EA037778B1 - Меченые ингибиторы простатического специфического мембранного антигена (псма), их применение в качестве агентов для визуализации и фармацевтических агентов для лечения рака предстательной железы - Google Patents
Меченые ингибиторы простатического специфического мембранного антигена (псма), их применение в качестве агентов для визуализации и фармацевтических агентов для лечения рака предстательной железы Download PDFInfo
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- EA037778B1 EA037778B1 EA201690495A EA201690495A EA037778B1 EA 037778 B1 EA037778 B1 EA 037778B1 EA 201690495 A EA201690495 A EA 201690495A EA 201690495 A EA201690495 A EA 201690495A EA 037778 B1 EA037778 B1 EA 037778B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutically acceptable
- compound
- pharmaceutical composition
- radionuclide
- metal complex
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- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP20130004991 EP2862857A1 (en) | 2013-10-18 | 2013-10-18 | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP14175612 | 2014-07-03 | ||
| PCT/EP2014/002808 WO2015055318A1 (en) | 2013-10-18 | 2014-10-17 | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
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| EA037778B1 true EA037778B1 (ru) | 2021-05-20 |
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| EP3699162B1 (en) | 2006-11-08 | 2022-06-29 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
| NZ583931A (en) | 2007-08-17 | 2012-06-29 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| KR102575825B1 (ko) | 2012-11-15 | 2023-09-06 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| SG11201602249RA (en) * | 2013-10-18 | 2016-05-30 | Deutsches Krebsforsch | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EA035171B1 (ru) | 2013-11-14 | 2020-05-08 | Эндосайт, Инк. | Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US20180236109A1 (en) * | 2015-08-20 | 2018-08-23 | Universitat Zu Koln | Pain Tracking by PET-imaging (Pain-TraP) |
| HRP20210183T1 (hr) * | 2015-09-30 | 2021-04-30 | Deutsches Krebsforschungszentrum | 18f-obilježeni inhibitori specifičnog membranskog antigena prostate (psma) i njihova uporaba kao sredstava za vizualizaciju raka prostate |
| US10688200B2 (en) * | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| KR20220063298A (ko) * | 2016-03-22 | 2022-05-17 | 더 존스 홉킨스 유니버시티 | 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제 |
| WO2017223357A1 (en) | 2016-06-23 | 2017-12-28 | Cornell University | Double targeted constructs to affect tumor kill |
| US10806806B2 (en) | 2016-06-23 | 2020-10-20 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
| US10980901B2 (en) * | 2016-12-15 | 2021-04-20 | The European Atomic Energy Community (Euratom), Represented By The European Commission | Treatment of PMSA expressing cancers |
| KR102724812B1 (ko) * | 2017-04-05 | 2024-11-01 | 코넬 유니버시티 | 영상화 및 항종양 치료요법에 유용한 조정 가능한 약동학을 갖는 삼작용성 작제물 |
| JP7373998B2 (ja) | 2017-05-02 | 2023-11-06 | コーネル・ユニバーシティー | 有効性がより大きくかつ毒性がより少ない腫瘍標的指向方法及び試薬 |
| IL270453B2 (en) | 2017-05-05 | 2025-05-01 | Fusion Pharmaceuticals Inc | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| BR112019023249A8 (pt) | 2017-05-05 | 2021-02-23 | Centre For Probe Dev And Commercialization | anticorpos monoclonais igf-1r e usos dos mesmos |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| WO2018233798A1 (en) | 2017-06-20 | 2018-12-27 | ITM Isotopen Technologien München AG | Novel psma-binding agents and uses thereof |
| US11629201B2 (en) * | 2017-05-24 | 2023-04-18 | ITM Isotope Technologies Munich SE | PSMA-binding agents and uses thereof |
| JP2020522506A (ja) * | 2017-05-30 | 2020-07-30 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 前立腺がんの内部放射線療法のための前立腺特異的膜抗原をターゲットとした高親和性薬剤 |
| CN110678198B (zh) | 2017-06-09 | 2024-02-02 | 阿文塞勒欧洲有限公司 | 针对表达通用嵌合抗原受体的免疫细胞的靶向模块及其在治疗癌症、感染和自身免疫性病症中的用途 |
| CN109510921B (zh) | 2017-09-15 | 2025-01-10 | 南昌欧菲光电技术有限公司 | 摄像模组 |
| CN109510925A (zh) | 2017-09-15 | 2019-03-22 | 南昌欧菲光电技术有限公司 | 摄像模组 |
| CN207184660U (zh) | 2017-09-15 | 2018-04-03 | 南昌欧菲光电技术有限公司 | 摄像模组 |
| KR102884167B1 (ko) * | 2017-10-22 | 2025-11-12 | 프로빈셜 헬스 서비시즈 오쏘리티 | 전립선 특이적 막 항원-발현 암의 진단 또는 치료를 위한 신규한 라디오메탈-결합 화합물 |
| US11452786B2 (en) | 2017-11-13 | 2022-09-27 | Deutsches Krebsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| US11638765B2 (en) | 2017-11-21 | 2023-05-02 | Deutsches Krebsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| EP4008359B1 (en) * | 2017-12-11 | 2024-09-11 | Technische Universität München | Psma ligands for imaging and endoradiotherapy |
| MX2020006112A (es) * | 2017-12-13 | 2020-08-24 | Sciencons AS | Complejo que comprende un compuesto orientado a psma vinculado a un radionucleido de plomo o torio. |
| IL276528B2 (en) * | 2018-02-06 | 2024-11-01 | Univ Johns Hopkins | PSMA Targeted Radiohalogenated Urea-Polyaminocarboxylates For Cancer Radiotherapy |
| MX380340B (es) | 2018-03-14 | 2025-03-11 | Instituto Nac De Investigaciones Nucleares | 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana. |
| MY197419A (en) | 2018-03-30 | 2023-06-16 | Futurechem Co Ltd | Psma-targeted radiopharmaceutical for diagnosing and treating prostate cancer |
| BR112020020961A2 (pt) | 2018-04-17 | 2021-01-19 | Endocyte, Inc. | Métodos de tratamento de câncer |
| CN121154858A (zh) * | 2018-09-21 | 2025-12-19 | 恩多塞特公司 | 治疗癌症的方法 |
| WO2020061293A1 (en) | 2018-09-21 | 2020-03-26 | Endocyte, Inc. | Shielding agents and their use |
| BR112021005931A2 (pt) * | 2018-09-28 | 2021-06-29 | Universität Heidelberg | composto, complexo e composição farmacêutica |
| DE102018126558A1 (de) | 2018-10-24 | 2020-04-30 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Markierungsvorläufer mit Quadratsäure-Kopplung |
| WO2020108753A1 (en) | 2018-11-28 | 2020-06-04 | ITM Isotopen Technologien München AG | Novel tumor antigen binding agents and uses thereof |
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| EP3923997A1 (en) | 2019-02-14 | 2021-12-22 | Deutsches Krebsforschungszentrum | Prostate specific membrane antigen (psma) ligands comprising an amylase cleavable linker |
| CN113710286A (zh) | 2019-02-14 | 2021-11-26 | 海德堡鲁普雷希特卡尔斯大学 | 具有改善的组织特异性的前列腺特异性膜抗原(psma)配体 |
| US11396535B2 (en) | 2019-03-01 | 2022-07-26 | Provincial Health Services Authority | Cyclic peptide analogs of melanocortin and amanitin and methods of making such |
| PL239934B1 (pl) | 2019-04-12 | 2022-01-31 | Narodowe Centrum Badan Jadrowych Osrodek Radioizotopow Polatom | Pochodne inhibitorów PSMA do znakowania ⁹⁹ᵐTc poprzez HYNIC, zestaw radiofarmaceutyczny, preparat radiofarmaceutyczny oraz ich zastosowanie w diagnostyce raka prostaty |
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| DE102019135564B4 (de) * | 2019-12-20 | 2022-05-19 | Johannes-Gutenberg-Universität Mainz | Verbindung für Smart-Drug-Delivery und pharmazeutisches Kit für duale nuklearmedizinisch-cytotoxische Theranostik |
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