EA201190170A1 - Композиции полимера мирцена - Google Patents

Композиции полимера мирцена

Info

Publication number
EA201190170A1
EA201190170A1 EA201190170A EA201190170A EA201190170A1 EA 201190170 A1 EA201190170 A1 EA 201190170A1 EA 201190170 A EA201190170 A EA 201190170A EA 201190170 A EA201190170 A EA 201190170A EA 201190170 A1 EA201190170 A1 EA 201190170A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
polymer
mirtsen
relates
present
Prior art date
Application number
EA201190170A
Other languages
English (en)
Other versions
EA021833B1 (ru
Inventor
Задик Хазан
Шимон Амселем
Original Assignee
Редженера Фарма Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Редженера Фарма Лтд. filed Critical Редженера Фарма Лтд.
Publication of EA201190170A1 publication Critical patent/EA201190170A1/ru
Publication of EA021833B1 publication Critical patent/EA021833B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)

Abstract

Настоящее изобретение относится к композициям и составам, содержащим полимер мирцена. В частности, настоящее изобретение относится к композициям, содержащим выделенную фракцию полимера мирцена в гидрофобном носителе и к составам, сохраняющим биологическую активность активного полимера.
EA201190170A 2009-03-04 2010-03-04 Композиции полимера мирцена EA021833B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15721609P 2009-03-04 2009-03-04
PCT/IL2010/000184 WO2010100651A2 (en) 2009-03-04 2010-03-04 Compositions of polymeric myrcene

Publications (2)

Publication Number Publication Date
EA201190170A1 true EA201190170A1 (ru) 2013-01-30
EA021833B1 EA021833B1 (ru) 2015-09-30

Family

ID=42536397

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201190170A EA021833B1 (ru) 2009-03-04 2010-03-04 Композиции полимера мирцена
EA201492273A EA201492273A1 (ru) 2009-03-04 2010-03-04 Композиции полимера мирцена

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201492273A EA201492273A1 (ru) 2009-03-04 2010-03-04 Композиции полимера мирцена

Country Status (15)

Country Link
US (4) US8722105B2 (ru)
EP (2) EP3578191A1 (ru)
CN (2) CN105147759A (ru)
AU (1) AU2010220057C1 (ru)
BR (1) BRPI1013222B8 (ru)
CA (1) CA2754565C (ru)
DK (1) DK2403512T3 (ru)
EA (2) EA021833B1 (ru)
ES (1) ES2739033T3 (ru)
HK (1) HK1218710A1 (ru)
HU (1) HUE045444T2 (ru)
IL (2) IL214923A (ru)
PL (1) PL2403512T3 (ru)
TR (1) TR201911270T4 (ru)
WO (1) WO2010100651A2 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974805C (en) 2009-03-04 2021-11-30 Regenera Pharma Ltd. Therapeutic uses of mastic gum fractions
HUE045444T2 (hu) 2009-03-04 2019-12-30 Regenera Pharma Ltd Polimer mircén kompozíciók
WO2011051945A1 (en) * 2009-10-28 2011-05-05 Regenera Pharma Ltd. Therapeutic uses of oligomeric and polymeric monoterpenes
DK2613777T3 (da) 2010-09-07 2019-07-01 Regenera Pharma Ltd Sammensætninger omfattende sure ekstrakter af mastiks-gummi
US8979797B2 (en) * 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
US10307292B2 (en) 2011-07-18 2019-06-04 Mor Research Applications Ltd Device for adjusting the intraocular pressure
CN102526163A (zh) * 2011-12-27 2012-07-04 浙江景岳堂药业有限公司 一种用于风痛灵中乳香和没药的提取方法
WO2013186766A1 (en) * 2012-06-11 2013-12-19 Regenera Pharma Ltd. Extracts and therapeutic uses thereof
US10053603B2 (en) 2014-04-02 2018-08-21 Kraton Polymers U.S. Llc Block copolymers containing a copolymer myrcene block
US9458362B2 (en) 2014-04-02 2016-10-04 Kraton Polymers U.S. Llc Adhesive compositions containing a block copolymer with polymyrcene
IL237621A0 (en) * 2015-03-08 2015-06-30 Regenera Pharma Ltd Use of isolated fractions of the gum goddess to treat optic neuropathy
CN108289907A (zh) 2015-09-24 2018-07-17 瑞吉纳拉制药公司 包含三萜类的组合物
CA2999822A1 (en) 2015-09-24 2017-03-30 Regenera Pharma Ltd. Compositions comprising triterpenoids
US11439676B2 (en) 2018-10-16 2022-09-13 Kaeco Group, Inc. Method for prevention or treating gastrointestinal distress in humans using mastic gum compositions
US10548917B2 (en) * 2016-05-23 2020-02-04 Kaeco Group Inc. Supplement for the prevention and treatment of gastrointestinal distress in horses and other species
CN109922798A (zh) * 2016-09-08 2019-06-21 瑞吉纳拉制药公司 包括乳香胶的酸性提取物的组合物及其用于治疗视神经病变的用途
US11207333B2 (en) 2016-09-08 2021-12-28 Regenera Pharma Ltd. Compositions comprising triterpenoids and uses thereof for treating optic neuropathy
IT201700016726A1 (it) 2017-02-15 2018-08-15 Phytoitalia Srl Frazioni arricchite in terpeni esenti da politerpeni estratte dal mastice di chios, dispositivi cosmetici, nutraceutici e medici, e composizioni farmaceutiche che le contengono
WO2019170239A1 (en) 2018-03-08 2019-09-12 Phytoitalia Srl Terpene enriched fractions free from polyterpenes extracted from chios mastic gum and cosmetic, nutraceutical, medical devices and pharmaceutical compositions containing them
JP7377562B2 (ja) * 2018-11-01 2023-11-10 イェディテペ・ウニヴェルシテシ 乾癬の治療のための医薬及びその製造方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374957A (en) 1981-10-29 1983-02-22 Michigan Molecular Institute Triblock polymers of a monovinyl aromatic compound and myrcene
US4564718A (en) 1984-08-14 1986-01-14 The University Of Manchester Institute Of Science And Technology Functionally terminated polymers from terpene monomers and their applications
US4713243A (en) 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
JPS63179908A (ja) * 1987-01-22 1988-07-23 Japan Synthetic Rubber Co Ltd ミルセン重合体およびその製造方法
DE3820218A1 (de) 1988-06-14 1989-12-28 Osama L M Dr Med Dr Rer N Omer Phytotherapeutikum zur behandlung von depressivem syndrom
US8178516B2 (en) 1992-06-30 2012-05-15 Sylvan Labs, LLC Compositions and method for treatment of chronic inflammatory diseases
US5506406A (en) 1993-05-17 1996-04-09 Atomic Energy Corporation Of South Africa Ltd. Method and apparatus for determining the concentration of a heavy element in a rock face
US5759569A (en) 1995-01-10 1998-06-02 The Procter & Gamble Company Biodegradable articles made from certain trans-polymers and blends thereof with other biodegradable components
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
GR950100243A (el) 1995-06-28 1997-02-28 �. �����- �. ����� �.�.�. Χρησιμοποιηση της φυσικης μαστιχας χιου η του εξαγομενου εξ'αυτης φυσικου μαστιχελαιου η συνθετικων παραγωγων του για την παρασεκυη οδοντοκρεμας, οδοντικου διαλυματος, αποσμητικου στοματος, αντιηλιακων, προιοντων μαλλιων, καθως και καλλυντικων προιοντων.
JPH10130254A (ja) * 1996-11-01 1998-05-19 Jumoku Seiri Kinousei Butsushitsu Gijutsu Kenkyu Kumiai ジヒドロクマリン系化合物およびエストロゲン作用剤
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
GR1003541B (el) 1999-05-11 2001-03-07 Αντιμικροβιακη και αντιμυκητιακη δραση του εξαγομενου απο τα κλαδια, φυλλα και καρπο της μαστιχας χιου -pistacia lentiscus var chia-, μαστιχελαιου, για χρηση σε καλλυντικες, φαρμακευτικες και παραφαρμακευτικεσς εφαρμογες καθως και στην παραγωγη οδοντοτσι
GR1003550B (el) 1999-09-22 2001-03-13 Σταθερο παρασκευασμα ισοεξυλοναφθαζαρινων με πεντα- και τετρα-κυκλικα τριτερπενια, συστατικα φυτικων ελαιορητινων και κομμεων
US6623728B2 (en) 2000-06-30 2003-09-23 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Cosmetic skin care compositions and containing gum mastic
US7056491B2 (en) 2000-11-08 2006-06-06 Wisconsin Alumni Research Foundation Monoterpenes and sesquiterpenes as chemotherapeutic and radiation sensitizers and immunomodulators
GR1003868B (el) * 2001-02-06 2002-04-19 Lavipharm S.A. Αξιολογηση των επουλωτικων, αντιοξειδωτικων και κυτταροστατικων ιδιοτητων της μαστιχας και των συστατικων της, και οι εφαρμογες τους
JP2004518707A (ja) 2001-02-13 2004-06-24 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム カロテノイドを充填されたリポソーム
US6534548B1 (en) 2001-10-02 2003-03-18 Kimberly-Clark Worldwide, Inc. Isoprenoid compositions for the inhibition of exoprotein production from gram positive bacteria
AU2003241345A1 (en) * 2002-05-01 2003-11-17 Lavipharm S.A. Use of mastic and its components for the control of microbial infections
JP2004083443A (ja) 2002-08-23 2004-03-18 Hideji Watanabe マスティックを用いた歯周病予防・治療用組成物及び歯周病予防・治療方法
JP4426527B2 (ja) 2002-12-20 2010-03-03 エクソンモービル・ケミカル・パテンツ・インク 重合プロセス
AU2003303313A1 (en) 2002-12-20 2004-08-23 Exxonmobil Chemical Patents Inc. Polymerization processes
US20050074509A1 (en) 2003-10-02 2005-04-07 Data Medica Padova S.P.A. Cancer treatment using natural plant products or essential oils extracted from some pistacia species or components
US20070219141A1 (en) 2003-12-08 2007-09-20 David Jones Plant Materials Extraction Method
ATE488535T1 (de) * 2004-03-04 2010-12-15 Riken Isotaktisches 3,4-isopren-polymer
WO2005112967A2 (en) * 2004-05-19 2005-12-01 Balfour Marketing Corp. Anticancer activity of chios mastic gum
CA2572870A1 (en) 2004-07-06 2006-01-12 Transpharma Medical Ltd. Delivery system for transdermal immunization
CN101068559B (zh) 2004-07-23 2011-08-31 福生生物科技股份有限公司 红球姜的抗超敏炎症和抗敏活性
KR20070086079A (ko) 2004-11-13 2007-08-27 메타프로테오믹스, 엘엘씨 사이클로옥시게나제-2의 억제를 나타내는 조성물
US20070036873A1 (en) 2005-07-27 2007-02-15 Shibnath Ghosal Method of treatment or management of stress
US20070148187A1 (en) 2005-12-27 2007-06-28 Intact Enterprises, Inc. Mastic gum composition for use as a dietary supplement in humans and animals
AR060847A1 (es) 2007-05-03 2008-07-16 Spannagel Lucia Antonia Formulacion a base de calendula, aloe y centella.
CA2974805C (en) 2009-03-04 2021-11-30 Regenera Pharma Ltd. Therapeutic uses of mastic gum fractions
HUE045444T2 (hu) 2009-03-04 2019-12-30 Regenera Pharma Ltd Polimer mircén kompozíciók

Also Published As

Publication number Publication date
IL248056A0 (en) 2016-11-30
WO2010100651A2 (en) 2010-09-10
WO2010100651A4 (en) 2010-12-23
TR201911270T4 (tr) 2019-08-21
IL214923A0 (en) 2011-11-30
DK2403512T3 (da) 2019-07-22
CA2754565C (en) 2020-12-29
EP2403512A2 (en) 2012-01-11
ES2739033T3 (es) 2020-01-28
US20170252387A1 (en) 2017-09-07
US20190255132A1 (en) 2019-08-22
CN105147759A (zh) 2015-12-16
EA201492273A1 (ru) 2015-04-30
EP3578191A1 (en) 2019-12-11
US20120039992A1 (en) 2012-02-16
US20140294928A1 (en) 2014-10-02
IL214923A (en) 2016-10-31
US9655938B2 (en) 2017-05-23
WO2010100651A3 (en) 2010-10-28
EP2403512B1 (en) 2019-05-15
AU2010220057B2 (en) 2015-04-02
CN102413834B (zh) 2016-11-09
CN102413834A (zh) 2012-04-11
HUE045444T2 (hu) 2019-12-30
BRPI1013222B1 (pt) 2021-03-16
BRPI1013222B8 (pt) 2021-05-25
IL248056B (en) 2019-07-31
BRPI1013222A2 (pt) 2017-09-26
HK1218710A1 (zh) 2017-03-10
US10307449B2 (en) 2019-06-04
CA2754565A1 (en) 2010-09-10
PL2403512T3 (pl) 2019-10-31
EA021833B1 (ru) 2015-09-30
US10806763B2 (en) 2020-10-20
AU2010220057A1 (en) 2011-10-13
US8722105B2 (en) 2014-05-13
AU2010220057C1 (en) 2015-10-29

Similar Documents

Publication Publication Date Title
EA201190170A1 (ru) Композиции полимера мирцена
EA201190168A1 (ru) Терапевтические применения фракций мастиковой смолы
MA34488B1 (fr) Composition pesticides
CO6571886A2 (es) Antagonistas de pcsk9
EA201390145A1 (ru) Конъюгаты, частицы, композиции и связанные с ними способы
EA201290880A1 (ru) Новые соединения - ингибиторы фермента
BR112013021509A2 (pt) composições para cuidado pessoal
GT201200276A (es) Combinaciones de compuestos activos
MA34519B1 (fr) Anticorps anti-fap et procédés d'utilisation
UA107822C2 (en) Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
MA34818B1 (fr) Anticorps anti-pcsk9 et procédés d'utilisation
ECSP12012105A (es) Antídotos de Anticoagulantes
BR112014016008A2 (pt) composição
PE20141821A1 (es) Composiciones herbicidas que contienen bentazon y el inhibidor als y el inhibidor accasa
BRPI0924425A2 (pt) "combinações de substâncias ativas sinergéticas".
EA201390260A1 (ru) Композиция для ухода за волосами
EA201171246A1 (ru) Содержащая трегалулозу композиция, ее получение и применение
EA201490688A1 (ru) 2-тиопиримидиноны
MY161868A (en) Anti-bv8 antibodies and uses thereof
GT200600121A (es) Novedosos derivados de triazolopirimidina
EA201390090A1 (ru) Дезинфицирующий и антисептический препарат, имеющий сниженное содержание йода
EA201390467A1 (ru) Композиции антител и способы применения
UY34360A (es) ?compuestos de tipo bisamida con actividad insecticida, procesos e intermediarios?
FR2957934B1 (fr) Bilirubine oxydase de bacillus pumilus et ses applications
TR200909785A1 (tr) Aktif ajan olarak sefdinir içeren farmasötik kompozisyonlar.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KG MD TJ TM