ZA9710878B - Pyrazoles as human non-pancreatic secretary phospholipase A2 inhibitors - Google Patents
Pyrazoles as human non-pancreatic secretary phospholipase A2 inhibitorsInfo
- Publication number
- ZA9710878B ZA9710878B ZA9710878A ZA9710878A ZA9710878B ZA 9710878 B ZA9710878 B ZA 9710878B ZA 9710878 A ZA9710878 A ZA 9710878A ZA 9710878 A ZA9710878 A ZA 9710878A ZA 9710878 B ZA9710878 B ZA 9710878B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazoles
- pancreatic
- inhibitors
- human non
- secretary
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3321696P | 1996-12-04 | 1996-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA9710878B true ZA9710878B (en) | 1999-06-03 |
Family
ID=21869147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9710878A ZA9710878B (en) | 1996-12-04 | 1997-12-03 | Pyrazoles as human non-pancreatic secretary phospholipase A2 inhibitors |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5972972A (es) |
| EP (1) | EP0846687B1 (es) |
| JP (1) | JP2002515053A (es) |
| KR (1) | KR20000057366A (es) |
| AR (1) | AR010743A1 (es) |
| AT (1) | ATE203985T1 (es) |
| AU (1) | AU5365598A (es) |
| BR (1) | BR9713993A (es) |
| CA (1) | CA2274048A1 (es) |
| CO (1) | CO4910169A1 (es) |
| DE (1) | DE69706027T2 (es) |
| DK (1) | DK0846687T3 (es) |
| ES (1) | ES2160897T3 (es) |
| HK (1) | HK1011865A1 (es) |
| HU (1) | HUP0000292A3 (es) |
| ID (1) | ID18983A (es) |
| IL (1) | IL130202A0 (es) |
| PE (1) | PE20599A1 (es) |
| PT (1) | PT846687E (es) |
| TW (1) | TW432051B (es) |
| WO (1) | WO1998024437A1 (es) |
| ZA (1) | ZA9710878B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6087381A (en) * | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-ａ]피라진 ｓＰＬＡ2 억제제 |
| JP4544446B2 (ja) | 1998-05-21 | 2010-09-15 | 塩野義製薬株式会社 | ｓＰＬＡ２阻害作用を有するピロロ［１，２−ｂ］ピリダジン誘導体 |
| DE69931963D1 (de) | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| WO2001005789A1 (fr) | 1999-07-19 | 2001-01-25 | Shionogi & Co., Ltd. | Composes tricycliques a action inhibitrice a l'encontre de spla¿2? |
| AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
| ES2171116B1 (es) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
| WO2002000621A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Composes inhibiteurs de la spla2 de type x |
| US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
| TWI314457B (es) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US7076539B2 (en) * | 2001-07-30 | 2006-07-11 | Hewlett-Packard Development Company, L.P. | Network connectivity establishment at user log-in |
| US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| US20050014158A1 (en) * | 2002-06-27 | 2005-01-20 | Adam Gail Isabel Reid | Therapeutic methods for reducing fat deposition and treating associated conditions |
| WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
| CN102924412A (zh) * | 2008-01-25 | 2013-02-13 | 先正达参股股份有限公司 | 用作杀虫剂的2-氰基苯基磺酰胺衍生物 |
| EP3791880A1 (en) | 2009-04-29 | 2021-03-17 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa |
| CN105017134A (zh) * | 2015-07-26 | 2015-11-04 | 陈吉美 | 一种4-吡啶丙烯酸的制备方法 |
| PL3752510T3 (pl) | 2018-02-15 | 2023-05-08 | Vertex Pharmaceuticals Incorporated | Makrocykle jako modulatory mukowiscydozowego przezbłonowego regulatora przewodnictwa, ich kompozycje farmaceutyczne, ich zastosowanie w leczeniu mukowiscydozy oraz proces ich wytwarzania |
| KR20220064366A (ko) | 2019-08-14 | 2022-05-18 | 버텍스 파마슈티칼스 인코포레이티드 | Cftr 조절제의 결정질 형태 |
| TW202120517A (zh) | 2019-08-14 | 2021-06-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| TW202115092A (zh) | 2019-08-14 | 2021-04-16 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| WO2022076628A1 (en) * | 2020-10-07 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3616681A1 (de) * | 1986-05-16 | 1987-11-19 | Bayer Ag | 1-aralkylpyrazole |
| JPH02229168A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
| JPH02229169A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
| ES2107434T3 (es) * | 1990-07-10 | 1997-12-01 | Ishihara Sangyo Kaisha | Derivados de diaminotrifluorometilpirimidina, su procedimiento de produccion e inhibidores de a2 fosfolipasa que los contiene. |
| EP0539034A1 (en) * | 1991-10-22 | 1993-04-28 | Konica Corporation | A novel photographic cyan coupler |
| US5541213A (en) * | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5500439A (en) * | 1993-12-09 | 1996-03-19 | Alteon Inc. | Aminopyrazoles |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1997
- 1997-11-27 ID IDP973793A patent/ID18983A/id unknown
- 1997-12-01 WO PCT/US1997/021795 patent/WO1998024437A1/en not_active Application Discontinuation
- 1997-12-01 AU AU53655/98A patent/AU5365598A/en not_active Abandoned
- 1997-12-01 PE PE1997001083A patent/PE20599A1/es not_active Application Discontinuation
- 1997-12-01 IL IL13020297A patent/IL130202A0/xx unknown
- 1997-12-01 KR KR1019990704898A patent/KR20000057366A/ko not_active Application Discontinuation
- 1997-12-01 CA CA002274048A patent/CA2274048A1/en not_active Abandoned
- 1997-12-01 HU HU0000292A patent/HUP0000292A3/hu unknown
- 1997-12-01 JP JP52568198A patent/JP2002515053A/ja not_active Withdrawn
- 1997-12-01 BR BR9713993-9A patent/BR9713993A/pt unknown
- 1997-12-02 EP EP97309701A patent/EP0846687B1/en not_active Expired - Lifetime
- 1997-12-02 DE DE69706027T patent/DE69706027T2/de not_active Expired - Fee Related
- 1997-12-02 CO CO97070453A patent/CO4910169A1/es unknown
- 1997-12-02 AT AT97309701T patent/ATE203985T1/de not_active IP Right Cessation
- 1997-12-02 DK DK97309701T patent/DK0846687T3/da active
- 1997-12-02 ES ES97309701T patent/ES2160897T3/es not_active Expired - Lifetime
- 1997-12-02 PT PT97309701T patent/PT846687E/pt unknown
- 1997-12-03 US US08/984,261 patent/US5972972A/en not_active Expired - Fee Related
- 1997-12-03 ZA ZA9710878A patent/ZA9710878B/xx unknown
- 1997-12-03 AR ARP970105678A patent/AR010743A1/es unknown
- 1997-12-05 TW TW086118237A patent/TW432051B/zh not_active IP Right Cessation
-
1998
- 1998-12-10 HK HK98113166A patent/HK1011865A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW432051B (en) | 2001-05-01 |
| AR010743A1 (es) | 2000-07-12 |
| DE69706027D1 (de) | 2001-09-13 |
| HUP0000292A2 (hu) | 2001-04-28 |
| EP0846687B1 (en) | 2001-08-08 |
| HK1011865A1 (en) | 1999-07-23 |
| ES2160897T3 (es) | 2001-11-16 |
| HUP0000292A3 (en) | 2002-01-28 |
| IL130202A0 (en) | 2000-06-01 |
| JP2002515053A (ja) | 2002-05-21 |
| ATE203985T1 (de) | 2001-08-15 |
| DK0846687T3 (da) | 2001-10-08 |
| AU5365598A (en) | 1998-06-29 |
| EP0846687A1 (en) | 1998-06-10 |
| WO1998024437A1 (en) | 1998-06-11 |
| CA2274048A1 (en) | 1998-06-11 |
| PT846687E (pt) | 2001-12-28 |
| PE20599A1 (es) | 1999-03-05 |
| BR9713993A (pt) | 2000-02-08 |
| CO4910169A1 (es) | 2000-04-24 |
| DE69706027T2 (de) | 2002-03-14 |
| KR20000057366A (ko) | 2000-09-15 |
| US5972972A (en) | 1999-10-26 |
| ID18983A (id) | 1998-05-28 |
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