ECSP088913A - Derivados de pirimidina tieno [3,2-d] utiles como inhibidores de fi3q - Google Patents

Derivados de pirimidina tieno [3,2-d] utiles como inhibidores de fi3q

Info

Publication number
ECSP088913A
ECSP088913A EC2008008913A ECSP088913A ECSP088913A EC SP088913 A ECSP088913 A EC SP088913A EC 2008008913 A EC2008008913 A EC 2008008913A EC SP088913 A ECSP088913 A EC SP088913A EC SP088913 A ECSP088913 A EC SP088913A
Authority
EC
Ecuador
Prior art keywords
inhibitors
disorders
fi3q
useful
pirimidine derivatives
Prior art date
Application number
EC2008008913A
Other languages
English (en)
Inventor
Stephen J Shuttleworth
Irina Chuckowree
Adrian FOLKES
Timothy Colin Hancox
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38645682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088913(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP088913A publication Critical patent/ECSP088913A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
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  • Psychology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
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  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)

Abstract

Tienopirimidinas de formula (I) consta gráfico.Y sales farmacéuticamente aceptables del mismo que tienen inhibidores del F13Q con selectividad para el subtipo F110? y puede ser usado para tratar enfermedades y desórdenes que provienen de el crecimiento anormal de células, función o comportamiento, particularmente aquellos asociados con la F13 quinasa, tales como, cáncer, desórdenes inmuno, enfermedades cardiovasculares, infección viral, inflamación, desórdenes del metabolismo/endocrinología y desórdenes neurológicos. Los procesos para sintetizar estos compuestos han sido descritos.
EC2008008913A 2006-04-26 2008-11-26 Derivados de pirimidina tieno [3,2-d] utiles como inhibidores de fi3q ECSP088913A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79496606P 2006-04-26 2006-04-26

Publications (1)

Publication Number Publication Date
ECSP088913A true ECSP088913A (es) 2008-12-30

Family

ID=38645682

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008913A ECSP088913A (es) 2006-04-26 2008-11-26 Derivados de pirimidina tieno [3,2-d] utiles como inhibidores de fi3q

Country Status (29)

Country Link
US (4) US7781433B2 (es)
JP (1) JP5148597B2 (es)
KR (1) KR101533461B1 (es)
CN (1) CN101472930B (es)
AR (1) AR060631A1 (es)
AT (1) ATE471940T1 (es)
AU (1) AU2007246793B2 (es)
BR (1) BRPI0710874A2 (es)
CA (1) CA2650303C (es)
CL (1) CL2007001165A1 (es)
CR (1) CR10455A (es)
DE (1) DE602007007323D1 (es)
DK (1) DK2024372T3 (es)
EC (1) ECSP088913A (es)
ES (1) ES2347187T3 (es)
HR (1) HRP20100446T1 (es)
IL (1) IL194784A (es)
MA (1) MA30412B1 (es)
MX (1) MX2008013578A (es)
MY (1) MY145306A (es)
NO (1) NO342593B1 (es)
NZ (1) NZ572812A (es)
PT (1) PT2024372E (es)
RS (1) RS51401B (es)
RU (1) RU2439074C2 (es)
TW (1) TWI409268B (es)
UA (1) UA95799C2 (es)
WO (1) WO2007129161A2 (es)
ZA (1) ZA200809967B (es)

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