DE69720034T2 - PHENYLGLYOXAMIDE ALS sPLA2-INHIBITOREN - Google Patents
PHENYLGLYOXAMIDE ALS sPLA2-INHIBITORENInfo
- Publication number
- DE69720034T2 DE69720034T2 DE69720034T DE69720034T DE69720034T2 DE 69720034 T2 DE69720034 T2 DE 69720034T2 DE 69720034 T DE69720034 T DE 69720034T DE 69720034 T DE69720034 T DE 69720034T DE 69720034 T2 DE69720034 T2 DE 69720034T2
- Authority
- DE
- Germany
- Prior art keywords
- phenylglyoxamides
- spla2 inhibitors
- spla2
- inhibitors
- class
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 title abstract 2
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3250996P | 1996-12-03 | 1996-12-03 | |
| PCT/US1997/021434 WO1998024794A1 (en) | 1996-12-03 | 1997-11-25 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69720034D1 DE69720034D1 (de) | 2003-04-24 |
| DE69720034T2 true DE69720034T2 (de) | 2003-12-04 |
Family
ID=21865305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69720034T Expired - Fee Related DE69720034T2 (de) | 1996-12-03 | 1997-11-25 | PHENYLGLYOXAMIDE ALS sPLA2-INHIBITOREN |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5916922A (de) |
| EP (1) | EP0944636B1 (de) |
| JP (1) | JP2001505882A (de) |
| KR (1) | KR20000069249A (de) |
| AT (1) | ATE234850T1 (de) |
| AU (1) | AU5454498A (de) |
| BR (1) | BR9713562A (de) |
| CA (1) | CA2274019A1 (de) |
| DE (1) | DE69720034T2 (de) |
| ES (1) | ES2195182T3 (de) |
| HU (1) | HUP9904218A2 (de) |
| IL (1) | IL130201A0 (de) |
| WO (1) | WO1998024794A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-ａ]피라진 ｓＰＬＡ2 억제제 |
| JP4544446B2 (ja) | 1998-05-21 | 2010-09-15 | 塩野義製薬株式会社 | ｓＰＬＡ２阻害作用を有するピロロ［１，２−ｂ］ピリダジン誘導体 |
| DE69934311D1 (de) | 1998-06-30 | 2007-01-18 | Lilly Co Eli | BICYCLISCHE sPLA 2-INHIBITOREN |
| DE69931963D1 (de) | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| WO2001005789A1 (fr) | 1999-07-19 | 2001-01-25 | Shionogi & Co., Ltd. | Composes tricycliques a action inhibitrice a l'encontre de spla¿2? |
| AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
| WO2002000621A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Composes inhibiteurs de la spla2 de type x |
| TWI314457B (de) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| EP3791880A1 (de) | 2009-04-29 | 2021-03-17 | Amarin Pharmaceuticals Ireland Limited | Pharmazeutische zusammensetzungen enthaltend epa |
| CN102631449B (zh) * | 2012-05-18 | 2013-09-11 | 崔新明 | 一种治疗急性胰腺炎的中药组合物 |
| IT201800003040A1 (it) * | 2018-02-26 | 2019-08-26 | Univ Pisa | Nuovi attivatori dell’enzima SIRT1 per il trattamento delle patologie cardiovascolari e cardiometaboliche |
| CN110845345B (zh) * | 2019-11-26 | 2021-11-09 | 中国科学院长春应用化学研究所 | 一种芳香型二胺单体及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2708184C3 (de) * | 1977-02-25 | 1980-02-07 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Verfahren zur Herstellung von a -Ketocarbonsäureamide!! (A) |
| DE2733181B2 (de) * | 1977-07-22 | 1979-08-30 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Verfahren zur Herstellung von N-substituierten a -Ketocarbonsäureamiden |
| RU2059603C1 (ru) * | 1991-05-09 | 1996-05-10 | Хоффманн-Ля Рош АГ | ПРОИЗВОДНЫЕ α -ЗАМЕЩЕННЫХ АРИЛУКСУСНЫХ КИСЛОТ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
| US5352690A (en) * | 1992-07-01 | 1994-10-04 | Eli Lilly And Company | 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists |
| ATE203744T1 (de) * | 1995-12-13 | 2001-08-15 | Lilly Co Eli | Naphthyl-acetamide als spla2-inhibitoren |
-
1997
- 1997-11-24 US US08/979,446 patent/US5916922A/en not_active Expired - Fee Related
- 1997-11-25 JP JP52563398A patent/JP2001505882A/ja not_active Ceased
- 1997-11-25 ES ES97948480T patent/ES2195182T3/es not_active Expired - Lifetime
- 1997-11-25 EP EP97948480A patent/EP0944636B1/de not_active Expired - Lifetime
- 1997-11-25 HU HU9904218A patent/HUP9904218A2/hu unknown
- 1997-11-25 WO PCT/US1997/021434 patent/WO1998024794A1/en active IP Right Grant
- 1997-11-25 DE DE69720034T patent/DE69720034T2/de not_active Expired - Fee Related
- 1997-11-25 AT AT97948480T patent/ATE234850T1/de not_active IP Right Cessation
- 1997-11-25 BR BR9713562-3A patent/BR9713562A/pt not_active IP Right Cessation
- 1997-11-25 KR KR1019997004848A patent/KR20000069249A/ko not_active Application Discontinuation
- 1997-11-25 IL IL13020197A patent/IL130201A0/xx unknown
- 1997-11-25 CA CA002274019A patent/CA2274019A1/en not_active Abandoned
- 1997-11-25 AU AU54544/98A patent/AU5454498A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5916922A (en) | 1999-06-29 |
| KR20000069249A (ko) | 2000-11-25 |
| WO1998024794A1 (en) | 1998-06-11 |
| CA2274019A1 (en) | 1998-06-11 |
| JP2001505882A (ja) | 2001-05-08 |
| ES2195182T3 (es) | 2003-12-01 |
| EP0944636A4 (de) | 2000-07-12 |
| AU5454498A (en) | 1998-06-29 |
| ATE234850T1 (de) | 2003-04-15 |
| DE69720034D1 (de) | 2003-04-24 |
| BR9713562A (pt) | 2001-06-19 |
| HUP9904218A2 (hu) | 2000-05-28 |
| IL130201A0 (en) | 2000-06-01 |
| EP0944636A1 (de) | 1999-09-29 |
| EP0944636B1 (de) | 2003-03-19 |
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| DE69720034T2 (de) | PHENYLGLYOXAMIDE ALS sPLA2-INHIBITOREN | |
| ATE203744T1 (de) | Naphthyl-acetamide als spla2-inhibitoren | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |