EA201500447A1 - НАЦЕЛЕННЫЕ СИНТЕТИЧЕСКИЕ НАНОНОСИТЕЛИ С pH-ЧУВСТВИТЕЛЬНЫМ ВЫСВОБОЖДЕНИЕМ ИММУНОМОДУЛИРУЮЩИХ СРЕДСТВ - Google Patents

НАЦЕЛЕННЫЕ СИНТЕТИЧЕСКИЕ НАНОНОСИТЕЛИ С pH-ЧУВСТВИТЕЛЬНЫМ ВЫСВОБОЖДЕНИЕМ ИММУНОМОДУЛИРУЮЩИХ СРЕДСТВ

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Publication number
EA201500447A1
EA201500447A1 EA201500447A EA201500447A EA201500447A1 EA 201500447 A1 EA201500447 A1 EA 201500447A1 EA 201500447 A EA201500447 A EA 201500447A EA 201500447 A EA201500447 A EA 201500447A EA 201500447 A1 EA201500447 A1 EA 201500447A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthetic nano
carriers
modulating means
nano carriers
targeted synthetic
Prior art date
Application number
EA201500447A
Other languages
English (en)
Inventor
Чарльз Зепп
Юнь Гао
Марк Дж. Киган
Сэм Болдуин
Фынь-ни Фу
Ллойд Джонстон
Грэйсон Б. Липфорд
Original Assignee
Селекта Байосайенсиз, Инк.
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Filing date
Publication date
Application filed by Селекта Байосайенсиз, Инк. filed Critical Селекта Байосайенсиз, Инк.
Publication of EA201500447A1 publication Critical patent/EA201500447A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Данное изобретение относится к композициям и соответствующим им способам на основе синтетических наноносителей, которые целенаправленно воздействуют на сайты действия клеток, таких как антигенпрезентирующие клетки (APC), и включает иммуномодулирующие средства, которые диссоциируют от синтетических наноносителей pH-зависимым способом. Также раскрыты композиции и способы, относящиеся к синтетическим наноносителям, которые инкапсулируют лабильные иммуномодулирующие средства, которые отделяются от синтетических наноносителей pH-зависимым способом.
EA201500447A 2009-05-27 2010-05-26 НАЦЕЛЕННЫЕ СИНТЕТИЧЕСКИЕ НАНОНОСИТЕЛИ С pH-ЧУВСТВИТЕЛЬНЫМ ВЫСВОБОЖДЕНИЕМ ИММУНОМОДУЛИРУЮЩИХ СРЕДСТВ EA201500447A1 (ru)

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