ATE298341T1 - Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum - Google Patents

Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum

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Publication number
ATE298341T1
ATE298341T1 AT02750855T AT02750855T ATE298341T1 AT E298341 T1 ATE298341 T1 AT E298341T1 AT 02750855 T AT02750855 T AT 02750855T AT 02750855 T AT02750855 T AT 02750855T AT E298341 T1 ATE298341 T1 AT E298341T1
Authority
AT
Austria
Prior art keywords
phthalocyanine
useful
photodynamic therapy
carriers
vivo
Prior art date
Application number
AT02750855T
Other languages
English (en)
Inventor
Gabrio Roncucci
Donata Dei
Filippis Maria De
Lia Fantetti
Daniele Nistri
Original Assignee
Molteni & C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molteni & C filed Critical Molteni & C
Application granted granted Critical
Publication of ATE298341T1 publication Critical patent/ATE298341T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02750855T 2001-03-21 2002-03-20 Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum ATE298341T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01106411 2001-03-21
PCT/EP2002/003108 WO2002090361A1 (en) 2001-03-21 2002-03-20 Metal substituted non centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic

Publications (1)

Publication Number Publication Date
ATE298341T1 true ATE298341T1 (de) 2005-07-15

Family

ID=8176785

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02750855T ATE298341T1 (de) 2001-03-21 2002-03-20 Metallsubstituierte, nicht zentrosymmetrische phthalocyanin-analoga, deren herstellung und verwendung zur photodynamischen therapie, und als in-vivo-diagnostikum

Country Status (14)

Country Link
US (1) US7153841B2 (de)
EP (1) EP1381611B1 (de)
JP (1) JP2004529171A (de)
CN (1) CN100351255C (de)
AT (1) ATE298341T1 (de)
AU (1) AU2002341034B2 (de)
CA (1) CA2441386C (de)
DE (1) DE60204767T2 (de)
DK (1) DK1381611T3 (de)
ES (1) ES2244793T3 (de)
IL (2) IL158032A0 (de)
PT (1) PT1381611E (de)
WO (1) WO2002090361A1 (de)
ZA (1) ZA200308093B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002226687B9 (en) 2001-01-26 2005-10-20 Btg International Limited Benzylamine analogue
ATE299705T1 (de) 2002-04-25 2005-08-15 Molteni & C Metallphthalocyanin-analoge enthaltende antibakterielle zusammensetzungen
ITFI20020200A1 (it) 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
ITFI20050093A1 (it) * 2005-05-05 2006-11-06 Molteni & C Processo per la preparazione di cloruri di derivati ftalocianinici comprendenti almeno un gruppo ammonio quaternario
ITFI20050092A1 (it) * 2005-05-05 2006-11-06 Molteni & C Derivati ftalocianinici, processo per la loro preparazione, composizioni farmaceutiche che li contengono e loro uso
AU2006263834B8 (en) 2005-06-29 2011-11-17 Molteni Therapeutics S.R.L. Self-sterilizing products
WO2007009101A2 (en) * 2005-07-14 2007-01-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tetraazaporphyrin-based compounds and their uses
CN1939919B (zh) * 2005-09-30 2010-06-09 中国科学院福建物质结构研究所 一种广谱、低毒性的酞菁类杀菌剂及其制备方法和用途
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
EP2072584B1 (de) 2007-12-17 2011-05-11 ILFORD Imaging Switzerland GmbH Phthalocyanin-Farbstoffe, ihre Herstellung und Verwendung
CN103003282B (zh) * 2010-01-22 2016-01-20 科学与工业研究会 一种制备新的卟啉衍生物的方法及其作为pdt试剂和荧光探针的用途
WO2012086857A1 (ko) * 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
ITFI20110166A1 (it) 2011-08-05 2013-02-06 Molteni & C Nuovi fotosensibilizzanti ad uso terapeutico.
CN103382205B (zh) * 2012-05-03 2015-10-28 中国医学科学院生物医学工程研究所 骨靶向的酞菁锌及制备方法及用途
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
RS65324B1 (sr) 2013-10-18 2024-04-30 Novartis Ag Obeleženi inhibitori membranskog antigena specifičnog za prostatu (psma), njihova upotreba kao agenasa za snimanje i farmaceutskih agenasa za lečenje karcinoma prostate
JP6269946B2 (ja) * 2014-03-25 2018-01-31 国立大学法人名古屋大学 細菌の増殖抑制
CN104262350B (zh) * 2014-10-09 2017-01-18 福州大学 一种酞菁金属配合物及其制备方法和应用
CN105418643B (zh) * 2015-12-22 2017-10-20 福州大学 一种双边生物素‑酞菁锌轭合物及其制备和应用
CN106866721B (zh) * 2017-03-10 2019-03-26 江苏省原子医学研究所 一种硅酞菁衍生物及其制备生物素受体靶向硅酞菁光敏剂的应用
CN108498855B (zh) * 2018-05-09 2021-04-27 福州大学 一种抗菌止血溶胶及其制备方法
EP4174071A1 (de) * 2020-06-24 2023-05-03 The University of Tokyo Photosensibilisierender farbstoff
CN112409365B (zh) * 2020-12-09 2021-11-02 福州大学 3-磺酸基丙烷巯基修饰酞菁及其制备方法与在制药领域的应用

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Publication number Priority date Publication date Assignee Title
JPH04500516A (ja) * 1988-09-08 1992-01-30 ブリティッシュ　テクノロジー　グループ　ユーエスエイ，インコーポレイテッド 赤色シフト―フタロシアニン及びテトラベンゾトリアザポルフィリン試薬
JPH0672873A (ja) * 1992-08-27 1994-03-15 Nippon Shokubai Co Ltd 腫瘍治療剤および腫瘍光化学診断薬
GB9405970D0 (en) * 1994-03-25 1994-05-11 Secr Defence Substituted phthalocyanines
CN1053906C (zh) * 1996-10-15 2000-06-28 福州大学 酞菁锌配合物及其制造方法和在制抗癌药中的应用
DE19731741A1 (de) * 1997-07-23 1999-01-28 Deutsches Krebsforsch Konjugat zur Unterscheidung von krankhaftem und gesundem Gewebe
IT1294325B1 (it) * 1997-08-14 1999-03-24 Molteni L E C Dei Fratelli Ali Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici
AU2192201A (en) * 1999-12-08 2001-06-18 Gentian As Substituted phthalocyanines and their precursors
JP4139539B2 (ja) * 2000-01-21 2008-08-27 富士フイルム株式会社 光重合性画像記録材料及び平版印刷版原版
DK1164135T3 (da) * 2000-06-15 2004-06-21 Molteni & C Substituerede metal-phthalocyaniner, fremstilling deraf og anvendelse deraf

Also Published As

Publication number Publication date
JP2004529171A (ja) 2004-09-24
IL158032A0 (en) 2004-03-28
DK1381611T3 (da) 2005-10-24
EP1381611A1 (de) 2004-01-21
DE60204767D1 (de) 2005-07-28
AU2002341034B2 (en) 2007-06-14
CN1633437A (zh) 2005-06-29
PT1381611E (pt) 2005-11-30
CA2441386C (en) 2010-12-21
DE60204767T2 (de) 2006-05-18
ZA200308093B (en) 2004-07-08
IL158032A (en) 2009-09-01
ES2244793T3 (es) 2005-12-16
CA2441386A1 (en) 2002-11-14
WO2002090361A1 (en) 2002-11-14
EP1381611B1 (de) 2005-06-22
US7153841B2 (en) 2006-12-26
CN100351255C (zh) 2007-11-28
WO2002090361A8 (en) 2004-05-21
US20040156787A1 (en) 2004-08-12

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