CL2017000546A1 - Análisis de coagulación universal microfluídico basado en chips - Google Patents
Análisis de coagulación universal microfluídico basado en chipsInfo
- Publication number
- CL2017000546A1 CL2017000546A1 CL2017000546A CL2017000546A CL2017000546A1 CL 2017000546 A1 CL2017000546 A1 CL 2017000546A1 CL 2017000546 A CL2017000546 A CL 2017000546A CL 2017000546 A CL2017000546 A CL 2017000546A CL 2017000546 A1 CL2017000546 A1 CL 2017000546A1
- Authority
- CL
- Chile
- Prior art keywords
- coagulation
- analysis
- blood
- agents
- total blood
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
<p>UN DISPOSITIVO DE ANÁLISIS BASADO EN CHIP MICROFLUÍDICO SE HA DESARROLLADO PARA LA MEDICIÓN DE LAS PROPIEDADES FÍSICAS DE UN ANALITO (EN PARTICULAR, SANGRE TOTAL O DERIVADOS DE LA SANGRE TOTAL). LAS TECNOLOGÍAS SE PUEDEN APLICAR PARA MEDIR LOS TIEMPOS DE COAGULACIÓN DE DERIVADOS DE LA SANGRE O DE LA SANGRE TOTAL, DETERMINAR LOS EFECTOS DE FÁRMACOS ANTICOAGULANTES EN LA CINÉTICA DE LA COAGULACIÓN, ASÍ COMO EVALUAR EL EFECTO DE LOS AGENTES DE REVERSIÓN ANTICOAGULANTES. ESTAS TECNOLOGÍAS PUEDEN UTILIZARSE ADICIONALMENTE PARA OPTIMIZAR LA DOSIFICACIÓN DE FÁRMACOS ANTICOAGULANTES Y/O SUS AGENTES DE REVERSIÓN. EL ANÁLISIS ES INDEPENDIENTE DE LA PRESENCIA DE ANTICOAGULANTE PUESTO QUE LA COAGULACIÓN SE ACTIVA MEDIANTE LA EXPOSICIÓN DE LA MUESTRA DE SANGRE EN EL DISPOSITIVO A UNA SUPERFICIE DE VIDRIO (U OTRO MATERIAL CARGADO NEGATIVAMENTE TAL COMO EL SILICIO OXIDADO), QUE ACTIVA LA VÍA INTRÍNSECA Y PUEDE ACELERARSE ADICIONALMENTE MEDIANTE LA APLICACIÓN DE FLUJO CORTANTE A TRAVÉS DE LA SUPERFICIE DE LOS MATERIALES ACTIVADORES. LA AUSENCIA DE AGENTES ACTIVADORES QUÍMICOS Y UN MICROAMBIENTE ALTAMENTE CONTROLADO Y REPRODUCIBLE PRODUCE UN ANÁLISIS DE COAGULACIÓN UNIVERSAL DE DIAGNÓSTICO INMEDIATO.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462048183P | 2014-09-09 | 2014-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017000546A1 true CL2017000546A1 (es) | 2017-10-20 |
Family
ID=54186304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017000546A CL2017000546A1 (es) | 2014-09-09 | 2017-03-08 | Análisis de coagulación universal microfluídico basado en chips |
Country Status (34)
Country | Link |
---|---|
US (5) | US9910053B2 (es) |
EP (2) | EP4109095A1 (es) |
JP (1) | JP6550126B2 (es) |
KR (1) | KR102533127B1 (es) |
CN (1) | CN107076733B (es) |
AP (1) | AP2017009807A0 (es) |
AU (1) | AU2015315159C1 (es) |
BR (1) | BR112017004506B1 (es) |
CA (1) | CA2959742C (es) |
CL (1) | CL2017000546A1 (es) |
CO (1) | CO2017003282A2 (es) |
CR (1) | CR20170133A (es) |
DK (1) | DK3191836T3 (es) |
EA (1) | EA033382B1 (es) |
EC (1) | ECSP17020834A (es) |
ES (1) | ES2936341T3 (es) |
FI (1) | FI3191836T3 (es) |
HR (1) | HRP20230171T1 (es) |
HU (1) | HUE060968T2 (es) |
IL (1) | IL250977B (es) |
LT (1) | LT3191836T (es) |
MX (1) | MX2017003043A (es) |
NZ (1) | NZ730056A (es) |
PE (1) | PE20170737A1 (es) |
PH (1) | PH12017500415A1 (es) |
PL (1) | PL3191836T3 (es) |
PT (1) | PT3191836T (es) |
RS (1) | RS64075B1 (es) |
SA (1) | SA517381058B1 (es) |
SG (1) | SG11201701596WA (es) |
SI (1) | SI3191836T1 (es) |
UA (1) | UA118986C2 (es) |
WO (1) | WO2016040490A1 (es) |
ZA (1) | ZA201702431B (es) |
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EP4109095A1 (en) | 2014-09-09 | 2022-12-28 | Perosphere Technologies Inc. | Microfluid chip-based, universal coagulation assay |
US10060948B2 (en) | 2016-08-12 | 2018-08-28 | Tiptek, LLC | Scanning probe and electron microscope probes and their manufacture |
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