MA27289A1 - Composition comprenant un inhibiteur de l'absorption du cholesterol, un inhibiteur de la hmg-coa reductase et un agent stabilisant. - Google Patents

Composition comprenant un inhibiteur de l'absorption du cholesterol, un inhibiteur de la hmg-coa reductase et un agent stabilisant.

Info

Publication number
MA27289A1
MA27289A1 MA28095A MA28095A MA27289A1 MA 27289 A1 MA27289 A1 MA 27289A1 MA 28095 A MA28095 A MA 28095A MA 28095 A MA28095 A MA 28095A MA 27289 A1 MA27289 A1 MA 27289A1
Authority
MA
Morocco
Prior art keywords
inhibitor
hmg
composition
coa reductase
cholesterol absorption
Prior art date
Application number
MA28095A
Other languages
English (en)
Inventor
William D Moore
Shaun Fitzpatrick
Christian Seiler
Robert Saklatvala
Catherine R Petts
Wing-Kee Philip Cho
Original Assignee
Merck Sharp & Dohme
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31188454&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27289(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Schering Corp filed Critical Merck Sharp & Dohme
Publication of MA27289A1 publication Critical patent/MA27289A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La présente invention fournit une composition pharmaceutique composée d'un inhibiteur de l'absorption du cholestérol et d'un inhibiteur de la HMG-CoA réductase, un ou plusieurs antioxydants, de la cellulose microcristalline, de l'hydroxypropyl-méthylcellulose, du stéarate de magnésium et du lactose. Il n'est pas nécessaire que la composition contienne de l'acide ascorbique pour obtenir une stabilité souhaitable.
MA28095A 2002-07-26 2005-02-11 Composition comprenant un inhibiteur de l'absorption du cholesterol, un inhibiteur de la hmg-coa reductase et un agent stabilisant. MA27289A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39869102P 2002-07-26 2002-07-26

Publications (1)

Publication Number Publication Date
MA27289A1 true MA27289A1 (fr) 2005-04-01

Family

ID=31188454

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28095A MA27289A1 (fr) 2002-07-26 2005-02-11 Composition comprenant un inhibiteur de l'absorption du cholesterol, un inhibiteur de la hmg-coa reductase et un agent stabilisant.

Country Status (39)

Country Link
US (4) US7229982B2 (fr)
EP (2) EP1531805B1 (fr)
JP (2) JP2005538104A (fr)
KR (2) KR20080070089A (fr)
CN (2) CN1310643C (fr)
AR (2) AR040588A1 (fr)
AT (1) ATE393628T1 (fr)
AU (2) AU2003261217B2 (fr)
BR (1) BR0312933A (fr)
CA (1) CA2493076A1 (fr)
CR (1) CR9767A (fr)
DE (1) DE60320652T2 (fr)
DK (1) DK1531805T3 (fr)
EA (1) EA008888B1 (fr)
EC (2) ECSP055573A (fr)
ES (1) ES2303603T3 (fr)
GE (1) GEP20084443B (fr)
GT (2) GT200300149A (fr)
HK (1) HK1080384A1 (fr)
HR (2) HRP20050081A2 (fr)
IL (2) IL166279A0 (fr)
IS (1) IS7637A (fr)
MA (1) MA27289A1 (fr)
ME (3) MEP4708A (fr)
MX (1) MXPA05001004A (fr)
MY (1) MY148689A (fr)
NO (2) NO20051033L (fr)
NZ (1) NZ537611A (fr)
PA (1) PA8577901A1 (fr)
PE (1) PE20050128A1 (fr)
PL (1) PL375065A1 (fr)
PT (1) PT1531805E (fr)
RS (2) RS50419B (fr)
SI (1) SI1531805T1 (fr)
TN (1) TNSN05022A1 (fr)
TW (2) TW200412944A (fr)
UA (1) UA82489C2 (fr)
WO (1) WO2004010993A1 (fr)
ZA (1) ZA200500196B (fr)

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