ATE308545T1 - Chlorophyll- und bacteriochlorophyllester, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Chlorophyll- und bacteriochlorophyllester, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE308545T1
ATE308545T1 AT00979916T AT00979916T ATE308545T1 AT E308545 T1 ATE308545 T1 AT E308545T1 AT 00979916 T AT00979916 T AT 00979916T AT 00979916 T AT00979916 T AT 00979916T AT E308545 T1 ATE308545 T1 AT E308545T1
Authority
AT
Austria
Prior art keywords
sub
sup
coxr
chlorophyll
bacteriochlorophyl
Prior art date
Application number
AT00979916T
Other languages
English (en)
Inventor
Hugo Scheer
Nina Kammhuber
Avigdor Scherz
Alexander Brandis
Yoram Salomon
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE308545T1 publication Critical patent/ATE308545T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
AT00979916T 1999-12-01 2000-12-01 Chlorophyll- und bacteriochlorophyllester, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen ATE308545T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13325399A IL133253A0 (en) 1999-12-01 1999-12-01 Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
PCT/IL2000/000811 WO2001040232A1 (en) 1999-12-01 2000-12-01 Chlorophyll and bacteriochlorophyll esters, and their preparation

Publications (1)

Publication Number Publication Date
ATE308545T1 true ATE308545T1 (de) 2005-11-15

Family

ID=11073554

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00979916T ATE308545T1 (de) 1999-12-01 2000-12-01 Chlorophyll- und bacteriochlorophyllester, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen

Country Status (18)

Country Link
US (1) US7169753B2 (de)
EP (1) EP1246826B1 (de)
JP (1) JP2003515538A (de)
CN (1) CN1222526C (de)
AT (1) ATE308545T1 (de)
AU (1) AU777761B2 (de)
BR (1) BR0016051A (de)
CA (1) CA2392989A1 (de)
DE (1) DE60023748T2 (de)
DK (1) DK1246826T3 (de)
ES (1) ES2250214T3 (de)
HU (1) HU224553B1 (de)
IL (1) IL133253A0 (de)
MX (1) MXPA02005455A (de)
NO (1) NO323208B1 (de)
PL (1) PL356391A1 (de)
RU (1) RU2250905C2 (de)
WO (1) WO2001040232A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060212025A1 (en) 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
RU2343829C2 (ru) 2002-05-08 2009-01-20 Йеда Рисерч Энд Дивелопмент Ко. Лтд Сенсибилизированный оперативный bold-mri способ получения изображения
IL152900A0 (en) 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
EP1648385B1 (de) 2003-07-31 2016-05-04 Gentlewaves Llc System und verfahren für die photodynamische behandlung von haut
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
WO2005120572A1 (en) 2004-06-09 2005-12-22 Qlt Inc. Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins
EP2322173B1 (de) * 2004-06-07 2016-08-10 Yeda Research And Development Co., Ltd. Kationische Bakteriochlorophyllderivate und Verwendungen dafür
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
RU2303966C2 (ru) * 2005-10-11 2007-08-10 Федеральное Государственное Учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" им. академика С.Н. Федорова Федерального агентства по здравоохранению и социальному развитию Способ снижения поверхностной дозы офтальмоаппликатора при проведении брахитерапии внутриглазных новообразований
RU2345803C2 (ru) * 2006-11-30 2009-02-10 Закрытое Акционерное Общество "Исследовательские лаборатории "РАДА-ФАРМА" Способ фотоиммунотерапии фотосенсибилизатором, активируемым волновой энергией вне организма человека
RU2336917C1 (ru) * 2007-05-29 2008-10-27 Государственное образовательное учреждение дополнительного профессионального образования Российская медицинская академия последипломного образования Федерального агентства по здравоохранению и социальному развитию (ГОУДПО РМАПО Росздрава) Способ лечения больных псориазом
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
FR2924021B1 (fr) * 2007-11-27 2010-08-13 Du Vernet Michele Eymard Composition pour le traitement de la peau par therapie photodynamique
WO2009095912A1 (en) * 2008-01-28 2009-08-06 Yeda Research And Development Co. Ltd Endoscopic imaging photodynamic therapy system and methods of use
RU2518296C2 (ru) 2008-02-27 2014-06-10 Йеда Рисерч Энд Дивелопмент Ко. Лтд Конъюгаты rgd-(бактерио)хлорофилл для фотодинамической терапии и визуализации некротических опухолей
BR112013017953A2 (pt) 2011-01-13 2017-08-29 Quadra Logic Tech Inc Composição farmacêutica, formulação tópica, método, e, composição fotossensibilizadora
RU2632439C2 (ru) * 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
JP2015522079A (ja) 2012-07-11 2015-08-03 ダーミラ， インク．Ｄｅｒｍｉｒａ， Ｉｎｃ． 光線感作物質の局所送達のための医薬組成物及びその使用
EP3019201B1 (de) 2013-07-12 2020-03-18 The United States of America, as represented by the Secretary, Department of Health and Human Services Photoaktivierbare lipidbasierte nanopartikel als träger für duale wirkstoffabgabe
AU2017250732B2 (en) * 2016-04-10 2022-11-10 Memorial Sloan-Kettering Cancer Center Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
CN108341827A (zh) * 2018-02-02 2018-07-31 浙江海正药业股份有限公司 一种制备脱镁细菌叶绿素a及脱镁细菌叶绿素a酯的方法
CN108191877A (zh) * 2018-02-05 2018-06-22 云南瑞宝生物科技股份有限公司 一种从蚕沙中提取和纯化叶绿素的方法
US12178907B2 (en) 2018-07-12 2024-12-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Binary lipid bilayer-containing vesicles comprising embedded cytotoxic agents and methods of making and using the same
CN111171030B (zh) * 2018-11-12 2022-11-22 浙江海正药业股份有限公司 细菌叶绿素衍生物及其制备方法
CN111848656B (zh) * 2020-06-24 2023-03-14 天津大学 离子修饰的原卟啉镓化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU857139A1 (ru) * 1979-11-02 1981-08-23 Предприятие П/Я В-2343 Способ получени порфиринов,содержащих изоциклическое метилциклопентановое кольцо
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) * 1991-07-02 1993-01-14 Scheer Hugo Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
DE4121867A1 (de) 1991-07-02 1993-01-07 Leifeld & Lemke Maschf Vorrichtung zur pruefung der dichtigkeit von mit deckeln luftdicht verschlossenen bechern
IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
NO323208B1 (no) 2007-01-22
CA2392989A1 (en) 2001-06-07
NO20022599L (no) 2002-07-11
US20030148926A1 (en) 2003-08-07
HU224553B1 (hu) 2005-10-28
DK1246826T3 (da) 2006-01-02
DE60023748T2 (de) 2006-08-03
AU1729201A (en) 2001-06-12
CN1222526C (zh) 2005-10-12
BR0016051A (pt) 2002-07-23
MXPA02005455A (es) 2002-11-29
JP2003515538A (ja) 2003-05-07
EP1246826B1 (de) 2005-11-02
HK1056557A1 (en) 2004-02-20
ES2250214T3 (es) 2006-04-16
DE60023748D1 (de) 2005-12-08
RU2250905C2 (ru) 2005-04-27
HUP0204167A2 (hu) 2003-03-28
PL356391A1 (en) 2004-06-28
WO2001040232A1 (en) 2001-06-07
EP1246826A1 (de) 2002-10-09
US7169753B2 (en) 2007-01-30
CN1425015A (zh) 2003-06-18
IL133253A0 (en) 2001-04-30
HUP0204167A3 (en) 2004-08-30
WO2001040232A9 (en) 2002-09-12
AU777761B2 (en) 2004-10-28
NO20022599D0 (no) 2002-05-31

Similar Documents

Publication Publication Date Title
ATE308545T1 (de) Chlorophyll- und bacteriochlorophyllester, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
Zhu et al. L‐Arg‐rich amphiphilic dendritic peptide as a versatile NO donor for NO/photodynamic synergistic treatment of bacterial infections and promoting wound healing
DE60211918T2 (de) Sulfonierte chlorine als photosensitizer
DE69731083T2 (de) Verfahren zur behandlung von viralen infektionen
ES2136673T3 (es) Utilizacion del factor de crecimiento de los queratinocitos para la obtencion de medicamentos.
GEP20022804B (en) Erythropoietin Derivatives
ATE267798T1 (de) Kombinierte wirkstoffe als methode zur gezielten wirkstoff-freisetzung
WO2000040269A3 (en) Pharmaceutical compositions for treatment of diseased tissues
BR9507506A (pt) Processo para exterminar uma célula processo para tratamento de càncer composição e kit terapéutico
RU94046426A (ru) Фармацевтические композиции, способы лечения лейкоза, способ повышения уровней стволовых клеток, антагонист с - kit - лиганда, антисмысловая нуклеиновая кислота, способ лечения меланомы, способ усиления трансфекции, способ переноса гена, способ увеличения уровней периферической крови, способ повышения уровней тромбоцитов, способы модификации биологической функции, способ лечения анемии, способ улучшения приживления костного мозга, способ ускорения восстановления костного мозга, способ лечения лейкопении
ATE336997T1 (de) Fulvinsäure und dessen verwendung zur behandlung von diversen krankheitszuständen
RU95110937A (ru) Хинолоновые и акридиноновые соединения, способ их получения, фармацевтическая композиция и промежуточные соединения
BR9813318A (pt) Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário
CA2449856A1 (en) Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
DE60031016D1 (de) Verwendung von Antiseptika zur Herstellung von Arzneimitteln zur Prophylaxe und Behandlung von Entzündungen im Korperinneren des Menschen
ATE301475T1 (de) Modifizierte kolloide und deren verwendung
RU2335539C2 (ru) Фармацевтический препарат и способ лечения злокачественных опухолей у человека с помощью аргининовой депривации
JPH10502371A (ja) リンホトキシンを用いる癌処置法
CN1163218C (zh) 新型护肤化妆品
ATE428438T1 (de) Tcf-ii enthaltende medizinische zusammensetzung
KR100488038B1 (ko) 기관 보호 활성을 지닌 신규한 신체 보호 화합물 펩티드염, 이의 제조 방법 및 치료에서의 이의 용도
ATE235909T1 (de) Biologisch kompatible und biologisch abbaubare zubereitungen enthaltend hyaluronsäure und deren derivate zur behandlung von geschwüren im verdauungsapparat
RU95105249A (ru) Гидрохлорид ng монометил-l-аргинина, способы его получения, способ получения фармацевтического препарата и способ лечения
KR20140107389A (ko) 상피의 관통 및 세포의 생물학적 이용률을 증가시키도록 화학적으로 개질된 광역학적 치료용 조성물

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1246826

Country of ref document: EP

REN Ceased due to non-payment of the annual fee