ES2139093T3 - Antimicrobianos del tipo de oxazin- y tiazin-oxazolidinonas sustituidas. - Google Patents
Antimicrobianos del tipo de oxazin- y tiazin-oxazolidinonas sustituidas.Info
- Publication number
- ES2139093T3 ES2139093T3 ES94925765T ES94925765T ES2139093T3 ES 2139093 T3 ES2139093 T3 ES 2139093T3 ES 94925765 T ES94925765 T ES 94925765T ES 94925765 T ES94925765 T ES 94925765T ES 2139093 T3 ES2139093 T3 ES 2139093T3
- Authority
- ES
- Spain
- Prior art keywords
- c8alkoxy
- spp
- mycobacterium
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000004599 antimicrobial Substances 0.000 title abstract 2
- -1 C1-C8alkoxy Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 abstract 1
- 241001148536 Bacteroides sp. Species 0.000 abstract 1
- 241001112696 Clostridia Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 241000186367 Mycobacterium avium Species 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 241001148470 aerobic bacillus Species 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11927993A | 1993-09-09 | 1993-09-09 | |
| US22615894A | 1994-04-11 | 1994-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2139093T3 true ES2139093T3 (es) | 2000-02-01 |
Family
ID=26817181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94925765T Expired - Lifetime ES2139093T3 (es) | 1993-09-09 | 1994-08-16 | Antimicrobianos del tipo de oxazin- y tiazin-oxazolidinonas sustituidas. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0717738B1 (https=) |
| JP (1) | JP3176630B2 (https=) |
| KR (1) | KR100301269B1 (https=) |
| CN (1) | CN1057087C (https=) |
| AT (1) | ATE185804T1 (https=) |
| AU (1) | AU687866B2 (https=) |
| CA (1) | CA2168560C (https=) |
| DE (2) | DE69421285T2 (https=) |
| DK (1) | DK0717738T3 (https=) |
| ES (1) | ES2139093T3 (https=) |
| GR (1) | GR3031809T3 (https=) |
| IL (1) | IL110802A (https=) |
| LV (1) | LV12605B (https=) |
| MY (1) | MY115155A (https=) |
| NL (1) | NL300079I1 (https=) |
| NZ (1) | NZ271805A (https=) |
| PH (1) | PH31634A (https=) |
| SI (1) | SI0717738T1 (https=) |
| TW (1) | TW293817B (https=) |
| WO (1) | WO1995007271A1 (https=) |
Families Citing this family (241)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT792273E (pt) * | 1994-11-15 | 2003-06-30 | Upjohn Co | Produtos antibacterianos de oxazolidinona substituida com oxazina e tiazina biciclicas |
| ATE205205T1 (de) * | 1995-02-03 | 2001-09-15 | Upjohn Co | Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel |
| DE69614847T2 (de) * | 1995-05-11 | 2002-04-04 | Pharmacia & Upjohn Co., Kalamazoo | Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone |
| DE69631347T2 (de) * | 1995-09-15 | 2004-10-07 | Upjohn Co | Aminoaryl oxazolidinone n-oxide |
| AU6902096A (en) * | 1995-09-15 | 1997-04-01 | Pharmacia & Upjohn Company | 5-amidomethyl alpha, beta-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| GB9604301D0 (en) * | 1996-02-29 | 1996-05-01 | Zeneca Ltd | Chemical compounds |
| DK1114819T3 (da) * | 1996-04-11 | 2008-04-14 | Pharmacia & Upjohn Co Llc | Fremgangsmåde til fremstilling af oxazolidinoner |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| DE19709443C1 (de) * | 1997-03-07 | 1998-10-08 | Clariant Gmbh | Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen und N-Carboxymethyl-3-fluor-4-morpholinoanilin und N-Carboxyisobutyl-3-fluor-4-morpholinoanilin |
| SK156499A3 (en) * | 1997-05-30 | 2000-06-12 | Upjohn Co | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| US6255304B1 (en) | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| EP1772453A1 (en) * | 1997-11-07 | 2007-04-11 | Pharmacia & Upjohn Company LLC | Process to produce Oxazolidinones |
| GB9725244D0 (en) * | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| BR9907183A (pt) * | 1998-01-23 | 2003-06-10 | Versicor Inc | Colet neas combinatórias de oxazolidinona, composições e processos de preparação |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| JP2002503655A (ja) * | 1998-02-13 | 2002-02-05 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体 |
| US6288234B1 (en) * | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| AU1379900A (en) * | 1998-11-17 | 2000-06-05 | Bayer Aktiengesellschaft | Novel substituted phenyloxazolidone derivatives |
| HK1040707A1 (zh) * | 1998-11-27 | 2002-06-21 | 法玛西雅厄普约翰美国公司 | 具有硫代羰基官能團的噁唑烷酮抗菌劑 |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| US6518285B2 (en) * | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| SK7572002A3 (en) * | 1999-12-21 | 2002-12-03 | Upjohn Co | Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents |
| KR100355345B1 (ko) * | 2000-01-21 | 2002-10-12 | 한국과학기술연구원 | 티오펜환을 함유한 신규한 옥사졸리디논 유도체, 그의 제조방법 및 조성물 |
| AR027261A1 (es) * | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| US6642238B2 (en) | 2000-02-10 | 2003-11-04 | Pharmacia And Upjohn Company | Oxazolidinone thioamides with piperazine amide substituents |
| US6562820B2 (en) * | 2000-07-05 | 2003-05-13 | Pharmacia & Upjohn Company | Method for treatment and prevention of mastitis |
| US6638908B1 (en) | 2000-08-09 | 2003-10-28 | Yale University | Crystals of the large ribosomal subunit |
| US6947844B2 (en) | 2000-08-09 | 2005-09-20 | Yale University | Modulators of ribosomal function and identification thereof |
| ES2256318T3 (es) * | 2000-10-17 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Metodos de produccion de compuestos de oxazolidinona. |
| YU52403A (sh) * | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
| US7160912B2 (en) | 2000-12-26 | 2007-01-09 | Dr.Reddy's Laboratories Ltd. | Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them |
| US6951863B2 (en) | 2001-02-07 | 2005-10-04 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenly oxazolidinone antibacterials, and related compositions and methods |
| GB0108764D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| GB0108793D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| GB0108794D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
| DE60212959T2 (de) * | 2001-04-07 | 2007-02-15 | Astrazeneca Ab | Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika |
| JP2004521937A (ja) | 2001-04-20 | 2004-07-22 | ファルマシア・アンド・アップジョン・カンパニー | オキサゾリジノンの製法 |
| ES2186550B2 (es) | 2001-06-27 | 2003-11-16 | Vita Lab | Nuevos derivados de oxazolidinonas como antibacterianos. |
| CA2453182A1 (en) * | 2001-07-10 | 2003-01-23 | Meredith L. Greene | Crystalline thiazine oxazolidinones |
| IL151012A0 (en) | 2001-08-03 | 2003-02-12 | Ribosomes Structure And Protei | Ribosomes structure and protein synthesis inhibitors |
| US6952650B2 (en) | 2001-08-03 | 2005-10-04 | Yale University | Modulators of ribosomal function and identification thereof |
| BR0307103A (pt) * | 2002-01-24 | 2004-12-28 | Upjohn Co | Dihidrotiazina e dihidrotiopirano oxazolidinovas antimicrobianas |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| CN1653064A (zh) * | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
| CN1649866A (zh) | 2002-02-28 | 2005-08-03 | 阿斯特拉曾尼卡有限公司 | 3-环状基-5-(含氮5-元环)甲基-噁唑烷酮衍生物及其作为抗菌药物的用途 |
| AU2003224345A1 (en) * | 2002-04-30 | 2003-11-17 | Orchid Chemicals & Pharmaceuticals | Antibacterial agents |
| DE60304360T2 (de) | 2002-08-12 | 2006-11-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | N-aryl-2-oxazolidinone und deren derivate |
| WO2004026848A1 (en) * | 2002-09-20 | 2004-04-01 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
| TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| KR100490643B1 (ko) * | 2002-10-29 | 2005-05-19 | 한국과학기술연구원 | 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법 |
| ATE344036T1 (de) | 2002-11-21 | 2006-11-15 | Pharmacia & Upjohn Co Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel |
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| JP4256744B2 (ja) * | 2003-08-14 | 2009-04-22 | 三菱レイヨン株式会社 | (メタ)アクリル系重合体の製造方法 |
| US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
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| US20070197529A1 (en) * | 2005-12-01 | 2007-08-23 | Viviana Braude | Isolated desfluoro-linezolid, preparation thereof and its use as a reference marker and standard |
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| CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
-
1994
- 1994-08-13 MY MYPI94002115A patent/MY115155A/en unknown
- 1994-08-16 KR KR1019960701191A patent/KR100301269B1/ko not_active Expired - Lifetime
- 1994-08-16 SI SI9430287T patent/SI0717738T1/xx unknown
- 1994-08-16 TW TW083107479A patent/TW293817B/zh not_active IP Right Cessation
- 1994-08-16 EP EP94925765A patent/EP0717738B1/en not_active Expired - Lifetime
- 1994-08-16 AU AU75570/94A patent/AU687866B2/en not_active Expired
- 1994-08-16 DE DE69421285T patent/DE69421285T2/de not_active Expired - Lifetime
- 1994-08-16 AT AT94925765T patent/ATE185804T1/de active
- 1994-08-16 NZ NZ271805A patent/NZ271805A/en not_active IP Right Cessation
- 1994-08-16 DE DE10299007C patent/DE10299007I2/de active Active
- 1994-08-16 CN CN94193313A patent/CN1057087C/zh not_active Expired - Lifetime
- 1994-08-16 ES ES94925765T patent/ES2139093T3/es not_active Expired - Lifetime
- 1994-08-16 CA CA002168560A patent/CA2168560C/en not_active Expired - Lifetime
- 1994-08-16 JP JP50866595A patent/JP3176630B2/ja not_active Expired - Lifetime
- 1994-08-16 DK DK94925765T patent/DK0717738T3/da active
- 1994-08-16 WO PCT/US1994/008904 patent/WO1995007271A1/en not_active Ceased
- 1994-08-22 PH PH48830A patent/PH31634A/en unknown
- 1994-08-29 IL IL11080294A patent/IL110802A/xx not_active IP Right Cessation
-
1999
- 1999-11-10 GR GR990402902T patent/GR3031809T3/el unknown
-
2000
- 2000-10-20 LV LVP-00-142A patent/LV12605B/en unknown
-
2002
- 2002-01-24 NL NL300079C patent/NL300079I1/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR960704866A (ko) | 1996-10-09 |
| CN1057087C (zh) | 2000-10-04 |
| DE69421285T2 (de) | 2000-02-24 |
| EP0717738B1 (en) | 1999-10-20 |
| AU687866B2 (en) | 1998-03-05 |
| MY115155A (en) | 2003-04-30 |
| SI0717738T1 (en) | 2000-02-29 |
| DE10299007I1 (de) | 2002-07-04 |
| CA2168560C (en) | 2001-08-14 |
| NZ271805A (en) | 1998-02-26 |
| IL110802A0 (en) | 1994-11-11 |
| NL300079I1 (nl) | 2002-04-02 |
| PH31634A (en) | 1999-01-12 |
| ATE185804T1 (de) | 1999-11-15 |
| AU7557094A (en) | 1995-03-27 |
| CA2168560A1 (en) | 1995-03-16 |
| DE10299007I2 (de) | 2008-09-18 |
| CN1130379A (zh) | 1996-09-04 |
| KR100301269B1 (ko) | 2001-10-22 |
| TW293817B (https=) | 1996-12-21 |
| IL110802A (en) | 2000-09-28 |
| DK0717738T3 (da) | 2000-05-08 |
| JP3176630B2 (ja) | 2001-06-18 |
| LV12605A (en) | 2001-01-20 |
| JPH09502436A (ja) | 1997-03-11 |
| GR3031809T3 (en) | 2000-02-29 |
| EP0717738A1 (en) | 1996-06-26 |
| LV12605B (en) | 2001-05-20 |
| WO1995007271A1 (en) | 1995-03-16 |
| DE69421285D1 (de) | 1999-11-25 |
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