AR051889A1 - Sulfonas de tripeptido y tetrapeptido - Google Patents
Sulfonas de tripeptido y tetrapeptidoInfo
- Publication number
- AR051889A1 AR051889A1 ARP060100041A ARP060100041A AR051889A1 AR 051889 A1 AR051889 A1 AR 051889A1 AR P060100041 A ARP060100041 A AR P060100041A AR P060100041 A ARP060100041 A AR P060100041A AR 051889 A1 AR051889 A1 AR 051889A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- bone marrow
- tripeptide
- 3alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Sulfonas de tripéptido y tetrapéptido, composiciones farmacéuticas que las contienen, su uso farmacéutico, y su preparacion. Los compuestos son utiles para potenciar los efectos citotoxicos de agentes quimioterapéuticos en células tumorales, ejercer toxicidad de modo selectivo en células tumorales, elevar la produccion de progenitores GM en la médula osea, estimular la diferenciacion de médula osea, mitigar los efectos mielosupresores de los agentes quimioterapéuticos, y modular la hematopoyesis en la médula osea. Reivindicacion 1: Un compuesto de la formula (1), X es L-gamma-glutamilo o L-gamma-glutamilglicilo; Y es H, alquilo opcionalmente sustituido, heteroalquilo opcionalmente sustituido, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, o heteroaralquilo opcionalmente sustituido; y Z es alquilo C5-9, arilo opcionalmente sustituido, aralquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, o heteroaralquilo opcionalmente sustituido; o su alquil C1-10, fenil-alquilC1-3, o heteroarilC5-6-alquilC1-3 mono- o di-éster; o una sal del compuesto o su mono- o di-éster.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64193205P | 2005-01-06 | 2005-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051889A1 true AR051889A1 (es) | 2007-02-14 |
Family
ID=36123437
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100042A AR051890A1 (es) | 2005-01-06 | 2006-01-05 | Tioeteres de tripeptido y tetrapeptido |
| ARP060100041A AR051889A1 (es) | 2005-01-06 | 2006-01-05 | Sulfonas de tripeptido y tetrapeptido |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100042A AR051890A1 (es) | 2005-01-06 | 2006-01-05 | Tioeteres de tripeptido y tetrapeptido |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7129215B2 (es) |
| EP (2) | EP1833978B1 (es) |
| JP (2) | JP4903716B2 (es) |
| KR (2) | KR101244609B1 (es) |
| CN (2) | CN101090977B (es) |
| AR (2) | AR051890A1 (es) |
| AT (2) | ATE410520T1 (es) |
| AU (2) | AU2006204022B2 (es) |
| BR (2) | BRPI0606520A2 (es) |
| CA (2) | CA2587284C (es) |
| DE (2) | DE602006003064D1 (es) |
| DK (2) | DK1833978T3 (es) |
| EA (2) | EA200701398A1 (es) |
| ES (2) | ES2314890T3 (es) |
| HK (2) | HK1106778A1 (es) |
| HR (2) | HRP20090128T3 (es) |
| IL (2) | IL182836A (es) |
| MX (2) | MX2007008255A (es) |
| NZ (2) | NZ555362A (es) |
| PL (2) | PL1833978T3 (es) |
| PT (2) | PT1833978E (es) |
| SI (2) | SI1833978T1 (es) |
| TW (2) | TWI317739B (es) |
| WO (2) | WO2006074249A1 (es) |
| ZA (2) | ZA200704487B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198247B2 (en) * | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
| NZ555362A (en) * | 2005-01-06 | 2009-05-31 | Telik Inc | Tripeptide and tetrapeptide thioethers |
| US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| WO2008056207A1 (en) * | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| KR20150058566A (ko) | 2007-06-04 | 2015-05-28 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도 |
| KR20210123406A (ko) | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
| DE102008060888A1 (de) | 2008-12-09 | 2010-06-10 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase |
| EP4067370A1 (en) | 2009-05-08 | 2022-10-05 | Chongxi Yu | High penetration prodrug compositions of peptides and peptide related compounds |
| JP2013528213A (ja) * | 2010-06-07 | 2013-07-08 | テリック，インコーポレイテッド | エザチオスタットの錠剤製剤 |
| US8841476B2 (en) | 2010-06-07 | 2014-09-23 | Telik, Inc. | Preparation of crystalline ezatiostat hydrochloride ansolvate form D |
| US20130035389A1 (en) * | 2011-08-05 | 2013-02-07 | Telik, Inc. | Methods for treating myelodysplastic syndrome with ezatiostat |
| JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
| CN106146616A (zh) * | 2015-04-03 | 2016-11-23 | 浙江海正药业股份有限公司 | 环肽类化合物及其制备和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599903A (en) | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5786336A (en) * | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5767086A (en) | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
| US5955432A (en) | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
| CA2105492C (en) | 1993-09-03 | 2000-02-01 | Lawrence M. Kauvar | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
| DE69633722T2 (de) | 1995-06-07 | 2005-11-03 | TELIK, INC., Palo Alto | Stoffwechseleffekt von bestimmten glutation analogen |
| AU4124697A (en) | 1996-09-02 | 1998-03-26 | Manchester Metropolitan University, The | S-blocked glutathiones |
| TW576838B (en) | 1998-04-16 | 2004-02-21 | Teijin Ltd | Glutathione derivatives and application form thereof |
| KR100750842B1 (ko) * | 1999-01-27 | 2007-08-22 | 텔리크 인코포레이티드 | 글루타티온 유사체를 함유하는 치료 조성물 |
| US7029695B2 (en) | 2001-07-10 | 2006-04-18 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| NZ555362A (en) | 2005-01-06 | 2009-05-31 | Telik Inc | Tripeptide and tetrapeptide thioethers |
-
2006
- 2006-01-04 NZ NZ555362A patent/NZ555362A/en not_active IP Right Cessation
- 2006-01-04 MX MX2007008255A patent/MX2007008255A/es active IP Right Grant
- 2006-01-04 ES ES06717426T patent/ES2314890T3/es active Active
- 2006-01-04 EP EP06717426A patent/EP1833978B1/en active Active
- 2006-01-04 SI SI200630153T patent/SI1833978T1/sl unknown
- 2006-01-04 CN CN2006800014949A patent/CN101090977B/zh not_active Expired - Fee Related
- 2006-01-04 JP JP2007550441A patent/JP4903716B2/ja not_active Expired - Fee Related
- 2006-01-04 CA CA2587284A patent/CA2587284C/en not_active Expired - Fee Related
- 2006-01-04 PT PT06717426T patent/PT1833978E/pt unknown
- 2006-01-04 AT AT06717426T patent/ATE410520T1/de active
- 2006-01-04 EA EA200701398A patent/EA200701398A1/ru unknown
- 2006-01-04 TW TW095100278A patent/TWI317739B/zh not_active IP Right Cessation
- 2006-01-04 PL PL06717426T patent/PL1833978T3/pl unknown
- 2006-01-04 US US11/325,846 patent/US7129215B2/en not_active Expired - Fee Related
- 2006-01-04 TW TW095100277A patent/TWI317738B/zh not_active IP Right Cessation
- 2006-01-04 DE DE602006003064T patent/DE602006003064D1/de active Active
- 2006-01-04 BR BRPI0606520-1A patent/BRPI0606520A2/pt not_active IP Right Cessation
- 2006-01-04 WO PCT/US2006/000219 patent/WO2006074249A1/en active Application Filing
- 2006-01-04 DK DK06717426T patent/DK1833978T3/da active
- 2006-01-04 KR KR1020077018022A patent/KR101244609B1/ko not_active IP Right Cessation
- 2006-01-04 AU AU2006204022A patent/AU2006204022B2/en not_active Ceased
- 2006-01-05 AR ARP060100042A patent/AR051890A1/es not_active Application Discontinuation
- 2006-01-05 CN CNA2006800013664A patent/CN101080418A/zh active Pending
- 2006-01-05 WO PCT/US2006/000532 patent/WO2006074409A1/en active Application Filing
- 2006-01-05 AU AU2006203901A patent/AU2006203901B2/en not_active Ceased
- 2006-01-05 JP JP2007550515A patent/JP4903717B2/ja not_active Expired - Fee Related
- 2006-01-05 ES ES06717699T patent/ES2314891T3/es active Active
- 2006-01-05 CA CA2587310A patent/CA2587310C/en not_active Expired - Fee Related
- 2006-01-05 AR ARP060100041A patent/AR051889A1/es not_active Application Discontinuation
- 2006-01-05 DK DK06717699T patent/DK1833842T3/da active
- 2006-01-05 MX MX2007008254A patent/MX2007008254A/es active IP Right Grant
- 2006-01-05 DE DE602006003063T patent/DE602006003063D1/de active Active
- 2006-01-05 PL PL06717699T patent/PL1833842T3/pl unknown
- 2006-01-05 EA EA200701399A patent/EA200701399A1/ru unknown
- 2006-01-05 NZ NZ555361A patent/NZ555361A/en not_active IP Right Cessation
- 2006-01-05 EP EP06717699A patent/EP1833842B1/en active Active
- 2006-01-05 SI SI200630154T patent/SI1833842T1/sl unknown
- 2006-01-05 AT AT06717699T patent/ATE410440T1/de active
- 2006-01-05 US US11/326,975 patent/US7192918B2/en not_active Expired - Fee Related
- 2006-01-05 PT PT06717699T patent/PT1833842E/pt unknown
- 2006-01-05 KR KR1020077012531A patent/KR20070091611A/ko not_active Application Discontinuation
- 2006-01-05 BR BRPI0606396-9A patent/BRPI0606396A2/pt not_active IP Right Cessation
-
2007
- 2007-04-26 IL IL182836A patent/IL182836A/en not_active IP Right Cessation
- 2007-05-10 IL IL183107A patent/IL183107A/en not_active IP Right Cessation
- 2007-05-20 ZA ZA200704487A patent/ZA200704487B/xx unknown
- 2007-05-30 ZA ZA200704488A patent/ZA200704488B/xx unknown
- 2007-12-21 HK HK07114049A patent/HK1106778A1/xx not_active IP Right Cessation
- 2007-12-21 HK HK07114048A patent/HK1106796A1/xx not_active IP Right Cessation
-
2009
- 2009-03-03 HR HR20090128T patent/HRP20090128T3/xx unknown
- 2009-03-06 HR HR20090134T patent/HRP20090134T3/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |