DE69228802D1 - System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe - Google Patents

System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe

Info

Publication number
DE69228802D1
DE69228802D1 DE69228802T DE69228802T DE69228802D1 DE 69228802 D1 DE69228802 D1 DE 69228802D1 DE 69228802 T DE69228802 T DE 69228802T DE 69228802 T DE69228802 T DE 69228802T DE 69228802 D1 DE69228802 D1 DE 69228802D1
Authority
DE
Germany
Prior art keywords
active substances
diagnostic
disposal
vivo
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69228802T
Other languages
English (en)
Other versions
DE69228802T2 (de
Inventor
Rune Nilsson
Lars Lindgren
Kristina Norrgren
Bengt Sandberg
Hans-Olof Sjoegren
Sven-Erik Strand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STRAND SVEN ERIK
Original Assignee
STRAND SVEN ERIK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STRAND SVEN ERIK filed Critical STRAND SVEN ERIK
Publication of DE69228802D1 publication Critical patent/DE69228802D1/de
Application granted granted Critical
Publication of DE69228802T2 publication Critical patent/DE69228802T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nanotechnology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69228802T 1991-01-17 1992-01-15 System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe Expired - Lifetime DE69228802T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9100142A SE9100142L (sv) 1991-01-17 1991-01-17 En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal
PCT/SE1992/000020 WO1992012730A1 (en) 1991-01-17 1992-01-15 A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose

Publications (2)

Publication Number Publication Date
DE69228802D1 true DE69228802D1 (de) 1999-05-06
DE69228802T2 DE69228802T2 (de) 1999-10-14

Family

ID=20381639

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228802T Expired - Lifetime DE69228802T2 (de) 1991-01-17 1992-01-15 System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe

Country Status (10)

Country Link
US (2) US6251394B1 (de)
EP (1) EP0567514B1 (de)
JP (1) JP3471352B2 (de)
AT (1) ATE178214T1 (de)
CA (1) CA2100256C (de)
DE (1) DE69228802T2 (de)
DK (1) DK0567514T3 (de)
ES (1) ES2130167T3 (de)
SE (1) SE9100142L (de)
WO (1) WO1992012730A1 (de)

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US6075010A (en) * 1992-06-09 2000-06-13 Neorx Corporation Small molecular weight ligand-hexose containing clearing agents
US6416738B1 (en) 1973-12-07 2002-07-09 Neorx Corporation Pretargeting methods and compounds
US5474772A (en) * 1989-08-02 1995-12-12 Cobe Laboratories, Inc. Method of treatment with medical agents
US6217869B1 (en) 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
US6358490B2 (en) 1992-06-09 2002-03-19 Neorx Corporation Three-step pretargeting methods and compounds
US5911969A (en) 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
EP0743956A4 (de) * 1993-12-07 1999-03-24 Neorx Corp Verfahren zum Verziehen und Mitteln
ES2236706T3 (es) * 1994-03-23 2005-07-16 Alexion Pharmaceuticals, Inc. Procedimiento para reducir las disfunciones de los sistemas inmunitario y hemostatico durante la circulacion extracorporal.
US6172045B1 (en) 1994-12-07 2001-01-09 Neorx Corporation Cluster clearing agents
US6908903B1 (en) 1994-12-07 2005-06-21 Aletheon Pharmaceuticals, Inc. Cluster clearing agents
WO1997025069A1 (en) * 1996-01-11 1997-07-17 Techniclone, Inc. Antibodies with reduced net positive charge
US20010023288A1 (en) 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
SI1049499T1 (en) * 1998-01-20 2004-04-30 Mitra Medical Technology Ab An apparatus for use in connection with removal of elements, especially exogenous antibodies, from blood or plasma
US6533734B1 (en) * 1999-06-11 2003-03-18 The Board Of Trustees Of The University Of Illinois Time-integrated sampler of bodily fluid
IT1310933B1 (it) * 1999-11-16 2002-02-27 Luigi Benatti Macchina multifunzionale per il monitoraggio ed il controllo diterapie locoregionali in oncologia.
BR0111726A (pt) * 2000-06-16 2003-05-27 Mitra Medical Technology Ab Derivados de biotina
SE0002287D0 (sv) 2000-06-16 2000-06-16 Department Of Radiation Oncolo Biotinderivat
EP1420641A4 (de) * 2001-08-01 2005-05-25 Anil K Chauhan Immunkomplexe
AU2003234194A1 (en) * 2002-04-23 2003-11-10 Meir Strahilevitz Methods and devices for targeting a site in a mammal and for removing species from a mammal
US20040077985A1 (en) * 2002-09-03 2004-04-22 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
US20040044300A1 (en) * 2002-09-03 2004-03-04 Donnie Rudd Method of replenishing cells damaged by treatment for cancer
WO2004071446A2 (en) * 2003-02-12 2004-08-26 Chauhan Anil K Immune complexes
US20080075704A1 (en) * 2005-02-28 2008-03-27 Wolf David A Method of providing readily available cellular material derived from peripheral blood, and a composition thereof
JP2008531051A (ja) * 2005-02-28 2008-08-14 リジェネテック，インコーポレイテッド すぐに利用できる末梢血由来の細胞物質を提供する方法およびその組成
US20110014151A1 (en) * 2006-01-11 2011-01-20 Biotech Igg Ab Macromolecule conjugate
WO2012142180A1 (en) * 2011-04-12 2012-10-18 Tianxin Wang Methods to detect and treat diseases
US9549953B2 (en) * 2011-12-08 2017-01-24 Eliaz Therapeutics, Inc. Galectin-3 plasmapheresis therapy
ES2652136T3 (es) 2012-02-16 2018-01-31 Atyr Pharma, Inc. Histidil-tRNA sintetasas para tratar enfermedades autoinmunitarias e inflamatorias
EP2970921B1 (de) 2013-03-15 2018-09-19 aTyr Pharma, Inc. Histidyl-trna-synthetase-fc-konjugate
WO2018195338A1 (en) 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation

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US4375414A (en) 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
US4371515A (en) 1978-12-26 1983-02-01 E-Y Laboratories, Inc. Method for forming an isolated lectin-immunological conjugate
US4223672A (en) 1979-02-08 1980-09-23 Baxter Travenol Laboratories, Inc. Variable volume plasma treatment chamber for an apparatus for the extracorporeal treatment of disease
US4215688A (en) 1979-02-09 1980-08-05 Baxter Travenol Laboratories, Inc. Apparatus for the extracorporeal treatment of disease
US4350156A (en) 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
US4824432A (en) 1981-03-24 1989-04-25 S.V.S. Laboratories, Inc. Method for treating AIDS and other immune deficiencies and immune disorders
US4687808A (en) 1982-08-12 1987-08-18 Biospecific Technologies, Inc. Activation of biocompatible polymers with biologicals whose binding complements are pathological effectors
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US4551435A (en) 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
US4863713A (en) 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US4877599A (en) 1986-11-10 1989-10-31 New England Deaconess Hospital Corporation Detection of vascular disease with labelled antibodies
US5122112A (en) * 1986-11-21 1992-06-16 Imre Corporation Antigen-specific removal of circulating immune complexes
US4800016A (en) 1986-11-24 1989-01-24 The University Of Michigan Extracorporeal blood de-heparinization system
DE3705637A1 (de) * 1987-02-21 1988-09-29 Bissendorf Peptide Gmbh Vorrichtung zur entfernung von lokal applizierten wirkstoffen gegen solide tumoren
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US4885207A (en) * 1987-07-13 1989-12-05 Uop Biocompatible protein or ligand immobilization system
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WO2000002050A1 (en) 1998-07-07 2000-01-13 Department Of Radiation Oncology, University Of Washington Trifunctional reagent for conjugation to a biomolecule

Also Published As

Publication number Publication date
EP0567514A1 (de) 1993-11-03
JPH06504542A (ja) 1994-05-26
CA2100256A1 (en) 1992-07-18
JP3471352B2 (ja) 2003-12-02
US6251394B1 (en) 2001-06-26
US6723318B1 (en) 2004-04-20
ATE178214T1 (de) 1999-04-15
SE9100142L (sv) 1992-07-18
EP0567514B1 (de) 1999-03-31
ES2130167T3 (es) 1999-07-01
SE9100142D0 (sv) 1991-01-17
WO1992012730A1 (en) 1992-08-06
DE69228802T2 (de) 1999-10-14
DK0567514T3 (da) 1999-10-18
CA2100256C (en) 2004-06-08

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Legal Events

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