DE602004018494D1 - Fluvastatin-natrium in der kristallform xiv, verfahren zu deren herstellung, diese enthaltende zusammensetzungen und enstprechende anwendungsverfahren - Google Patents
Fluvastatin-natrium in der kristallform xiv, verfahren zu deren herstellung, diese enthaltende zusammensetzungen und enstprechende anwendungsverfahrenInfo
- Publication number
- DE602004018494D1 DE602004018494D1 DE602004018494T DE602004018494T DE602004018494D1 DE 602004018494 D1 DE602004018494 D1 DE 602004018494D1 DE 602004018494 T DE602004018494 T DE 602004018494T DE 602004018494 T DE602004018494 T DE 602004018494T DE 602004018494 D1 DE602004018494 D1 DE 602004018494D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- production
- crystal form
- fluvastatin sodium
- form xiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47918203P | 2003-06-18 | 2003-06-18 | |
US48309903P | 2003-06-30 | 2003-06-30 | |
US48574803P | 2003-07-10 | 2003-07-10 | |
US49379303P | 2003-08-11 | 2003-08-11 | |
US50795403P | 2003-10-03 | 2003-10-03 | |
US54546604P | 2004-02-19 | 2004-02-19 | |
PCT/US2004/019879 WO2004113291A2 (en) | 2003-06-18 | 2004-06-18 | Fluvastatin sodium crystal forms xiv, lxxiii,lxxix, lxxx and lxxxvii, processes for preparing them, compositions containing them and methods of using them |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004018494D1 true DE602004018494D1 (de) | 2009-01-29 |
Family
ID=33545688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004018494T Expired - Fee Related DE602004018494D1 (de) | 2003-06-18 | 2004-06-18 | Fluvastatin-natrium in der kristallform xiv, verfahren zu deren herstellung, diese enthaltende zusammensetzungen und enstprechende anwendungsverfahren |
Country Status (14)
Country | Link |
---|---|
US (4) | US7414140B2 (de) |
EP (9) | EP1752448A3 (de) |
JP (3) | JP4037898B2 (de) |
KR (6) | KR20060024428A (de) |
CN (1) | CN1849304A (de) |
AT (1) | ATE417827T1 (de) |
CA (6) | CA2529820A1 (de) |
DE (1) | DE602004018494D1 (de) |
ES (1) | ES2317012T3 (de) |
IL (2) | IL172514A0 (de) |
MX (2) | MXPA05013895A (de) |
PL (1) | PL1638937T3 (de) |
PT (1) | PT1638937E (de) |
WO (2) | WO2004113291A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100871621B1 (ko) * | 2003-06-02 | 2008-12-02 | 테바 파마슈티컬 인더스트리즈 리미티드 | 발라시클로비르 히드로클로라이드의 신규한 결정질 형태 |
US7368468B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
US7368581B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of fluvastatin sodium crystal from XIV |
JP4037898B2 (ja) * | 2003-06-18 | 2008-01-23 | テバ ファーマシューティカル インダストリーズ リミティド | フルバスタチンナトリウム結晶形xiv、lxxiii、lxxix、lxxx及びxxxvii型、それらの調製方法、それらを含有する組成物及びそれらの使用方法 |
US7432380B2 (en) | 2003-10-16 | 2008-10-07 | Ciba Specialty Chemicals Corp. | Crystalline form of Fluvastatin sodium |
US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2005080332A1 (en) * | 2004-01-14 | 2005-09-01 | Cadila Healthcare Limited | Novel form of fluvastatin sodium |
WO2006030304A2 (en) * | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof |
JP2008515878A (ja) * | 2004-10-05 | 2008-05-15 | バイオコン・リミテッド | アモルファス型フルバスタチンナトリウムの製造方法 |
US7795451B2 (en) * | 2005-02-11 | 2010-09-14 | Jubilant Organosys Limited | Polymorphic forms of fluvastatin sodium and process for preparing the same |
US20080171884A1 (en) * | 2005-03-22 | 2008-07-17 | Tarur Venkatasubramanian Radha | Novel Polymorph Form G of Fluvastatin Sodium and Process For the Preparation Thereof |
WO2006109147A1 (en) * | 2005-04-12 | 2006-10-19 | Glenmark Pharmaceuticals Limited | Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same |
MX2007013286A (es) * | 2006-02-27 | 2008-03-07 | Teva Pharma | Formas novedosas de sodio de fluvastatina y preparacion de ellas. |
DE602006006899D1 (de) | 2006-04-20 | 2009-07-02 | Italiana Sint Spa | Verfahren zur Herstellung von Fluvastatin-Natrium |
US20110052688A1 (en) * | 2006-11-21 | 2011-03-03 | San-Laung Chow | Solid dispersion composition |
ES2321571B1 (es) * | 2007-07-18 | 2010-03-11 | Ercros Industrial, S.A. | Solvatos de fluvastatina sodica y su utilizacion como intermedios en la obtencion de fluvastatina sodica amorfa. |
CN101250153B (zh) * | 2008-02-26 | 2013-09-18 | 深圳信立泰药业股份有限公司 | 一种制备氟伐他汀钠晶型的工艺 |
EP2419407B1 (de) * | 2009-04-15 | 2012-11-14 | Pharmathen S.A. | Verbessertes verfahren zur herstellung von fluvastatin und salzen davon |
WO2011117875A1 (en) * | 2010-03-26 | 2011-09-29 | Hetero Research Foundation | Salts of fluvastatin and process for the preparation of substantially amorphous fluvastatin sodium |
KR101220266B1 (ko) * | 2012-04-19 | 2013-01-09 | 홍종옥 | 수치지도 이미지 제작을 위한 항공영상 이미지 기반 정밀 영상도화 시스템 |
KR101308745B1 (ko) * | 2012-07-04 | 2013-09-16 | 주식회사 동운 | 지리공간정보가 적용된 멀티 기능 기반의 수치지도 시스템 |
KR101220271B1 (ko) * | 2012-07-05 | 2013-01-10 | 대한항업(주) | 지피에스 기반 실사 지상물의 게시를 위한 수치지도 제작 시스템 |
KR101273416B1 (ko) * | 2012-07-25 | 2013-06-11 | 주식회사 동운 | 좌표정보 및 지형정보 합성을 통한 정밀 수치지도 제작 시스템 |
KR101217854B1 (ko) * | 2012-09-14 | 2013-01-02 | (주)아세아항측 | 정밀 디에스엠 및 디티엠 정보와 지상 기준점 정보의 정밀해석을 통한 수치지도 높이오차 확인시스템 |
TWI665190B (zh) | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途 |
WO2017106642A1 (en) * | 2015-12-17 | 2017-06-22 | Arqule, Inc. | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
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JP4037898B2 (ja) | 2003-06-18 | 2008-01-23 | テバ ファーマシューティカル インダストリーズ リミティド | フルバスタチンナトリウム結晶形xiv、lxxiii、lxxix、lxxx及びxxxvii型、それらの調製方法、それらを含有する組成物及びそれらの使用方法 |
US7368468B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
US7432380B2 (en) * | 2003-10-16 | 2008-10-07 | Ciba Specialty Chemicals Corp. | Crystalline form of Fluvastatin sodium |
US7241800B2 (en) * | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
WO2006030304A2 (en) | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof |
JP2008515878A (ja) | 2004-10-05 | 2008-05-15 | バイオコン・リミテッド | アモルファス型フルバスタチンナトリウムの製造方法 |
WO2006109147A1 (en) | 2005-04-12 | 2006-10-19 | Glenmark Pharmaceuticals Limited | Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same |
US7432980B2 (en) * | 2005-08-05 | 2008-10-07 | Terawins, Inc. | Method for reducing analog PLL jitter in video application |
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2004
- 2004-06-18 JP JP2006517508A patent/JP4037898B2/ja not_active Expired - Fee Related
- 2004-06-18 PL PL04755797T patent/PL1638937T3/pl unknown
- 2004-06-18 CA CA002529820A patent/CA2529820A1/en not_active Abandoned
- 2004-06-18 CA CA002610635A patent/CA2610635A1/en not_active Abandoned
- 2004-06-18 KR KR1020057024401A patent/KR20060024428A/ko not_active Application Discontinuation
- 2004-06-18 DE DE602004018494T patent/DE602004018494D1/de not_active Expired - Fee Related
- 2004-06-18 EP EP06017519A patent/EP1752448A3/de not_active Withdrawn
- 2004-06-18 JP JP2006517509A patent/JP2007524619A/ja active Pending
- 2004-06-18 CA CA002613021A patent/CA2613021A1/en not_active Abandoned
- 2004-06-18 CN CNA2004800233152A patent/CN1849304A/zh active Pending
- 2004-06-18 KR KR1020077016996A patent/KR20070092993A/ko not_active Application Discontinuation
- 2004-06-18 EP EP04755798A patent/EP1636184A2/de not_active Withdrawn
- 2004-06-18 EP EP06017518A patent/EP1719760A3/de not_active Withdrawn
- 2004-06-18 MX MXPA05013895A patent/MXPA05013895A/es unknown
- 2004-06-18 EP EP07003278A patent/EP1790635A3/de not_active Withdrawn
- 2004-06-18 EP EP04755797A patent/EP1638937B1/de not_active Expired - Lifetime
- 2004-06-18 KR KR1020077016997A patent/KR20070092994A/ko not_active Application Discontinuation
- 2004-06-18 KR KR1020077016998A patent/KR20070092995A/ko not_active Application Discontinuation
- 2004-06-18 CA CA002610633A patent/CA2610633A1/en not_active Abandoned
- 2004-06-18 AT AT04755797T patent/ATE417827T1/de not_active IP Right Cessation
- 2004-06-18 MX MXPA05013896A patent/MXPA05013896A/es unknown
- 2004-06-18 EP EP07000489A patent/EP1780200A1/de not_active Withdrawn
- 2004-06-18 US US10/872,089 patent/US7414140B2/en not_active Expired - Fee Related
- 2004-06-18 EP EP06017225A patent/EP1719759A3/de not_active Withdrawn
- 2004-06-18 ES ES04755797T patent/ES2317012T3/es not_active Expired - Lifetime
- 2004-06-18 WO PCT/US2004/019879 patent/WO2004113291A2/en active Application Filing
- 2004-06-18 KR KR1020077016994A patent/KR20070094805A/ko not_active Application Discontinuation
- 2004-06-18 PT PT04755797T patent/PT1638937E/pt unknown
- 2004-06-18 WO PCT/US2004/019882 patent/WO2004113292A2/en active Application Filing
- 2004-06-18 KR KR1020057024355A patent/KR20060024426A/ko not_active Application Discontinuation
- 2004-06-18 EP EP06017224A patent/EP1726583A3/de not_active Withdrawn
- 2004-06-18 EP EP07000490A patent/EP1790634A3/de not_active Withdrawn
- 2004-06-18 CA CA002613013A patent/CA2613013A1/en not_active Abandoned
- 2004-06-18 CA CA002529859A patent/CA2529859A1/en not_active Abandoned
-
2005
- 2005-12-12 IL IL172514A patent/IL172514A0/en unknown
- 2005-12-12 IL IL172512A patent/IL172512A0/en unknown
-
2007
- 2007-01-29 US US11/699,659 patent/US7687642B2/en not_active Expired - Fee Related
- 2007-08-09 JP JP2007208562A patent/JP2007302693A/ja active Pending
-
2008
- 2008-04-30 US US12/150,949 patent/US20090118518A1/en not_active Abandoned
-
2009
- 2009-03-25 US US12/383,721 patent/US20090209611A1/en not_active Abandoned
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