DK2970921T3 - Histidyl-tRNA-syntetase-Fc-konjugater - Google Patents

Histidyl-tRNA-syntetase-Fc-konjugater Download PDF

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Publication number
DK2970921T3
DK2970921T3 DK14727652.1T DK14727652T DK2970921T3 DK 2970921 T3 DK2970921 T3 DK 2970921T3 DK 14727652 T DK14727652 T DK 14727652T DK 2970921 T3 DK2970921 T3 DK 2970921T3
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spindle
housing
bearing
outer tube
actuator
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DK14727652.1T
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English (en)
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Ying Buechler
Kyle Chiang
Minh-Ha Do
Darin Lee
Kristi Piehl
Marc Thomas
Jeffry D Watkins
Chi-Fang Wu
John D Mendlein
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Atyr Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Connection Of Motors, Electrical Generators, Mechanical Devices, And The Like (AREA)

Claims (9)

  1. Patentkrav;
    1. Lineær aktuator omfattende et kabinet (1), bestående af mindst to dele (1a.1b), en monteringskonso! (2), en reverserbar motor (7) med en transmission (22), en spindel (5) der via transmissionen trækkes af den reverserbare motor (7), et leje (31) tor lejring af spindlen (5), en spindelmøtrik (6) fastholdt mod rotation på spindlen (5), et yderrør (3) som omgiver spindien (5), et aktiveringseiement (4), teleskopisk lejret i yderrøret (3) og forbundet fil spindelmøtrikken (6), et frontfæste (3) på aktiveringselementets (4) yderende, et bagfæste (9) placeret I kabinettet (1), og hvor der i bagfæstet (9) er en lejeskåi (35) for spindlens (5) leje (31), og hvor den reverserbare motor (7), transmission (22) og yderrøret (3) er fastgjort ti! monteringskonsoilen (2), og hvor monteringskonsoilen (2) er udformet som et separat element, der udgør den lineære aktuators bærende chassis, kendetegnet ved, at monteringskonsolien (2) er udformet med et vægeiement (2a) hvorom og hvorpå kabinettets (1) to dele (1a, 1b), den reverserbare motor (7), transmissionen (22) og den lineære aktuators yderrør (3) er monteret, og hvor den ydre kontur af monteringskonsollens (2) vægelement (2a) stemmer overens med, eller i det væsentlige stemmet-overens med den ydre kontur i tværsnittet af kabinettet.
  2. 2. Aktuator ifølge krav 1,kendetegnet ved, at motoren (7) er arrangeret paralieit med spindlen (5).
  3. 3. Aktuator ifølge krav 1,kendetegnef ved, at motoren (7) er beliggende iangs en skattende (5a) af spindlen (5)
  4. 4. Aktuator ifølge krav 1,kendetegnet ved, at kabinettet består af to dele {1a,1 b) med et samlepian vinkelret på spindlens (5) længdeakse.
  5. 5. Aktuator ifølge krav 1, kendetegnet ved, at monteringskonsolien (2) er udformet med et hus (1b), der rummer transmissionen (22).
  6. 6. Aktuator ifølge krav 1,kendetegnet ved, at monteringskonsoilen (2) har en rørformet studs (43), hvis indre og ydre kontur stemmer overens, eller i det væsentlige stemmer overens med, den indre og ydre kontur af yderrøret (3), sa yderrøret (3) står på en fri kant af den rørformede studs (43).
  7. 7. Aktuator ifølge krav 5, k e n d e t e g n e t ved, at yderret et (3) er fastgjort til monteringskonsoilen (2) med skuer, idet der i yderrøret t3i er udformet skruekanaler (42) ti! formålet.
  8. 8. Aktuator ifølge krav 1,kendetegnet ved, at den omfatter en printpiade (53) med endestopswitehe (54,55), monteret på siden af den rørformede studs (43), og at der på printpladen (53) er en skyder med en arm (58) til aktivering af endestopswitchene, hvor spindelmøtrikken (6) i en inderste endestiliing påvirker armen (58) på skyderen, og at der er en i yderrøret (3) aksialt forskydelig lejret stang (52), der med sin ene ende er fastgjort til armen (58), mens den anden ende har et anslag (52b), der påvirkes af spindelmøtrikken (6) i dennes anden endestilling.
  9. 9, Aktuator tfølge krav 1, k e n de feg net ved, at bagfæstet (9) er udformet med en iejeskål (35) for spindlens leje (31), og af lejeskålen (35) står i forbindelse med en åbning (37), der fører ud på siden af bagfæstet (9), så spindlens leje (31) kan indføres sideværts i iejeskåien (35). tO. Aktuator ifølge krav 1 eiler 9, kendetegne t ved, at bagfæstet (9) er udformet som et separat element, og fastholdt mellem huset på monteringskonsollen (2) og en endevæg på kabinettets bagende.
DK14727652.1T 2013-03-15 2014-03-14 Histidyl-tRNA-syntetase-Fc-konjugater DK2970921T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789011P 2013-03-15 2013-03-15
PCT/US2014/029699 WO2014145050A1 (en) 2013-03-15 2014-03-14 Histidyl-trna synthetase-fc conjugates

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DK2970921T3 true DK2970921T3 (da) 2019-01-14

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DK14727652.1T DK2970921T3 (da) 2013-03-15 2014-03-14 Histidyl-tRNA-syntetase-Fc-konjugater
DK18194251.7T DK3460054T3 (da) 2013-03-15 2014-03-14 Histidyl-tRNA-syntetase-Fc-konjugater

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US (6) US9587235B2 (da)
EP (2) EP2970921B1 (da)
JP (4) JP6397479B2 (da)
CN (2) CN105378075B (da)
AU (1) AU2014233436B2 (da)
CA (1) CA2907046C (da)
DK (2) DK2970921T3 (da)
ES (2) ES2708565T3 (da)
HK (1) HK1220226A1 (da)
WO (1) WO2014145050A1 (da)

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