MX2017003043A - Analisis de coagulacion universal microfluidico basado en chips. - Google Patents

Analisis de coagulacion universal microfluidico basado en chips.

Info

Publication number
MX2017003043A
MX2017003043A MX2017003043A MX2017003043A MX2017003043A MX 2017003043 A MX2017003043 A MX 2017003043A MX 2017003043 A MX2017003043 A MX 2017003043A MX 2017003043 A MX2017003043 A MX 2017003043A MX 2017003043 A MX2017003043 A MX 2017003043A
Authority
MX
Mexico
Prior art keywords
clotting
anticoagulant
whole blood
assay
technologies
Prior art date
Application number
MX2017003043A
Other languages
English (en)
Inventor
Bakhru Sasha
Laulicht Bryan
Zappe Stefan
Steiner Solomon
Original Assignee
Perosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere Inc filed Critical Perosphere Inc
Publication of MX2017003043A publication Critical patent/MX2017003043A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Un dispositivo de análisis basado en chip microfluídico se ha desarrollado para la medición de las propiedades físicas de un analito (en particular, sangre total o derivados de la sangre total). Las tecnologías se pueden aplicar para medir los tiempos de coagulación de derivados de la sangre o de la sangre total, determinar los efectos de fármacos anticoagulantes en la cinética de la coagulación, así como evaluar el efecto de los agentes de reversión anticoagulantes. Estas tecnologías pueden utilizarse adicionalmente para optimizar la dosificación de fármacos anticoagulantes y/o sus agentes de reversión. El análisis es independiente de la presencia de anticoagulante puesto que la coagulación se activa mediante la exposición de la muestra de sangre en el dispositivo a una superficie de vidrio (u otro material cargado negativamente tal como el silicio oxidado), que activa la vía intrínseca y puede acelerarse adicionalmente mediante la aplicación de flujo cortante a través de la superficie de los materiales activadores. La ausencia de agentes activadores químicos y un microambiente altamente controlado y reproducible produce un análisis de coagulación universal de diagnóstico inmediato.
MX2017003043A 2014-09-09 2015-09-09 Analisis de coagulacion universal microfluidico basado en chips. MX2017003043A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462048183P 2014-09-09 2014-09-09
PCT/US2015/049198 WO2016040490A1 (en) 2014-09-09 2015-09-09 Microfluid chip-based, universal coagulation assay

Publications (1)

Publication Number Publication Date
MX2017003043A true MX2017003043A (es) 2017-10-18

Family

ID=54186304

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017003043A MX2017003043A (es) 2014-09-09 2015-09-09 Analisis de coagulacion universal microfluidico basado en chips.

Country Status (34)

Country Link
US (5) US9910053B2 (es)
EP (2) EP3191836B1 (es)
JP (1) JP6550126B2 (es)
KR (1) KR102533127B1 (es)
CN (1) CN107076733B (es)
AP (1) AP2017009807A0 (es)
AU (1) AU2015315159C1 (es)
BR (1) BR112017004506B1 (es)
CA (1) CA2959742C (es)
CL (1) CL2017000546A1 (es)
CO (1) CO2017003282A2 (es)
CR (1) CR20170133A (es)
DK (1) DK3191836T3 (es)
EA (1) EA033382B1 (es)
EC (1) ECSP17020834A (es)
ES (1) ES2936341T3 (es)
FI (1) FI3191836T3 (es)
HR (1) HRP20230171T1 (es)
HU (1) HUE060968T2 (es)
IL (1) IL250977B (es)
LT (1) LT3191836T (es)
MX (1) MX2017003043A (es)
NZ (1) NZ730056A (es)
PE (1) PE20170737A1 (es)
PH (1) PH12017500415A1 (es)
PL (1) PL3191836T3 (es)
PT (1) PT3191836T (es)
RS (1) RS64075B1 (es)
SA (1) SA517381058B1 (es)
SG (1) SG11201701596WA (es)
SI (1) SI3191836T1 (es)
UA (1) UA118986C2 (es)
WO (1) WO2016040490A1 (es)
ZA (1) ZA201702431B (es)

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Also Published As

Publication number Publication date
US20220155326A1 (en) 2022-05-19
CA2959742C (en) 2019-08-20
JP6550126B2 (ja) 2019-07-24
EP4109095A1 (en) 2022-12-28
US11852639B2 (en) 2023-12-26
BR112017004506A2 (pt) 2018-01-23
ES2936341T3 (es) 2023-03-16
SI3191836T1 (sl) 2023-04-28
KR20170057310A (ko) 2017-05-24
WO2016040490A1 (en) 2016-03-17
AP2017009807A0 (en) 2017-03-31
PL3191836T3 (pl) 2023-04-24
CR20170133A (es) 2017-07-21
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