CO2017003282A2 - Microchip de prueba y dispositivo de microanálisis para medir el tiempo de coagulación - Google Patents

Microchip de prueba y dispositivo de microanálisis para medir el tiempo de coagulación

Info

Publication number
CO2017003282A2
CO2017003282A2 CONC2017/0003282A CO2017003282A CO2017003282A2 CO 2017003282 A2 CO2017003282 A2 CO 2017003282A2 CO 2017003282 A CO2017003282 A CO 2017003282A CO 2017003282 A2 CO2017003282 A2 CO 2017003282A2
Authority
CO
Colombia
Prior art keywords
anticoagulant
whole blood
clotting
blood
technologies
Prior art date
Application number
CONC2017/0003282A
Other languages
English (en)
Inventor
Sasha Bakhru
Bryan Laulicht
Stefan Zappe
Solomon Steiner
Original Assignee
Perosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere Inc filed Critical Perosphere Inc
Publication of CO2017003282A2 publication Critical patent/CO2017003282A2/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater

Abstract

Un dispositivo de análisis basado en chip microfluídico se ha desarrollado para la medición de las propiedades físicas de un analito (en particular, sangre total o derivados de la sangre total). Las tecnologías se pueden aplicar para medir los tiempos de coagulación de derivados de la sangre o de la sangre total, determinar los efectos de fármacos anticoagulantes en la cinética de la coagulación, así como evaluar el efecto de los agentes de reversión anticoagulantes. Estas tecnologías pueden utilizarse adicionalmente para optimizar la dosificación de fármacos anticoagulantes y/o sus agentes de reversión. El análisis es independiente de la presencia de anticoagulante puesto que la coagulación se activa mediante la exposición de la muestra de sangre en el dispositivo a una superficie de vidrio (u otro material cargado negativamente tal como el silicio oxidado), que activa la vía intrínseca y puede acelerarse adicionalmente mediante la aplicación de flujo cortante a través de la superficie de los materiales activadores. La ausencia de agentes activadores químicos y un microambiente altamente controlado y reproducible produce un análisis de coagulación universal de diagnóstico inmediato.
CONC2017/0003282A 2014-09-09 2017-04-04 Microchip de prueba y dispositivo de microanálisis para medir el tiempo de coagulación CO2017003282A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462048183P 2014-09-09 2014-09-09
PCT/US2015/049198 WO2016040490A1 (en) 2014-09-09 2015-09-09 Microfluid chip-based, universal coagulation assay

Publications (1)

Publication Number Publication Date
CO2017003282A2 true CO2017003282A2 (es) 2017-08-31

Family

ID=54186304

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0003282A CO2017003282A2 (es) 2014-09-09 2017-04-04 Microchip de prueba y dispositivo de microanálisis para medir el tiempo de coagulación

Country Status (34)

Country Link
US (5) US9910053B2 (es)
EP (2) EP4109095A1 (es)
JP (1) JP6550126B2 (es)
KR (1) KR102533127B1 (es)
CN (1) CN107076733B (es)
AP (1) AP2017009807A0 (es)
AU (1) AU2015315159C1 (es)
BR (1) BR112017004506B1 (es)
CA (1) CA2959742C (es)
CL (1) CL2017000546A1 (es)
CO (1) CO2017003282A2 (es)
CR (1) CR20170133A (es)
DK (1) DK3191836T3 (es)
EA (1) EA033382B1 (es)
EC (1) ECSP17020834A (es)
ES (1) ES2936341T3 (es)
FI (1) FI3191836T3 (es)
HR (1) HRP20230171T1 (es)
HU (1) HUE060968T2 (es)
IL (1) IL250977B (es)
LT (1) LT3191836T (es)
MX (1) MX2017003043A (es)
NZ (1) NZ730056A (es)
PE (1) PE20170737A1 (es)
PH (1) PH12017500415A1 (es)
PL (1) PL3191836T3 (es)
PT (1) PT3191836T (es)
RS (1) RS64075B1 (es)
SA (1) SA517381058B1 (es)
SG (1) SG11201701596WA (es)
SI (1) SI3191836T1 (es)
UA (1) UA118986C2 (es)
WO (1) WO2016040490A1 (es)
ZA (1) ZA201702431B (es)

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US11852639B2 (en) 2023-12-26
EP3191836A1 (en) 2017-07-19
EA201790443A1 (ru) 2017-07-31
PH12017500415A1 (en) 2017-07-17
KR20170057310A (ko) 2017-05-24
AU2015315159B2 (en) 2018-11-15
CA2959742A1 (en) 2016-03-17
PE20170737A1 (es) 2017-07-04
AU2015315159A1 (en) 2017-03-23
EP4109095A1 (en) 2022-12-28
RS64075B1 (sr) 2023-04-28
SI3191836T1 (sl) 2023-04-28
WO2016040490A1 (en) 2016-03-17
AU2015315159C1 (en) 2019-05-02
ECSP17020834A (es) 2017-07-31
JP6550126B2 (ja) 2019-07-24
CL2017000546A1 (es) 2017-10-20
SG11201701596WA (en) 2017-03-30
US20180252734A1 (en) 2018-09-06
ZA201702431B (en) 2018-08-29
AP2017009807A0 (en) 2017-03-31
PT3191836T (pt) 2023-01-25
US9910053B2 (en) 2018-03-06
BR112017004506A2 (pt) 2018-01-23
US20160069913A1 (en) 2016-03-10
CN107076733A (zh) 2017-08-18
US11243219B2 (en) 2022-02-08
NZ730056A (en) 2018-10-26
US10534006B2 (en) 2020-01-14
IL250977B (en) 2020-04-30
US20200249247A1 (en) 2020-08-06
US20240085440A1 (en) 2024-03-14
UA118986C2 (uk) 2019-04-10
IL250977A0 (en) 2017-04-30
DK3191836T3 (da) 2023-02-20
HRP20230171T1 (hr) 2023-03-31
ES2936341T3 (es) 2023-03-16
CR20170133A (es) 2017-07-21
PL3191836T3 (pl) 2023-04-24
HUE060968T2 (hu) 2023-04-28
CA2959742C (en) 2019-08-20
FI3191836T3 (fi) 2023-03-15
JP2017530349A (ja) 2017-10-12
LT3191836T (lt) 2023-01-25
SA517381058B1 (ar) 2020-07-19
CN107076733B (zh) 2021-04-30
MX2017003043A (es) 2017-10-18
EP3191836B1 (en) 2022-11-23
BR112017004506B1 (pt) 2023-12-19
US20220155326A1 (en) 2022-05-19
EA033382B1 (ru) 2019-10-31
KR102533127B1 (ko) 2023-05-17

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