BR112019004261A2 - sonda de coleta e métodos para seu uso - Google Patents
sonda de coleta e métodos para seu usoInfo
- Publication number
- BR112019004261A2 BR112019004261A2 BR112019004261A BR112019004261A BR112019004261A2 BR 112019004261 A2 BR112019004261 A2 BR 112019004261A2 BR 112019004261 A BR112019004261 A BR 112019004261A BR 112019004261 A BR112019004261 A BR 112019004261A BR 112019004261 A2 BR112019004261 A2 BR 112019004261A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- collection probe
- samples
- collection
- devices
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000523 sample Substances 0.000 title 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 238000007479 molecular analysis Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0404—Capillaries used for transferring samples or ions
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4055—Concentrating samples by solubility techniques
- G01N2001/4061—Solvent extraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Clinical Laboratory Science (AREA)
- Electrochemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
são fornecidos métodos e dispositivos para avaliar amostras de tecido a partir de uma pluralidade de sítios teciduais em um sujeito usando análise molecular. em certos aspectos, os dispositivos das modalidades permitem a coleta de amostras de tecido líquidas e a distribuição das amostras para a análise por espectrometria de massa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662383234P | 2016-09-02 | 2016-09-02 | |
US201662411321P | 2016-10-21 | 2016-10-21 | |
US201762462524P | 2017-02-23 | 2017-02-23 | |
PCT/US2017/049689 WO2018045208A1 (en) | 2016-09-02 | 2017-08-31 | Collection probe and methods for the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019004261A2 true BR112019004261A2 (pt) | 2019-06-04 |
Family
ID=62243007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019004261A BR112019004261A2 (pt) | 2016-09-02 | 2017-08-31 | sonda de coleta e métodos para seu uso |
Country Status (12)
Country | Link |
---|---|
US (5) | US10643832B2 (pt) |
EP (2) | EP3496859B1 (pt) |
JP (2) | JP7195002B2 (pt) |
KR (1) | KR102543773B1 (pt) |
CN (2) | CN109789420B (pt) |
AU (1) | AU2017318661B2 (pt) |
BR (1) | BR112019004261A2 (pt) |
CA (1) | CA3035743A1 (pt) |
ES (1) | ES2971214T3 (pt) |
IL (1) | IL265129B2 (pt) |
MX (1) | MX2019002471A (pt) |
SG (1) | SG11201901866TA (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109789420B (zh) | 2016-09-02 | 2021-09-24 | 得克萨斯大学体系董事会 | 收集探针及其使用方法 |
EP3526811A4 (en) * | 2016-10-14 | 2020-06-17 | DH Technologies Development Pte. Ltd. | METHODS AND SYSTEMS FOR INCREASING THE SENSITIVITY OF DIRECT SCAN INTERFACES FOR MASS SPECTROMETRIC ANALYSIS |
US20210343515A1 (en) * | 2017-06-08 | 2021-11-04 | Board Of Regents, The University Of Texas System | Systems and methods for microarray droplet ionization analysis |
US11348780B2 (en) * | 2017-11-21 | 2022-05-31 | Dh Technologies Development Pte. Ltd. | Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis |
SG11202004568UA (en) * | 2017-11-27 | 2020-06-29 | Univ Texas | Minimally invasive collection probe and methods for the use thereof |
US10147052B1 (en) * | 2018-01-29 | 2018-12-04 | C-SATS, Inc. | Automated assessment of operator performance |
EP3522201B1 (en) * | 2018-02-02 | 2020-10-07 | Tofwerk AG | Autosampler |
US11219393B2 (en) | 2018-07-12 | 2022-01-11 | Trace Matters Scientific Llc | Mass spectrometry system and method for analyzing biological samples |
WO2019234708A1 (en) | 2018-06-07 | 2019-12-12 | Dh Technologies Development Pte. Ltd. | Sampling interface for a mass spectrometer |
EP3647763B1 (en) * | 2018-10-29 | 2021-07-14 | FEI Company | A method of preparing a biological sample for study in an analysis device |
WO2020154477A1 (en) | 2019-01-25 | 2020-07-30 | Board Of Regents, The University Of Texas System | Apparatus and methods for cleaning and/or exchanging medical devices |
US20220208538A1 (en) * | 2019-05-31 | 2022-06-30 | Purdue Research Foundation | Integrated microfluidic probe (imfp) and methods of use thereof |
CN114008455A (zh) * | 2019-06-06 | 2022-02-01 | 得克萨斯大学体系董事会 | 使用质谱鉴别子宫内膜异位组织 |
WO2021144713A1 (en) * | 2020-01-14 | 2021-07-22 | Dh Technologies Development Pte. Ltd. | Method of mass analysis –controlling viscosity of solvent for opp operation |
CN111351831A (zh) * | 2020-02-26 | 2020-06-30 | 西安交通大学医学院第二附属医院 | 基于质谱分析组织术中检测、标记设备及其检测方法 |
EP4143563A4 (en) * | 2020-04-27 | 2024-05-15 | Board of Regents, The University of Texas System | DETECTION OF CHEMICAL COMPOUNDS FOR FORENSIC ANALYSIS |
AU2021265090A1 (en) * | 2020-04-27 | 2022-11-17 | Board Of Regents, The University Of Texas System | Identifying and classifying microorganisms |
CN112017942B (zh) * | 2020-09-04 | 2021-03-02 | 中国地质科学院地质研究所 | 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法 |
CN117083691A (zh) * | 2021-02-02 | 2023-11-17 | Dh科技发展私人贸易有限公司 | 用于清洗质谱系统中使用的采样探针的方法和设备 |
CN113764257B (zh) * | 2021-08-25 | 2024-01-12 | 清华大学深圳国际研究生院 | 一种基于3d打印的解吸电喷雾离子化装置 |
US11848094B2 (en) | 2022-04-08 | 2023-12-19 | Ohio State Innovation Foundation | Multidimensional optical tissue classification and display |
WO2023200850A1 (en) * | 2022-04-14 | 2023-10-19 | Board Of Regents, The University Of Texas System | Collection probe and methods of use thereof |
CN116169005B (zh) * | 2023-02-28 | 2023-07-28 | 厦门金诺花科学仪器有限公司 | 一次性疏水纳升点样针头及点样测试方法 |
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US10643832B2 (en) | 2020-05-05 |
CA3035743A1 (en) | 2018-03-08 |
US20230386815A1 (en) | 2023-11-30 |
US20210257202A1 (en) | 2021-08-19 |
EP4357784A2 (en) | 2024-04-24 |
ES2971214T3 (es) | 2024-06-04 |
JP7195002B2 (ja) | 2022-12-23 |
US11756778B2 (en) | 2023-09-12 |
EP3496859C0 (en) | 2024-01-10 |
CN113834869A (zh) | 2021-12-24 |
US20200279728A1 (en) | 2020-09-03 |
IL265129B2 (en) | 2024-02-01 |
AU2017318661A1 (en) | 2019-03-21 |
US11239065B2 (en) | 2022-02-01 |
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