001009130A1 (fr) | 1999-08-02 | 2001-02-08 | Shionogi & Co., Ltd. | COMPOSES TRICYCLIQUES A ACTIVITES INHIBANT sPLA¿2? |
JP4623483B2 (ja) | 1999-08-23 | 2011-02-02 | 塩野義製薬株式会社 | sPLA2阻害作用を有するピロロトリアジン誘導体 |
US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
JP2003509491A (ja) * | 1999-09-20 | 2003-03-11 | イーライ・リリー・アンド・カンパニー | 新規なsPLA2インヒビター |
AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
AU1304801A (en) | 1999-11-15 | 2001-05-30 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect |
AU2252201A (en) * | 1999-12-16 | 2001-06-25 | Eli Lilly And Company | Carbon monoxide-based synthesis of spla2 inhibitors |
AU2050001A (en) * | 1999-12-16 | 2001-06-25 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
EP1259260A1 (en) * | 2000-01-06 | 2002-11-27 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
US20030096854A1 (en) * | 2002-06-12 | 2003-05-22 | Ho-Shen Lin | Substituted tricyclics |
EP1248769A2 (en) * | 2000-01-07 | 2002-10-16 | Eli Lilly And Company | Carbazole derivatives as inhibitors of spla2 |
EP1265607A2 (en) * | 2000-03-09 | 2002-12-18 | Eli Lilly And Company | METHOD FOR THE TREATMENT OF RENAL DYSFUNCTION WITH sPLA 2 INHIBITORS |
BR0002188A (pt) * | 2000-03-30 | 2001-11-13 | Brasil Compressores Sa | Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas |
WO2001081306A2 (en) * | 2000-04-19 | 2001-11-01 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
AU2001267823A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
AU2001267826A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for alzheimer's disease |
WO2002000255A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre le cancer |
WO2002005796A2 (en) * | 2000-07-14 | 2002-01-24 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
AU2001280461A1 (en) * | 2000-08-04 | 2002-02-18 | Eli Lilly And Company | Substituted pyrrole compounds and their use as spla2 inhibitors |
EP1358156B1 (en) | 2000-12-18 | 2007-02-21 | Eli Lilly And Company | Benz(g) indoles and their use as spla2 inhibitors |
TWI314457B (da) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
US6903104B2 (en) | 2001-12-06 | 2005-06-07 | National Health Research Institutes | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
MX2008005664A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de indol que tienen sustituyentes c4-acidos y uso de los mismos como inhibidores de fosfolipasa a2. |
JP2009517341A (ja) * | 2005-11-03 | 2009-04-30 | イリプサ, インコーポレイテッド | C4−アミド置換基を有するインドール化合物およびホスホリパーゼa2インヒビターとしてのその使用 |
MX2008005662A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de azaindol y uso de los mismos como inhibidores de la fosfolipasa a2. |
MX2008005666A (es) | 2005-11-03 | 2009-03-02 | Ilypsa Inc | Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2. |
US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
CN102015656A (zh) * | 2008-04-28 | 2011-04-13 | 旭化成制药株式会社 | 苯丙酸衍生物及其用途 |
WO2010081022A1 (en) * | 2009-01-08 | 2010-07-15 | Anthera Pharmaceuticals, Inc. | Secretory phospholipase a2 (spla2) inhibitor and niacin drug compositions and methods for treating cardiovascular disease and dyslipidemia |
NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
CN101838232B (zh) * | 2009-07-07 | 2012-02-22 | 爱斯医药科技(南京)有限公司 | Varespladib的制备方法 |
MA40998A (fr) | 2014-11-21 | 2017-09-26 | Ophirex Inc | Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés |
US10894035B2 (en) * | 2015-08-31 | 2021-01-19 | Diaccurate | Use of indole compounds to stimulate the immune system |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2825734A (en) | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
US2825743A (en) | 1955-08-30 | 1958-03-04 | Celanese Corp | Catalytic hydrogenation of unsaturated aldehydes and ketones |
US3242163A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
GB1089071A (en) | 1964-02-28 | 1967-11-01 | Merck & Co Inc | Indole derivatives |
NL287416A (da) | 1964-04-25 | |||
US3449363A (en) | 1966-12-22 | 1969-06-10 | American Cyanamid Co | 3-substituted 4-trifluoromethyl indoles |
IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
US3691194A (en) * | 1970-07-30 | 1972-09-12 | Little Inc A | 3-indole-glyoxamides |
US3686213A (en) | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
US4012513A (en) * | 1971-11-03 | 1977-03-15 | Imperial Chemical Industries Limited | Indole derivatives for providing analgesic and anti-inflammatory effects |
US4397850A (en) | 1981-10-07 | 1983-08-09 | Sandoz, Inc. | Isoxazolyl indolamines |
US4552876A (en) * | 1984-07-09 | 1985-11-12 | Usv Pharmaceutical Corp. | Bisbenzoxazines and pharmaceutical use |
US4792555A (en) * | 1987-03-20 | 1988-12-20 | American Home Products Corporation | Phospholipase A2 inhibitors |
NZ234883A (en) * | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
US5334719A (en) * | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
MY112897A (en) | 1994-04-01 | 2001-10-31 | Lilly Co Eli | Ih-indole-3-glyoxylamide spla2 inhibitors |
US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
SK77598A3 (en) | 1995-12-14 | 1999-01-11 | Merck & Co Inc | Nonpeptide derivatives, pharmaceutical composition containing them and their use |
WO1997021704A1 (en) * | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2001520991A (ja) * | 1997-10-27 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | インドールsPLA2阻害剤のN,N−ジエチルグリコールアミドエステルプロドラッグ |
-
1995
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 FI FI951553A patent/FI114793B/fi not_active IP Right Cessation
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
-
1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
- 1997-12-16 US US08/991,149 patent/US5919943A/en not_active Expired - Lifetime
-
1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
-
2000
- 2000-11-16 US US09/714,364 patent/US6433001B1/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE220394T1 (de) | 1h-indol-3-glyoxylamid spla2 inhibitoren | |
IL130338A0 (en) | Pyrroles as sPLA2 inhibitors | |
RU94012931A (ru) | Гидразиды 1н-индол-3-уксусной кислоты как ингибиторы spla2 | |
YU20194A (sh) | 1H-INDOL-3-ACETAMIDI KAO INHIBITORI s PLA2 | |
ATE203744T1 (de) | Naphthyl-acetamide als spla2-inhibitoren | |
EP1100492A4 (en) | SPLA 2 INHIBITORS? INDOLE TYPE | |
DE69720034T2 (de) | PHENYLGLYOXAMIDE ALS sPLA2-INHIBITOREN | |
DE69910432D1 (de) | Substituierte pyrroloindole | |
DE60032774D1 (de) | Spla2 inhibitoren | |
AU7053700A (en) | Novel spla2 inhibitors |