EA201790443A1 - Универсальный анализ коагуляции на основе микрожидкостного чипа - Google Patents
Универсальный анализ коагуляции на основе микрожидкостного чипаInfo
- Publication number
- EA201790443A1 EA201790443A1 EA201790443A EA201790443A EA201790443A1 EA 201790443 A1 EA201790443 A1 EA 201790443A1 EA 201790443 A EA201790443 A EA 201790443A EA 201790443 A EA201790443 A EA 201790443A EA 201790443 A1 EA201790443 A1 EA 201790443A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- coagulation
- anticoagulant
- whole blood
- analysis
- technologies
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Optical Measuring Cells (AREA)
Abstract
Устройство для анализа на основе микрожидкостного чипа было разработано для измерения физических свойств анализируемого материала (в частности, цельной крови или производных цельной крови). Технологии могут применяться для измерения времени свертывания цельной крови или производных крови, для определения эффектов антикоагулянтных лекарственных средств на динамику свертывания/коагуляции, а также для оценки эффекта антагонистов антикоагулянтов. Эти технологии дополнительно могут применяться для оптимизации дозировки антикоагулянтных лекарственных средств и/или их антагонистов. Анализ не зависит от присутствия антикоагулянта; свертывание активируется путем воздействия на образец крови в устройстве поверхностью стекла (или другого материала с отрицательным зарядом, такого как окисленный кремний), которая активирует внутренний путь, и может быть дополнительно ускорено применением сдвигового потока, проходящего поперек поверхности активирующих материалов. Отсутствие химических активирующих агентов и хорошо контролируемая и воспроизводимая микросреда обеспечивают универсальный анализ свертывания, осуществляемый на месте предоставления медицинских услуг.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462048183P | 2014-09-09 | 2014-09-09 | |
PCT/US2015/049198 WO2016040490A1 (en) | 2014-09-09 | 2015-09-09 | Microfluid chip-based, universal coagulation assay |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201790443A1 true EA201790443A1 (ru) | 2017-07-31 |
EA033382B1 EA033382B1 (ru) | 2019-10-31 |
Family
ID=54186304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790443A EA033382B1 (ru) | 2014-09-09 | 2015-09-09 | Универсальный анализ коагуляции на основе микрожидкостного чипа |
Country Status (34)
Country | Link |
---|---|
US (5) | US9910053B2 (ru) |
EP (2) | EP4109095A1 (ru) |
JP (1) | JP6550126B2 (ru) |
KR (1) | KR102533127B1 (ru) |
CN (1) | CN107076733B (ru) |
AP (1) | AP2017009807A0 (ru) |
AU (1) | AU2015315159C1 (ru) |
BR (1) | BR112017004506B1 (ru) |
CA (1) | CA2959742C (ru) |
CL (1) | CL2017000546A1 (ru) |
CO (1) | CO2017003282A2 (ru) |
CR (1) | CR20170133A (ru) |
DK (1) | DK3191836T3 (ru) |
EA (1) | EA033382B1 (ru) |
EC (1) | ECSP17020834A (ru) |
ES (1) | ES2936341T3 (ru) |
FI (1) | FI3191836T3 (ru) |
HR (1) | HRP20230171T1 (ru) |
HU (1) | HUE060968T2 (ru) |
IL (1) | IL250977B (ru) |
LT (1) | LT3191836T (ru) |
MX (1) | MX2017003043A (ru) |
NZ (1) | NZ730056A (ru) |
PE (1) | PE20170737A1 (ru) |
PH (1) | PH12017500415A1 (ru) |
PL (1) | PL3191836T3 (ru) |
PT (1) | PT3191836T (ru) |
RS (1) | RS64075B1 (ru) |
SA (1) | SA517381058B1 (ru) |
SG (1) | SG11201701596WA (ru) |
SI (1) | SI3191836T1 (ru) |
UA (1) | UA118986C2 (ru) |
WO (1) | WO2016040490A1 (ru) |
ZA (1) | ZA201702431B (ru) |
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