BR112017004506A2 - dispositivo de microensaio, e, método para a medição de tempo de coagulação - Google Patents

dispositivo de microensaio, e, método para a medição de tempo de coagulação

Info

Publication number
BR112017004506A2
BR112017004506A2 BR112017004506-0A BR112017004506A BR112017004506A2 BR 112017004506 A2 BR112017004506 A2 BR 112017004506A2 BR 112017004506 A BR112017004506 A BR 112017004506A BR 112017004506 A2 BR112017004506 A2 BR 112017004506A2
Authority
BR
Brazil
Prior art keywords
whole blood
coagulation
anticoagulant
assay
agents
Prior art date
Application number
BR112017004506-0A
Other languages
English (en)
Other versions
BR112017004506B1 (pt
Inventor
Bakhru Sasha
Laulicht Bryan
Zappe Stefan
Steiner Solomon
Original Assignee
Perosphere, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perosphere, Inc. filed Critical Perosphere, Inc.
Publication of BR112017004506A2 publication Critical patent/BR112017004506A2/pt
Publication of BR112017004506B1 publication Critical patent/BR112017004506B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

um dispositivo de ensaio à base de chip microfluídico foi desenvolvido para a medição de propriedades físicas de um analito (particularmente, sangue total ou derivados de sangue total). as tecnologias podem ser aplicadas para medir tempos de coagulação de sangue total ou derivados de sangue total, determinar os efeitos de fármacos anticoagulantes sobre a cinética de coagulação/formação de coágulo, bem como avaliar o efeito de agentes de reversão de anticoagulante. essas tecnologias podem ser adicionalmente usadas para otimizar a dosagem de fármacos de anticoagulação e/ou seus agentes de reversão. o ensaio é independente da presença de anticoagulante; a coagulação é ativada pela exposição da amostra de sangue no dispositivo a uma superfície de vidro (ou outro material carregado negativamente, como silício oxidado), que ativa a rota intrínseca e pode ser acelerada ainda mais pela aplicação de fluxo de cisalhamento através da superfície de materiais de ativação. a ausência de agentes químicos de ativação e o microambiente altamente controlado e reproduzível rendem um ensaio de coagulação universal no local de atendimento.
BR112017004506-0A 2014-09-09 2015-09-09 Microchip de ensaio para a medição de coagulação em uma amostra de sangue ou plasma, dispositivo de microensaio para a medição de coagulação em uma amostra de sangue ou plasma de um indíviduo e método para medição de tempo de coagulação BR112017004506B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462048183P 2014-09-09 2014-09-09
US62/048,183 2014-09-09
PCT/US2015/049198 WO2016040490A1 (en) 2014-09-09 2015-09-09 Microfluid chip-based, universal coagulation assay

Publications (2)

Publication Number Publication Date
BR112017004506A2 true BR112017004506A2 (pt) 2018-01-23
BR112017004506B1 BR112017004506B1 (pt) 2023-12-19

Family

ID=54186304

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004506-0A BR112017004506B1 (pt) 2014-09-09 2015-09-09 Microchip de ensaio para a medição de coagulação em uma amostra de sangue ou plasma, dispositivo de microensaio para a medição de coagulação em uma amostra de sangue ou plasma de um indíviduo e método para medição de tempo de coagulação

Country Status (34)

Country Link
US (5) US9910053B2 (pt)
EP (2) EP4109095A1 (pt)
JP (1) JP6550126B2 (pt)
KR (1) KR102533127B1 (pt)
CN (1) CN107076733B (pt)
AP (1) AP2017009807A0 (pt)
AU (1) AU2015315159C1 (pt)
BR (1) BR112017004506B1 (pt)
CA (1) CA2959742C (pt)
CL (1) CL2017000546A1 (pt)
CO (1) CO2017003282A2 (pt)
CR (1) CR20170133A (pt)
DK (1) DK3191836T3 (pt)
EA (1) EA033382B1 (pt)
EC (1) ECSP17020834A (pt)
ES (1) ES2936341T3 (pt)
FI (1) FI3191836T3 (pt)
HR (1) HRP20230171T1 (pt)
HU (1) HUE060968T2 (pt)
IL (1) IL250977B (pt)
LT (1) LT3191836T (pt)
MX (1) MX2017003043A (pt)
NZ (1) NZ730056A (pt)
PE (1) PE20170737A1 (pt)
PH (1) PH12017500415A1 (pt)
PL (1) PL3191836T3 (pt)
PT (1) PT3191836T (pt)
RS (1) RS64075B1 (pt)
SA (1) SA517381058B1 (pt)
SG (1) SG11201701596WA (pt)
SI (1) SI3191836T1 (pt)
UA (1) UA118986C2 (pt)
WO (1) WO2016040490A1 (pt)
ZA (1) ZA201702431B (pt)

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Also Published As

Publication number Publication date
AP2017009807A0 (en) 2017-03-31
UA118986C2 (uk) 2019-04-10
CO2017003282A2 (es) 2017-08-31
PL3191836T3 (pl) 2023-04-24
US20180252734A1 (en) 2018-09-06
HUE060968T2 (hu) 2023-04-28
US11243219B2 (en) 2022-02-08
EA033382B1 (ru) 2019-10-31
KR20170057310A (ko) 2017-05-24
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