SG10201809158TA - Device and method for detecting blood group antigens by means of an incomplete antibody - Google Patents

Device and method for detecting blood group antigens by means of an incomplete antibody

Info

Publication number
SG10201809158TA
SG10201809158TA SG10201809158TA SG10201809158TA SG10201809158TA SG 10201809158T A SG10201809158T A SG 10201809158TA SG 10201809158T A SG10201809158T A SG 10201809158TA SG 10201809158T A SG10201809158T A SG 10201809158TA SG 10201809158T A SG10201809158T A SG 10201809158TA
Authority
SG
Singapore
Prior art keywords
antibody
cellular
indicator zone
directed against
bound analyte
Prior art date
Application number
SG10201809158TA
Inventor
Peter Schwind
Ariane Caesar
Original Assignee
Grifols Diagnostic Solutions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols Diagnostic Solutions Inc filed Critical Grifols Diagnostic Solutions Inc
Publication of SG10201809158TA publication Critical patent/SG10201809158TA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/559—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody through a gel, e.g. Ouchterlony technique
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells

Abstract

Device and method for detecting blood group antigens by means of an incomplete antibody The invention relates to a device for determining a cellular-bound analyte in a liquid sample, comprising a separation matrix with at least one indicator zone. The invention is characterized in that the indicator zone comprises a first antibody directed against the cellular-bound analyte or a fragment thereof and a binding element directed against the first antibody, the first antibody being an incomplete antibody. The separation matrix is preferably designed in the form of the membrane of a lateral flow assay device or as a gel matrix. In a particularly preferable manner, the device comprises a membrane (2) with a charging zone (5) for applying the liquid sample, at least one indicator zone which can interact with the cellular-bound analyte, and at least one absorption region (3) which absorbs the liquid after passing the indicator zone. The indicator zone lies between the charging zone (5) and the absorption region (3). The invention is characterized in that the indicator zone comprises an antibody directed against the cellular-bound analyte or a fragment thereof and a binding element directed against the first antibody, the first antibody being an incomplete antibody. [No Suitable Figure]
SG10201809158TA 2014-05-26 2015-05-23 Device and method for detecting blood group antigens by means of an incomplete antibody SG10201809158TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102014007851.5A DE102014007851B3 (en) 2014-05-26 2014-05-26 Apparatus and method for the determination of blood group antigens with an incomplete antibody

Publications (1)

Publication Number Publication Date
SG10201809158TA true SG10201809158TA (en) 2018-11-29

Family

ID=53276057

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201809158TA SG10201809158TA (en) 2014-05-26 2015-05-23 Device and method for detecting blood group antigens by means of an incomplete antibody
SG11201608647TA SG11201608647TA (en) 2014-05-26 2015-05-23 Device and method for detecting blood group antigens by means of an incomplete antibody

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201608647TA SG11201608647TA (en) 2014-05-26 2015-05-23 Device and method for detecting blood group antigens by means of an incomplete antibody

Country Status (14)

Country Link
US (2) US11169160B2 (en)
EP (1) EP3149477A1 (en)
JP (1) JP6683626B2 (en)
KR (1) KR102364928B1 (en)
CN (1) CN106415273B (en)
AU (2) AU2015266394B2 (en)
CA (1) CA2945622A1 (en)
CL (1) CL2016003038A1 (en)
DE (1) DE102014007851B3 (en)
IL (1) IL248373B (en)
MX (1) MX2016013429A (en)
RU (1) RU2726452C2 (en)
SG (2) SG10201809158TA (en)
WO (1) WO2015180834A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108680756A (en) * 2018-05-21 2018-10-19 中国科学院苏州生物医学工程技术研究所 A kind of incomplete antibody detection kit and detection method
CN114137231B (en) * 2022-01-29 2022-04-29 北京大有天弘科技有限公司 Detection kit for blood group irregular antibody and application thereof

Family Cites Families (21)

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DE3445816C1 (en) * 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flat diagnostic agent
JPS61271455A (en) 1985-05-28 1986-12-01 Olympus Optical Co Ltd Immunological analysis
DE3686474T2 (en) * 1985-10-11 1993-02-11 Abbott Lab DIAGNOSTIC SAMPLE.
US4816413A (en) 1986-09-08 1989-03-28 Immucor, Inc. Solid phase indicator red blood cells and method
AU8328287A (en) 1986-11-13 1988-06-01 Genelabs Incorporated Blood affinity diagnostic method
US4943522A (en) * 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
US5338689A (en) * 1987-08-24 1994-08-16 Stiftung Fur Diagnostische Forschung Method and card for detecting antigens and/or antibodies
US5780248A (en) * 1993-07-15 1998-07-14 Ortho Diagnostic Systems, Inc. Foil sealed cassette for agglutination reactions and liner therefor
JP2001133457A (en) 1999-11-05 2001-05-18 Dainabot Co Ltd Immunoanalysis device with improved stability, and method for improving its stability
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
WO2003023354A2 (en) 2001-09-07 2003-03-20 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
CN1186636C (en) 2002-12-31 2005-01-26 江西中德生物工程有限公司 Method for detecting ABO blood type using immuno-chromatography, its prepared indicator paper and use
EP1642139A1 (en) 2003-07-08 2006-04-05 Inverness Medical Switzerland GmbH Particle agglutination detection method and device
DE10330981B4 (en) * 2003-07-09 2010-04-01 Medion Diagnostics Ag Apparatus and method for simultaneously performing blood grouping, serum cross-checking and antibody-screening
DE10330982A1 (en) 2003-07-09 2005-02-17 Prisma Diagnostika Gmbh Apparatus and method for the simultaneous determination of blood group antigens
CN103091487A (en) 2005-11-12 2013-05-08 平台诊断有限公司 Agglutination assay
DE102006062619B4 (en) 2006-12-29 2012-04-26 Medion Diagnostics Ag Method for the determination of minor cell populations in heterogeneous cell populations
JP4806645B2 (en) 2007-03-23 2011-11-02 ベックマン コールター， インコーポレイテッド Carrier for immunological examination and examination method using the carrier
CN201053966Y (en) 2007-05-21 2008-04-30 四川省迈克科技有限责任公司 Quick detection reagent kit for blood type and transfusion matching type
CN101603967B (en) 2008-06-10 2015-02-18 英科新创(厦门)科技有限公司 Method for fast testing human ABO/Rh/MN blood type and kit
CN101957370A (en) 2009-07-15 2011-01-26 英科新创(厦门)科技有限公司 Method and detection strip for rapidly detecting human blood group antibodies

Also Published As

Publication number Publication date
US11169160B2 (en) 2021-11-09
SG11201608647TA (en) 2016-11-29
IL248373A0 (en) 2016-11-30
WO2015180834A1 (en) 2015-12-03
US20220003789A1 (en) 2022-01-06
IL248373B (en) 2020-05-31
AU2015266394B2 (en) 2020-06-04
DE102014007851B3 (en) 2015-11-12
RU2726452C2 (en) 2020-07-14
CL2016003038A1 (en) 2017-10-13
EP3149477A1 (en) 2017-04-05
NZ725664A (en) 2021-10-29
AU2015266394A1 (en) 2016-11-17
CN106415273A (en) 2017-02-15
RU2016142888A3 (en) 2018-11-01
CA2945622A1 (en) 2015-12-03
JP2017519972A (en) 2017-07-20
KR102364928B1 (en) 2022-02-17
MX2016013429A (en) 2017-05-04
CN106415273B (en) 2019-04-19
RU2016142888A (en) 2018-06-26
US20170122968A1 (en) 2017-05-04
JP6683626B2 (en) 2020-04-22
KR20170005008A (en) 2017-01-11
AU2020203425A1 (en) 2020-06-11
AU2020203425B2 (en) 2022-06-30

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SG10201809158TA (en) Device and method for detecting blood group antigens by means of an incomplete antibody