ES2160897T3 - Pirazoles como inhibidores de la secretora fosfolipasa a2 humana no pancreatica. - Google Patents
Pirazoles como inhibidores de la secretora fosfolipasa a2 humana no pancreatica.Info
- Publication number
- ES2160897T3 ES2160897T3 ES97309701T ES97309701T ES2160897T3 ES 2160897 T3 ES2160897 T3 ES 2160897T3 ES 97309701 T ES97309701 T ES 97309701T ES 97309701 T ES97309701 T ES 97309701T ES 2160897 T3 ES2160897 T3 ES 2160897T3
- Authority
- ES
- Spain
- Prior art keywords
- pirazoles
- secretora
- phosfolipasa
- pancreatica
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCUBRE UNA CLASE DE NUEVOS PIRAZOLES JUNTO CON EL USO DE DICHOS COMPUESTOS PARA LA INHIBICION DE LA LIBERACION MEDIADA POR PLA{SUB,2} DE ACIDOS GRASOS PARA EL TRATAMIENTO DE ESTADOS TALES COMO EL CHOQUE SEPTICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3321696P | 1996-12-04 | 1996-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160897T3 true ES2160897T3 (es) | 2001-11-16 |
Family
ID=21869147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97309701T Expired - Lifetime ES2160897T3 (es) | 1996-12-04 | 1997-12-02 | Pirazoles como inhibidores de la secretora fosfolipasa a2 humana no pancreatica. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5972972A (es) |
EP (1) | EP0846687B1 (es) |
JP (1) | JP2002515053A (es) |
KR (1) | KR20000057366A (es) |
AR (1) | AR010743A1 (es) |
AT (1) | ATE203985T1 (es) |
AU (1) | AU5365598A (es) |
BR (1) | BR9713993A (es) |
CA (1) | CA2274048A1 (es) |
CO (1) | CO4910169A1 (es) |
DE (1) | DE69706027T2 (es) |
DK (1) | DK0846687T3 (es) |
ES (1) | ES2160897T3 (es) |
HK (1) | HK1011865A1 (es) |
HU (1) | HUP0000292A3 (es) |
ID (1) | ID18983A (es) |
IL (1) | IL130202A0 (es) |
PE (1) | PE20599A1 (es) |
PT (1) | PT846687E (es) |
TW (1) | TW432051B (es) |
WO (1) | WO1998024437A1 (es) |
ZA (1) | ZA9710878B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
EP1019394A1 (en) | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
HUP0102981A3 (en) | 1998-03-31 | 2002-10-28 | Shionogi & Co | Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof |
AU748787B2 (en) | 1998-05-21 | 2002-06-13 | Shionogi & Co., Ltd. | Pyrrolo(1,2-b)pyridazine derivatives having sPLA2 inhibitory effect |
EP1157704B1 (en) | 1998-10-14 | 2006-06-14 | Shionogi & Co., Ltd. | Spla2 inhibitors for the treatment of ischaemic reperfusion injury |
US6703385B1 (en) | 1999-07-19 | 2004-03-09 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
US6673781B1 (en) | 1999-08-02 | 2004-01-06 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
ES2171116B1 (es) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
AU2001267825A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
AU2001267823A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
TWI314457B (es) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US7076539B2 (en) * | 2001-07-30 | 2006-07-11 | Hewlett-Packard Development Company, L.P. | Network connectivity establishment at user log-in |
US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
WO2004002296A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
BRPI0906577A2 (pt) * | 2008-01-25 | 2019-09-24 | Syngenta Partcipations Ag | compostos químicos |
US11033523B2 (en) | 2009-04-29 | 2021-06-15 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising EPA and a cardiovascular agent and methods of using the same |
CN105017134A (zh) * | 2015-07-26 | 2015-11-04 | 陈吉美 | 一种4-吡啶丙烯酸的制备方法 |
SG11202006614VA (en) | 2018-02-15 | 2020-08-28 | Vertex Pharma | Macrocycles as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cycstic fibrosis, and process for making them |
JP2022544383A (ja) | 2019-08-14 | 2022-10-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cftrモジュレータの結晶形態 |
TW202120517A (zh) | 2019-08-14 | 2021-06-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
TW202115092A (zh) | 2019-08-14 | 2021-04-16 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
WO2022076628A1 (en) * | 2020-10-07 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3616681A1 (de) * | 1986-05-16 | 1987-11-19 | Bayer Ag | 1-aralkylpyrazole |
JPH02229169A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
JPH02229168A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
ATE157969T1 (de) * | 1990-07-10 | 1997-09-15 | Ishihara Sangyo Kaisha | Diaminotrifluoromethylpyrimidinderivate, verfahren zu ihrer herstellung und diese enthaltende phospholipase-a2-inhibitoren |
EP0539034A1 (en) * | 1991-10-22 | 1993-04-28 | Konica Corporation | A novel photographic cyan coupler |
US5541213A (en) * | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
US5500439A (en) * | 1993-12-09 | 1996-03-19 | Alteon Inc. | Aminopyrazoles |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1997
- 1997-11-27 ID IDP973793A patent/ID18983A/id unknown
- 1997-12-01 HU HU0000292A patent/HUP0000292A3/hu unknown
- 1997-12-01 AU AU53655/98A patent/AU5365598A/en not_active Abandoned
- 1997-12-01 BR BR9713993-9A patent/BR9713993A/pt unknown
- 1997-12-01 IL IL13020297A patent/IL130202A0/xx unknown
- 1997-12-01 JP JP52568198A patent/JP2002515053A/ja not_active Withdrawn
- 1997-12-01 KR KR1019990704898A patent/KR20000057366A/ko not_active Application Discontinuation
- 1997-12-01 WO PCT/US1997/021795 patent/WO1998024437A1/en not_active Application Discontinuation
- 1997-12-01 CA CA002274048A patent/CA2274048A1/en not_active Abandoned
- 1997-12-01 PE PE1997001083A patent/PE20599A1/es not_active Application Discontinuation
- 1997-12-02 EP EP97309701A patent/EP0846687B1/en not_active Expired - Lifetime
- 1997-12-02 CO CO97070453A patent/CO4910169A1/es unknown
- 1997-12-02 ES ES97309701T patent/ES2160897T3/es not_active Expired - Lifetime
- 1997-12-02 PT PT97309701T patent/PT846687E/pt unknown
- 1997-12-02 DE DE69706027T patent/DE69706027T2/de not_active Expired - Fee Related
- 1997-12-02 AT AT97309701T patent/ATE203985T1/de not_active IP Right Cessation
- 1997-12-02 DK DK97309701T patent/DK0846687T3/da active
- 1997-12-03 US US08/984,261 patent/US5972972A/en not_active Expired - Fee Related
- 1997-12-03 AR ARP970105678A patent/AR010743A1/es unknown
- 1997-12-03 ZA ZA9710878A patent/ZA9710878B/xx unknown
- 1997-12-05 TW TW086118237A patent/TW432051B/zh not_active IP Right Cessation
-
1998
- 1998-12-10 HK HK98113166A patent/HK1011865A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2274048A1 (en) | 1998-06-11 |
US5972972A (en) | 1999-10-26 |
CO4910169A1 (es) | 2000-04-24 |
BR9713993A (pt) | 2000-02-08 |
AR010743A1 (es) | 2000-07-12 |
IL130202A0 (en) | 2000-06-01 |
TW432051B (en) | 2001-05-01 |
WO1998024437A1 (en) | 1998-06-11 |
DK0846687T3 (da) | 2001-10-08 |
PT846687E (pt) | 2001-12-28 |
ID18983A (id) | 1998-05-28 |
ZA9710878B (en) | 1999-06-03 |
JP2002515053A (ja) | 2002-05-21 |
DE69706027T2 (de) | 2002-03-14 |
EP0846687B1 (en) | 2001-08-08 |
ATE203985T1 (de) | 2001-08-15 |
KR20000057366A (ko) | 2000-09-15 |
HUP0000292A2 (hu) | 2001-04-28 |
DE69706027D1 (de) | 2001-09-13 |
AU5365598A (en) | 1998-06-29 |
PE20599A1 (es) | 1999-03-05 |
HK1011865A1 (en) | 1999-07-23 |
HUP0000292A3 (en) | 2002-01-28 |
EP0846687A1 (en) | 1998-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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