EE05216B1 - Pregabaliini asmmeetriline sntees - Google Patents
Pregabaliini asmmeetriline snteesInfo
- Publication number
- EE05216B1 EE05216B1 EEP200200403A EEP200200403A EE05216B1 EE 05216 B1 EE05216 B1 EE 05216B1 EE P200200403 A EEP200200403 A EE P200200403A EE P200200403 A EEP200200403 A EE P200200403A EE 05216 B1 EE05216 B1 EE 05216B1
- Authority
- EE
- Estonia
- Prior art keywords
- pregabalin
- asymmetric synthesis
- asymmetric
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17835900P | 2000-01-27 | 2000-01-27 | |
US19042700P | 2000-03-17 | 2000-03-17 | |
PCT/IB2001/000024 WO2001055090A1 (en) | 2000-01-27 | 2001-01-11 | Asymmetric synthesis of pregabalin |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200200403A EE200200403A (et) | 2003-10-15 |
EE05216B1 true EE05216B1 (et) | 2009-10-15 |
Family
ID=26874236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200403A EE05216B1 (et) | 2000-01-27 | 2001-01-11 | Pregabaliini asmmeetriline sntees |
Country Status (50)
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
PL203985B1 (pl) * | 2000-01-27 | 2009-11-30 | Warner Lambert Co | Sposób wytwarzania pochodnych kwasu (S)-3-cyjano-5-metyloheksanowego, pośrednie związki cyjanoolefinowe, sposób wytwarzania estrów kwasu (S)-3-cyjano-5-metyloheksanowego, sole kwasu (S)-3-cyjano-5-metyloheksanowego i sposób wytwarzania pregabaliny |
US6687187B2 (en) * | 2000-08-11 | 2004-02-03 | Phonak Ag | Method for directional location and locating system |
EP1543831A1 (en) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Pregabalin composition |
KR100823758B1 (ko) * | 2004-03-12 | 2008-04-21 | 워너-램버트 캄파니 엘엘씨 | C1-대칭 비스포스핀 리간드 및 프레가발린의 비대칭합성에서의 이들의 용도 |
UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
CN102102114B (zh) * | 2004-06-21 | 2013-08-14 | 沃尼尔·朗伯有限责任公司 | 普瑞巴林和相关化合物的制备 |
CN101160281A (zh) * | 2005-04-06 | 2008-04-09 | 特瓦制药工业有限公司 | 结晶形态的普瑞巴林 |
US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
CA2603215A1 (en) * | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
ATE486841T1 (de) * | 2005-05-10 | 2010-11-15 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
EP1879853A1 (en) * | 2005-05-10 | 2008-01-23 | Teva Pharmaceutical Industries Ltd | Pregabalin free of isobutylglutaric acid and a process for preparation thereof |
MX2007014129A (es) * | 2005-05-10 | 2008-01-11 | Teva Pharma | Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico. |
US20060270871A1 (en) * | 2005-05-30 | 2006-11-30 | Khanduri Chandra H | Polymorphic form i of pregabalin and processes for its preparation |
CN100410242C (zh) * | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
WO2007035789A1 (en) | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin |
NL2000281C2 (nl) * | 2005-11-02 | 2007-08-07 | Pfizer Prod Inc | Vaste farmaceutische samenstellingen die pregabaline bevatten. |
KR20080016658A (ko) * | 2006-04-24 | 2008-02-21 | 테바 파마슈티컬 인더스트리즈 리미티드 | 3-이소부틸글루타르산의 합성 방법 |
TW200815323A (en) * | 2006-05-24 | 2008-04-01 | Teva Pharma | Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof |
BRPI0702897A2 (pt) * | 2006-05-31 | 2011-03-15 | Teva Pharmaceutical Ind Ltda | processo para preparar um intermediário de pregabalina |
EP1912931A2 (en) * | 2006-05-31 | 2008-04-23 | Teva Pharmaceutical Industries Ltd. | Preparation of (s)-pregabalin-nitrile |
EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
KR101036536B1 (ko) * | 2007-03-22 | 2011-05-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | (s)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성 |
US8168828B2 (en) | 2007-06-25 | 2012-05-01 | Msn Laboratories, Limited | Process for the preparation of pregabalin |
KR100846419B1 (ko) * | 2007-08-10 | 2008-07-15 | 한국과학기술원 | 프레가발린의 신규한 제조 방법 |
US20090137842A1 (en) * | 2007-10-03 | 2009-05-28 | Vollerner Yuri | Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof |
EP2053040A1 (en) * | 2007-10-26 | 2009-04-29 | Chemo Ibérica, S.A. | Pregabalin intermediates and process for preparing them and Pregabalin |
WO2009087674A2 (en) * | 2007-12-18 | 2009-07-16 | Watson Pharma Private Limited | Improved process for the preparation of (s)-pregabalin |
CA2710152A1 (en) * | 2007-12-26 | 2009-07-02 | Generics (Uk) Limited | Processes to pregabalin |
JP5526538B2 (ja) * | 2008-01-10 | 2014-06-18 | 住友化学株式会社 | 3−(2−シアノ−1−プロペニル)−2,2−ジメチルシクロプロパンカルボン酸化合物の製造方法およびその中間体 |
EP2110372A1 (en) | 2008-04-16 | 2009-10-21 | Chemo Ibérica, S.A. | Intermediates for the preparation of Pregabalin and process for their preparation |
EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
WO2009141362A2 (en) | 2008-05-21 | 2009-11-26 | Sandoz Ag | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester |
KR20100107500A (ko) * | 2008-06-23 | 2010-10-05 | 테바 파마슈티컬 인더스트리즈 리미티드 | (s) 또는 (r)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법 |
WO2010070593A2 (en) | 2008-12-19 | 2010-06-24 | Pfizer Ireland Pharmaceuticals | Malonate esters |
CN101987826A (zh) * | 2009-08-04 | 2011-03-23 | 铜陵凯顺生物科技有限公司 | 一种(3s)-3-氨甲基-5-甲基己酸的合成方法 |
WO2011141923A2 (en) | 2010-05-14 | 2011-11-17 | Lupin Limited | Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin |
US8212072B2 (en) | 2010-08-13 | 2012-07-03 | Divi's Laboratories, Ltd. | Process for the preparation of pregabalin |
WO2012025861A1 (en) | 2010-08-23 | 2012-03-01 | Pfizer Manufacturing Ireland | Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin |
CN102464594B (zh) * | 2010-11-17 | 2014-06-25 | 凯瑞斯德生化(苏州)有限公司 | 普瑞巴林的中间体化合物的制备方法 |
US9422230B2 (en) | 2013-05-09 | 2016-08-23 | Council Of Scientific And Industrial Research | Process for the preparation of an anticonvulsant agent pregabalin hydrochloride |
WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
WO2017019791A1 (en) | 2015-07-27 | 2017-02-02 | Teva Pharmaceuticals International Gmbh | Synthesis of (s)-pregabalin |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS588390B2 (ja) * | 1978-05-23 | 1983-02-15 | 住友化学工業株式会社 | 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法 |
US4939288A (en) * | 1989-01-23 | 1990-07-03 | Monsanto Company | Method of preparing (R)-succinic acid derivatives |
US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
US5171892A (en) | 1991-07-02 | 1992-12-15 | E. I. Du Pont De Nemours And Company | Chiral phospholanes via chiral 1,4-diol cyclic sulfates |
US5616793A (en) * | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5840965A (en) * | 1996-06-24 | 1998-11-24 | E. I. Du Pont De Nemours And Company | Process for the production of purified telephthalic acid |
CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
US6127418A (en) | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
CA2309668A1 (en) | 1997-12-17 | 1999-06-24 | Chirotech Technology Limited | Asymmetric hydrogenation |
AU3433199A (en) | 1998-04-09 | 1999-11-01 | Chirotech Technology Limited | Asymmetric hydrogenation |
PL203985B1 (pl) * | 2000-01-27 | 2009-11-30 | Warner Lambert Co | Sposób wytwarzania pochodnych kwasu (S)-3-cyjano-5-metyloheksanowego, pośrednie związki cyjanoolefinowe, sposób wytwarzania estrów kwasu (S)-3-cyjano-5-metyloheksanowego, sole kwasu (S)-3-cyjano-5-metyloheksanowego i sposób wytwarzania pregabaliny |
-
2001
- 2001-01-11 PL PL357077A patent/PL203985B1/pl unknown
- 2001-01-11 ES ES01900035T patent/ES2219493T3/es not_active Expired - Lifetime
- 2001-01-11 ME MEP-2008-447A patent/ME00921B/me unknown
- 2001-01-11 PT PT01900035T patent/PT1250311E/pt unknown
- 2001-01-11 US US10/182,656 patent/US6891059B2/en not_active Expired - Lifetime
- 2001-01-11 AP APAP/P/2002/002588A patent/AP1438A/en active
- 2001-01-11 DK DK01900035T patent/DK1250311T3/da active
- 2001-01-11 BR BRPI0107863A patent/BRPI0107863B8/pt not_active IP Right Cessation
- 2001-01-11 JP JP2001555033A patent/JP4235384B2/ja not_active Expired - Fee Related
- 2001-01-11 AU AU22138/01A patent/AU777046B2/en not_active Ceased
- 2001-01-11 CA CA002396090A patent/CA2396090C/en not_active Expired - Fee Related
- 2001-01-11 OA OA1200200227A patent/OA12167A/en unknown
- 2001-01-11 EA EA200200642A patent/EA004934B1/ru not_active IP Right Cessation
- 2001-01-11 EE EEP200200403A patent/EE05216B1/xx not_active IP Right Cessation
- 2001-01-11 RS YU56202A patent/RS50257B/sr unknown
- 2001-01-11 WO PCT/IB2001/000024 patent/WO2001055090A1/en active IP Right Grant
- 2001-01-11 SI SI200130109T patent/SI1250311T1/sl unknown
- 2001-01-11 NZ NZ519551A patent/NZ519551A/en not_active IP Right Cessation
- 2001-01-11 DZ DZ013268A patent/DZ3268A1/fr active
- 2001-01-11 CZ CZ20022520A patent/CZ302838B6/cs not_active IP Right Cessation
- 2001-01-11 MX MXPA02007307A patent/MXPA02007307A/es active IP Right Grant
- 2001-01-11 DE DE60102356T patent/DE60102356T2/de not_active Expired - Lifetime
- 2001-01-11 GE GEAP20016551A patent/GEP20043236B/en unknown
- 2001-01-11 AT AT01900035T patent/ATE261930T1/de active
- 2001-01-11 EP EP01900035A patent/EP1250311B1/en not_active Expired - Lifetime
- 2001-01-11 TR TR2004/00953T patent/TR200400953T4/xx unknown
- 2001-01-11 IL IL15063301A patent/IL150633A0/xx unknown
- 2001-01-11 KR KR1020027009629A patent/KR100549748B1/ko not_active IP Right Cessation
- 2001-01-11 SK SK1078-2002A patent/SK287303B6/sk not_active IP Right Cessation
- 2001-01-11 CN CNB018041701A patent/CN1210253C/zh not_active Expired - Fee Related
- 2001-01-11 HU HU0204307A patent/HU228815B1/hu not_active IP Right Cessation
- 2001-01-19 TW TW090101221A patent/TWI288128B/zh not_active IP Right Cessation
- 2001-01-23 MY MYPI20010329A patent/MY127152A/en unknown
- 2001-01-23 PA PA20018510501A patent/PA8510501A1/es unknown
- 2001-01-24 CO CO01005266A patent/CO5251411A1/es active IP Right Grant
- 2001-01-24 EG EG20010073A patent/EG24138A/xx active
- 2001-01-24 HN HN2001000010A patent/HN2001000010A/es unknown
- 2001-01-24 PE PE2001000078A patent/PE20011063A1/es not_active Application Discontinuation
- 2001-01-25 AR ARP010100316A patent/AR028499A1/es not_active Application Discontinuation
- 2001-01-26 TN TNTNSN01016A patent/TNSN01016A1/fr unknown
- 2001-01-26 SV SV2001000295A patent/SV2002000295A/es active IP Right Grant
- 2001-11-01 UA UA2002065143A patent/UA75584C2/uk unknown
-
2002
- 2002-06-19 CU CU20020122A patent/CU23221A3/es unknown
- 2002-06-19 IS IS6430A patent/IS2038B/is unknown
- 2002-06-20 BG BG106849A patent/BG65560B1/bg unknown
- 2002-07-08 IL IL150633A patent/IL150633A/en not_active IP Right Cessation
- 2002-07-16 CR CR6703A patent/CR6703A/es unknown
- 2002-07-23 MA MA26738A patent/MA26869A1/fr unknown
- 2002-07-24 HR HR20020627A patent/HRP20020627B1/xx not_active IP Right Cessation
- 2002-07-26 NO NO20023582A patent/NO327958B1/no not_active IP Right Cessation
-
2004
- 2004-12-20 CY CY2004011C patent/CY2004011I1/el unknown
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2008
- 2008-09-30 JP JP2008254068A patent/JP4886753B2/ja not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
HC1A | Change of owner name | ||
MM4A | Lapsed by not paying the annual fees |
Effective date: 20180111 |