SE9100142L - En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal - Google Patents
En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaalInfo
- Publication number
- SE9100142L SE9100142L SE9100142A SE9100142A SE9100142L SE 9100142 L SE9100142 L SE 9100142L SE 9100142 A SE9100142 A SE 9100142A SE 9100142 A SE9100142 A SE 9100142A SE 9100142 L SE9100142 L SE 9100142L
- Authority
- SE
- Sweden
- Prior art keywords
- substances
- diagnostic
- extracoral
- preparing
- removal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100142A SE9100142L (sv) | 1991-01-17 | 1991-01-17 | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
US08/090,047 US6251394B1 (en) | 1991-01-17 | 1992-01-15 | Method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose |
EP92903020A EP0567514B1 (en) | 1991-01-17 | 1992-01-15 | A system for enhanced in-vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion of agents |
CA002100256A CA2100256C (en) | 1991-01-17 | 1992-01-15 | A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion,and the use of said agents for said purpose |
PCT/SE1992/000020 WO1992012730A1 (en) | 1991-01-17 | 1992-01-15 | A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose |
ES92903020T ES2130167T3 (es) | 1991-01-17 | 1992-01-15 | Un sistema para la eliminacion mejorada in vivo de agentes de diagnostico y/o agentes terapeuticos por agotamiento extracorpores de los agentes. |
DE69228802T DE69228802T2 (de) | 1991-01-17 | 1992-01-15 | System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe |
DK92903020T DK0567514T3 (da) | 1991-01-17 | 1992-01-15 | System til forøget in vivo udskillelse af diagnostiske og/eller terapeutiske midler ved ekstrakorporal depletering af midle |
AT92903020T ATE178214T1 (de) | 1991-01-17 | 1992-01-15 | System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe |
JP50311992A JP3471352B2 (ja) | 1991-01-17 | 1992-01-15 | 体外除去による診断及び/又は治療剤の高インビボクリアランス方法及び系と上記目的に関する上記剤の用法 |
US09/689,421 US6723318B1 (en) | 1991-01-17 | 2000-10-12 | Targeting of biomolecules |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9100142A SE9100142L (sv) | 1991-01-17 | 1991-01-17 | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
Publications (2)
Publication Number | Publication Date |
---|---|
SE9100142D0 SE9100142D0 (sv) | 1991-01-17 |
SE9100142L true SE9100142L (sv) | 1992-07-18 |
Family
ID=20381639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9100142A SE9100142L (sv) | 1991-01-17 | 1991-01-17 | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
Country Status (10)
Country | Link |
---|---|
US (2) | US6251394B1 (sv) |
EP (1) | EP0567514B1 (sv) |
JP (1) | JP3471352B2 (sv) |
AT (1) | ATE178214T1 (sv) |
CA (1) | CA2100256C (sv) |
DE (1) | DE69228802T2 (sv) |
DK (1) | DK0567514T3 (sv) |
ES (1) | ES2130167T3 (sv) |
SE (1) | SE9100142L (sv) |
WO (1) | WO1992012730A1 (sv) |
Families Citing this family (31)
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US6075010A (en) * | 1992-06-09 | 2000-06-13 | Neorx Corporation | Small molecular weight ligand-hexose containing clearing agents |
US6416738B1 (en) | 1973-12-07 | 2002-07-09 | Neorx Corporation | Pretargeting methods and compounds |
US5474772A (en) * | 1989-08-02 | 1995-12-12 | Cobe Laboratories, Inc. | Method of treatment with medical agents |
US6358490B2 (en) | 1992-06-09 | 2002-03-19 | Neorx Corporation | Three-step pretargeting methods and compounds |
US6217869B1 (en) | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
US5911969A (en) | 1992-06-09 | 1999-06-15 | Neorx Corporation | Pretargeting protocols for enhanced localization of active agents to target sites |
EP0743956A4 (en) * | 1993-12-07 | 1999-03-24 | Neorx Corp | Warping and averaging procedures |
US6015897A (en) * | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
ES2236706T3 (es) * | 1994-03-23 | 2005-07-16 | Alexion Pharmaceuticals, Inc. | Procedimiento para reducir las disfunciones de los sistemas inmunitario y hemostatico durante la circulacion extracorporal. |
US6172045B1 (en) | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
US6908903B1 (en) | 1994-12-07 | 2005-06-21 | Aletheon Pharmaceuticals, Inc. | Cluster clearing agents |
KR100485240B1 (ko) * | 1996-01-11 | 2006-10-24 | 테크니클론 인크. | 감소된순양전하를갖는항체 |
US20010023288A1 (en) | 1999-07-07 | 2001-09-20 | Wilbur D. Scott | Trifunctional reagent for conjugation to a biomolecule |
PT1049499E (pt) * | 1998-01-20 | 2004-03-31 | Mitra Medical Technology Ab | Aparelho para uso na extraccao de elementos especialmente anticorpos exogenos presentes no sangue ou no plasma |
US6533734B1 (en) * | 1999-06-11 | 2003-03-18 | The Board Of Trustees Of The University Of Illinois | Time-integrated sampler of bodily fluid |
IT1310933B1 (it) * | 1999-11-16 | 2002-02-27 | Luigi Benatti | Macchina multifunzionale per il monitoraggio ed il controllo diterapie locoregionali in oncologia. |
PL359328A1 (en) * | 2000-06-16 | 2004-08-23 | Mitra Medical Technology Ab | Reusable extracorporeal colums loaded with ligand-dibiotin conjugates |
SE0002287D0 (sv) * | 2000-06-16 | 2000-06-16 | Department Of Radiation Oncolo | Biotinderivat |
WO2003012396A2 (en) * | 2001-08-01 | 2003-02-13 | Chauhan Anil K | Immune complexes |
EP1507557A4 (en) * | 2002-04-23 | 2006-06-14 | Meir Strahilevitz | METHODS AND DEVICES FOR TARGETING A SITE IN A MAMMAL AND DETERMINING CHEMICAL SPECIES FROM A MAMMAL |
US20040044300A1 (en) * | 2002-09-03 | 2004-03-04 | Donnie Rudd | Method of replenishing cells damaged by treatment for cancer |
US20040077985A1 (en) * | 2002-09-03 | 2004-04-22 | Donnie Rudd | Method of replenishing cells damaged by treatment for cancer |
US20040208865A1 (en) * | 2003-02-12 | 2004-10-21 | Chauhan Anil K. | Immune complexes |
KR20070114378A (ko) * | 2005-02-28 | 2007-12-03 | 리제네텍 인코포레이티드 | 말초혈액으로부터 유도된 쉽게 이용가능한 세포 물질을 제공하는 방법 및 그의 조성물 |
US20080075704A1 (en) * | 2005-02-28 | 2008-03-27 | Wolf David A | Method of providing readily available cellular material derived from peripheral blood, and a composition thereof |
WO2007080114A2 (en) * | 2006-01-11 | 2007-07-19 | Biotech Igg Ab | Macromolecule conjugate |
WO2012142180A1 (en) * | 2011-04-12 | 2012-10-18 | Tianxin Wang | Methods to detect and treat diseases |
US9549953B2 (en) * | 2011-12-08 | 2017-01-24 | Eliaz Therapeutics, Inc. | Galectin-3 plasmapheresis therapy |
CN104334196B (zh) | 2012-02-16 | 2018-04-10 | Atyr 医药公司 | 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶 |
US9587235B2 (en) | 2013-03-15 | 2017-03-07 | Atyr Pharma, Inc. | Histidyl-tRNA synthetase-Fc conjugates |
CN110536694A (zh) | 2017-04-20 | 2019-12-03 | Atyr 医药公司 | 用于治疗肺部炎症的组合物和方法 |
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US4375414A (en) | 1971-05-20 | 1983-03-01 | Meir Strahilevitz | Immunological methods for removing species from the blood circulatory system and devices therefor |
US4371515A (en) | 1978-12-26 | 1983-02-01 | E-Y Laboratories, Inc. | Method for forming an isolated lectin-immunological conjugate |
US4223672A (en) | 1979-02-08 | 1980-09-23 | Baxter Travenol Laboratories, Inc. | Variable volume plasma treatment chamber for an apparatus for the extracorporeal treatment of disease |
US4215688A (en) | 1979-02-09 | 1980-08-05 | Baxter Travenol Laboratories, Inc. | Apparatus for the extracorporeal treatment of disease |
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US4877599A (en) | 1986-11-10 | 1989-10-31 | New England Deaconess Hospital Corporation | Detection of vascular disease with labelled antibodies |
US5122112A (en) * | 1986-11-21 | 1992-06-16 | Imre Corporation | Antigen-specific removal of circulating immune complexes |
US4800016A (en) | 1986-11-24 | 1989-01-24 | The University Of Michigan | Extracorporeal blood de-heparinization system |
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US4846786A (en) | 1987-04-30 | 1989-07-11 | Massachusetts Institute Of Technology | Bioreactor containing suspended, immobilized species |
US4885207A (en) * | 1987-07-13 | 1989-12-05 | Uop | Biocompatible protein or ligand immobilization system |
US4865841A (en) | 1987-10-23 | 1989-09-12 | Imre Corporation | Methods and compositions for transient elimination of humoral immune antibodies |
US5069662A (en) * | 1988-10-21 | 1991-12-03 | Delcath Systems, Inc. | Cancer treatment |
US5149425A (en) | 1988-11-09 | 1992-09-22 | Chembiomed, Ltd. | Affinity supports for hemoperfusion |
KR0185967B1 (ko) | 1989-01-23 | 1999-05-01 | 에프. 쥐. 엠. 헤르만스; 에이. 쥐. 제이. 베르미렌 | 치료용 약물의 부위 특이적 생체내 활성작용 |
US5252466A (en) * | 1989-05-19 | 1993-10-12 | Biotechnology Research And Development Corporation | Fusion proteins having a site for in vivo post-translation modification and methods of making and purifying them |
EP0436717B1 (en) | 1989-08-02 | 2003-02-26 | Mitra Medical Technology AB | System for use in a method of therapeutic or diagnostic treatment |
US5474772A (en) * | 1989-08-02 | 1995-12-12 | Cobe Laboratories, Inc. | Method of treatment with medical agents |
WO2000002050A1 (en) | 1998-07-07 | 2000-01-13 | Department Of Radiation Oncology, University Of Washington | Trifunctional reagent for conjugation to a biomolecule |
-
1991
- 1991-01-17 SE SE9100142A patent/SE9100142L/sv not_active Application Discontinuation
-
1992
- 1992-01-15 US US08/090,047 patent/US6251394B1/en not_active Expired - Fee Related
- 1992-01-15 CA CA002100256A patent/CA2100256C/en not_active Expired - Lifetime
- 1992-01-15 JP JP50311992A patent/JP3471352B2/ja not_active Expired - Fee Related
- 1992-01-15 AT AT92903020T patent/ATE178214T1/de not_active IP Right Cessation
- 1992-01-15 WO PCT/SE1992/000020 patent/WO1992012730A1/en active IP Right Grant
- 1992-01-15 DK DK92903020T patent/DK0567514T3/da active
- 1992-01-15 ES ES92903020T patent/ES2130167T3/es not_active Expired - Lifetime
- 1992-01-15 EP EP92903020A patent/EP0567514B1/en not_active Expired - Lifetime
- 1992-01-15 DE DE69228802T patent/DE69228802T2/de not_active Expired - Lifetime
-
2000
- 2000-10-12 US US09/689,421 patent/US6723318B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
SE9100142D0 (sv) | 1991-01-17 |
EP0567514B1 (en) | 1999-03-31 |
ATE178214T1 (de) | 1999-04-15 |
EP0567514A1 (en) | 1993-11-03 |
US6251394B1 (en) | 2001-06-26 |
JP3471352B2 (ja) | 2003-12-02 |
US6723318B1 (en) | 2004-04-20 |
DK0567514T3 (da) | 1999-10-18 |
JPH06504542A (ja) | 1994-05-26 |
CA2100256A1 (en) | 1992-07-18 |
DE69228802D1 (de) | 1999-05-06 |
DE69228802T2 (de) | 1999-10-14 |
ES2130167T3 (es) | 1999-07-01 |
WO1992012730A1 (en) | 1992-08-06 |
CA2100256C (en) | 2004-06-08 |
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