DK2705049T3 - Hepatitis c-virusinhibitorer - Google Patents

Hepatitis c-virusinhibitorer Download PDF

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DK2705049T3
DK2705049T3 DK12723993.7T DK12723993T DK2705049T3 DK 2705049 T3 DK2705049 T3 DK 2705049T3 DK 12723993 T DK12723993 T DK 12723993T DK 2705049 T3 DK2705049 T3 DK 2705049T3
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dioxo
hexadecahydrocyclopropa
diazacyclopentadecin
dimethyl
pyrrole
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DK12723993.7T
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Sheldon Hiebert
Ramkumar Rajamani
Li-Qiang Sun
Eric Mull
Eric P Gillis
Michael S Bowsher
Qian Zhao
Nicholas A Meanwell
Kishore V Renduchintala
Kandhasamy Sarkunam
Pulicharla Nagalakshmi
P V K Suresh Babu
Paul Michael Scola
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Bristol Myers Squibb Co
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Claims (18)

  1. HEPATITIS C-VIRUSINHIBITORER
    1. Forbindelse med formel (I)
    G). eller et farmaceutisk acceptabelt salt deraf, hvor p er 1 eller 2; -----er en enkelt eller dobbelt binding; R1 er udvalgt fra °g
    hvor R1 er forbundet med modermolekyledelen gennem et hvilket som helst substituerbart carbonatom i gruppen; m er 0, 1 eller 2; n er 0, 1, 2, 3, 4, 5 eller 6; X° er udvalgt fra CH og N; X1 er udvalgt fra CH og N; X2 og X3 uafhængigt er udvalgt fra CH, C(Ra) og N; under forudsætning af at mindst én af X1, X2, og X3 er andet end N; hver Ra uafhængigt er udvalgt fra alkenyloxy, alkoxy, alkoxyalkoxy, alkyl, benzodioxanyl, carboxamid, carboxy, carboxyalkoxy, cyan, cycloalkylalkoxy, cycloalkyloxy, deuteroalkoxy, dialkylamino, halo, haloalkyl, haloalkoxy, haloalkoxycarbonyl, hydroxy, morpholinyl, phenyl, piperazinyl, pyrazolyl, og pyridinyl, pyrrolidinyl, hvor morpholinyl, phenyl, piperazinyl, pyridinyl, og pyrrolidinyl eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkoxy, alkyl, alkylsulfonyl, halo, haloalkoxy, haloalkyl, og morpholinyl; og hvor to tilstødende Ra-grupper sammen med de carbonatomer, til hvilke de er bundet, eventuelt kan danne en ring udvalgt fra dioxanyl, dioxolanyl, morpholinyl, pyranyl, og phenyl, hvor ringen eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkyl og halo; Rb er alkyl; Rx er udvalgt fra methyl og ethyl; Ry og Rz uafhængigt er udvalgt fra hydrogen og hydroxy; under forudsætning af at når-----er en dobbelt binding, er Ry og Rz hver hydrogen; R2 cr udvalgt fra hydrogen, alkyl, halo, haloalkoxy, haloalkyl, og hydroxyalkyl; og R3 er udvalgt fra hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalkoxycarbonyl, deuterohaloalkoxycarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylcarbonyl, haloalkoxycarbonyl, haloalkylaminocarbonyl, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, phenylcarbonyl, og phenyloxycarbonyl, hvor cycloalkyldelen af cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, og cycloalkyloxycarbonyl, heterocyclyldelen af heterocyclylcarbonylet og heterocyclyloxycarbonylet, og phenyldelen af phenylcarbonyl og phenyloxycarbonyl, eventuelt er substitueret med en, to, eller tre grupper uafhængigt udvalgt fra alkyl, alkylamino, alkylcarbonyl, cycloalkyl, dialkylamino, halo, haloalkoxy, og haloalkyl.
  2. 2. Forbindelse ifølge krav 1, eller et farmaceutisk acceptabelt salt deraf, hvor m er 1.
  3. 3. Forbindelse ifølge krav 1, eller et farmaceutisk acceptabelt salt deraf, hvor-----er en dobbelt binding.
  4. 4. Forbindelse ifølge krav 3, eller et farmaceutisk acceptabelt salt deraf, hvor Rx er methyl.
  5. 5. Forbindelse ifølge krav 1, eller et farmaceutisk acceptabelt salt deraf, hvor R1 er
    hvor X1 og X2 er N; X3 er C(Ra); n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er hvor X1 er N; X2 og X3 uafhængigt er udvalgt fra CH og C(Ra); n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er
    hvor X1 og X3 er N; X2 er C(Ra); n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er hvor X1 og X3 er N; X2 er udvalgt fra CH og C(Ra); n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er
    hvor X1 og X2 uafhængigt er udvalgt fra CH og C(Ra); X3 erN; n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er
    hvor X1 og X3 er N; X2 er CH; n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen, eller hvor R1 er
    hvor X° og X3 er N; X2 er udvalgt fra CH og C(Ra); n og Ra er som defineret ifølge krav 1; og
    betegner forbindelsespunktet til modermolekyledelen.
  6. 6. Forbindelse med formel (II)
    (Π), eller et farmaceutisk acceptabelt salt deraf, hvor n er 0, 1, 2, 3, 4, 5 eller 6; X1 er udvalgt fra CH og N; X2 og X3 uafhængigt er udvalgt fra CH, C(R3) og N; Ra er udvalgt fra methyl og ethyl; hver R1 uafhængigt er udvalgt fra alkoxy, alkyl, carboxamid, carboxy, cyan, cycloalkyloxy, dialkylamino, halo, haloalkyl, haloalkoxy, phcnyl, og pyridinyl, hvor phcnyl og pyridinyl eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkoxy, alkyl, halo, haloalkoxy, og haloalkyl; R2 er udvalgt fra hydrogen, alkyl, halo, og haloalkyl; og R3 er udvalgt fra alkoxycarbonyl, alkylcarbonyl, haloalkoxycarbonyl, haloalkylcarbonyl, og phenylcarbonyl, hvor phenyl eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkyl og halo.
  7. 7. Forbindelse ifølge krav 1, der har formlen (III)
    OH), eller et farmaceutisk acceptabelt salt deraf, hvor nerO, 1, 2, 3, 4, 5 eller 6; hver Ra uafhængigt er udvalgt fra alkoxy, alkyl, carboxamid, carboxy, cyan, cycloalkyloxy, dialkylamino, halo, haloalkyl, haloalkoxy, og phenyl, hvor phenyl eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkoxy, alkyl, halo, haloalkoxy, og haloalkyl; R2 er udvalgt fra hydrogen, alkyl, halo, og haloalkyl; og R3 er udvalgt fra alkoxycarbonyl, alkylcarbonyl, haloalkoxycarbonyl, haloalkylcarbonyl, og phenylcarbonyl, hvor phenyl eventuelt er substitueret med en eller to grupper uafhængigt udvalgt fra alkyl og halo; eller et farmaceutisk acceptabelt salt deraf.
  8. 8. Forbindelse ifølge krav 1 eller 6 udvalgt fra tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tcrt-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-isopropyl-4-oxo-3,4-diliydroplithalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-isopropyl-4-oxo-3,4-diliydroplithalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -isopropyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2-methoxyethyl)-4-oxo- 3.4- dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(2-methoxyethyl)-4-oxo- 3.4- dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazm-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2-methoxyethyl)-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2,2-dilluorethoxy)isoquinolm-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-1,1,1 -trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; oxetan-3 -yl ((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-mcthylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-pentyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methyloxetan-3 -yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3- (trifluormethyl)oxetan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 4- (trifluormethyl)tetrahydro-2H-pyran-4-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-melhoxyisoquiriolin-l-yl)oxy)-7,9-dimelhyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 4-(trifluormethyl)tetrahydro-2H-pyran-4-yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l-methoxy-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l-methoxy-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 4-methyltetrahydro-2H-pyran-4-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)- 14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l;13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 4-methyltetrahydro-2H-pyran-4-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(((l-(fluormethyl)cydopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-isopropyloxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-isopropyloxetan-3 -yl ((2R,6 S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluonnetliyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methyltetrahydro-2H-pyran-3-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)- 14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methyltetrahydro-2H-pyran-3-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3 -yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-cyclopropyloxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-cyclopropyloxetan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(iluormetliyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 4.4.4- trifluor-2-mcthylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 4.4.4- trifluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methyltetrahydrofuran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methyltetrahydrofuran-3 -yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydrofuran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydrofuran-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulibnyl)carbamoyl)-2-((4-rnethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-cMor-3-(2,2-difluorethoxy)isoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopeutadeciu-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((5-chlor-3 -(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-cHor-3-propoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)suironyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifliiorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (15.55) -bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-propoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoqumolin-l-yl)oxy)-7,9-dimethyl- 14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocydopropa[e]pyrrc>l[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-diiluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-(2,2-dinuorethoxy)isoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dime thyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-dilluorethoxy)isoquinolm-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3 -(2,2-diiluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-diiluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (R)-l,l,l-trifhiorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3 -isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-isopropoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifhiorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-dinuorethoxy)isoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-mcthylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolm-1 -yl)oxy)-7,9-dimethyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2,2-difluorethoxy)isoquinolin-1 -yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3 -(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-melhylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((5-chlor-3-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-chlor-3-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)oxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)oxetan-3-yl ((2R,6S,7R,9R,13aS, 14aR,16aS,Z)-2-((3,6-dimethoxjdsoquinolin-l-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluorniethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-diniethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; oxctan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimcthoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3-(ethyl(methyl)amino)-6-methoxyisoquinolin-1 -yl)oxy)-14a-(((l-(nuormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(ethyl(methyl)amino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(ethyl(methyl)amino)-6-methoxyisoquinolin-1 -yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(ethyl(methyl)amino)-6-methoxyisoquinolin-1 -yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3-(ethyl(methyl)amino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(ethyl(methyl)amino)-6-methoxyisoqmnolin-l-yl)oxy)-14a-(((l-(fluomethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)oxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)oxetan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-mcthylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-mcthoxy-4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; oxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; oxetan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; oxetan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; oxetan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-4-(2-methoxyethoxy)isoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-chlor-4-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-chlor-4-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-chlor-6-methoxyisoquinolin-l-yl)oxy)-14a-(((1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-chlor-6-methoxyisoquinolin-l-yl)oxy)-14a-(((1 -(nuormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-chlor-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfoiiyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -chlor-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormetliyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-4-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-4-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrc>cyclopropa[e]py:rrc>l[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluomietliyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-metlioxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3 -yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-3-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-4-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-4-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(iluormetliyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-metlioxy-4-(tririuormelliyl)isoqumolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormcthyl)tctrahydro-2H-pyran-3 -yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxy-4-(trifluormethyl)isoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)tetrahydro-2H-pyran-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-(((l-(difluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3,6-dimethoxyisoquinolm-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]py:rrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(difluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3,6-dimethoxyisoquinolm-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-difluor-2-methylbutan-2-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(difluormethyl)eyelopropyl)sulfonyl)earbamoyl)-2-((3,6-dimethoxyisoquinolm-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS)-2-((4-cyclopropoxyisoquinolin-1 -yl)oxy)-12-hydro xy-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13S, 13aR, 14aR, 16a)-2-((4-cyclopropoxyisoquinolin-1 -yl)oxy)-13-hydro xy-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 2-((l-(((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-6-((tert-butoxycarbonyl)amino)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-2-yl)oxy)isoquinolin-6-yl)oxy)eddikesyre; tert-butyl tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-fluor-4-methoxyisoquinolin-l -yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-fluor-4-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinoliii-l-yk>xy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-etlioxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(6-methoxy-4-(4-methylpiperazin-1 -yl)isoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-methoxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(l-fluorcyclopropylsulfonyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-6-pivalamid-l,2,3,5,6,7,8,9,10,l 1,13a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; isopropyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-( 1 -fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-isopropoxyisoquinolin-1 -yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; isobutyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-( 1 -fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; cyclopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (R)-1,1,1 -trifluorpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-chlor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-ethoxyisoquinolin-1 -yloxy)- 14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-chlor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -riuorcyclopropylsuironylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-6-(2-fluorbenzamid)-N-(l-fluorcyclopropylsulfonyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-(cyclopropylmethoxy)isoquinolin-l-yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-(difluormethoxy)isoquinolin-l-yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-methoxyquinazolin-4-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-methoxyquinazolin-4-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-methoxyquinazolin-4-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (1-methyl eye lopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-£luorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; cyclohexyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (lR,5S)-bicyclo[3.1.0]hexan-3-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadeeahydroeyelopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(isoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-chlor-6-methoxyisoquinolin-l-yloxy)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-chlor-6-methoxyisoqumolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; l,l,l-trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-(7-chlor-6-methoxyisoqumolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-l-yloxy)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; ncopcntyl (2R, 6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(7-fluor-4-mcthoxyisoquinolin-1 -yloxy)-14a-(l -£luorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; (1-methyl eye lopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-l-yloxy)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-fluor-6-metlioxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; (1 -methyleyelopropyl)methyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; neopentyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-14a-(l-fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy) - 14a-( 1 -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1 -methylcyclopropyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; cyclohexyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-cyclopropoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-cyclopropoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-methoxyisoquinolm-l-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluor-4-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxy-7-fluorisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxy-7-fluorisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(3 -(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(3 -(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (R)-1,1,1 -trifliiorpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-cthoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-(cyclopropylmethoxy)-7-fluorisoquinolin-1 -yloxy)-l 4a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -fluorcyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluorisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluorisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1 -methylcyclopropyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluorisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-chlor-4-ethoxyisoquinolin-l-yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-chlor-4-ethoxyisoquinolin-1 -yloxy)-7,9-dimethyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [l,4]diazaeyelopentadeein-6-ylearbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-ethylcyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolm-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(3 -(4-tert-butylphenyl)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(3 -(4-tert-butylphenyl)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4,6-dimethoxyisoquinolin-l -yloxy)-7,9-dimethyl -14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoqumolin-l-yloxy)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(6-methoxyquinoxalin-2-yloxy)-7,9-dimethyl- 14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydroeyelopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadeein-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(6-methoxy-4-(6-methoxypyridin-3-yl)isoquinolin- 1- yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)- 2- (7-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13a, 14,14a, 15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-6-(l-(triiluormethyl)cyclopropanecarboxamid)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-6-(3,3,3-trifluor-2,2-dimethylpropanamid)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-(difluormetliyl)cyclopropylsuironylcarbamoyl)-2-(7-nuor-6-methoxyisoqumolm-l-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(difluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-fluor-6-methoxyisoquinolm-l-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-(difluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(difluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-6-(2-(trifluormethyl)benzamid)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-6-(2,4-difluorbenzamid)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-N-(l-(flunnnethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13a,14aR,16aS,Z)-6-(2,2-difluorethylamino)-N-(l- (fluormethyl)cyclopropylsulfonyl)-2-(7-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(6-fluorquinoxalin-2-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxy-4-morpholimsoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-hydroxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocydopropa[e]pyrrc)l[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)-14a-( 1 -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(6-methoxy-4-((l,l,l-lrifluor-2-methylpropan-2-yloxy)carbonyloxy)isoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 - methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxy-3-methylquinoxalin-2-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-methoxy-3-methylquinoxalin-2-yloxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-methoxy-3-methylquinoxalin-2-yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocydopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-amino-N-(l-(hydroxymethyl)cyclopropylsulfonyl)-2-(4-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-amino-N-(l-(hydroxymethyl)cyclopropylsulfonyl)-2-(4-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-( 1 -(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolm-1 -yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-N-(l- (fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-6-pivalamid- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimcthoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-6-(2,4,6-tri£luorbenzamid)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [[ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-6-(2,4-difluorbenzamid)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimetliyl-5,16-dioxo-6-(l-(trifluonnethyl)cyclopropanecarboxamid)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxy-4-morpholinisoquinolin-l-yloxy)-7,9-dimethyl- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fLuor-4,6-dimethoxyisoquinolin-l-yloxy)-14a-(l-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-14a-(l-(hydroxymethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-chlorcyclopropylsulfonylcarbamoyl)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-chlorcyclopropylsulfonylcarbamoyl)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-ethylcyclopropylsulfonylcarbamoyl)-2-(7-fl.uor-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-ethylcyclopropylsulfonylcarbamoyl)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yloxy)- 7.9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(5-chlor-4-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)- 7.9- dimethyl-5,16-dioxo-2-(quinoxalin-2-yloxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l ,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-((2S,6R)-2,6-dimethylmorpholin)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-((2S,6R)-2,6-dimethylmorpholin)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-l 4a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13aS,14aR, 16aS,Z)-7,9-dimethyl- 14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-2-(4-(( 1,1,1 -trifluor-2-methylpropan-2-yloxy)carbonyloxy)isoquinolin-l-yloxy)-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-2-(4-(vinyloxy)isoquinolin-1 -yloxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(6-methoxy-4-morpholinisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(6-methoxy-4-morpholimsoquinolin-l-yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 2,4-difluorphcnyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-cthoxyisoquinolin-l-yloxy)-7,9-dimethyl-14a-( 1 -methyLcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 2-fluorphenyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; phenyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy)-7,9-dimethyl- 14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-6-(l-acctylpipcridin-4-carboxamid)-2-(4,6-dimethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-N-( 1 -methylcyclopropylsulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-6-(3-fluorisonicotinamid)- 7,9-dimethyl-N-(l-methylcyclopropylsulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-7,9-dimethyl-6-(l-methyl-2-oxo-1,2-dihydropyridine-4-carboxamid)-N-(l -methylcyclopropylsulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-methoxyquinazolin-4-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(8-chlorquinazolin-4-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-( 1 -(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; l,l,l-trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l- (fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(2-(4-isopropoxyphenyl)-7-methoxyquinolin-4-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1,1,1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin-1 -yloxy)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-(4-cthoxyisoquinolin-l-yloxy)-14a-(l-(fluormethyl)cyclopropylsulfbnylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-chlorcyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-1 -yloxy)-14a-( 1 -(fluomethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(iluormethyl)cyclopropylsuironylcarbamoyl)-2-(4-metlioxyisoquinolm-l-yloxy)-7,9-diniethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-metliylpropaii-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-(cyclopropylmethoxy)isoqumolin-l-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-1 -yloxy)-14a-( 1 -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fhrormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(7-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(6-methoxyquinoxalin-2-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-fluor-4,6-dimethoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-N-(l- (iluormethyl)cyclopropylsuironyl)-7,9-dimethyl-5,16-dioxo-6-pivalamid- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-(cyclopropylmethoxy)-7-fluorisoquinolin-1 -yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadeem-6-ylcarbamat; (2R,6S,7R,9R,13aS, 14aR,16aS,Z)-6-(2,2-difluorethylamino)-N-(l-(fluormethyl)cyclopropylsulfonyl)-2-(7 -methoxyquinoxalin-2-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-6-(3-fluorisordcothramid)-N-(l-(fluormethyl)cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(2-(4-isopropoxyphenyl)-7-methoxyqumolm-4-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-(4-(2,2-difluorethyl)piperazin-1 -yl)-6-methoxyisoquinolin-1 -yloxy)-7,9-dimethyl-14a-( 1 -ethylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl(2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-7-ethyl-2-(4-methoxyisoqumolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-l-yloxy)-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; (R)-1,1,1 -trifluorpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-7-ethyl-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl(2R,6S,7R,9R, 13aS, 14aR,16aS,Z)-2-(6-methoxy-4-(6-methoxypyridin-3-yl)isoquinolin-l-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamate tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-fluorquinoxalin-2-yloxy)-7,9-dimethyl- 14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4-ethoxyisoquinolin- l-yloxy)-7-ethyl-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-4-methoxyisoquinolin-l-yloxy)-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(6-methoxyisoquinolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(7-methoxy-3 -(trifluormethyl)quinoxalin-2-yloxy)- 7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-ethoxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-lluor-4-methoxyisoquinolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-chlor-4-methoxyisoquinolin-1 -yloxy)-7-ethyl-9-methyl-14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-methoxyquinazolin-4-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-chlor-4-methoxyisoquinolin-l-yloxy)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)-7-ethyl-9-methyl-14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-6-methoxy-4-morpholinisoquinolin-l-yloxy)-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fLuor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluonnetliyl)cyclopropylsulfonylcarbamoyl)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(7-methoxyquinoxalin-2-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(7-methoxy-3-(trifluormethyl)quinoxalin-2-yloxy)-7,9-dimethyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl) -5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-(4,6-dimethoxyisoquinolin-l-yloxy)-7-ethyl-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4,6-dimethoxyisoquinolin-1 -yloxy)-7-ethyl-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(7-methoxyquinolin-4-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(2-chlor-7-methoxyquinolin-4-yloxy)-14a-(l-(iluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(4-cthoxyisoquinolin-1 -yloxy)-7-ethyl-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; tert-butyl (2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl- 14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-14a-(l-(fluormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(6-methoxy-4-morpholimsoquinolin-1 -yloxy)-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-(6-methoxy-4-morpholinisoquinolin-1 -yloxy)-9-methyl-14a-( 1 -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-4,6-dimethoxyisoquinolin-l-yloxy)-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-metliylpropaii-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(diinetliylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tcrt-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3-(dimcthylamino)-6-mcthoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclobutylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclobutylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclobutylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclobutylsulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aR,14aR,16aS)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aR, 14aR, 16aS)- 14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tcrt-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((2-(dimcthylamino)-7-mcthoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2-(dimethylamino)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((2-(dimcthylamino)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2-(dimethylamino)-7-methoxyqumazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((2-(dimethylamino)-7-methoxyquinazolin-4-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2-(dimethylamino)-7-methoxyquinazolin-4-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2-(4-isopropoxyphenyl)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2-(4-isopropoxyphenyl)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((2-(dimethylamino)-7-methoxyquinazolin-4-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfbnyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2-(dimethylamino)-7-methoxyquinazolin-4-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((2-(4-isopropoxyphenyl)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2-(4-isopropoxyphenyl)-7-metho xyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-14a-((( 1 -(fluormethyl)cydopropyl)sulfonyl)carbamoyl)-2-((7-methoxy-2-(pyrrolidin-l-yl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((7-methoxy-2-(pyrrolidin-l-yl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,7-dimethoxyquinazolin-4-yl)oxy)-14a-(((l-(fluomiethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2-(4-isopropoxyphenyl)-7 -methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopeutadeciu-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2-(4-isopropoxyphenyl)-7 -methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((7-methoxy-2-(pyrrolidin-l-yl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((7-methoxy-2-(pyrrolidin-l-yl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2,7-dimethoxyquinazolin-4-yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2-(4-isopropoxyphenyl)-7-methoxyquinazolin-4-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2-(4-isopropoxyphenyl)-7-methoxyquinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-2-((5-methoxyisoquinolin-1 -yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-((5-methoxyisoquinolin-1 -yl)oxy)-9-methyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-2-((5-methoxyisoquinolin-1 -yl)oxy)-9-methyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,3aS,4aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[ 1,2-a] [1,4]diazacyclopentadecin-14a-carboxamid, 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (2R,6S,7R,9S,3aS,4aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7-ethyl-2-((5-methoxyisoquinolin-l-yl)oxy)-9-methyl-N-((l-methylcyclopropyl)sulfrmyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7-ethyl-2-((5-methoxyisoquinolin-l- yl)oxy)-9-methyl-N-((l-methylcyclopropyl)sulfbnyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((5-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfoiiyl)carbamoyl)-2-((3-(4-fluorpheiiyl)-6-methoxyisoquinoliri-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-chlor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]py:rrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((eyelopropylsulfonyl)earbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-methoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazaeyelopentadeein-6-yl)earbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]py:rrc>l[l,2-a] [l,4]diazaeyelopentadecin-6-yl)earbamal; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyplieiiyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyplienyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyl eye lopropyl)methyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (l-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((3 -(3 -fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((eyelopropylsulfonyl)earbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hcxan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methykyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifliiorpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(3-fLuor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(3-fluor-4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbaniat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolm-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1-methyl eye lopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(4-fluorphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)- 7.9- dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)- 7.9- dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)mcthyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-mcthoxy-3-morpholimsoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-3-morpholimsoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-3-morpholimsoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-methoxy-3 -morpholimsoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-3 -morpholimsoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-methoxy-3-morpholinisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methyleyelopropyl)sulfonyl)earbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxy-3-morpholinisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazaeyelopentadeein-6-yl)earbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfoiiyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 R,3r,5 S)-bicyclo[3.1,0]hexan-3 -yl((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-morpholinisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3 -morpholinisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3 -morpholinisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6- methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6- methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)suironyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimcthylamino)-6-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifLuorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 - methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 - methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-methoxy-3 -(pyrrolidin-1 -yl)isoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-12,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-3-(pyrrolidin-1-yl)isoquinolin-1-yl)oxy)-7,9-dimelhyl-14a-((( 1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-1 -yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoqmnolin-l-yl)oxy)-14a-(((l-(fluomethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfbnyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnetliyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-diinetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(dimetliylamino)-6-methoxyisoqmnolin-l-yl)oxy)-14a-(((l-(fluomethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(dimethylamino)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrc>cyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-ethoxy-4-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-ethoxy-4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-1 -yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-(dimethylamino)-4-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-fluor-4-methoxyisoquinolin-1 -yl)oxy)-14a-(((l-(fluomiethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-fluor-4-methoxyisoquinolin-l-yl)oxy)-14a-(((1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-metlioxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((5-fluor-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)mcthyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sullbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-£luor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolm-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-metlioxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1-methyleyelopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-£luor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)mcthyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-1 -yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrc>cyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((7-£luor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnetliyl)cyclopropyl)suironyl)carbamoyl)-7,9-dimetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sultbnyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3 -(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3 -(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- hifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hcxan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((7-fluor-3-(4-isopropoxyphenyl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,11,13a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-methoxy-2-(4-methoxyphenyl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((7-methoxy-2-(4-methoxyphenyl)quinazolin-4-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S, 13 aS,4aR, 16aS,Z)-6-(3 -(tcrt-butyl)urcido)-2-((4-mcthoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((4-methoxyphthalazin-l-yl)oxy)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hcxan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-mcthoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((4-methoxyphthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((4-methoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-7-ethyl-2-((4-methoxyphthalazin-1 -yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1.2.3.5.6.7.8.9.10.11.13 a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-2-((4-methoxyphthalazin-1 -yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1.2.3.5.6.7.8.9.10.11.13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7-ethyl-2-((4-methoxyphthalazin-l-yl)oxy)-9-methyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7-ethyl-2-((4-methoxyphthalazin-l-yl)oxy)-9-methyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-((4-methoxyphthalazin-l-yl)oxy)-9-methyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-((4-methoxyphthalazm-l-yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((4-ethoxyphthalazin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((4-ethoxyphthalazm-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7-ethyl-9-methyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-ethoxyphthalazin-l-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-difluor-2-methylbutan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((4-ethoxyphthalazin-l -yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalaziii-1-yl)oxy)-7,9-dimethyl-14a-((( 1-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-N-((l -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-N-((l -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(4-(dimethylamino)benzamid)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-N-((l -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,3aS,4aR,16aS,Z)-6-(4-(dimethylamino)benzamid)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-N-((l -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; Nl-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,l 6-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; Nl-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-cthyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)- 7.9- dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)- 7.9- dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dime thyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-(dimethylamino)benzamid)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-(dimethylamino)benzamid)-2-((3-ethyl-4-oxo-3,4-dihydrophthalazin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; Nl-((2R,6S,7R,9S,3aS,4aR,16aS,Z)-14a-((cyclopropylsulfbnyl)carbamoyl)-2-((3-cthyl-4-oxo-3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; Nl-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-ethyl-4-oxo- 3,4-dihydrophthalazin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-ethyl-4-oxo-3,4-dihydrophthalaziii-1 -yl)oxy)-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tcrt-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimcthyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S, 13aS,14aR, 16aS,Z)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-1rifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l -yl)oxy)- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimcthyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,3aS, 14aR, 16aS,Z)-7,9-dimethyl-N-((l -methylcyclopropyl)sulfonyl)-5,16-dioxo-2-((4-propoxyisoqidnolin-1 -yl)oxy)-6-(3-( 1,1,1 -trifluor-2-methylpropan-2-yl)ureido)- 1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-7,9-dimethyl-N-((1 -methylcyclopropyl)sulfonyl)-5,16-dioxo-2-((4-propoxyisoqidnolin-1 -yl)oxy)-6-(3-( 1,1,1 -trifluor-2-methylpropan-2-yl)ureido)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,l 1,13a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo [1,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquiiiolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1-methyl eye lopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-N-(cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-1 -yl)oxy)-6-(3 -(1,1,1 -trifluor-2-methylpropan-2-yl)ureido)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-7,9-dimethyl-5,16-dioxo-2-((4-propoxyisoquinolin-1 -yl)oxy)-6-(3 -(1,1,1 -trifluor-2-methylpropan-2-yl)ureido)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methyleyelopropyl)sulfonyl)earbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazaeyclopentadeem-6-yl)earbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluonnethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13a,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7,9-dimethyl-N-(l-methylcyclopropyl)sulfonyl)-5,16-dioxo-2-((4-(trideuterometlioxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aR,14aR,16aS)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)octadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aR, 14aR, 16aS)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-2-((4-(trideuteromethoxy)isoquinolin-l-yl)oxy)octadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((4-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((4-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aR,14aR,16aS)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aR,14aR,16aS)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((4-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9R,13aR,14aR,16aS)-6-(3-(tert-butyl)ureido)-N-((l-(fluormethyl)cyclopropyl)sulfonyl)-2-((4-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxooctadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-2-((5-morpholinisoquinolin-l-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-etlioxyisoquinoliii-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyl eye lopropyl)methyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazaeyclopentadeem-6-yl)earbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-ethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-6-(3-(l,l,l-trifluor-2-methylpropan-2-yl)ureido)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-l 4a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-ethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-6-(3-(l,l,l-trifluor-2-methylpropan-2-yl)ureido)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazaeyelopentadeein-6-yl)earbamat; (R)-l,l,l-trifluorpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]py:rrc>l[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1,3,3,3 -hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9R, 13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-2-((6-isopropoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifliiorpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-irifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S, 13aS,14aR, 16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 R,3r,5 S)-bicyclo[3.1,0]hexan-3 -yl((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexachlor-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexachlor-2-methylpropan-2-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-isopropoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexachlor-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexachlor-2-(trifluomethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimetliyl-5,16-dioxo-2-((6-propoxyisoquinolin-l-yl)oxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(triiluonnetliyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-methylpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dhnethyl-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(4-(dimethylamino)benzamid)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-N-((1 -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-6-(4-(dhnethylamino)benzamid)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-N-((1 -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-2-(phenanthridin-6-yloxy)-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-2-(phenanthridin-6-yloxy)-l,2,3,5,6,7,8,9,10,l 1,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-(phenanthridin-6-yloxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-2-(phenanthridin-6-yloxy)-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3 -phenylisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3 -phenylisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-phenylisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a- ((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-phenylisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-phenylisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-phenylisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((6-methoxy-3-(4-morpholinphenyl)isoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-2-((6-methoxy-3 -(4-morpholinphenyl)isoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((6-methoxy-3 -(4-morpholinphenyl)isoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)- 5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridm-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfoiiyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hcxan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cydopropylsulfonyl)carbamoyl)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormetliyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrc)cyclopropa[e]py:rrc)l[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfbnyl)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin- 3-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,3aS,4aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hcxan-3-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(6-isopropoxypyridin-3 -yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-N-((1 -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-2-((3-(6-isopropoxypyridin-3-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-N-((1 -methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b][l,4]dioxin-6-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b][l,4]dioxin-6-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)suironyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2,3-drhydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-l -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(2,3-diliydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(2,3 -dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(2,3 -dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trilluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3 -(2,3 -dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxino[2,3-flisoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxino[2,3-flisoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [l,4]dioxino[2,3-£]isoquinolin-7-yl)oxy)-7,9-dimethyl- 14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2,3 -dihydro- [1.4] dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [1.4] dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [1.4] dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (l-methylcyclopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methylcyclopropyl)methyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-((2,3-dihydro- [1.4] dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyi)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-diliydro-[l,4]dioxino[2,3-£]isoquinolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxino[2,3-l]isoqumolin-7-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[ 1,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[ 1,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfoiiyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxmo[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-i]isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)pentan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-1] isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-(trifluormethyl)pentan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f|isoqumolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f|isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-methylpentan-3-yl ((2R,6S,7R,9S, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-£]isoquinolin-7-yl)oxy)-7,9-dime thyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3-mcthylpcntan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1-methyleyelopropyl)methyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-1] isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (1 -methyleyelopropyl)methyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfbnyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,2-difluor-[l,3]dioxolo[4,5-f]isoquinolin-6-yl)oxy)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoqumolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoqumolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazm[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-£]isoquinolm-7-yl)oxy)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; 1.1.1.3.3.3- hcxadcutcro-2-mcthylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolm-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1,3,3,3 -hexadeutero-2-(trideuteromethyl)propan-2-yl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-(dimethylamino)benzamid)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-i]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-(dimethylamino)benzamid)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-£]isoquinolm-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazm[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-diliydro-2H- [l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H- [l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S, 13 aS, 14aR, 16aS,Z)-7,9-dimethyl-2-((4-methyl- 3.4- dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7,9-dimethyl-2-((4-methyl- 3.4- dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-inethyl-3,4-diliydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a][l,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-i]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-l]isoqmnolin-7-yl)oxy)-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(4-(dimethylamino)benzamid)-7,9-dimethyl-2-((4-methyl-3,4- dihydro-2H-[l,4]oxazin[2,3-£]isoquinolin-7-yl)oxy)-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13aS,14aR,16aS,Z)-6-(4-(dimcthylamino)bcnzamid)-7,9-dimcthyl-2-((4-mcthyl- 3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoqumolin-7-yl)oxy)-N-((l-methylcyclopropyl)sulfonyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; Nl-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H- [1.4] oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamide; Nl-((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7,9-dimethyl-2-((4-methyl-3,4-dihydro-2H- [1.4] oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamide; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquiiiolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)- 14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cydopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfbnyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormethyl)propan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1.3.3.3- hexadeutero-2-(trifluormetliyl)propan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-£]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]py:rrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (lR,3r,5S)-bicyclo[3.1.0]hexan-3-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (2R,6S,7R,9S,13aS,14aR,16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-6-(3-(tert-butyl)ureido)-N-(cyclopropylsulfonyl)-7-ethyl-9-methyl-2 -((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-14a-carboxamid; Nl-((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-l]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; N1 -((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)-N2,N2-dimethyloxalamid; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxmo[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [l,4]dioxmo[2,3-£]isoquinolin-7-yl)oxy)-14a-(((l-(riuomiethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9- dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pynOl[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2,3 -dihydro- [1.4] dioxino[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecaliydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-9-methyl-2-((4-methyl- 3.4- dihydro-2H-[l,4]oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-9-metliyl-2-((4-methyl- 3.4- dihydro-2H-[l,4]oxazm[2,3-£]isoquinolin-7-yl)oxy)-14a-(((l-melhylcyclopropyl)suironyl)carbamoyl)- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H- [1.4] oxazin[2,3-l]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-9-methyl-2-((4-methyl-3,4-dihydro-2H- [1.4] oxazin[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[ 1,4]dioxino[2,3 -f]isoquinolin-7-yl)oxy)-7 -ethyl-9-methyl- 14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[ 1,4]dioxino[2,3 -f]isoquinolin-7-yl)oxy)-7 -ethyl-9-methyl- 14a-(((l- methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[ 1,4]dioxino[2,3 -f]isoquinolin-7-yl)oxy)-7 -ethyl-9-methyl- 14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2,3 -dihydro-[ 1,4]dioxino[2,3 -f]isoquinolin-7-yl)oxy)-7 -ethyl-9-methyl- 14a-(((l- methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-diliydro-[l,4]dioxmo[2,3-f]isoquinolin-7-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsullbnyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-l]isoqumolin-7-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-l]isoqumolin-7-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,l l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxiao[2,3-f]isoquinolm-7-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro-[l,4]dioxmo[2,3-f]isoquinolin-7-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((2,3-dihydro-[l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-7-ethyl-9-methyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-mcthylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)- 4.6- dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)- 4.6- dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; l,l,l-trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)- 4.6- dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1,1,1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; (R)-l,l,l-trifluorpropan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-(4-isopropoxyphenyl)-4,6-dimethoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2-a] [ 1,4]diazacyclopentadecm-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((3 -methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((3-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-7-ethyl-2-((3-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-((3-methoxyisoquinolin-l-yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-((3-methoxyisoquinolin-l-yl)oxy)-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-2-((3-methoxyisoquinolin-1 -yl)oxy)-9-methyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-7-ethyl-2-((3 -methoxyisoquinolin-1 -yl)oxy)-9-methyl-14a-(((l -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-metlioxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoqumolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-7-ethyl-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrc>l[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-7-ethyl-14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoqumolin-l-yl)oxy)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3 -methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)- 14a-((( 1 -(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trilluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinohn-6-yl)oxy)-7,9-dime thyl-14a-(((l-me thylcyclopropyl)sulfonyl)carbamoyl)-5,16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-mcthylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7 -ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; tert-butyl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinohn-6-yl)oxy)-7-ethyl-9-melhyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinohn-6-yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinohn-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinohn-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl- 5.16- dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbaniat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2H-pyran[3,2-c]isoquinolin-6-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((3,4-dihydro-2F[-pyran[3,2-c]isoquinolin-6-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3.3- difluor-2-methylbutan-2-yl((2R,6S,7R,9S,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a][ 1,4]diazacyclopentadecin-6-yl)carbamat; og 3.3- difluor-2-methylbutan-2-yl((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((3-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l, 2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; eller et farmaceutisk acceptabelt salt deraf.
  9. 9. Forbindelse ifølge krav 1 udvalgt fra
    eller et farmaceutisk acceptabelt salt deraf.
  10. 10. Forbindelse ifølge krav 1 udvalgt fra: l,l,l-trifluor-2-methylpropan-2-yl(2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a- (cyclopropylsulfonylcarbamoyl)-7-ethyl-2-(4-methoxyisoquinolin-l-yloxy)-9-methyl-5,16-dioxo- l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-mcthylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-cthyl-2-(7-fLuor-6-methoxyisoqumolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-4-methoxyisoquinolin-1 -yloxy)-9-methyl- 14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13 a, 14,14a, 15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-14a-((cyclopropylsulfonyl)carbamoyl)-2-((3-(5-isopropoxypyridin-2-yl)-6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 3,3-diiluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-2-((6-methoxyisoquinolin-l-yl)oxy)-7,9-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,1 l,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluormethyl)cyclopropylsulfonylcarbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((7-fluor-5-methoxyisoquinolin-l-yl)oxy)-14a-(((l-(fluonnetliyl)cyclopropyl)suironyl)carbamoyl)-7,9-diinetliyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((3,6-dimethoxyisoquinolin-1 -yl)oxy)-7-ethyl-9-methyl-14a-((( 1 -methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-methoxyquinoxalin-2-yloxy)-9-methyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl ((2R,6S,7R,9S,13aS,14aR,16aS,Z)-2-((3-(2,3-dihydrobenzo[b] [ 1,4]dioxin-6-yl)-6-methoxyisoquinolin-1 -yl)oxy)-7,9-dimethyl-14a-((( 1 -methylcyclopropyl)sulfbnyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fluor-6-methoxyisoquinolin-1 -yloxy)- 14a-(l -(fluormethyl)cyclopropylsulfonylcarbamoyl)-9-methyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-14a-(l-(fhiormethyl)cyclopropylsulfonylcarbamoyl)-2-(6-methoxyisoquinolin-l-yloxy)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 1.1.1 -trifluor-2-methylpropan-2-yl ((2R,6S,7R,9R, 13aS, 14aR, 16aS,Z)-2-((2-(4-isopropoxyphenyl)-7-metho xyquinazolin-4-yl)oxy)-7,9-dimethyl-14a-(((l-methylcyclopropyl)sulfonyl)carbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[ 1,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-7-ethyl-2-(7-fLuor-4,6-dimethoxyisoquinoliii-l-yloxy)-9-metliyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; 3,3-difluor-2-methylbutan-2-yl ((2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-((2,3-dihydro- [l,4]dioxino[2,3-f]isoquinolin-7-yl)oxy)-14a-(((l-(fluormethyl)cyclopropyl)sulfonyl)carbamoyl)-7,9-dimethyl-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-yl)carbamat; 1.1.1- trifluor-2-methylpropan-2-yl (2R,6S,7R,9R,13aS,14aR,16aS,Z)-2-(4-ethoxy-6-methoxyisoquinolin-1 -yloxy)-7-ethyl-9-methyl-14a-(l -methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo-l,2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2- a][ 1,4]diazacyclopentadecin-6-ylcarbamat; og 1.1.1 -trifluor-2-methylpropan-2-yl (2R,6S,7R,9R, 13 aS, 14aR, 16aS,Z)-2-(2-(4-isopropoxyphenyl)-7-methoxyquinolin-4-yloxy)-7,9-dimethyl-14a-(l-methylcyclopropylsulfonylcarbamoyl)-5,16-dioxo- I, 2,3,5,6,7,8,9,10,ll,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrol[l,2-a] [ 1,4]diazacyclopentadecin-6-ylcarbamat; eller et farmaceutisk acceptabelt salt deraf. II. Sammensætning, der omfatter en forbindelse ifølge et hvilket som helst af kravene 1 til 10, eller et farmaceutisk acceptabelt salt deraf, og en farmaceutisk acceptabel bærer.
  11. 12. Sammensætning ifølge krav 11, der endvidere omfatter mindst én yderligere forbindelse, der har anti-HC V- aktivitet.
  12. 13. Sammensætning ifølge krav 12, hvor mindst én af de yderligere forbindelser er et interferon eller en ribavirin.
  13. 14. Sammensætning ifølge krav 13, hvor interferonet er udvalgt fra interferon alpha 2B, pegyleret interferon alpha, konsensus-interferon, interferon alpha 2A og lymphoblastoid interferon tau.
  14. 15. Sammensætning ifølge krav 12, hvor mindst én af de yderligere forbindelser er udvalgt fra interleukin 2, interleukin 6, interleukin 12, Imiquimod, ribavirin, en inosin-5'-monophosphat-dehydrogenaseinhibitor, amantadin og rimantadin.
  15. 16. Sammensætning ifølge krav 12, hvor mindst én af de yderligere forbindelser er effektive til at hæmme funktionen af et mål udvalgt fra HCV-metalloprotease, HCV-serinprotease, HCV-polymerase, HCV-helicase, HCV NS4B-protein, HCV-indgang, HCV-samling, HCV-udgang, HCV NS5A-protein og IMPDH til behandling af en HCV-infektion.
  16. 17. Forbindelse ifølge et hvilket som helst af kravene 1 til 10, eller et farmaceutisk acceptabelt salt deraf, til anvendelse i en fremgangsmåde til behandling af en HCV-infektion.
  17. 18. Forbindelse til anvendelse ifølge krav 17, der endvidere omfatter administration af mindst én yderligere forbindelse, der har anti-HCV-aktivitet forud for, efter, eller samtidigt med forbindelsen med formlen (I), eller et farmaceutisk acceptabelt salt deraf.
  18. 19. Forbindelse til anvendelse ifølge krav 18, hvor den yderligere forbindelse cr som defineret ifølge et hvilket som helst af kravene 13 til 16.
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