PT1638937E - Forma xiv cristalina de fluvastatina sódica, processos para a sua preparação, composições que a contêm e métodos de utilização - Google Patents

Forma xiv cristalina de fluvastatina sódica, processos para a sua preparação, composições que a contêm e métodos de utilização Download PDF

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Publication number
PT1638937E
PT1638937E PT04755797T PT04755797T PT1638937E PT 1638937 E PT1638937 E PT 1638937E PT 04755797 T PT04755797 T PT 04755797T PT 04755797 T PT04755797 T PT 04755797T PT 1638937 E PT1638937 E PT 1638937E
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PT
Portugal
Prior art keywords
processes
preparing
methods
compositions containing
crystal form
Prior art date
Application number
PT04755797T
Other languages
English (en)
Inventor
Judith Aronhime
Revital Lifshitz-Liron
Tamas Koltai
Nurit Perlman
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of PT1638937E publication Critical patent/PT1638937E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT04755797T 2003-06-18 2004-06-18 Forma xiv cristalina de fluvastatina sódica, processos para a sua preparação, composições que a contêm e métodos de utilização PT1638937E (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US47918203P 2003-06-18 2003-06-18
US48309903P 2003-06-30 2003-06-30
US48574803P 2003-07-10 2003-07-10
US49379303P 2003-08-11 2003-08-11
US50795403P 2003-10-03 2003-10-03
US54546604P 2004-02-19 2004-02-19

Publications (1)

Publication Number Publication Date
PT1638937E true PT1638937E (pt) 2009-01-27

Family

ID=33545688

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04755797T PT1638937E (pt) 2003-06-18 2004-06-18 Forma xiv cristalina de fluvastatina sódica, processos para a sua preparação, composições que a contêm e métodos de utilização

Country Status (14)

Country Link
US (4) US7414140B2 (pt)
EP (9) EP1752448A3 (pt)
JP (3) JP4037898B2 (pt)
KR (6) KR20060024428A (pt)
CN (1) CN1849304A (pt)
AT (1) ATE417827T1 (pt)
CA (6) CA2529820A1 (pt)
DE (1) DE602004018494D1 (pt)
ES (1) ES2317012T3 (pt)
IL (2) IL172514A0 (pt)
MX (2) MXPA05013895A (pt)
PL (1) PL1638937T3 (pt)
PT (1) PT1638937E (pt)
WO (2) WO2004113291A2 (pt)

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US7368468B2 (en) * 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
US7368581B2 (en) * 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
JP4037898B2 (ja) * 2003-06-18 2008-01-23 テバ ファーマシューティカル インダストリーズ リミティド フルバスタチンナトリウム結晶形ｘｉｖ、ｌｘｘｉｉｉ、ｌｘｘｉｘ、ｌｘｘｘ及びｘｘｘｖｉｉ型、それらの調製方法、それらを含有する組成物及びそれらの使用方法
US7432380B2 (en) 2003-10-16 2008-10-07 Ciba Specialty Chemicals Corp. Crystalline form of Fluvastatin sodium
US20070179166A1 (en) * 2003-12-24 2007-08-02 Valerie Niddam-Hildesheim Process for preparation of statins with high syn to anti ratio
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
WO2005080332A1 (en) * 2004-01-14 2005-09-01 Cadila Healthcare Limited Novel form of fluvastatin sodium
WO2006030304A2 (en) * 2004-09-17 2006-03-23 Ranbaxy Laboratories Limited Novel forms of fluvastatin sodium, processes for preparation and pharmaceutical compositions thereof
JP2008515878A (ja) * 2004-10-05 2008-05-15 バイオコン・リミテッド アモルファス型フルバスタチンナトリウムの製造方法
US7795451B2 (en) * 2005-02-11 2010-09-14 Jubilant Organosys Limited Polymorphic forms of fluvastatin sodium and process for preparing the same
US20080171884A1 (en) * 2005-03-22 2008-07-17 Tarur Venkatasubramanian Radha Novel Polymorph Form G of Fluvastatin Sodium and Process For the Preparation Thereof
WO2006109147A1 (en) * 2005-04-12 2006-10-19 Glenmark Pharmaceuticals Limited Substantially pure amorphous fluvastatin, processes for its preparation and pharmaceutical compositions containing same
MX2007013286A (es) * 2006-02-27 2008-03-07 Teva Pharma Formas novedosas de sodio de fluvastatina y preparacion de ellas.
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US20110052688A1 (en) * 2006-11-21 2011-03-03 San-Laung Chow Solid dispersion composition
ES2321571B1 (es) * 2007-07-18 2010-03-11 Ercros Industrial, S.A. Solvatos de fluvastatina sodica y su utilizacion como intermedios en la obtencion de fluvastatina sodica amorfa.
CN101250153B (zh) * 2008-02-26 2013-09-18 深圳信立泰药业股份有限公司 一种制备氟伐他汀钠晶型的工艺
EP2419407B1 (en) * 2009-04-15 2012-11-14 Pharmathen S.A. Improved process for the preparation of fluvastatin and salts thereof
WO2011117875A1 (en) * 2010-03-26 2011-09-29 Hetero Research Foundation Salts of fluvastatin and process for the preparation of substantially amorphous fluvastatin sodium
KR101220266B1 (ko) * 2012-04-19 2013-01-09 홍종옥 수치지도 이미지 제작을 위한 항공영상 이미지 기반 정밀 영상도화 시스템
KR101308745B1 (ko) * 2012-07-04 2013-09-16 주식회사 동운 지리공간정보가 적용된 멀티 기능 기반의 수치지도 시스템
KR101220271B1 (ko) * 2012-07-05 2013-01-10 대한항업(주) 지피에스 기반 실사 지상물의 게시를 위한 수치지도 제작 시스템
KR101273416B1 (ko) * 2012-07-25 2013-06-11 주식회사 동운 좌표정보 및 지형정보 합성을 통한 정밀 수치지도 제작 시스템
KR101217854B1 (ko) * 2012-09-14 2013-01-02 (주)아세아항측 정밀 디에스엠 및 디티엠 정보와 지상 기준점 정보의 정밀해석을 통한 수치지도 높이오차 확인시스템
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途
WO2017106642A1 (en) * 2015-12-17 2017-06-22 Arqule, Inc. Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

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US7368468B2 (en) * 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
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Also Published As

Publication number Publication date
EP1780200A1 (en) 2007-05-02
EP1726583A2 (en) 2006-11-29
CA2529859A1 (en) 2004-12-29
CA2610635A1 (en) 2004-12-29
MXPA05013896A (es) 2006-03-09
EP1790635A3 (en) 2007-06-13
KR20060024426A (ko) 2006-03-16
JP2007302693A (ja) 2007-11-22
US20050032884A1 (en) 2005-02-10
KR20070094805A (ko) 2007-09-21
JP4037898B2 (ja) 2008-01-23
CN1849304A (zh) 2006-10-18
IL172512A0 (en) 2006-04-10
US20090118518A1 (en) 2009-05-07
MXPA05013895A (es) 2006-03-09
DE602004018494D1 (de) 2009-01-29
EP1790635A2 (en) 2007-05-30
IL172514A0 (en) 2006-04-10
US20080146817A1 (en) 2008-06-19
US7414140B2 (en) 2008-08-19
ES2317012T3 (es) 2009-04-16
WO2004113292A2 (en) 2004-12-29
EP1638937B1 (en) 2008-12-17
EP1790634A3 (en) 2007-06-13
EP1719759A2 (en) 2006-11-08
EP1638937A2 (en) 2006-03-29
EP1719760A3 (en) 2007-03-21
CA2610633A1 (en) 2004-12-29
KR20070092995A (ko) 2007-09-14
EP1726583A3 (en) 2007-05-09
WO2004113291A2 (en) 2004-12-29
EP1719759A3 (en) 2007-03-21
WO2004113292A3 (en) 2005-10-20
US7687642B2 (en) 2010-03-30
EP1636184A2 (en) 2006-03-22
KR20070092994A (ko) 2007-09-14
EP1752448A2 (en) 2007-02-14
CA2613013A1 (en) 2004-12-29
EP1790634A2 (en) 2007-05-30
ATE417827T1 (de) 2009-01-15
JP2007524619A (ja) 2007-08-30
WO2004113292B1 (en) 2005-11-10
CA2613021A1 (en) 2004-12-29
CA2529820A1 (en) 2004-12-29
US20090209611A1 (en) 2009-08-20
EP1719760A2 (en) 2006-11-08
JP2007525469A (ja) 2007-09-06
PL1638937T3 (pl) 2009-06-30
WO2004113291A3 (en) 2005-04-14
KR20070092993A (ko) 2007-09-14
EP1752448A3 (en) 2007-03-14
KR20060024428A (ko) 2006-03-16

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