BRPI0606396A2 - sulfonas tripeptìdicas e tetrapeptìdicas, composição farmacêutica contendo as mesmas, uso relacionado e método de preparação das referidas sulfonas - Google Patents
sulfonas tripeptìdicas e tetrapeptìdicas, composição farmacêutica contendo as mesmas, uso relacionado e método de preparação das referidas sulfonasInfo
- Publication number
- BRPI0606396A2 BRPI0606396A2 BRPI0606396-9A BRPI0606396A BRPI0606396A2 BR PI0606396 A2 BRPI0606396 A2 BR PI0606396A2 BR PI0606396 A BRPI0606396 A BR PI0606396A BR PI0606396 A2 BRPI0606396 A2 BR PI0606396A2
- Authority
- BR
- Brazil
- Prior art keywords
- sulfones
- preparation
- tetrapeptide
- pharmaceutical composition
- composition containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SULFONAS TRIPEPTìDICAS E TETRAPEPTìDICAS, COMPOSIçãO FARMACêUTICA CONTENDO AS MESMAS, USO RELACIONADO E MéTODO DE PREPARAçãO DAS REFERIDAS SULFONAS. A presente invenção refere-se a suífonas tripetídicas e tetrapeptídicas, composições farmacêuticas contendo as mesmas, seu uso farmacêutico e sua preparação. Os compostos são úteis na potencialização dos efeitos citotóxicos de agentes quimioterápicos em células de tumor, no emprego seletivo da citotoxicidade em células de tumor, na elevação da produçáo de progenitores de GM na medula óssea, na estimulação da diferenciação da medula óssea, na atenuação dos efeitos mielossupressores de agentes quimioterápicos e na modulação da hematopoiese na medula óssea.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64193205P | 2005-01-06 | 2005-01-06 | |
| PCT/US2006/000532 WO2006074409A1 (en) | 2005-01-06 | 2006-01-05 | Tripeptide and tetrapeptide sulfones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606396A2 true BRPI0606396A2 (pt) | 2009-06-23 |
Family
ID=36123437
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606520-1A BRPI0606520A2 (pt) | 2005-01-06 | 2006-01-04 | tripeptìdeo e tetrapeptìdeo tioéteres |
| BRPI0606396-9A BRPI0606396A2 (pt) | 2005-01-06 | 2006-01-05 | sulfonas tripeptìdicas e tetrapeptìdicas, composição farmacêutica contendo as mesmas, uso relacionado e método de preparação das referidas sulfonas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606520-1A BRPI0606520A2 (pt) | 2005-01-06 | 2006-01-04 | tripeptìdeo e tetrapeptìdeo tioéteres |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7129215B2 (pt) |
| EP (2) | EP1833978B1 (pt) |
| JP (2) | JP4903716B2 (pt) |
| KR (2) | KR101244609B1 (pt) |
| CN (2) | CN101090977B (pt) |
| AR (2) | AR051889A1 (pt) |
| AT (2) | ATE410520T1 (pt) |
| AU (2) | AU2006204022B2 (pt) |
| BR (2) | BRPI0606520A2 (pt) |
| CA (2) | CA2587284C (pt) |
| DE (2) | DE602006003064D1 (pt) |
| DK (2) | DK1833978T3 (pt) |
| EA (2) | EA200701398A1 (pt) |
| ES (2) | ES2314890T3 (pt) |
| HK (2) | HK1106796A1 (pt) |
| HR (2) | HRP20090128T3 (pt) |
| IL (2) | IL182836A (pt) |
| MX (2) | MX2007008255A (pt) |
| NZ (2) | NZ555362A (pt) |
| PL (2) | PL1833978T3 (pt) |
| PT (2) | PT1833978E (pt) |
| SI (2) | SI1833978T1 (pt) |
| TW (2) | TWI317738B (pt) |
| WO (2) | WO2006074249A1 (pt) |
| ZA (2) | ZA200704487B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198247B2 (en) | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
| AU2006204022B2 (en) * | 2005-01-06 | 2011-01-20 | Telik, Inc. | Tripeptide and tetrapeptide thioethers |
| US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| CN101541743A (zh) * | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药系统 |
| AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| KR101853971B1 (ko) | 2007-06-04 | 2018-05-02 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| RU2765463C2 (ru) | 2008-12-04 | 2022-01-31 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
| DE102008060888A1 (de) | 2008-12-09 | 2010-06-10 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase |
| CN109232716A (zh) | 2009-05-08 | 2019-01-18 | 上海泰飞尔生化技术有限公司 | 多肽和多肽相关化合物的高穿透力前药组合物 |
| WO2011156045A2 (en) * | 2010-06-07 | 2011-12-15 | Telik, Inc. | Tablet formulation of ezatiostat |
| US8841476B2 (en) | 2010-06-07 | 2014-09-23 | Telik, Inc. | Preparation of crystalline ezatiostat hydrochloride ansolvate form D |
| US20130035389A1 (en) * | 2011-08-05 | 2013-02-07 | Telik, Inc. | Methods for treating myelodysplastic syndrome with ezatiostat |
| JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
| CN106146616A (zh) * | 2015-04-03 | 2016-11-23 | 浙江海正药业股份有限公司 | 环肽类化合物及其制备和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599903A (en) | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5556942A (en) | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5786336A (en) * | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
| US5955432A (en) | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
| US5767086A (en) | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
| CA2105492C (en) * | 1993-09-03 | 2000-02-01 | Lawrence M. Kauvar | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
| JPH11507056A (ja) * | 1995-06-07 | 1999-06-22 | テラピン テクノロジーズ、インク． | グルタチオンアナログの代謝的効果 |
| WO1998009986A1 (en) * | 1996-09-02 | 1998-03-12 | The Manchester Metropolitan University | S-blocked glutathiones |
| EP1072608B1 (en) * | 1998-04-16 | 2005-06-15 | Teijin Limited | Glutathione derivatives and dosage forms thereof |
| PT1143992E (pt) * | 1999-01-27 | 2005-05-31 | Telik Inc | Composicoes farmaceuticas contendo analogos de glutationa |
| US7029695B2 (en) | 2001-07-10 | 2006-04-18 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| AU2006204022B2 (en) | 2005-01-06 | 2011-01-20 | Telik, Inc. | Tripeptide and tetrapeptide thioethers |
-
2006
- 2006-01-04 AU AU2006204022A patent/AU2006204022B2/en not_active Ceased
- 2006-01-04 BR BRPI0606520-1A patent/BRPI0606520A2/pt not_active IP Right Cessation
- 2006-01-04 EA EA200701398A patent/EA200701398A1/ru unknown
- 2006-01-04 DK DK06717426T patent/DK1833978T3/da active
- 2006-01-04 KR KR1020077018022A patent/KR101244609B1/ko not_active IP Right Cessation
- 2006-01-04 DE DE602006003064T patent/DE602006003064D1/de active Active
- 2006-01-04 JP JP2007550441A patent/JP4903716B2/ja not_active Expired - Fee Related
- 2006-01-04 WO PCT/US2006/000219 patent/WO2006074249A1/en active Application Filing
- 2006-01-04 TW TW095100277A patent/TWI317738B/zh not_active IP Right Cessation
- 2006-01-04 TW TW095100278A patent/TWI317739B/zh not_active IP Right Cessation
- 2006-01-04 EP EP06717426A patent/EP1833978B1/en active Active
- 2006-01-04 AT AT06717426T patent/ATE410520T1/de active
- 2006-01-04 CN CN2006800014949A patent/CN101090977B/zh not_active Expired - Fee Related
- 2006-01-04 US US11/325,846 patent/US7129215B2/en not_active Expired - Fee Related
- 2006-01-04 CA CA2587284A patent/CA2587284C/en not_active Expired - Fee Related
- 2006-01-04 PT PT06717426T patent/PT1833978E/pt unknown
- 2006-01-04 PL PL06717426T patent/PL1833978T3/pl unknown
- 2006-01-04 NZ NZ555362A patent/NZ555362A/en not_active IP Right Cessation
- 2006-01-04 MX MX2007008255A patent/MX2007008255A/es active IP Right Grant
- 2006-01-04 SI SI200630153T patent/SI1833978T1/sl unknown
- 2006-01-04 ES ES06717426T patent/ES2314890T3/es active Active
- 2006-01-05 CA CA2587310A patent/CA2587310C/en not_active Expired - Fee Related
- 2006-01-05 WO PCT/US2006/000532 patent/WO2006074409A1/en active Application Filing
- 2006-01-05 KR KR1020077012531A patent/KR20070091611A/ko not_active Application Discontinuation
- 2006-01-05 MX MX2007008254A patent/MX2007008254A/es active IP Right Grant
- 2006-01-05 DK DK06717699T patent/DK1833842T3/da active
- 2006-01-05 SI SI200630154T patent/SI1833842T1/sl unknown
- 2006-01-05 AT AT06717699T patent/ATE410440T1/de active
- 2006-01-05 EP EP06717699A patent/EP1833842B1/en active Active
- 2006-01-05 AR ARP060100041A patent/AR051889A1/es not_active Application Discontinuation
- 2006-01-05 PT PT06717699T patent/PT1833842E/pt unknown
- 2006-01-05 JP JP2007550515A patent/JP4903717B2/ja not_active Expired - Fee Related
- 2006-01-05 CN CNA2006800013664A patent/CN101080418A/zh active Pending
- 2006-01-05 NZ NZ555361A patent/NZ555361A/en not_active IP Right Cessation
- 2006-01-05 AU AU2006203901A patent/AU2006203901B2/en not_active Ceased
- 2006-01-05 EA EA200701399A patent/EA200701399A1/ru unknown
- 2006-01-05 US US11/326,975 patent/US7192918B2/en not_active Expired - Fee Related
- 2006-01-05 AR ARP060100042A patent/AR051890A1/es not_active Application Discontinuation
- 2006-01-05 DE DE602006003063T patent/DE602006003063D1/de active Active
- 2006-01-05 ES ES06717699T patent/ES2314891T3/es active Active
- 2006-01-05 BR BRPI0606396-9A patent/BRPI0606396A2/pt not_active IP Right Cessation
- 2006-01-05 PL PL06717699T patent/PL1833842T3/pl unknown
-
2007
- 2007-04-26 IL IL182836A patent/IL182836A/en not_active IP Right Cessation
- 2007-05-10 IL IL183107A patent/IL183107A/en not_active IP Right Cessation
- 2007-05-20 ZA ZA200704487A patent/ZA200704487B/xx unknown
- 2007-05-30 ZA ZA200704488A patent/ZA200704488B/xx unknown
- 2007-12-21 HK HK07114048A patent/HK1106796A1/xx not_active IP Right Cessation
- 2007-12-21 HK HK07114049A patent/HK1106778A1/xx not_active IP Right Cessation
-
2009
- 2009-03-03 HR HR20090128T patent/HRP20090128T3/xx unknown
- 2009-03-06 HR HR20090134T patent/HRP20090134T3/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: REF. A RPI NO 2154 DE 17/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |