AR051890A1 - Tioeteres de tripeptido y tetrapeptido - Google Patents
Tioeteres de tripeptido y tetrapeptidoInfo
- Publication number
- AR051890A1 AR051890A1 ARP060100042A ARP060100042A AR051890A1 AR 051890 A1 AR051890 A1 AR 051890A1 AR P060100042 A ARP060100042 A AR P060100042A AR P060100042 A ARP060100042 A AR P060100042A AR 051890 A1 AR051890 A1 AR 051890A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- bone marrow
- 3alkyl
- heteroaryl
- gamma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Tioéteres de tripéptidos y tetrapéptidos, composiciones farmacéuticas que los contienen, su uso farmacéutico, y su preparacion. Los compuestos son utiles para potenciar los efectos citotoxicos de agentes quimioterapéuticos en células tumorales, ejercer toxicidad de modo selectivo en células tumorales, elevar la produccion de progenitores GM en la médula osea, estimular la diferenciacion de médula osea, mitigar los efectos mielosupresores de los agentes quimioterapéuticos, y modular la hematopoyesis en la médula osea. Reivindicacion 1: Un compuesto de la formula (1), en donde: n es 0 o 1; W es L-gamma-glutamilo o L-gamma-glutamilglicilo; X es cicloalquilo C5-6 opcionalmente sustituido, heterocicloalquilo C5-6 opcionalmente sustituido, fenilo opcionalmente sustituido, o heteroarilo C5-6 opcionalmente sustituido; Y es =O, =N-OH, o =N-O (alquilo C1-3 opcionalmente sustituido); y Z es fenilo opcionalmente sustituido o heteroarilo C5-6 opcionalmente sustituido; o su alquil C1-10, fenil-alquilC1-3, o heteroarilC5-6-alquilC1-3 mono- o di-éster; o una sal del compuesto o su mono- o di-éster.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64193205P | 2005-01-06 | 2005-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051890A1 true AR051890A1 (es) | 2007-02-14 |
Family
ID=36123437
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100041A AR051889A1 (es) | 2005-01-06 | 2006-01-05 | Sulfonas de tripeptido y tetrapeptido |
| ARP060100042A AR051890A1 (es) | 2005-01-06 | 2006-01-05 | Tioeteres de tripeptido y tetrapeptido |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100041A AR051889A1 (es) | 2005-01-06 | 2006-01-05 | Sulfonas de tripeptido y tetrapeptido |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7129215B2 (es) |
| EP (2) | EP1833978B1 (es) |
| JP (2) | JP4903716B2 (es) |
| KR (2) | KR101244609B1 (es) |
| CN (2) | CN101090977B (es) |
| AR (2) | AR051889A1 (es) |
| AT (2) | ATE410520T1 (es) |
| AU (2) | AU2006204022B2 (es) |
| BR (2) | BRPI0606520A2 (es) |
| CA (2) | CA2587284C (es) |
| DE (2) | DE602006003064D1 (es) |
| DK (2) | DK1833978T3 (es) |
| EA (2) | EA200701398A1 (es) |
| ES (2) | ES2314890T3 (es) |
| HK (2) | HK1106796A1 (es) |
| HR (2) | HRP20090128T3 (es) |
| IL (2) | IL182836A (es) |
| MX (2) | MX2007008255A (es) |
| NZ (2) | NZ555362A (es) |
| PL (2) | PL1833978T3 (es) |
| PT (2) | PT1833978E (es) |
| SI (2) | SI1833978T1 (es) |
| TW (2) | TWI317739B (es) |
| WO (2) | WO2006074249A1 (es) |
| ZA (2) | ZA200704487B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198247B2 (en) | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
| SI1833978T1 (sl) * | 2005-01-06 | 2009-04-30 | Telik Inc | Tripeptidni in tetrapeptidni tioetri |
| US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| CN101541743A (zh) * | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药系统 |
| CN105820107B (zh) | 2007-06-04 | 2022-09-09 | 泰飞尔公司 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
| KR20200022525A (ko) | 2008-12-04 | 2020-03-03 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
| DE102008060888A1 (de) | 2008-12-09 | 2010-06-10 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase |
| CN108084246A (zh) | 2009-05-08 | 2018-05-29 | 上海泰飞尔生化技术有限公司 | 多肽和多肽相关化合物的高穿透力前药组合物 |
| JP2013528214A (ja) | 2010-06-07 | 2013-07-08 | テリック，インコーポレイテッド | 結晶性エザチオスタット塩酸塩非溶媒和物ｄ型の調製 |
| EP2576591A2 (en) * | 2010-06-07 | 2013-04-10 | Telik, Inc. | Tablet formulation of ezatiostat |
| US20130035389A1 (en) * | 2011-08-05 | 2013-02-07 | Telik, Inc. | Methods for treating myelodysplastic syndrome with ezatiostat |
| JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
| CN106146616A (zh) * | 2015-04-03 | 2016-11-23 | 浙江海正药业股份有限公司 | 环肽类化合物及其制备和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5599903A (en) * | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5786336A (en) | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5767086A (en) * | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
| US5955432A (en) * | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
| CA2105492C (en) * | 1993-09-03 | 2000-02-01 | Lawrence M. Kauvar | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
| DK0831877T3 (da) | 1995-06-07 | 2005-02-14 | Telik Inc | Metabolske virkninger af visse glutathionanaloge |
| WO1998009986A1 (en) * | 1996-09-02 | 1998-03-12 | The Manchester Metropolitan University | S-blocked glutathiones |
| KR20010042752A (ko) * | 1998-04-16 | 2001-05-25 | 야스이 쇼사꾸 | 글루타티온 유도체 및 이의 투여 형태 |
| JP2002535359A (ja) | 1999-01-27 | 2002-10-22 | テリック，インコーポレイテッド | グルタチオン類縁体を含有する治療用組成物 |
| US7029695B2 (en) * | 2001-07-10 | 2006-04-18 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| SI1833978T1 (sl) * | 2005-01-06 | 2009-04-30 | Telik Inc | Tripeptidni in tetrapeptidni tioetri |
-
2006
- 2006-01-04 SI SI200630153T patent/SI1833978T1/sl unknown
- 2006-01-04 DE DE602006003064T patent/DE602006003064D1/de active Active
- 2006-01-04 CA CA2587284A patent/CA2587284C/en not_active Expired - Fee Related
- 2006-01-04 TW TW095100278A patent/TWI317739B/zh not_active IP Right Cessation
- 2006-01-04 EP EP06717426A patent/EP1833978B1/en active Active
- 2006-01-04 NZ NZ555362A patent/NZ555362A/en not_active IP Right Cessation
- 2006-01-04 MX MX2007008255A patent/MX2007008255A/es active IP Right Grant
- 2006-01-04 AT AT06717426T patent/ATE410520T1/de active
- 2006-01-04 BR BRPI0606520-1A patent/BRPI0606520A2/pt not_active IP Right Cessation
- 2006-01-04 WO PCT/US2006/000219 patent/WO2006074249A1/en active Application Filing
- 2006-01-04 US US11/325,846 patent/US7129215B2/en not_active Expired - Fee Related
- 2006-01-04 DK DK06717426T patent/DK1833978T3/da active
- 2006-01-04 TW TW095100277A patent/TWI317738B/zh not_active IP Right Cessation
- 2006-01-04 KR KR1020077018022A patent/KR101244609B1/ko not_active IP Right Cessation
- 2006-01-04 EA EA200701398A patent/EA200701398A1/ru unknown
- 2006-01-04 PT PT06717426T patent/PT1833978E/pt unknown
- 2006-01-04 AU AU2006204022A patent/AU2006204022B2/en not_active Ceased
- 2006-01-04 ES ES06717426T patent/ES2314890T3/es active Active
- 2006-01-04 CN CN2006800014949A patent/CN101090977B/zh not_active Expired - Fee Related
- 2006-01-04 PL PL06717426T patent/PL1833978T3/pl unknown
- 2006-01-04 JP JP2007550441A patent/JP4903716B2/ja not_active Expired - Fee Related
- 2006-01-05 SI SI200630154T patent/SI1833842T1/sl unknown
- 2006-01-05 CA CA2587310A patent/CA2587310C/en not_active Expired - Fee Related
- 2006-01-05 AT AT06717699T patent/ATE410440T1/de active
- 2006-01-05 KR KR1020077012531A patent/KR20070091611A/ko not_active Application Discontinuation
- 2006-01-05 AU AU2006203901A patent/AU2006203901B2/en not_active Ceased
- 2006-01-05 JP JP2007550515A patent/JP4903717B2/ja not_active Expired - Fee Related
- 2006-01-05 EA EA200701399A patent/EA200701399A1/ru unknown
- 2006-01-05 DE DE602006003063T patent/DE602006003063D1/de active Active
- 2006-01-05 CN CNA2006800013664A patent/CN101080418A/zh active Pending
- 2006-01-05 DK DK06717699T patent/DK1833842T3/da active
- 2006-01-05 AR ARP060100041A patent/AR051889A1/es not_active Application Discontinuation
- 2006-01-05 US US11/326,975 patent/US7192918B2/en not_active Expired - Fee Related
- 2006-01-05 ES ES06717699T patent/ES2314891T3/es active Active
- 2006-01-05 PL PL06717699T patent/PL1833842T3/pl unknown
- 2006-01-05 AR ARP060100042A patent/AR051890A1/es not_active Application Discontinuation
- 2006-01-05 PT PT06717699T patent/PT1833842E/pt unknown
- 2006-01-05 NZ NZ555361A patent/NZ555361A/en not_active IP Right Cessation
- 2006-01-05 MX MX2007008254A patent/MX2007008254A/es active IP Right Grant
- 2006-01-05 BR BRPI0606396-9A patent/BRPI0606396A2/pt not_active IP Right Cessation
- 2006-01-05 WO PCT/US2006/000532 patent/WO2006074409A1/en active Application Filing
- 2006-01-05 EP EP06717699A patent/EP1833842B1/en active Active
-
2007
- 2007-04-26 IL IL182836A patent/IL182836A/en not_active IP Right Cessation
- 2007-05-10 IL IL183107A patent/IL183107A/en not_active IP Right Cessation
- 2007-05-20 ZA ZA200704487A patent/ZA200704487B/xx unknown
- 2007-05-30 ZA ZA200704488A patent/ZA200704488B/xx unknown
- 2007-12-21 HK HK07114048A patent/HK1106796A1/xx not_active IP Right Cessation
- 2007-12-21 HK HK07114049A patent/HK1106778A1/xx not_active IP Right Cessation
-
2009
- 2009-03-03 HR HR20090128T patent/HRP20090128T3/xx unknown
- 2009-03-06 HR HR20090134T patent/HRP20090134T3/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR051890A1 (es) | Tioeteres de tripeptido y tetrapeptido | |
| CY1112084T1 (el) | Παραγωγα 5-φαινυλθειαζολης και χρηση ως αναστολεις της κινασης ρi3 | |
| SV2008002969A (es) | Derivados de pirimidina para el tratamiento del crecimiento celular anormal | |
| UY29234A1 (es) | Derivados de adamantano, composiciones farmacéuticas que los contienen, procedimientos de preparación de ambos y aplicaciones. | |
| AR029226A1 (es) | Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales | |
| BRPI0507653A (pt) | derivados de imidazopiridina e imidazopiridina formulação farmacêutica compreendendo os mesmos e uso | |
| AR024060A1 (es) | Nuevos compuestos farmaceuticamente activos | |
| AR018686A1 (es) | Compuestos de 1-piperidil benzoimidazol 2-sustituidos como agonistas de receptores orl1, composicion farmaceutica, su uso en medicina, procedimiento de preparacion e intermediarios | |
| AR076778A1 (es) | Composiciones orales que contienen compuestos de poliguanidinio y metodos de preparacion y uso de las mismas | |
| CY1113011T1 (el) | Νεα κρυσταλλικη μορφη v της αγομελατινης, μεθοδος παρασκευης αυτης και φαρμακευτικες συνθεσεις που περιεχουν αυτην | |
| IL173810A0 (en) | Imidazopyridine derivatives and pharmaceutical compositions containing the same | |
| AR047466A1 (es) | Compuestos derivados de 3h - imidazo[4,5 - b]piridina con actividad inhibidora de quinasa, composiciones farmacéuticas que los contienen como principio activo y su uso en la fabricacion de un medicamento para el tratatmiento de neoplasmas susceptibles. | |
| AR029210A1 (es) | DERIVADOS DE N-(5-SULFAMOIL-1,3-TIAZOL-2-IL) ACETAMIDA, PROCEDIMIENTO PARA SU PREPARACIoN, COMPUESTOS INTERMEDIARIOS, COMPOSICIoN FARMACÉUTICA, Y EL USO DE DICHOS DERIVADOS PARA LA PRODUCCIoN DE MEDICAMENTOS | |
| AR083879A1 (es) | Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos | |
| CY1109366T1 (el) | Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης | |
| EA200700144A1 (ru) | Производные пиридопиримидина, их получение, их применение в терапии | |
| IL163625A0 (en) | Alkoxy-pyridine derivatives and pharmaceutical compositions containing the same | |
| TW200504029A (en) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| EA200400475A1 (ru) | Замещенные производные бензимидазола и их применение для лечения злокачественной опухоли | |
| IL173809A0 (en) | Imidazopyridine derivatives and pharmaceutical compositions containing the same | |
| SG145570A1 (en) | 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents | |
| MXPA05013050A (es) | Derivados de bencimidazol, composiciones que los contienen preparacion de los mismos y usos de los mismos. | |
| IL173629A0 (en) | Imidazo(4,5-b) pyridine derivatives and pharmaceutical compositions containing the same | |
| SE0300105D0 (sv) | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof | |
| AR024219A1 (es) | COMPUESTOS DE QUINOLONAS 2-(NH- U O-SUSTITUIDAS) UTILES COMO INHIBIDORES DE LA METIONIL t-RNA SINTETASA (MRS) COMPOSICIONES FARMACEUTICAS FORMULADAS CONDICHOS COMPUESTOS; PROCEDIMIENTO PARA SU PREPARACION Y USO DE DICHOS COMPUESTOS PARA PREPARAR MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIONES BACTER |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |