ES2575778T3 - Procedimiento de detección para hallar muestras con una alteración en la funcionalidad de la interacción GPIb-factor de von Willebrand - Google Patents

Procedimiento de detección para hallar muestras con una alteración en la funcionalidad de la interacción GPIb-factor de von Willebrand Download PDF

Info

Publication number
ES2575778T3
ES2575778T3 ES13156498.1T ES13156498T ES2575778T3 ES 2575778 T3 ES2575778 T3 ES 2575778T3 ES 13156498 T ES13156498 T ES 13156498T ES 2575778 T3 ES2575778 T3 ES 2575778T3
Authority
ES
Spain
Prior art keywords
gpib
alteration
functionality
von willebrand
willebrand factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13156498.1T
Other languages
English (en)
Inventor
Juergen Dr. Patzke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Siemens Healthcare Diagnostics Products GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Products GmbH filed Critical Siemens Healthcare Diagnostics Products GmbH
Application granted granted Critical
Publication of ES2575778T3 publication Critical patent/ES2575778T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Procedimiento para hallar una muestra de paciente con una interacción VWF-GPIb alterada, en el que a. se pone en contacto una muestra de sangre, plasma o suero de un paciente con proteína GPIbα aislada, con proteína VWF y con una fase sólida que está asociada a un anticuerpo con especificidad por la proteína GPIbα aislada y b. se determina la formación de complejo entre proteína VWF, proteína GPIbα y la fase sólida.

Description

imagen1
imagen2
imagen3
imagen4
imagen5

Claims (1)

  1. imagen1
ES13156498.1T 2012-03-05 2013-02-25 Procedimiento de detección para hallar muestras con una alteración en la funcionalidad de la interacción GPIb-factor de von Willebrand Active ES2575778T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12158022 2012-03-05
EP12158022.9A EP2637024A1 (de) 2012-03-05 2012-03-05 Screeningverfahren zum Auffinden von Proben mit einer Störung der Funktionalität der GPIb-Von Willebrand Faktor-Interaktion

Publications (1)

Publication Number Publication Date
ES2575778T3 true ES2575778T3 (es) 2016-07-01

Family

ID=47722189

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13156498.1T Active ES2575778T3 (es) 2012-03-05 2013-02-25 Procedimiento de detección para hallar muestras con una alteración en la funcionalidad de la interacción GPIb-factor de von Willebrand

Country Status (4)

Country Link
US (1) US9766234B2 (es)
EP (2) EP2637024A1 (es)
JP (1) JP6199050B2 (es)
ES (1) ES2575778T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007031708A1 (de) * 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
EP2637024A1 (de) 2012-03-05 2013-09-11 Siemens Healthcare Diagnostics Products GmbH Screeningverfahren zum Auffinden von Proben mit einer Störung der Funktionalität der GPIb-Von Willebrand Faktor-Interaktion
ES2614352T3 (es) 2014-03-11 2017-05-30 Siemens Healthcare Diagnostics Products Gmbh Método para la detección de moduladores de la interacción de GPIb-trombina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074564B1 (en) 1998-04-23 2008-12-10 Ajinomoto Co., Inc. Substance with antithrombotic activity and method for detecting glycokallidin
US7622259B1 (en) 1999-07-05 2009-11-24 K.U. Leuven Research & Development Detection of von-Willebrand factor (vWF) activity
DE102006019520A1 (de) * 2006-04-27 2007-11-08 Dade Behring Marburg Gmbh Verfahren zur Bestimmung hoher Ristocetin-Kofaktor-Aktivitäten des von-Willebrand-Faktors
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin
WO2009026551A1 (en) 2007-08-23 2009-02-26 Bloodcenter Of Wisconsin, Inc. Methods and kits for measuring von willebrand factor
EP2637024A1 (de) 2012-03-05 2013-09-11 Siemens Healthcare Diagnostics Products GmbH Screeningverfahren zum Auffinden von Proben mit einer Störung der Funktionalität der GPIb-Von Willebrand Faktor-Interaktion

Also Published As

Publication number Publication date
US9766234B2 (en) 2017-09-19
EP2637024A1 (de) 2013-09-11
US20130230868A1 (en) 2013-09-05
EP2637025A2 (de) 2013-09-11
JP2013186124A (ja) 2013-09-19
EP2637025A3 (de) 2013-11-20
JP6199050B2 (ja) 2017-09-20
EP2637025B1 (de) 2016-04-13

Similar Documents

Publication Publication Date Title
TR201900160T4 (tr) Bir anti-ilaç antikoru varlığının veya miktarının saptanmasına yönelik analizler.
CL2015002756A1 (es) Moléculas fc biespecíficas
CR20130621A (es) Anticuerpos anti-angptl3 y usos de los mismos
EA201690731A1 (ru) Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах
BR112016003665A2 (pt) anticorpos e ensaios para detecção do receptor 1 de folato
CO2019008675A2 (es) Anticuerpos anti-lag3 radiomarcados para la obtención de imágenes mediante inmuno-pet
MX2015012823A (es) Ensayo de combinacion de antigeno-anticuerpo del virus de la hepatitis c (vhc) y metodos y composiciones para usarlo.
EP4649966A3 (en) Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
EP2542581A4 (en) APOLIPOPROTEIN-SPECIFIC ANTIBODY AND METHOD OF USE THEREOF
BR112014018970A8 (pt) Dispositivos de coleta de amostra com agentes de estabilização sanguínea
EP3665187A4 (en) TEST PROCEDURES FOR IMPROVED ANALYTE DETECTION
MX361502B (es) Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano.
BR112013023540A2 (pt) anticorpo, kit e método para a determinação de peptídeos amilóides
PE20140612A1 (es) Estratificaciones a base de bcma y terapia para pacientes con mieloma multiple
MX2016011809A (es) Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y metodos de produccion y uso de los mismos.
MX2016001573A (es) Ensayos para timp2 con mejor rendimiento en muestras biológicas.
BRPI0923199B8 (pt) método para determinar a presença de anticorpos de fixação de complemento
CL2015002517A1 (es) Proteínas de unión a antígeno.
MX386714B (es) Anticuerpos de dominio simple dirigidos al grupo de diferenciación 1d (cd1d).
BR112018017336A2 (pt) método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
EP3642603A4 (en) NANOSCALE ELECTROCHEMICAL INTERFACE FOR DETECTION OF ANALYTES
PE20160657A1 (es) Composiciones y metodos para identificar un riesgo de cancer en un sujeto
RU2015104737A (ru) Способ обнаружения мультиспецифического связывающего агента
EA201991506A1 (ru) Системы и способы для тестирования и скрининга с использованием связанных с соединениями субстратов
WO2013106778A3 (en) Non-equilibrium two-site assays for linear, ultrasensitive analyte detection