MX2007008255A - Tioeteres de tripeptido y tetrapeptido. - Google Patents
Tioeteres de tripeptido y tetrapeptido.Info
- Publication number
- MX2007008255A MX2007008255A MX2007008255A MX2007008255A MX2007008255A MX 2007008255 A MX2007008255 A MX 2007008255A MX 2007008255 A MX2007008255 A MX 2007008255A MX 2007008255 A MX2007008255 A MX 2007008255A MX 2007008255 A MX2007008255 A MX 2007008255A
- Authority
- MX
- Mexico
- Prior art keywords
- tripeptide
- bone marrow
- tumor cells
- chemotherapeutic agents
- tetrapeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Se describen tioeteres de tripeptido y tetrapeptido, composiciones farmaceuticas que los contienen, su uso farmaceutico y su preparacion. Los compuestos son utiles para potenciar los efectos citotoxicos de agentes quimioterapeuticos en celulas de tumor, ejercer en forma selectiva toxicidad en celulas de tumor, elevar la produccion de progenitores GM en medula osea, estimular la diferenciacion de la medula osea, mitigar los efectos mielosupresores de agentes quimioterapeuticos y modular la hematopoyesis en medula osea.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64193205P | 2005-01-06 | 2005-01-06 | |
PCT/US2006/000219 WO2006074249A1 (en) | 2005-01-06 | 2006-01-04 | Tripeptide and tetrapeptide thioethers |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007008255A true MX2007008255A (es) | 2007-09-11 |
Family
ID=36123437
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007008255A MX2007008255A (es) | 2005-01-06 | 2006-01-04 | Tioeteres de tripeptido y tetrapeptido. |
MX2007008254A MX2007008254A (es) | 2005-01-06 | 2006-01-05 | Sulfonas de tripeptidos y tetrapeptidos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007008254A MX2007008254A (es) | 2005-01-06 | 2006-01-05 | Sulfonas de tripeptidos y tetrapeptidos. |
Country Status (25)
Country | Link |
---|---|
US (2) | US7129215B2 (es) |
EP (2) | EP1833978B1 (es) |
JP (2) | JP4903716B2 (es) |
KR (2) | KR101244609B1 (es) |
CN (2) | CN101090977B (es) |
AR (2) | AR051890A1 (es) |
AT (2) | ATE410520T1 (es) |
AU (2) | AU2006204022B2 (es) |
BR (2) | BRPI0606520A2 (es) |
CA (2) | CA2587284C (es) |
DE (2) | DE602006003064D1 (es) |
DK (2) | DK1833978T3 (es) |
EA (2) | EA200701398A1 (es) |
ES (2) | ES2314890T3 (es) |
HK (2) | HK1106778A1 (es) |
HR (2) | HRP20090128T3 (es) |
IL (2) | IL182836A (es) |
MX (2) | MX2007008255A (es) |
NZ (2) | NZ555362A (es) |
PL (2) | PL1833978T3 (es) |
PT (2) | PT1833978E (es) |
SI (2) | SI1833978T1 (es) |
TW (2) | TWI317739B (es) |
WO (2) | WO2006074249A1 (es) |
ZA (2) | ZA200704487B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198247B2 (en) * | 2004-12-21 | 2012-06-12 | Telik, Inc. | Process for and intermediates in the preparation of canfosfamide and its salts |
KR101244609B1 (ko) * | 2005-01-06 | 2013-03-25 | 텔리크 인코포레이티드 | 트리펩티드 및 테트라펩티드 티오에테르 |
US20070154963A1 (en) * | 2005-12-30 | 2007-07-05 | Danying Cai | Method to determine whether a compound is a cellular GSTpi inhibitor |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
WO2008056207A1 (en) * | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
AU2007354632B2 (en) | 2007-06-04 | 2014-06-26 | Techfields Inc | Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses |
MX362949B (es) | 2008-12-04 | 2019-02-27 | Yu Chongxi | Composiciones de alta penetracion y sus aplicaciones. |
DE102008060888A1 (de) | 2008-12-09 | 2010-06-10 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung von Acrolein umfassend die Aufarbeitung einer Rohglycerin-Phase |
KR101784528B1 (ko) | 2009-05-08 | 2017-10-12 | 테크필즈 바이오켐 코., 엘티디. | 펩티드 및 펩티드관련 화합물의 고침투성 전구약물 조성물 |
CA2797458A1 (en) * | 2010-06-07 | 2011-12-15 | Telik, Inc. | Tablet formulation of ezatiostat |
EP2576592A1 (en) | 2010-06-07 | 2013-04-10 | Telik, Inc. | Preparation of crystalline ezatiostat hydrochloride ansolvate form d |
US20130035389A1 (en) * | 2011-08-05 | 2013-02-07 | Telik, Inc. | Methods for treating myelodysplastic syndrome with ezatiostat |
JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
CN106146616A (zh) * | 2015-04-03 | 2016-11-23 | 浙江海正药业股份有限公司 | 环肽类化合物及其制备和用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599903A (en) * | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
US5786336A (en) * | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
US5767086A (en) * | 1992-04-03 | 1998-06-16 | Terrapin Technologies, Inc. | Bone marrow stimulation by certain glutathione analogs |
US5955432A (en) * | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
CA2105492C (en) | 1993-09-03 | 2000-02-01 | Lawrence M. Kauvar | Glutathione analogs and paralog panels comprising glutathione mimics |
US5908919A (en) * | 1993-10-01 | 1999-06-01 | Terrapin Technologies | Urethane mediated, GST specific molecular release systems |
WO1996040205A1 (en) | 1995-06-07 | 1996-12-19 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
GB2332676B (en) * | 1996-09-02 | 2001-01-24 | Univ Manchester Metropolitan | S-Blocked glutathiones |
EP1072608B1 (en) * | 1998-04-16 | 2005-06-15 | Teijin Limited | Glutathione derivatives and dosage forms thereof |
WO2000044366A2 (en) | 1999-01-27 | 2000-08-03 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
US7029695B2 (en) * | 2001-07-10 | 2006-04-18 | Telik, Inc. | Therapeutic compositions containing glutathione analogs |
TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
KR101244609B1 (ko) * | 2005-01-06 | 2013-03-25 | 텔리크 인코포레이티드 | 트리펩티드 및 테트라펩티드 티오에테르 |
-
2006
- 2006-01-04 KR KR1020077018022A patent/KR101244609B1/ko not_active IP Right Cessation
- 2006-01-04 PT PT06717426T patent/PT1833978E/pt unknown
- 2006-01-04 BR BRPI0606520-1A patent/BRPI0606520A2/pt not_active IP Right Cessation
- 2006-01-04 DK DK06717426T patent/DK1833978T3/da active
- 2006-01-04 CA CA2587284A patent/CA2587284C/en not_active Expired - Fee Related
- 2006-01-04 CN CN2006800014949A patent/CN101090977B/zh not_active Expired - Fee Related
- 2006-01-04 TW TW095100278A patent/TWI317739B/zh not_active IP Right Cessation
- 2006-01-04 PL PL06717426T patent/PL1833978T3/pl unknown
- 2006-01-04 US US11/325,846 patent/US7129215B2/en not_active Expired - Fee Related
- 2006-01-04 SI SI200630153T patent/SI1833978T1/sl unknown
- 2006-01-04 WO PCT/US2006/000219 patent/WO2006074249A1/en active Application Filing
- 2006-01-04 DE DE602006003064T patent/DE602006003064D1/de active Active
- 2006-01-04 ES ES06717426T patent/ES2314890T3/es active Active
- 2006-01-04 JP JP2007550441A patent/JP4903716B2/ja not_active Expired - Fee Related
- 2006-01-04 AU AU2006204022A patent/AU2006204022B2/en not_active Ceased
- 2006-01-04 NZ NZ555362A patent/NZ555362A/en not_active IP Right Cessation
- 2006-01-04 EA EA200701398A patent/EA200701398A1/ru unknown
- 2006-01-04 EP EP06717426A patent/EP1833978B1/en active Active
- 2006-01-04 AT AT06717426T patent/ATE410520T1/de active
- 2006-01-04 TW TW095100277A patent/TWI317738B/zh not_active IP Right Cessation
- 2006-01-04 MX MX2007008255A patent/MX2007008255A/es active IP Right Grant
- 2006-01-05 US US11/326,975 patent/US7192918B2/en not_active Expired - Fee Related
- 2006-01-05 BR BRPI0606396-9A patent/BRPI0606396A2/pt not_active IP Right Cessation
- 2006-01-05 NZ NZ555361A patent/NZ555361A/en not_active IP Right Cessation
- 2006-01-05 DE DE602006003063T patent/DE602006003063D1/de active Active
- 2006-01-05 CA CA2587310A patent/CA2587310C/en not_active Expired - Fee Related
- 2006-01-05 KR KR1020077012531A patent/KR20070091611A/ko not_active Application Discontinuation
- 2006-01-05 PT PT06717699T patent/PT1833842E/pt unknown
- 2006-01-05 SI SI200630154T patent/SI1833842T1/sl unknown
- 2006-01-05 PL PL06717699T patent/PL1833842T3/pl unknown
- 2006-01-05 JP JP2007550515A patent/JP4903717B2/ja not_active Expired - Fee Related
- 2006-01-05 AT AT06717699T patent/ATE410440T1/de active
- 2006-01-05 CN CNA2006800013664A patent/CN101080418A/zh active Pending
- 2006-01-05 AR ARP060100042A patent/AR051890A1/es not_active Application Discontinuation
- 2006-01-05 AR ARP060100041A patent/AR051889A1/es not_active Application Discontinuation
- 2006-01-05 DK DK06717699T patent/DK1833842T3/da active
- 2006-01-05 EP EP06717699A patent/EP1833842B1/en active Active
- 2006-01-05 AU AU2006203901A patent/AU2006203901B2/en not_active Ceased
- 2006-01-05 EA EA200701399A patent/EA200701399A1/ru unknown
- 2006-01-05 MX MX2007008254A patent/MX2007008254A/es active IP Right Grant
- 2006-01-05 WO PCT/US2006/000532 patent/WO2006074409A1/en active Application Filing
- 2006-01-05 ES ES06717699T patent/ES2314891T3/es active Active
-
2007
- 2007-04-26 IL IL182836A patent/IL182836A/en not_active IP Right Cessation
- 2007-05-10 IL IL183107A patent/IL183107A/en not_active IP Right Cessation
- 2007-05-20 ZA ZA200704487A patent/ZA200704487B/xx unknown
- 2007-05-30 ZA ZA200704488A patent/ZA200704488B/xx unknown
- 2007-12-21 HK HK07114049A patent/HK1106778A1/xx not_active IP Right Cessation
- 2007-12-21 HK HK07114048A patent/HK1106796A1/xx not_active IP Right Cessation
-
2009
- 2009-03-03 HR HR20090128T patent/HRP20090128T3/xx unknown
- 2009-03-06 HR HR20090134T patent/HRP20090134T3/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |