GT200600221A - Tigeciclina y metodos de preparacion - Google Patents

Tigeciclina y metodos de preparacion

Info

Publication number
GT200600221A
GT200600221A GT200600221A GT200600221A GT200600221A GT 200600221 A GT200600221 A GT 200600221A GT 200600221 A GT200600221 A GT 200600221A GT 200600221 A GT200600221 A GT 200600221A GT 200600221 A GT200600221 A GT 200600221A
Authority
GT
Guatemala
Prior art keywords
tigecicline
preparation methods
methods
compositions
tetraciclines
Prior art date
Application number
GT200600221A
Other languages
English (en)
Inventor
Lalitha Krishnan
Phaik-Eng Sum
Sylvain Daineault
Michel Bernatzchez
Anthony Scott Pilcher
Jeffrey Marshall Horne
Adam Joseph Tuper
Joseph James Mccauley Iii
Adam P Michaud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200600221A publication Critical patent/GT200600221A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REVELAN MÉTODOS PARA PREPARAR Y PURIFICAR TETRACICLINAS, TALES COMO TIGECICLINA. TAMBIÉN SE REVELAN COMPOSICIONES DE TETRACICLINAS, TALES COMO COMPOSICIONES DE TIGECICLINA, PREPARADAS POR ESTOS MÉTODOS.
GT200600221A 2005-05-27 2006-05-25 Tigeciclina y metodos de preparacion GT200600221A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68528505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
GT200600221A true GT200600221A (es) 2009-08-28

Family

ID=37023025

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600221A GT200600221A (es) 2005-05-27 2006-05-25 Tigeciclina y metodos de preparacion

Country Status (21)

Country Link
US (1) US20070049562A1 (es)
EP (1) EP1888507A1 (es)
JP (1) JP2008545701A (es)
KR (1) KR20080015470A (es)
CN (1) CN101228112A (es)
AR (1) AR057032A1 (es)
AU (1) AU2006252783A1 (es)
BR (1) BRPI0610648A2 (es)
CA (1) CA2609306A1 (es)
CR (1) CR9541A (es)
EC (1) ECSP078059A (es)
GT (1) GT200600221A (es)
IL (1) IL187360A0 (es)
MX (1) MX2007014731A (es)
NI (1) NI200700301A (es)
NO (1) NO20076001L (es)
PE (1) PE20070009A1 (es)
RU (1) RU2007143157A (es)
TW (1) TW200718676A (es)
WO (1) WO2006130418A1 (es)
ZA (1) ZA200710153B (es)

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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2016045B1 (en) * 2006-04-24 2014-10-29 Teva Pharmaceutical Industries, Ltd. A tigecycline crystalline form and processes for its preparation
EP2236491A3 (en) * 2006-11-29 2010-11-03 Teva Pharmaceutical Industries, Ltd. Crystalline form of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
US20090099376A1 (en) * 2007-10-16 2009-04-16 Wyeth Tigecycline and methods of preparing intermediates
CN101861300B (zh) 2007-11-14 2014-07-09 桑多斯股份公司 盐酸替吉环素的晶型
WO2009092680A2 (en) * 2008-01-23 2009-07-30 Sandoz Ag Antibiotic compounds
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
WO2010070093A1 (en) 2008-12-18 2010-06-24 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
EP2406213A1 (en) 2009-03-12 2012-01-18 Wyeth LLC Nitration of tetracyclines
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika
EP2544692A4 (en) * 2010-03-10 2013-08-07 Univ Health Network USE OF TIGECYCLINE FOR THE TREATMENT OF CANCER
CN102276497A (zh) * 2010-06-10 2011-12-14 武汉启瑞药业有限公司 替加环素的合成方法
CN102746183B (zh) 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
MX350575B (es) 2012-09-27 2017-09-11 Bayer Cropscience Ag Procedimiento para la preparación de fenil y piridil pirrolidinas opcionalmente sustituidas.
CN102911077B (zh) * 2012-11-12 2015-01-07 成都百裕科技制药有限公司 4r-替加环素的制备方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104230744B (zh) * 2014-09-01 2016-06-08 湖南尔康制药股份有限公司 一种替加环素原料药的生产方法
CN107365359B (zh) * 2017-07-17 2021-06-04 昆明理工大学 一种万古霉素手性功能单体合成方法
WO2019160037A1 (ja) * 2018-02-14 2019-08-22 国立大学法人 東京大学 酸ハロゲン化物による化合物の製造方法

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Also Published As

Publication number Publication date
CR9541A (es) 2008-02-20
KR20080015470A (ko) 2008-02-19
NO20076001L (no) 2008-02-19
AR057032A1 (es) 2007-11-14
JP2008545701A (ja) 2008-12-18
PE20070009A1 (es) 2007-01-29
ECSP078059A (es) 2008-01-23
IL187360A0 (en) 2008-04-13
US20070049562A1 (en) 2007-03-01
RU2007143157A (ru) 2009-07-10
CN101228112A (zh) 2008-07-23
EP1888507A1 (en) 2008-02-20
TW200718676A (en) 2007-05-16
WO2006130418A1 (en) 2006-12-07
CA2609306A1 (en) 2006-12-07
ZA200710153B (en) 2009-08-26
BRPI0610648A2 (pt) 2010-07-13
MX2007014731A (es) 2008-02-15
NI200700301A (es) 2008-07-24
AU2006252783A1 (en) 2006-12-07

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