AR086657A1 - Ensayo de la lisil oxidasa-like 2 y sus metodos de empleo - Google Patents
Ensayo de la lisil oxidasa-like 2 y sus metodos de empleoInfo
- Publication number
- AR086657A1 AR086657A1 ARP120101959A ARP120101959A AR086657A1 AR 086657 A1 AR086657 A1 AR 086657A1 AR P120101959 A ARP120101959 A AR P120101959A AR P120101959 A ARP120101959 A AR P120101959A AR 086657 A1 AR086657 A1 AR 086657A1
- Authority
- AR
- Argentina
- Prior art keywords
- loxl2
- individual
- antibody
- disease
- level
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Silicon Polymers (AREA)
Abstract
Reivindicación 1: Un método para detectar, predecir o monitorizar una enfermedad o afección, comprendiendo el método: a) poner en contacto una muestra líquida obtenida de un individuo con un anticuerpo específico para la lisil oxidasa-like 2 (LOXL2); y b) detectar la unión del anticuerpo con la LOXL2 que esté presente en la muestra líquida, detectando de este modo un nivel de LOXL2 en la muestra líquida, donde el nivel detectado de LOXL2 indica la presencia o ausencia de la enfermedad o afección en el individuo o la probabilidad de que el individuo responda a un tratamiento de la enfermedad o afección.Reivindicación 25: El método de cualquiera de las reivindicaciones 1 - 24, donde el nivel detectado indica que el individuo padece una enfermedad fibrótica activa o una enfermedad fibrótica en estadio avanzado. Reivindicación 27: Un dispositivo de ensayo para utilizar en la determinación del nivel de un polipéptido lisil oxidasa-like 2 (LOXL2) en una muestra biológica líquida obtenida de un individuo, comprendiendo el dispositivo: una matriz que define una ruta de flujo axial, comprendiendo la matriz: i) una zona receptora de muestra en un extremo anterior de la ruta de flujo que recibe la muestra fluida; ii) una o más zonas de prueba situadas en la ruta de flujo y después de la zona receptora de muestra, comprendiendo cada una de las zonas de prueba un anticuerpo específico para LOXL2, donde cada uno de los anticuerpos específicos para LOXL2 es capaz de unirse a un polipéptido LOXL2 que esté presente en la muestra líquida para formar un complejo de anticuerpo anti-LOXL2/LOXL2; y iii) una o más zonas de control situadas en la ruta de flujo y después de la zona receptora de muestra. Reivindicación 36: Un kit para determinar el nivel de un polipéptido lisil oxidasa-like 2 (LOXL2) en una muestra biológica obtenida de un individuo, comprendiendo el kit: a) un primer anticuerpo específico para LOXL2; y b) un segundo anticuerpo específico para LOXL2.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492210P | 2011-06-01 | 2011-06-01 | |
| US201161550895P | 2011-10-24 | 2011-10-24 | |
| US201161578813P | 2011-12-21 | 2011-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086657A1 true AR086657A1 (es) | 2014-01-15 |
Family
ID=46208194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101959A AR086657A1 (es) | 2011-06-01 | 2012-06-01 | Ensayo de la lisil oxidasa-like 2 y sus metodos de empleo |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US20120309020A1 (es) |
| EP (1) | EP2714744A1 (es) |
| JP (3) | JP2014523521A (es) |
| KR (1) | KR20140048156A (es) |
| CN (1) | CN103946241A (es) |
| AP (1) | AP2013007285A0 (es) |
| AR (1) | AR086657A1 (es) |
| AU (2) | AU2012261883A1 (es) |
| BR (1) | BR112013030682A2 (es) |
| CA (1) | CA2837534A1 (es) |
| CL (1) | CL2013003445A1 (es) |
| CO (1) | CO6940375A2 (es) |
| CR (1) | CR20130657A (es) |
| EA (1) | EA201391627A1 (es) |
| EC (1) | ECSP13013092A (es) |
| IL (1) | IL229631A0 (es) |
| MA (1) | MA35212B1 (es) |
| MD (1) | MD20130098A2 (es) |
| MX (1) | MX2013013905A (es) |
| PE (1) | PE20141450A1 (es) |
| TW (1) | TW201319572A (es) |
| UY (1) | UY34115A (es) |
| WO (1) | WO2012167181A1 (es) |
| ZA (1) | ZA201308812B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| JP5659014B2 (ja) * | 2007-08-02 | 2015-01-28 | ジリード バイオロジクス，インク． | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| BR112012008054A2 (pt) | 2009-08-21 | 2017-05-23 | Gilead Biologics Inc | domínios catalíticos de lisil oxidase e loxl2 |
| RU2549684C2 (ru) * | 2010-02-04 | 2015-04-27 | Джилид Байолоджикс, Инк. | Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения |
| CN107982531A (zh) * | 2012-10-30 | 2018-05-04 | 吉利德科学公司 | 与赖氨酰氧化酶样蛋白2 (loxl2)相关的治疗和诊断方法 |
| US20150342943A1 (en) | 2014-06-03 | 2015-12-03 | Gilead Sciences, Inc. | Methods of treating liver disease |
| JP6353082B2 (ja) * | 2014-06-11 | 2018-07-04 | ギリアード サイエンシーズ， インコーポレイテッド | 心血管疾患を処置するための方法 |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| WO2017152062A1 (en) | 2016-03-04 | 2017-09-08 | Gilead Sciences, Inc. | Compositions and combinations of autotaxin inhibitors |
| JP2019513737A (ja) | 2016-04-08 | 2019-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | がん、炎症性疾患および自己免疫疾患を処置するための組成物および方法 |
| GB201704206D0 (en) * | 2017-03-16 | 2017-05-03 | Nordic Bioscience As | Lysyl oxidase like-2 assay |
| US20230152330A1 (en) * | 2021-11-17 | 2023-05-18 | AmMax Bio, Inc. | Detection and treatment of idiopathic pulmonary fibrosis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6352862B1 (en) * | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| FI92882C (fi) * | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi |
| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| JP5659014B2 (ja) | 2007-08-02 | 2015-01-28 | ジリード バイオロジクス，インク． | 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物 |
| JP2010038735A (ja) * | 2008-08-05 | 2010-02-18 | Terumo Corp | 腹膜機能の評価方法および腹膜機能評価用イムノクロマト試験紙 |
| KR20120054077A (ko) * | 2009-08-21 | 2012-05-29 | 길리아드 바이오로직스, 인크. | 폐 섬유증 장애의 치료를 위한 방법 및 조성물 |
| RU2549684C2 (ru) * | 2010-02-04 | 2015-04-27 | Джилид Байолоджикс, Инк. | Антитела, связывающиеся с лизилоксидазоподобным ферментом-2 (loxl2), и способы их применения |
| WO2012154432A2 (en) * | 2011-05-10 | 2012-11-15 | Borgwarner Inc. | Turbocharger with variable turbine geometry |
-
2012
- 2012-06-01 AU AU2012261883A patent/AU2012261883A1/en not_active Abandoned
- 2012-06-01 US US13/487,109 patent/US20120309020A1/en not_active Abandoned
- 2012-06-01 MX MX2013013905A patent/MX2013013905A/es not_active Application Discontinuation
- 2012-06-01 KR KR1020137034711A patent/KR20140048156A/ko not_active Application Discontinuation
- 2012-06-01 CA CA2837534A patent/CA2837534A1/en not_active Abandoned
- 2012-06-01 PE PE2013002739A patent/PE20141450A1/es not_active Application Discontinuation
- 2012-06-01 EP EP12725601.4A patent/EP2714744A1/en not_active Withdrawn
- 2012-06-01 BR BR112013030682A patent/BR112013030682A2/pt not_active IP Right Cessation
- 2012-06-01 UY UY0001034115A patent/UY34115A/es not_active Application Discontinuation
- 2012-06-01 AP AP2013007285A patent/AP2013007285A0/xx unknown
- 2012-06-01 US US14/122,984 patent/US20140206017A1/en not_active Abandoned
- 2012-06-01 MD MDA20130098A patent/MD20130098A2/ro not_active Application Discontinuation
- 2012-06-01 CN CN201280037235.7A patent/CN103946241A/zh active Pending
- 2012-06-01 JP JP2014513770A patent/JP2014523521A/ja not_active Withdrawn
- 2012-06-01 WO PCT/US2012/040585 patent/WO2012167181A1/en active Application Filing
- 2012-06-01 AR ARP120101959A patent/AR086657A1/es unknown
- 2012-06-01 TW TW101119847A patent/TW201319572A/zh unknown
- 2012-06-01 EA EA201391627A patent/EA201391627A1/ru unknown
-
2013
- 2013-11-25 ZA ZA2013/08812A patent/ZA201308812B/en unknown
- 2013-11-26 IL IL229631A patent/IL229631A0/en unknown
- 2013-11-29 CL CL2013003445A patent/CL2013003445A1/es unknown
- 2013-12-13 CR CR20130657A patent/CR20130657A/es unknown
- 2013-12-19 EC ECSP13013092 patent/ECSP13013092A/es unknown
- 2013-12-27 CO CO13301122A patent/CO6940375A2/es unknown
- 2013-12-30 MA MA36627A patent/MA35212B1/fr unknown
-
2016
- 2016-06-09 JP JP2016115175A patent/JP2016164578A/ja active Pending
- 2016-10-12 AU AU2016244254A patent/AU2016244254B2/en not_active Ceased
- 2016-12-01 US US15/366,986 patent/US20170269085A1/en not_active Abandoned
-
2017
- 2017-11-16 JP JP2017221000A patent/JP2018049033A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013030682A2 (pt) | 2016-12-06 |
| CO6940375A2 (es) | 2014-05-09 |
| US20120309020A1 (en) | 2012-12-06 |
| KR20140048156A (ko) | 2014-04-23 |
| UY34115A (es) | 2013-01-03 |
| IL229631A0 (en) | 2014-01-30 |
| CN103946241A (zh) | 2014-07-23 |
| US20140206017A1 (en) | 2014-07-24 |
| JP2014523521A (ja) | 2014-09-11 |
| AU2016244254B2 (en) | 2018-10-18 |
| CL2013003445A1 (es) | 2014-07-25 |
| PE20141450A1 (es) | 2014-11-06 |
| MX2013013905A (es) | 2014-05-14 |
| CR20130657A (es) | 2014-05-16 |
| MD20130098A2 (ro) | 2014-06-30 |
| TW201319572A (zh) | 2013-05-16 |
| ZA201308812B (en) | 2014-08-27 |
| EA201391627A1 (ru) | 2014-08-29 |
| AU2012261883A1 (en) | 2013-05-02 |
| WO2012167181A1 (en) | 2012-12-06 |
| CA2837534A1 (en) | 2012-12-06 |
| JP2016164578A (ja) | 2016-09-08 |
| US20170269085A1 (en) | 2017-09-21 |
| ECSP13013092A (es) | 2014-08-29 |
| MA35212B1 (fr) | 2014-06-02 |
| EP2714744A1 (en) | 2014-04-09 |
| NZ618682A (en) | 2016-04-29 |
| JP2018049033A (ja) | 2018-03-29 |
| AU2016244254A1 (en) | 2016-11-03 |
| AP2013007285A0 (en) | 2013-11-30 |
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Legal Events
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|---|---|---|---|
| FB | Suspension of granting procedure |