CO2018009434A2 - Anticuerpos monoclonales de proteína ns1 anti-virus del dengue - Google Patents

Anticuerpos monoclonales de proteína ns1 anti-virus del dengue

Info

Publication number
CO2018009434A2
CO2018009434A2 CONC2018/0009434A CO2018009434A CO2018009434A2 CO 2018009434 A2 CO2018009434 A2 CO 2018009434A2 CO 2018009434 A CO2018009434 A CO 2018009434A CO 2018009434 A2 CO2018009434 A2 CO 2018009434A2
Authority
CO
Colombia
Prior art keywords
dengue virus
present
sample
matching
serotypes
Prior art date
Application number
CONC2018/0009434A
Other languages
English (en)
Inventor
Irene Bosch
Kimberly Schifferli-Hamad
Jose Marquez-Gomez
Puig Helena De
Lee Gehrke
Original Assignee
Massachusetts Inst Technology
The Us Secretary Department Of Health And Human Services “The Government”
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, The Us Secretary Department Of Health And Human Services “The Government” filed Critical Massachusetts Inst Technology
Publication of CO2018009434A2 publication Critical patent/CO2018009434A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona pares de anticuerpos coincidentes para la detección específica de uno o más de los cuatro serotipos del virus del dengue en una muestra biológica que puede contener uno o más de tales serotipos del virus del dengue. Cada par de anticuerpos coincidentes es capaz de detectar no más de un serotipo de la proteína NS1 del virus del dengue que puede estar presente en la muestra y no tendrá reacción cruzada con otros serotipos que puedan estar presentes en la muestra. Se pueden usar múltiples pares coincidentes para detectar uno o más serotipos del virus del dengue que pueden estar presentes en una muestra. Dichos anticuerpos de pares coincidentes facilitan el desarrollo de pruebas diagnósticas confirmatorias in vitro tales como inmunoensayos intercalados, que detectan y distinguen la presencia de uno o más serotipos del virus del dengue en una muestra biológica, preferiblemente una muestra derivada de un sujeto humano. La invención también proporciona kits que comprenden los pares de anticuerpos coincidentes de la invención y métodos para usar los kits para inmunoensayos para la detección específica de uno o más serotipos del virus del dengue en una población de pacientes. La presente invención también proporciona anticuerpos monoclonales específicos para la proteína NS1 del virus del dengue y composiciones terapéuticas y métodos para tratar la infección por el virus del dengue.
CONC2018/0009434A 2016-02-11 2018-09-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue CO2018009434A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662293990P 2016-02-11 2016-02-11
PCT/US2017/017385 WO2017139587A2 (en) 2016-02-11 2017-02-10 Anti-dengue virus ns1 protein monoclonal antibodies

Publications (1)

Publication Number Publication Date
CO2018009434A2 true CO2018009434A2 (es) 2018-12-14

Family

ID=58098711

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0009434A CO2018009434A2 (es) 2016-02-11 2018-09-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue

Country Status (6)

Country Link
US (2) US10551381B2 (es)
EP (2) EP3750916A3 (es)
BR (1) BR112018016337A2 (es)
CO (1) CO2018009434A2 (es)
MX (1) MX2018009738A (es)
WO (1) WO2017139587A2 (es)

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CN109081869B (zh) * 2018-08-28 2022-06-03 东莞市朋志生物科技有限公司 Ns1蛋白的结合蛋白
CN109053883B (zh) * 2018-08-28 2022-06-03 东莞市朋志生物科技有限公司 Ns1蛋白的结合蛋白
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CN110346557B (zh) * 2019-07-15 2023-03-31 深圳海思安生物技术有限公司 一种检测试剂盒
KR102061769B1 (ko) * 2019-11-25 2020-01-02 한국세라믹기술원 금속나노입자-어피바디를 포함하는 뎅기열 바이러스 elisa 키트 및 상기 키트를 이용한 뎅기열 바이러스의 검출 방법
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Also Published As

Publication number Publication date
EP3750916A2 (en) 2020-12-16
US10551381B2 (en) 2020-02-04
EP3750916A3 (en) 2021-03-24
MX2018009738A (es) 2019-02-07
WO2017139587A3 (en) 2017-09-21
US20170233460A1 (en) 2017-08-17
EP3414265A2 (en) 2018-12-19
US11320433B2 (en) 2022-05-03
WO2017139587A2 (en) 2017-08-17
BR112018016337A2 (pt) 2019-02-26
US20200363415A1 (en) 2020-11-19

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