BR0016051A - ésteres clorofìlicos e bacterioclorofìlicos, sua preparação e composições farmacêuticas que os compreendem - Google Patents
ésteres clorofìlicos e bacterioclorofìlicos, sua preparação e composições farmacêuticas que os compreendemInfo
- Publication number
- BR0016051A BR0016051A BR0016051-2A BR0016051A BR0016051A BR 0016051 A BR0016051 A BR 0016051A BR 0016051 A BR0016051 A BR 0016051A BR 0016051 A BR0016051 A BR 0016051A
- Authority
- BR
- Brazil
- Prior art keywords
- chlorophyll
- esters
- coxr
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 229930002875 chlorophyll Natural products 0.000 title abstract 2
- 235000019804 chlorophyll Nutrition 0.000 title abstract 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000012678 infectious agent Substances 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Abstract
"éSTERES CLOROFìLICOS E BACTERIOCLOROFìLICOS, SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS QUE OS COMPREENDEM". A presente invenção proporciona novos compostos de derivados de clorofila e bacterioclorofila C-13^ 2^-COXR~ 1~, C-17^ 2^-COXR~ 2~ e C-13^ 2^-COXR~ 1~, C-17^ 2^-COXR~ 1~, onde X é O, S ou N e R~ 1~, e R~ 2~, os mesmos ou diferentes, poderão ser um radical hidrocarbila opcionalmente substituído, aminoácido, peptídeo, proteína ou sacarídeo. Os compostos são para uso em terapia fotodinâmica (PDT), para diagnose de tumores, e para eliminação de células e agentes infecciosos tais como bactérias e vírus, tanto em produtos biológicos quanto em tecidos vivos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13325399A IL133253A0 (en) | 1999-12-01 | 1999-12-01 | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| PCT/IL2000/000811 WO2001040232A1 (en) | 1999-12-01 | 2000-12-01 | Chlorophyll and bacteriochlorophyll esters, and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0016051A true BR0016051A (pt) | 2002-07-23 |
Family
ID=11073554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0016051-2A BR0016051A (pt) | 1999-12-01 | 2000-12-01 | ésteres clorofìlicos e bacterioclorofìlicos, sua preparação e composições farmacêuticas que os compreendem |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7169753B2 (pt) |
| EP (1) | EP1246826B1 (pt) |
| JP (1) | JP2003515538A (pt) |
| CN (1) | CN1222526C (pt) |
| AT (1) | ATE308545T1 (pt) |
| AU (1) | AU777761B2 (pt) |
| BR (1) | BR0016051A (pt) |
| CA (1) | CA2392989A1 (pt) |
| DE (1) | DE60023748T2 (pt) |
| DK (1) | DK1246826T3 (pt) |
| ES (1) | ES2250214T3 (pt) |
| HK (1) | HK1056557A1 (pt) |
| HU (1) | HU224553B1 (pt) |
| IL (1) | IL133253A0 (pt) |
| MX (1) | MXPA02005455A (pt) |
| NO (1) | NO323208B1 (pt) |
| PL (1) | PL356391A1 (pt) |
| RU (1) | RU2250905C2 (pt) |
| WO (1) | WO2001040232A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
| US9192780B2 (en) | 1998-11-30 | 2015-11-24 | L'oreal | Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders |
| US20060212025A1 (en) | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
| WO2002013820A1 (en) * | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| AU2003230164B2 (en) | 2002-05-08 | 2008-05-01 | Yeda Research And Development Co. Ltd. | Sensitized online BOLD-MRI imaging method |
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| ES2572976T3 (es) | 2003-07-31 | 2016-06-03 | Gentlewaves Llc | Sistema y método para el tratamiento fotodinámico de la piel |
| CA2437638A1 (en) | 2003-08-20 | 2005-02-20 | John Robert North | Photodynamic therapy |
| CA2457214A1 (en) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
| EP2322173B1 (en) * | 2004-06-07 | 2016-08-10 | Yeda Research And Development Co., Ltd. | Cationic bacteriochlorophyll derivatives and uses thereof |
| CA2568744A1 (en) | 2004-06-09 | 2005-12-22 | Qlt Inc. | Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins |
| US20090036952A1 (en) | 2007-07-30 | 2009-02-05 | National Yang-Ming University | Induction driven light module and use thereof |
| FR2924021B1 (fr) * | 2007-11-27 | 2010-08-13 | Du Vernet Michele Eymard | Composition pour le traitement de la peau par therapie photodynamique |
| US20110040170A1 (en) * | 2008-01-28 | 2011-02-17 | Yeda Research And Development Co., Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
| AU2009219682B2 (en) | 2008-02-27 | 2015-06-18 | Yeda Research & Development Co. Ltd | RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors |
| AU2012205410A1 (en) | 2011-01-13 | 2013-08-01 | Qlt Inc. | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
| HUE053321T2 (hu) * | 2011-08-23 | 2021-06-28 | Yeda Res & Dev | (Bakterio)klorofill fotoszenzitizátorok szembetegségek és rendellenességek kezelésére |
| EP2872178A1 (en) | 2012-07-11 | 2015-05-20 | Dermira, Inc. | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
| US10117942B2 (en) | 2013-07-12 | 2018-11-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery |
| AU2017250732B2 (en) * | 2016-04-10 | 2022-11-10 | Memorial Sloan-Kettering Cancer Center | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
| CN108341827A (zh) * | 2018-02-02 | 2018-07-31 | 浙江海正药业股份有限公司 | 一种制备脱镁细菌叶绿素a及脱镁细菌叶绿素a酯的方法 |
| CN108191877A (zh) * | 2018-02-05 | 2018-06-22 | 云南瑞宝生物科技股份有限公司 | 一种从蚕沙中提取和纯化叶绿素的方法 |
| CN111171030B (zh) * | 2018-11-12 | 2022-11-22 | 浙江海正药业股份有限公司 | 细菌叶绿素衍生物及其制备方法 |
| CN111848656B (zh) * | 2020-06-24 | 2023-03-14 | 天津大学 | 离子修饰的原卟啉镓化合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| DE4121876A1 (de) * | 1991-07-02 | 1993-01-14 | Scheer Hugo | Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung |
| DE4121867A1 (de) | 1991-07-02 | 1993-01-07 | Leifeld & Lemke Maschf | Vorrichtung zur pruefung der dichtigkeit von mit deckeln luftdicht verschlossenen bechern |
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-01 IL IL13325399A patent/IL133253A0/xx unknown
-
2000
- 2000-12-01 PL PL00356391A patent/PL356391A1/xx not_active Application Discontinuation
- 2000-12-01 BR BR0016051-2A patent/BR0016051A/pt not_active Application Discontinuation
- 2000-12-01 JP JP2001540987A patent/JP2003515538A/ja not_active Abandoned
- 2000-12-01 RU RU2002117287/04A patent/RU2250905C2/ru not_active IP Right Cessation
- 2000-12-01 AT AT00979916T patent/ATE308545T1/de not_active IP Right Cessation
- 2000-12-01 MX MXPA02005455A patent/MXPA02005455A/es active IP Right Grant
- 2000-12-01 EP EP00979916A patent/EP1246826B1/en not_active Expired - Lifetime
- 2000-12-01 DK DK00979916T patent/DK1246826T3/da active
- 2000-12-01 US US10/148,552 patent/US7169753B2/en not_active Expired - Fee Related
- 2000-12-01 WO PCT/IL2000/000811 patent/WO2001040232A1/en active IP Right Grant
- 2000-12-01 ES ES00979916T patent/ES2250214T3/es not_active Expired - Lifetime
- 2000-12-01 HU HU0204167A patent/HU224553B1/hu not_active IP Right Cessation
- 2000-12-01 DE DE60023748T patent/DE60023748T2/de not_active Expired - Fee Related
- 2000-12-01 CN CNB008186030A patent/CN1222526C/zh not_active Expired - Fee Related
- 2000-12-01 AU AU17292/01A patent/AU777761B2/en not_active Ceased
- 2000-12-01 CA CA002392989A patent/CA2392989A1/en not_active Abandoned
-
2002
- 2002-05-31 NO NO20022599A patent/NO323208B1/no unknown
-
2003
- 2003-12-04 HK HK03108847A patent/HK1056557A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204167A3 (en) | 2004-08-30 |
| WO2001040232A9 (en) | 2002-09-12 |
| DE60023748T2 (de) | 2006-08-03 |
| NO20022599L (no) | 2002-07-11 |
| NO20022599D0 (no) | 2002-05-31 |
| HK1056557A1 (en) | 2004-02-20 |
| NO323208B1 (no) | 2007-01-22 |
| DK1246826T3 (da) | 2006-01-02 |
| MXPA02005455A (es) | 2002-11-29 |
| IL133253A0 (en) | 2001-04-30 |
| ATE308545T1 (de) | 2005-11-15 |
| DE60023748D1 (de) | 2005-12-08 |
| HU224553B1 (hu) | 2005-10-28 |
| HUP0204167A2 (hu) | 2003-03-28 |
| ES2250214T3 (es) | 2006-04-16 |
| EP1246826B1 (en) | 2005-11-02 |
| AU1729201A (en) | 2001-06-12 |
| WO2001040232A1 (en) | 2001-06-07 |
| JP2003515538A (ja) | 2003-05-07 |
| PL356391A1 (en) | 2004-06-28 |
| CN1222526C (zh) | 2005-10-12 |
| US7169753B2 (en) | 2007-01-30 |
| US20030148926A1 (en) | 2003-08-07 |
| AU777761B2 (en) | 2004-10-28 |
| EP1246826A1 (en) | 2002-10-09 |
| RU2250905C2 (ru) | 2005-04-27 |
| CA2392989A1 (en) | 2001-06-07 |
| CN1425015A (zh) | 2003-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] |
Free format text: DE ACORDO COM ART. 34 " II " DA LPI ( LEI 9279, DE 14/05/96 ) , O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO. |
|
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |