ECSP17020834A - Análisis de coagulación universal microfluídico basado en chips - Google Patents

Análisis de coagulación universal microfluídico basado en chips

Info

Publication number
ECSP17020834A
ECSP17020834A ECIEPI201720834A ECPI201720834A ECSP17020834A EC SP17020834 A ECSP17020834 A EC SP17020834A EC IEPI201720834 A ECIEPI201720834 A EC IEPI201720834A EC PI201720834 A ECPI201720834 A EC PI201720834A EC SP17020834 A ECSP17020834 A EC SP17020834A
Authority
EC
Ecuador
Prior art keywords
anticoagulant
whole blood
clotting
blood
technologies
Prior art date
Application number
ECIEPI201720834A
Other languages
English (en)
Inventor
Stefan Zappe
Sasha Bakhru
Solomon Steiner
Bryan Laulicht
Original Assignee
Perosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere Inc filed Critical Perosphere Inc
Publication of ECSP17020834A publication Critical patent/ECSP17020834A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Un dispositivo de análisis basado en chip microfluídico se ha desarrollado para la medición de las propiedades físicas de un analito (en particular, sangre total o derivados de la sangre total). Las tecnologías se pueden aplicar para medir los tiempos de coagulación de derivados de la sangre o de la sangre total, determinar los efectos de fármacos anticoagulantes en la cinética de la coagulación, así como evaluar el efecto de los agentes de reversión anticoagulantes. Estas tecnologías pueden utilizarse adicionalmente para optimizar la dosificación de fármacos anticoagulantes y/o sus agentes de reversión. El análisis es independiente de la presencia de anticoagulante puesto que la coagulación se activa mediante la exposición de la muestra de sangre en el dispositivo a una superficie de vidrio (u otro material cargado negativamente tal como el silicio oxidado), que activa la vía intrínseca y puede acelerarse adicionalmente mediante la aplicación de flujo cortante a través de la superficie de los materiales activadores. La ausencia de agentes activadores químicos y un microambiente altamente controlado y reproducible produce un análisis de coagulación universal de diagnóstico inmediato.
ECIEPI201720834A 2014-09-09 2017-04-04 Análisis de coagulación universal microfluídico basado en chips ECSP17020834A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462048183P 2014-09-09 2014-09-09

Publications (1)

Publication Number Publication Date
ECSP17020834A true ECSP17020834A (es) 2017-07-31

Family

ID=54186304

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201720834A ECSP17020834A (es) 2014-09-09 2017-04-04 Análisis de coagulación universal microfluídico basado en chips

Country Status (34)

Country Link
US (5) US9910053B2 (es)
EP (2) EP3191836B1 (es)
JP (1) JP6550126B2 (es)
KR (1) KR102533127B1 (es)
CN (1) CN107076733B (es)
AP (1) AP2017009807A0 (es)
AU (1) AU2015315159C1 (es)
BR (1) BR112017004506B1 (es)
CA (1) CA2959742C (es)
CL (1) CL2017000546A1 (es)
CO (1) CO2017003282A2 (es)
CR (1) CR20170133A (es)
DK (1) DK3191836T3 (es)
EA (1) EA033382B1 (es)
EC (1) ECSP17020834A (es)
ES (1) ES2936341T3 (es)
FI (1) FI3191836T3 (es)
HR (1) HRP20230171T1 (es)
HU (1) HUE060968T2 (es)
IL (1) IL250977B (es)
LT (1) LT3191836T (es)
MX (1) MX2017003043A (es)
NZ (1) NZ730056A (es)
PE (1) PE20170737A1 (es)
PH (1) PH12017500415A1 (es)
PL (1) PL3191836T3 (es)
PT (1) PT3191836T (es)
RS (1) RS64075B1 (es)
SA (1) SA517381058B1 (es)
SG (1) SG11201701596WA (es)
SI (1) SI3191836T1 (es)
UA (1) UA118986C2 (es)
WO (1) WO2016040490A1 (es)
ZA (1) ZA201702431B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013001066B4 (de) * 2013-01-23 2022-01-20 Brose Fahrzeugteile Se & Co. Kommanditgesellschaft, Bamberg Kapazitiver Näherungssensor
US10088456B2 (en) 2014-03-31 2018-10-02 Texas Instruments Incorporated Scanning acoustic microscopy system and method
US9995701B2 (en) 2014-06-02 2018-06-12 Case Western Reserve University Capacitive sensing apparatuses, systems and methods of making same
US9910053B2 (en) 2014-09-09 2018-03-06 Perosphere Technologies Inc. Microfluidic chip-based, universal coagulation assay
JP6033499B2 (ja) * 2014-09-29 2016-11-30 三菱電機株式会社 絶縁劣化監視装置
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
US10228398B2 (en) * 2015-04-02 2019-03-12 Rosemount Aerospace Inc. System and method for minimizing magnetic field effect on an isolated magnetometer
WO2016209735A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Camera imaging system for a fluid sample assay and method of using same
WO2016209731A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Test card for assay and method of manufacturing same
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
KR101582825B1 (ko) * 2015-06-30 2016-01-07 정현아 태양전지 모니터링장치
US10502696B2 (en) * 2015-07-28 2019-12-10 Furuno Electric Co., Ltd. Water vapor observing apparatus
CN105092907B (zh) * 2015-08-28 2017-06-16 深圳市华星光电技术有限公司 信号转接装置及测试系统
KR102032071B1 (ko) * 2015-09-02 2019-10-14 가부시키가이샤 히다치 하이테크놀로지즈 회로 검사 방법 및 시료 검사 장치
KR102340973B1 (ko) * 2015-09-18 2021-12-17 삼성전자주식회사 반도체 테스트 장치 및 방법과 데이터 분석 장치
EP3182169B1 (en) * 2015-12-17 2018-12-05 Mettler-Toledo Safeline Limited Metal detection apparatus
US11175252B2 (en) 2016-01-15 2021-11-16 Case Western Reserve University Dielectric sensing for blood characterization
US10674931B2 (en) 2016-01-15 2020-06-09 Case Western Reserve University Dielectric sensing for sample characterization
CA3029905C (en) 2016-07-12 2021-11-30 EMULATE, Inc. Uses of microfluidic devices comprising additive channels
CN107688107B (zh) * 2016-08-04 2019-11-22 创意电子股份有限公司 测试装置与其探针连接器
US10197640B2 (en) * 2016-09-30 2019-02-05 International Business Machines Corporation Carrier-resolved multiple dipole line magnet photo-hall system
WO2018194700A1 (en) 2017-04-20 2018-10-25 Hewlett-Packard Development Company, L.P. Microfluidic reaction system
US20200088715A1 (en) * 2017-04-20 2020-03-19 Hewlett-Packard Development Company, L.P. Architecture for coagulation analysis with tissue factor
EP3619517A4 (en) * 2017-05-04 2020-11-11 University of Connecticut SET FOR MEASURING THE VISCOSITY OF FLUIDS USING MICROChannels
SG11202000688UA (en) * 2017-07-28 2020-02-27 Massachusetts Inst Technology Methods and devices for detection of anticoagulants in plasma and whole blood
WO2019099342A1 (en) * 2017-11-16 2019-05-23 Georgia Tech Research Corporation Methods and systems for consistent thrombus formation and measurement thereof
US10968423B2 (en) 2018-02-26 2021-04-06 General Electric Company System and method for electric pulse based activation of biological samples
KR102083514B1 (ko) * 2018-06-22 2020-03-02 광주과학기술원 적혈구 변형성 측정장치 및 측정방법
CN109100394B (zh) * 2018-07-18 2020-10-02 浙江大学 一种凝血时间检测仪及其检测方法
WO2020027741A1 (en) * 2018-07-29 2020-02-06 Koc Universitesi Microfluidic thromboelastometry instrument
CN109085367B (zh) * 2018-07-31 2023-09-26 美德太平洋（天津）生物科技股份有限公司 一种携带方便且具备防护装置的凝血仪
WO2020106536A1 (en) 2018-11-20 2020-05-28 Xa Tek, Inc. Portable dielectric spectroscopy device
AU2019384106A1 (en) 2018-11-20 2021-04-29 Xatek, Inc. Dielectric spectroscopy sensing apparaus and method of use
CN111289556B (zh) * 2018-12-06 2023-06-23 北京碧澄生物科技有限公司 检测液体相变的装置和方法
CN109765269B (zh) * 2018-12-27 2020-07-28 西安交通大学 一种声波驱动的血液凝固测试系统
US11774388B2 (en) 2019-04-02 2023-10-03 Case Western Reserve University Dielectric sensing to characterize hemostatic dysfunction
US11408844B2 (en) 2019-04-02 2022-08-09 Case Western Reserve University Dielectric sensing to characterize hemostatic dysfunction
CN110596241A (zh) * 2019-10-22 2019-12-20 世纪亿康（天津）医疗科技发展有限公司 一种方便采样的凝血功能测试盒
CN114981656A (zh) * 2020-01-17 2022-08-30 A&T株式会社 血液凝固测定装置、血液凝固时间的测定方法、血液凝固反应的完成判定方法以及血液自动离心分离装置
AU2021260947A1 (en) 2020-04-24 2022-12-01 Perosphere Technologies Inc. Whole blood control sample systems and method of preparing and using the same
US12073926B2 (en) 2020-09-21 2024-08-27 Instrumentation Laboratory Company Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample
EP4237149A1 (en) * 2020-10-30 2023-09-06 The Trustees of The University of Pennsylvania A human vascular injury-on-a-chip model of hemostasis
KR102618172B1 (ko) * 2020-12-24 2023-12-29 경북대학교 산학협력단 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법
WO2022145475A1 (ja) * 2020-12-28 2022-07-07 藤森工業株式会社 血液凝固能の評価方法および血栓症リスクの検査方法
CN114054109B (zh) * 2021-11-08 2022-12-27 北京化工大学 基于导电弹性体材料的血液凝固检测微流控芯片
WO2024073059A2 (en) 2022-09-30 2024-04-04 Coagulo Medical Technologies, Inc. Modular apparatus for testing microfluidic cartridge, useful for point-of-care medical diagnostics and other applications

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1006094A (en) 1908-08-01 1911-10-17 Henry E Bullock Cotton-picker.
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
US5089415A (en) * 1990-09-17 1992-02-18 International Technidyne Corp. Method for clotting heparized blood by the addition of protamine, thrombin and snake venom
US5167145B1 (en) * 1990-09-19 2000-05-23 David M Butler Measurement of blood coagulation time using infrared electromagnetic energy
US5302348A (en) * 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
DE19512710A1 (de) 1995-04-10 1996-10-17 Behringwerke Ag Biosensor
ES2219374T3 (es) * 1999-07-02 2004-12-01 Clondiag Chip Technologies Gmbh Dispositivo de matriz de microchip para la multiplicacion y la caracterizacion de acidos nucleicos.
US6437551B1 (en) * 1999-11-02 2002-08-20 The Regents Of The University Of California Microfabricated AC impedance sensor
JP2002214241A (ja) * 2000-11-20 2002-07-31 Minolta Co Ltd マイクロチップ
GB0030929D0 (en) * 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US20030064414A1 (en) * 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
JP2003004752A (ja) * 2001-06-15 2003-01-08 Minolta Co Ltd マイクロチップおよび該マイクロチップを用いる検査装置
US20060062696A1 (en) * 2001-07-27 2006-03-23 Caliper Life Sciences, Inc. Optimized high throughput analytical systems
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US7291310B2 (en) 2002-12-17 2007-11-06 The Regents Of The University Of Michigan Microsystem for determining clotting time of blood and low-cost, single-use device for use therein
US20050129580A1 (en) * 2003-02-26 2005-06-16 Swinehart Philip R. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US7857761B2 (en) * 2003-04-16 2010-12-28 Drexel University Acoustic blood analyzer for assessing blood properties
US7887750B2 (en) * 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
EP1920246B1 (en) * 2005-08-31 2010-03-10 Egomedical Technologies AG Coagulation test system
EP1963817A2 (en) 2005-12-22 2008-09-03 Honeywell International Inc. Portable sample analyzer cartridge
US8473216B2 (en) * 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
KR100834385B1 (ko) * 2006-12-12 2008-06-09 주식회사 리오메디텍 교반을 이용한 혈구 응집률 측정 장치 및 방법
EP2040073A1 (en) * 2007-09-20 2009-03-25 Iline Microsystems, S.L. Microfluidic device and method for fluid clotting time determination
US7821620B2 (en) 2007-10-03 2010-10-26 University Of Central Florida Research Foundation, Inc. Optical coagulation monitor and method of use
KR100969667B1 (ko) 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
WO2010012281A1 (en) 2008-07-29 2010-02-04 Jacques Jonsmann A microfluidic device
FR2943789B1 (fr) * 2009-03-26 2013-07-26 Commissariat Energie Atomique Procede et dispositif pour la caracterisation de la dynamique de coagulation ou sedimentation d'un fluide tel que le sang ou le plasma sanguin
JP5816613B2 (ja) * 2009-04-23 2015-11-18 ダブリン シティ ユニバーシティ 凝固をモニタするための側方流動分析装置及びその方法
US8450078B2 (en) * 2009-12-18 2013-05-28 Entegrion, Inc. Portable coagulation monitoring device and method of assessing coagulation response
JP5752055B2 (ja) * 2010-02-10 2015-07-22 藤森工業株式会社 血小板検査用マイクロチップ及びそれを用いた血小板検査装置
US8486349B2 (en) * 2010-03-12 2013-07-16 Colorado School Of Mines Microfluidic flow assay for measuring hemostatic phenotypes
TWI461689B (zh) * 2010-04-01 2014-11-21 Univ Nat Cheng Kung 含有乾粉狀試劑的血液凝固測試用生醫晶片
KR101222585B1 (ko) * 2010-12-23 2013-01-16 고려대학교 산학협력단 광투과량을 이용한 혈액 응고 측정 장치 및 방법, 이에 구비되는 미세교반칩
US8697449B2 (en) 2011-04-01 2014-04-15 Spectral Sciences, Inc. Optical blood coagulation monitor and method
ES2886583T3 (es) 2011-05-26 2021-12-20 Massachusetts Gen Hospital Sistema de tromboelastografía óptica y método para la evaluación de las métricas de coagulación sanguínea
US9518905B2 (en) 2012-01-16 2016-12-13 Abram Scientific, Inc. Methods, devices, and systems for measuring physical properties of fluid
JP2013257154A (ja) * 2012-06-11 2013-12-26 Nippon Telegr & Teleph Corp <Ntt> 測定チップ
US9952149B2 (en) * 2012-11-30 2018-04-24 The University Of North Carolina At Chapel Hill Methods, systems, and computer readable media for determining physical properties of a specimen in a portable point of care diagnostic device
WO2014100378A1 (en) 2012-12-19 2014-06-26 The General Hospital Corporation Optical blood-coagulation sensor
US9297816B1 (en) 2012-12-21 2016-03-29 University Of South Florida Devices and methods for measuring blood coagulation
CN105228749B (zh) * 2013-03-13 2018-03-27 塔霍农村卫生研究所有限公司 便携式血细胞计数监测器
US20140270458A1 (en) * 2013-03-13 2014-09-18 The Regents Of The University Of California Portable Blood Count Monitor
KR102146122B1 (ko) 2013-10-28 2020-08-20 삼성디스플레이 주식회사 표시 장치 및 이의 구동 방법
MX357251B (es) 2013-11-15 2018-07-03 Entegrion Inc Dispositivos, sistemas y metodos portatiles de control de coagulacion.
EP3137878A1 (en) 2014-04-30 2017-03-08 Instrumentation Laboratory Company Methods and systems for point-of-care coagulation assays by optical detection
US9910053B2 (en) 2014-09-09 2018-03-06 Perosphere Technologies Inc. Microfluidic chip-based, universal coagulation assay
US10060948B2 (en) 2016-08-12 2018-08-28 Tiptek, LLC Scanning probe and electron microscope probes and their manufacture

Also Published As

Publication number Publication date
IL250977B (en) 2020-04-30
US20220155326A1 (en) 2022-05-19
CL2017000546A1 (es) 2017-10-20
CA2959742A1 (en) 2016-03-17
PE20170737A1 (es) 2017-07-04
SA517381058B1 (ar) 2020-07-19
AU2015315159B2 (en) 2018-11-15
SI3191836T1 (sl) 2023-04-28
CA2959742C (en) 2019-08-20
CN107076733A (zh) 2017-08-18
EP3191836A1 (en) 2017-07-19
KR20170057310A (ko) 2017-05-24
PT3191836T (pt) 2023-01-25
WO2016040490A1 (en) 2016-03-17
EA201790443A1 (ru) 2017-07-31
PL3191836T3 (pl) 2023-04-24
AU2015315159A1 (en) 2017-03-23
CN107076733B (zh) 2021-04-30
BR112017004506A2 (pt) 2018-01-23
IL250977A0 (en) 2017-04-30
CR20170133A (es) 2017-07-21
JP6550126B2 (ja) 2019-07-24
RS64075B1 (sr) 2023-04-28
US10534006B2 (en) 2020-01-14
BR112017004506B1 (pt) 2023-12-19
CO2017003282A2 (es) 2017-08-31
US9910053B2 (en) 2018-03-06
EA033382B1 (ru) 2019-10-31
US11243219B2 (en) 2022-02-08
ES2936341T3 (es) 2023-03-16
LT3191836T (lt) 2023-01-25
JP2017530349A (ja) 2017-10-12
US20240085440A1 (en) 2024-03-14
NZ730056A (en) 2018-10-26
EP4109095A1 (en) 2022-12-28
US11852639B2 (en) 2023-12-26
FI3191836T3 (fi) 2023-03-15
US20160069913A1 (en) 2016-03-10
US20200249247A1 (en) 2020-08-06
AU2015315159C1 (en) 2019-05-02
MX2017003043A (es) 2017-10-18
PH12017500415A1 (en) 2017-07-17
US20180252734A1 (en) 2018-09-06
EP3191836B1 (en) 2022-11-23
AP2017009807A0 (en) 2017-03-31
HUE060968T2 (hu) 2023-04-28
DK3191836T3 (da) 2023-02-20
HRP20230171T1 (hr) 2023-03-31
KR102533127B1 (ko) 2023-05-17
UA118986C2 (uk) 2019-04-10
ZA201702431B (en) 2018-08-29
SG11201701596WA (en) 2017-03-30

Similar Documents

Publication Publication Date Title
ECSP17020834A (es) Análisis de coagulación universal microfluídico basado en chips
Li et al. Blood coagulation screening using a paper-based microfluidic lateral flow device
AR112132A1 (es) Sistema de pruebas universal para análisis cuantitativo
BR112019006930A2 (pt) dispositivos e métodos para análise de amostra
AR113305A1 (es) Medición de campo de la concentración de elementos en el suelo
CL2020001300A1 (es) Sistemas y procedimientos para el cribado de laboratorio de muestras biológicas.
BR112018000851A2 (pt) sistemas e métodos para detecção e quantificação aprimoradas de analitos
DOP2006000206A (es) Voltametria regulada
UY29681A1 (es) Amperometria regulada
BR112014032110A2 (pt) dispositivo e método de teste rápido
MX2017003454A (es) Sistemas y metodos para la integracion de la recoleccion de microfluido lagrimal y el analisis por flujo lateral de analitos de interes.
SG169968A1 (en) Adhesive composition for use in an immunosensor
ECSP12011981A (es) Dispositivo portátil de monitorización de la coagulación y método de evaluación de la respuesta de coagulación
Khnouf et al. Microfluidics-based device for the measurement of blood viscosity and its modeling based on shear rate, temperature, and heparin concentration
AR086657A1 (es) Ensayo de la lisil oxidasa-like 2 y sus metodos de empleo
BR112017009151A2 (pt) ensaios para detectar subgrupos imunológicos de célula t e métodos de uso dos mesmos
BR112018010902A2 (pt) método de eletroquimioluminescência, aparelho para executar um método de eletroquimioluminescência e produto de programa de computador
BR112016024730A2 (pt) dispositivo, método e conjunto de análise imunocromatográfica
BR112017011026A2 (pt) métodos analíticos e arranjos para uso nos mesmos
MX2019000592A (es) Dispositivo dispensador de reactivos analiticos liquidos, y kits analiticos y metodos de uso relacionados.
CL2020002664A1 (es) Aparato y método para determinar la velocidad de sedimentación de los eritrocitos y otros parámetros relacionados
BR112019025079A2 (pt) Biossensores eletroquímicos
BR112019007138A2 (pt) método e sistema de análise para testagem de uma amostra
EA202090709A1 (ru) Устройство для полного анализа крови
BR112018076346A2 (pt) métodos e sistemas para detectar e quantificar o peroxiácido e o peróxido em fluidos