HRP20230171T1 - Univerzalni test koagulacije na bazi mikrofluidnog čipa - Google Patents
Univerzalni test koagulacije na bazi mikrofluidnog čipa Download PDFInfo
- Publication number
- HRP20230171T1 HRP20230171T1 HRP20230171TT HRP20230171T HRP20230171T1 HR P20230171 T1 HRP20230171 T1 HR P20230171T1 HR P20230171T T HRP20230171T T HR P20230171TT HR P20230171 T HRP20230171 T HR P20230171T HR P20230171 T1 HRP20230171 T1 HR P20230171T1
- Authority
- HR
- Croatia
- Prior art keywords
- clotting
- sample
- microfluidic chip
- optical properties
- measured
- Prior art date
Links
- 238000007820 coagulation assay Methods 0.000 title 1
- 206010053567 Coagulopathies Diseases 0.000 claims 7
- 230000035602 clotting Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000003287 optical effect Effects 0.000 claims 5
- 238000012360 testing method Methods 0.000 claims 3
- 230000005540 biological transmission Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000004891 communication Methods 0.000 claims 2
- 230000036760 body temperature Effects 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
Claims (7)
1. Postupak za mjerenje vremena zgrušavanja koji obuhvaća uvođenje uzorka krvi ili plazme u mikrofluidni čip (10), mikrofluidni čip (10) koji obuhvaća:
a) ulaz (16) u komunikaciji sa jednim ili više mikrokanala (14), pri čemu dužina kanala varira od desetaka mikrona do milimetara, sa visinom i dubinom u opsegu od desetaka mikrona do stotina mikrona;
b) jedan ili više mikrokanala (14) koji sadrže najmanje jednu anionski naelektriziranu površinu koja aktivira zgrušavanje, pri čemu anionski naelektrizirana površina ne uključuje kemijske agense koji aktiviraju zgrušavanje; i gdje je uvedeni uzorak krvi ili plazme u kontaktu sa navedenom anionski naelektriziranom površinom koja služi da aktivira kaskadu zgrušavanja bez uporabe dodatnih kemijskih ili bioloških reagenasa za zgrušavanje;
c) svaki mikrokanal (14) koji sadrži komoru (12a, 12b) za testiranje u kojoj se mogu mjeriti promjene viskoznosti, impedancije, akustičkih svojstava ili optičkih svojstava; i
d) izlaz (28b) u komunikaciji sa jednim ili više mikrokanala (14),
pri čemu se mikrofluidni čip ubacuje u čitač (50,80), pri čemu čitač (50, 80) sadrži:
(i) detektor koji određuje promjene viskoznosti, impedancije, akustičkih svojstava ili optičkih svojstava u uzorku u komori za testiranje kako bi se izmjerilo vrijeme zgrušavanja;
(ii) element za kontrolu temperature, i
pri čemu je detektor konfiguriran da šalje izmjereno vrijeme zgrušavanja određeno na osnovu promjene viskoznosti, impedancije, akustičkih svojstava ili optičkih svojstava, na monitor, ekran ili u memorijski uređaj.
2. Postupak prema patentnom zahtjevu 1, naznačen time što je mikrofluidni čip (10) sačinjen od jednog mikrokanala.
3. Postupak prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačen time što se promjena optičkih svojstava uzoraka mjeri putem mjerenja transmisije IR svijetlosti kroz komoru za testiranje mikrofluidnog čipa (10).
4. Postupak prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time što detektor sadrži IR LED i fotodiodu za mjerenje promjena optičkih svojstava uzorka.
5. Postupak prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time što se transmisija kroz uzorak mjeri kako bi se odredilo vrijeme do trenutka maksimalnog zgrušavanja, pri čemu se, poželjno, mjerenje obavlja pomoću svijetlosti između 500 i 10000 nm, poželjno 1300 nm.
6. Postupak prema bilo kojem od patentnih zahtjeva 1 do 5 naznačen time što se temperatura uzorka uvedenog u mikročip koji se ubacuje u čitač održava na tjelesnoj temperaturi.
7. Postupak prema bilo kojem od patentnih zahtjeva 1 do 6, naznačen time što je anionski naelektrizirana površina staklo i/ili oksidirani silicij.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048183P | 2014-09-09 | 2014-09-09 | |
| PCT/US2015/049198 WO2016040490A1 (en) | 2014-09-09 | 2015-09-09 | Microfluid chip-based, universal coagulation assay |
| EP15767657.8A EP3191836B1 (en) | 2014-09-09 | 2015-09-09 | Microfluid chip-based, universal coagulation assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230171T1 true HRP20230171T1 (hr) | 2023-03-31 |
Family
ID=54186304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230171TT HRP20230171T1 (hr) | 2014-09-09 | 2015-09-09 | Univerzalni test koagulacije na bazi mikrofluidnog čipa |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US9910053B2 (hr) |
| EP (2) | EP4109095A1 (hr) |
| JP (1) | JP6550126B2 (hr) |
| KR (1) | KR102533127B1 (hr) |
| CN (1) | CN107076733B (hr) |
| AP (1) | AP2017009807A0 (hr) |
| AU (1) | AU2015315159C1 (hr) |
| BR (1) | BR112017004506B1 (hr) |
| CA (1) | CA2959742C (hr) |
| CL (1) | CL2017000546A1 (hr) |
| CO (1) | CO2017003282A2 (hr) |
| CR (1) | CR20170133A (hr) |
| DK (1) | DK3191836T3 (hr) |
| EA (1) | EA033382B1 (hr) |
| EC (1) | ECSP17020834A (hr) |
| ES (1) | ES2936341T3 (hr) |
| FI (1) | FI3191836T3 (hr) |
| HR (1) | HRP20230171T1 (hr) |
| HU (1) | HUE060968T2 (hr) |
| IL (1) | IL250977B (hr) |
| LT (1) | LT3191836T (hr) |
| MX (1) | MX2017003043A (hr) |
| NZ (1) | NZ730056A (hr) |
| PE (1) | PE20170737A1 (hr) |
| PH (1) | PH12017500415A1 (hr) |
| PL (1) | PL3191836T3 (hr) |
| PT (1) | PT3191836T (hr) |
| RS (1) | RS64075B1 (hr) |
| SA (1) | SA517381058B1 (hr) |
| SG (1) | SG11201701596WA (hr) |
| SI (1) | SI3191836T1 (hr) |
| UA (1) | UA118986C2 (hr) |
| WO (1) | WO2016040490A1 (hr) |
| ZA (1) | ZA201702431B (hr) |
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