ATE350367T1 - Spla2 inhibitoren - Google Patents

Spla2 inhibitoren

Info

Publication number
ATE350367T1
ATE350367T1 AT00944673T AT00944673T ATE350367T1 AT E350367 T1 ATE350367 T1 AT E350367T1 AT 00944673 T AT00944673 T AT 00944673T AT 00944673 T AT00944673 T AT 00944673T AT E350367 T1 ATE350367 T1 AT E350367T1
Authority
AT
Austria
Prior art keywords
spla2 inhibitors
class
compounds
treatment
fatty acids
Prior art date
Application number
AT00944673T
Other languages
English (en)
Inventor
Ho-Shen Lin
Michael Enrico Richett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE350367T1 publication Critical patent/ATE350367T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT00944673T 1999-07-19 2000-07-11 Spla2 inhibitoren ATE350367T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14450299P 1999-07-19 1999-07-19

Publications (1)

Publication Number Publication Date
ATE350367T1 true ATE350367T1 (de) 2007-01-15

Family

ID=22508894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00944673T ATE350367T1 (de) 1999-07-19 2000-07-11 Spla2 inhibitoren

Country Status (7)

Country Link
EP (1) EP1202963B1 (de)
JP (1) JP2003505372A (de)
AT (1) ATE350367T1 (de)
AU (1) AU5873400A (de)
CA (1) CA2379208A1 (de)
DE (1) DE60032774D1 (de)
WO (1) WO2001005761A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001066111A1 (en) * 2000-03-09 2001-09-13 Eli Lilly And Company Compositions containing potential spla2 inhibitors for the treatment of pain
AU2002237655A1 (en) * 2000-12-18 2002-07-01 Eli Lilly And Company Substituted benzoindoles as spla2 inhibitors
JP2009514893A (ja) 2005-11-03 2009-04-09 イリプサ， インコーポレイテッド 多価インドール化合物およびホスホリパーゼａ２インヒビターとしてのその使用
US20090306171A1 (en) * 2005-11-03 2009-12-10 Han-Ting Chang Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors
GB201014633D0 (en) * 2010-09-02 2010-10-13 Avexxin As Rheumatoid arthritis treatment
GB201604316D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
EP3515422A1 (de) 2016-09-21 2019-07-31 Avexxin AS Pharmazeutische zusammensetzung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
MX9501608A (es) * 1994-04-01 1997-02-28 Lilly Co Eli 1h-indol-3-glioxilamidas inhibidoras de spla2.
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
EP1030661A4 (de) * 1997-10-27 2002-07-17 Lilly Co Eli N,n-diethylglycolamidoester des indols als medikamentvorstufen von spla 2 inhibitoren
DE69830335T2 (de) * 1997-10-27 2006-02-02 Eli Lilly And Co., Indianapolis MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
AU2373600A (en) * 1998-12-22 2000-07-12 Eli Lilly And Company Novel spla2 inhibitors

Also Published As

Publication number Publication date
WO2001005761A1 (en) 2001-01-25
EP1202963A1 (de) 2002-05-08
DE60032774D1 (de) 2007-02-15
AU5873400A (en) 2001-02-05
EP1202963B1 (de) 2007-01-03
JP2003505372A (ja) 2003-02-12
CA2379208A1 (en) 2001-01-25

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties