EA200500279A1 - Композиции, включающие ингибитор абсорбции холестерина, ингибитор hmg-coa-редуктазы и стабилизирующий агент - Google Patents

Композиции, включающие ингибитор абсорбции холестерина, ингибитор hmg-coa-редуктазы и стабилизирующий агент

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Publication number
EA200500279A1
EA200500279A1 EA200500279A EA200500279A EA200500279A1 EA 200500279 A1 EA200500279 A1 EA 200500279A1 EA 200500279 A EA200500279 A EA 200500279A EA 200500279 A EA200500279 A EA 200500279A EA 200500279 A1 EA200500279 A1 EA 200500279A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitor
hmg
coa reductase
cholesterol absorption
stabilizing agent
Prior art date
Application number
EA200500279A
Other languages
English (en)
Other versions
EA008888B1 (ru
Inventor
Уилльям Д. Мур
Шон Фитцпатрик
Кристиан Зайлер
Роберт Саклатвала
Кэтрин Р. Петтс
Винг-Ки Филип Чо
Original Assignee
Мерк Шарп Энд Домэ Лимитед
Шеринг Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31188454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500279(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мерк Шарп Энд Домэ Лимитед, Шеринг Корпорейшн filed Critical Мерк Шарп Энд Домэ Лимитед
Publication of EA200500279A1 publication Critical patent/EA200500279A1/ru
Publication of EA008888B1 publication Critical patent/EA008888B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)

Abstract

Настоящее изобретение предлагает фармацевтическую композицию, включающую ингибитор абсорбции холестерина и ингибитор HMG-CoA-редуктазы, один или более антиоксидантов, микрокристаллическую целлюлозу, гидроксипропилметилцеллюлозу, стеарат магния и лактозу. Для получения желаемой стабильности нет необходимости содержания аскорбиновой кислоты в композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500279A 2002-07-26 2003-07-22 Композиции, включающие ингибитор абсорбции холестерина, ингибитор hmg-coa-редуктазы и стабилизирующий агент EA008888B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39869102P 2002-07-26 2002-07-26
PCT/US2003/022889 WO2004010993A1 (en) 2002-07-26 2003-07-22 Composition comprising a cholesterol absorption inhibitor, an hmg-coa reductase inhibitor and a stabilizing agent

Publications (2)

Publication Number Publication Date
EA200500279A1 true EA200500279A1 (ru) 2005-06-30
EA008888B1 EA008888B1 (ru) 2007-08-31

Family

ID=31188454

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500279A EA008888B1 (ru) 2002-07-26 2003-07-22 Композиции, включающие ингибитор абсорбции холестерина, ингибитор hmg-coa-редуктазы и стабилизирующий агент

Country Status (39)

Country Link
US (4) US7229982B2 (ru)
EP (2) EP1992343A1 (ru)
JP (2) JP2005538104A (ru)
KR (2) KR20050045993A (ru)
CN (2) CN1310643C (ru)
AR (2) AR040588A1 (ru)
AT (1) ATE393628T1 (ru)
AU (2) AU2003261217B2 (ru)
BR (1) BR0312933A (ru)
CA (1) CA2493076A1 (ru)
CR (1) CR9767A (ru)
DE (1) DE60320652T2 (ru)
DK (1) DK1531805T3 (ru)
EA (1) EA008888B1 (ru)
EC (2) ECSP055573A (ru)
ES (1) ES2303603T3 (ru)
GE (1) GEP20084443B (ru)
GT (2) GT200300149AA (ru)
HK (1) HK1080384A1 (ru)
HR (2) HRP20050081A2 (ru)
IL (2) IL166279A0 (ru)
IS (1) IS7637A (ru)
MA (1) MA27289A1 (ru)
ME (3) ME00008B (ru)
MX (1) MXPA05001004A (ru)
MY (1) MY148689A (ru)
NO (2) NO20051033L (ru)
NZ (1) NZ537611A (ru)
PA (1) PA8577901A1 (ru)
PE (1) PE20050128A1 (ru)
PL (1) PL375065A1 (ru)
PT (1) PT1531805E (ru)
RS (2) RS50419B (ru)
SI (1) SI1531805T1 (ru)
TN (1) TNSN05022A1 (ru)
TW (2) TW200412944A (ru)
UA (1) UA82489C2 (ru)
WO (1) WO2004010993A1 (ru)
ZA (1) ZA200500196B (ru)

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