DK3050563T3 - ESTER-PRO DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL FOR TREATMENT OF SKIN DISEASES AND CONDITIONS - Google Patents
ESTER-PRO DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL FOR TREATMENT OF SKIN DISEASES AND CONDITIONS Download PDFInfo
- Publication number
- DK3050563T3 DK3050563T3 DK16161920.0T DK16161920T DK3050563T3 DK 3050563 T3 DK3050563 T3 DK 3050563T3 DK 16161920 T DK16161920 T DK 16161920T DK 3050563 T3 DK3050563 T3 DK 3050563T3
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- ethyl
- imidazol
- benzyl ester
- acid
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims abstract description 22
- 208000017520 skin disease Diseases 0.000 title claims description 38
- 229940002612 prodrug Drugs 0.000 title abstract description 49
- 239000000651 prodrug Substances 0.000 title abstract description 49
- HTQCEFAVROSRIW-UHFFFAOYSA-N [3-[1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methanol Chemical compound C=1C=CC(CO)=C(C)C=1C(C)C1=CNC=N1 HTQCEFAVROSRIW-UHFFFAOYSA-N 0.000 title abstract description 5
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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- OCDFPGPDJGLJPM-ATIQYGATSA-N [3-[(1s)-1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methyl 2-[(2-amino-3-methylbutanoyl)amino]-3-methylbutanoate Chemical compound CC(C)C(N)C(=O)NC(C(C)C)C(=O)OCC1=CC=CC([C@H](C)C=2N=CNC=2)=C1C OCDFPGPDJGLJPM-ATIQYGATSA-N 0.000 claims description 5
- AEVJNFZGAAUTEL-KTQQKIMGSA-N [3-[(1s)-1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methyl 2-[(2-aminoacetyl)amino]-3-methylbutanoate Chemical compound NCC(=O)NC(C(C)C)C(=O)OCC1=CC=CC([C@H](C)C=2N=CNC=2)=C1C AEVJNFZGAAUTEL-KTQQKIMGSA-N 0.000 claims description 5
- URPYHGYXPGIQRI-CWQZNGJJSA-N [3-[(1s)-1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methyl 2-amino-3-methylbutanoate Chemical compound CC(C)C(N)C(=O)OCC1=CC=CC([C@H](C)C=2N=CNC=2)=C1C URPYHGYXPGIQRI-CWQZNGJJSA-N 0.000 claims description 5
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- NNKGWFWJLBHWQF-HNNXBMFYSA-N [3-[(1s)-1-(1h-imidazol-5-yl)ethyl]-2-methylphenyl]methyl benzoate Chemical compound C1([C@@H](C)C=2C(=C(COC(=O)C=3C=CC=CC=3)C=CC=2)C)=CNC=N1 NNKGWFWJLBHWQF-HNNXBMFYSA-N 0.000 claims 3
- BAWWYHBYJWSHKF-SFHVURJKSA-N [2-methyl-3-[(1s)-1-[1-(3-methylbutanoyl)imidazol-4-yl]ethyl]phenyl]methyl 3-methylbutanoate Chemical compound CC(C)CC(=O)OCC1=CC=CC([C@H](C)C=2N=CN(C=2)C(=O)CC(C)C)=C1C BAWWYHBYJWSHKF-SFHVURJKSA-N 0.000 claims 2
- PPKXDSFAMKWUBK-CGAIIQECSA-N [2-methyl-3-[(1s)-1-[1-(3-phenylpropanoyl)imidazol-4-yl]ethyl]phenyl]methyl 2-phenylpropanoate Chemical compound C1=NC([C@@H](C)C=2C=CC=C(C=2C)COC(=O)C(C)C=2C=CC=CC=2)=CN1C(=O)CCC1=CC=CC=C1 PPKXDSFAMKWUBK-CGAIIQECSA-N 0.000 claims 2
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- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
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- PEECTLLHENGOKU-UHFFFAOYSA-N n,n-dimethylpyridin-4-amine Chemical compound CN(C)C1=CC=NC=C1.CN(C)C1=CC=NC=C1 PEECTLLHENGOKU-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38337010P | 2010-09-16 | 2010-09-16 | |
| EP11760961.0A EP2616067B1 (en) | 2010-09-16 | 2011-09-16 | Ester pro-drugs of [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol for treating skin diseases and conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3050563T3 true DK3050563T3 (en) | 2018-08-13 |
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Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16161920.0T DK3050563T3 (en) | 2010-09-16 | 2011-09-16 | ESTER-PRO DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL FOR TREATMENT OF SKIN DISEASES AND CONDITIONS |
| DK16161923T DK3050564T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]-methanol |
| DK18157147.2T DK3338777T3 (da) | 2010-09-16 | 2011-09-16 | Ester-pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til behandling af nethindesygdomme |
| DK19194325.7T DK3636263T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]-methanol |
| DK11760963.6T DK2616069T3 (en) | 2010-09-16 | 2011-09-16 | ESTER prodrugs of [3- (1- (1H-imidazol-4-yl) ethyl) -2-methyl-phenyl] -methanol |
| DK11760962.8T DK2616068T3 (en) | 2010-09-16 | 2011-09-16 | ESTER prodrugs of the [3- (1- (1H-imidazol-4-yl) ethyl) -2-methyl-phenyl] -methanol for lowering intraocular pressure |
| DK16161922.6T DK3053576T3 (en) | 2010-09-16 | 2011-09-16 | ESTER PRO-DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL TO REDUCE INTRAOCULAR PRESSURE |
| DK18160174.1T DK3348264T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til sænkning af intraokulært tryk |
| DK16161921.8T DK3078376T3 (da) | 2010-09-16 | 2011-09-16 | Ester-pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til behandling af nethindesygdomme |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16161923T DK3050564T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]-methanol |
| DK18157147.2T DK3338777T3 (da) | 2010-09-16 | 2011-09-16 | Ester-pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til behandling af nethindesygdomme |
| DK19194325.7T DK3636263T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]-methanol |
| DK11760963.6T DK2616069T3 (en) | 2010-09-16 | 2011-09-16 | ESTER prodrugs of [3- (1- (1H-imidazol-4-yl) ethyl) -2-methyl-phenyl] -methanol |
| DK11760962.8T DK2616068T3 (en) | 2010-09-16 | 2011-09-16 | ESTER prodrugs of the [3- (1- (1H-imidazol-4-yl) ethyl) -2-methyl-phenyl] -methanol for lowering intraocular pressure |
| DK16161922.6T DK3053576T3 (en) | 2010-09-16 | 2011-09-16 | ESTER PRO-DRUGS OF [3- (1- (1H-IMIDAZOL-4-YL) ETHYL) -2-METHYLPHENYL] METHANOL TO REDUCE INTRAOCULAR PRESSURE |
| DK18160174.1T DK3348264T3 (da) | 2010-09-16 | 2011-09-16 | Ester pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til sænkning af intraokulært tryk |
| DK16161921.8T DK3078376T3 (da) | 2010-09-16 | 2011-09-16 | Ester-pro-drugs af [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl] methanol til behandling af nethindesygdomme |
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| BR (4) | BR112013006352A2 (enExample) |
| CA (8) | CA2811559A1 (enExample) |
| CL (4) | CL2013000736A1 (enExample) |
| CY (3) | CY1121024T1 (enExample) |
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| IL (4) | IL225281A0 (enExample) |
| MX (4) | MX2013003009A (enExample) |
| MY (4) | MY168763A (enExample) |
| NZ (1) | NZ608751A (enExample) |
| PL (7) | PL3050563T3 (enExample) |
| PT (7) | PT3050564T (enExample) |
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| SG (4) | SG188573A1 (enExample) |
| SI (5) | SI3050564T1 (enExample) |
| TR (1) | TR201909249T4 (enExample) |
| TW (4) | TW201240661A (enExample) |
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| WO (4) | WO2012037453A1 (enExample) |
| ZA (4) | ZA201302194B (enExample) |
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| WO2010093930A1 (en) | 2009-02-13 | 2010-08-19 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl)methanol |
| JP6196041B2 (ja) | 2010-01-11 | 2017-09-13 | オレキシジェン・セラピューティクス・インコーポレーテッド | 大うつ病を有する患者において減量療法を提供する方法 |
| US8492557B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
| CA2842866A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Alpha-2 adrenergic modulators for treating visual disorders mediated by central visual projections from the eye |
| WO2013078151A1 (en) | 2011-11-21 | 2013-05-30 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| USD794650S1 (en) | 2014-11-28 | 2017-08-15 | Samsung Electronics Co., Ltd. | Display screen or portion thereof with a graphical user interface |
| CN108310442B (zh) * | 2017-01-17 | 2021-08-27 | 台北科技大学 | 眼科用组合物 |
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