DE69719755T2 - Polymorphe verbindungen - Google Patents
Polymorphe verbindungenInfo
- Publication number
- DE69719755T2 DE69719755T2 DE69719755T DE69719755T DE69719755T2 DE 69719755 T2 DE69719755 T2 DE 69719755T2 DE 69719755 T DE69719755 T DE 69719755T DE 69719755 T DE69719755 T DE 69719755T DE 69719755 T2 DE69719755 T2 DE 69719755T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- fluvastatin sodium
- fluvastatin
- sodium form
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9602477A SE9602477D0 (sv) | 1996-06-24 | 1996-06-24 | Polymorphic compounds |
SE9700751A SE9700751D0 (sv) | 1997-03-03 | 1997-03-03 | Polymorphic compounds |
PCT/SE1997/001097 WO1997049681A1 (en) | 1996-06-24 | 1997-06-18 | Polymorphic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69719755D1 DE69719755D1 (de) | 2003-04-17 |
DE69719755T2 true DE69719755T2 (de) | 2003-11-20 |
Family
ID=26662685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719755T Expired - Lifetime DE69719755T2 (de) | 1996-06-24 | 1997-06-18 | Polymorphe verbindungen |
Country Status (11)
Country | Link |
---|---|
US (1) | US6124340A (de) |
EP (1) | EP0907639B1 (de) |
JP (2) | JP4282092B2 (de) |
AT (1) | ATE234282T1 (de) |
AU (1) | AU3366297A (de) |
CY (1) | CY2461B1 (de) |
DE (1) | DE69719755T2 (de) |
DK (1) | DK0907639T3 (de) |
ES (1) | ES2194202T3 (de) |
PT (1) | PT907639E (de) |
WO (1) | WO1997049681A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9902202D0 (sv) * | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
US6242003B1 (en) | 2000-04-13 | 2001-06-05 | Novartis Ag | Organic compounds |
JP2004513112A (ja) | 2000-10-31 | 2004-04-30 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | フルバスタチンナトリウムの結晶形 |
US20060127474A1 (en) | 2001-04-11 | 2006-06-15 | Oskar Kalb | Pharmaceutical compositions comprising fluvastatin |
PL366905A1 (en) * | 2001-08-03 | 2005-02-07 | Ciba Specialty Chemicals Holding Inc. | Crystalline forms of fluvastatin sodium |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
DE10316087A1 (de) * | 2003-04-08 | 2004-11-11 | Ratiopharm Gmbh | Polymorphstabilisierung von Fluvastatin-Natrium in Pharmazeutischen Formulierungen |
WO2004096765A2 (en) * | 2003-05-01 | 2004-11-11 | Morepen Laboratories Ltd. | A novel crystalline polymorph of fluvastatin sodium and a process for preparing it |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
US7368581B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of fluvastatin sodium crystal from XIV |
DE602004018494D1 (de) | 2003-06-18 | 2009-01-29 | Teva Pharma | Fluvastatin-natrium in der kristallform xiv, verfahren zu deren herstellung, diese enthaltende zusammensetzungen und enstprechende anwendungsverfahren |
US7368468B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
US7432380B2 (en) | 2003-10-16 | 2008-10-07 | Ciba Specialty Chemicals Corp. | Crystalline form of Fluvastatin sodium |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
US7241800B2 (en) | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
WO2006008656A2 (en) * | 2004-07-21 | 2006-01-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Oatp-c gene c463a polymorphism underlies variable response of statin therapy |
US7371906B2 (en) * | 2004-08-24 | 2008-05-13 | Eastman Kodak Company | Process for photo-oxidative stability improvements |
WO2006021967A1 (en) * | 2004-08-26 | 2006-03-02 | Biocon Limited | Process for the preparation of fluvastatin sodium form a. |
WO2006030304A2 (en) * | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof |
CA2583312A1 (en) * | 2004-10-05 | 2006-04-13 | Biocon Limited | Process for the preparation of amorphous fluvastatin sodium |
US7795451B2 (en) * | 2005-02-11 | 2010-09-14 | Jubilant Organosys Limited | Polymorphic forms of fluvastatin sodium and process for preparing the same |
WO2006109147A1 (en) * | 2005-04-12 | 2006-10-19 | Glenmark Pharmaceuticals Limited | Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same |
CA2642180A1 (en) * | 2006-02-27 | 2007-09-07 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium novel forms and preparation therof |
DE602006006899D1 (de) | 2006-04-20 | 2009-07-02 | Italiana Sint Spa | Verfahren zur Herstellung von Fluvastatin-Natrium |
CN101250153B (zh) * | 2008-02-26 | 2013-09-18 | 深圳信立泰药业股份有限公司 | 一种制备氟伐他汀钠晶型的工艺 |
PT2419407E (pt) * | 2009-04-15 | 2013-01-28 | Pharmathen Sa | Processo melhorado para a preparação de fluvastatina e dos seus sais |
CN114280181B (zh) * | 2021-12-23 | 2024-06-18 | 浙江海翔川南药业有限公司 | 一种瑞舒伐他汀中间体及其有关物质的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU204253B (en) * | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
HU217629B (hu) * | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
-
1997
- 1997-06-18 AT AT97929654T patent/ATE234282T1/de active
- 1997-06-18 AU AU33662/97A patent/AU3366297A/en not_active Abandoned
- 1997-06-18 ES ES97929654T patent/ES2194202T3/es not_active Expired - Lifetime
- 1997-06-18 DK DK97929654T patent/DK0907639T3/da active
- 1997-06-18 US US08/875,203 patent/US6124340A/en not_active Expired - Lifetime
- 1997-06-18 DE DE69719755T patent/DE69719755T2/de not_active Expired - Lifetime
- 1997-06-18 WO PCT/SE1997/001097 patent/WO1997049681A1/en active IP Right Grant
- 1997-06-18 JP JP50282198A patent/JP4282092B2/ja not_active Expired - Lifetime
- 1997-06-18 PT PT97929654T patent/PT907639E/pt unknown
- 1997-06-18 EP EP97929654A patent/EP0907639B1/de not_active Expired - Lifetime
-
2004
- 2004-06-17 CY CY0400049A patent/CY2461B1/xx unknown
-
2009
- 2009-01-09 JP JP2009003704A patent/JP2009149654A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1997049681A1 (en) | 1997-12-31 |
US6124340A (en) | 2000-09-26 |
DK0907639T3 (da) | 2003-06-23 |
PT907639E (pt) | 2003-06-30 |
JP4282092B2 (ja) | 2009-06-17 |
EP0907639A1 (de) | 1999-04-14 |
CY2461B1 (en) | 2005-06-03 |
JP2000512992A (ja) | 2000-10-03 |
ES2194202T3 (es) | 2003-11-16 |
ATE234282T1 (de) | 2003-03-15 |
AU3366297A (en) | 1998-01-14 |
DE69719755D1 (de) | 2003-04-17 |
EP0907639B1 (de) | 2003-03-12 |
JP2009149654A (ja) | 2009-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |