DK2565206T3 - Antistofrensning ved kationbytningskromatografi - Google Patents
Antistofrensning ved kationbytningskromatografi Download PDFInfo
- Publication number
- DK2565206T3 DK2565206T3 DK12189190.7T DK12189190T DK2565206T3 DK 2565206 T3 DK2565206 T3 DK 2565206T3 DK 12189190 T DK12189190 T DK 12189190T DK 2565206 T3 DK2565206 T3 DK 2565206T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- ser
- thr
- val
- gly
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Claims (5)
1. Fremgangsmåde til rensning af et antistof, som er et anti-CD20-antistof, fra en sammensætning omfattende antistoffet og mindst én kontaminant, hvilken fremgangsmåde omfatter de sekventielle trin: (a) fyldning af sammensætningen på et kationbytningsmateriale, hvor sammensætningen har en pH på 4,5 til 5,5 og har en konduktivitet på 2,5 til 5,5 mS/cm; (b) vask af kationbytningsmaterialet med en første vaskepuffer, hvor den første vaskepuffers pH er 7,5 til 8,1, og hvor den første vaskepuffer omfatter 15 til 35 mM HEPES og har en konduktivitet på 0,5 til 1,5 mS/cm; (c) vask af kationbytningsmaterialet med en anden vaskepuffer, hvor den anden vaskepuffers pH er fra 5,0 til 6,0, og hvor den anden vaskepuffer omfatter 14 til 23 mM MES og 5 til 15 mM NaCI og har en konduktivitet på 0,6 til 2,2 mS/cm; og (d) eluering af antistoffet fra kationbytningsmaterialet med en elueringspuffer, hvor elueringspufferens pH er fra 5,3 til 5,7, og hvor elueringspufferen omfatter 14 til 23 mM MES og 140 til 180 mM NaCI og har en konduktivitet på 13,4 til 17,2 mS/cm.
2. Fremgangsmåde ifølge krav 1, hvor anti-CD20-antistoffet omfatter en tung kæde omfattende CDR H1 anført som SEQ ID NO:5, CDR H2 anført som SEQ ID NO:6, CDR H3 anført som SEQ ID NO:7; og en let kæde omfattende CDR L1 anført som SEQ ID NO:8, CDR L2 anført som SEQ ID NO:9 og CDR L3 anført som SEQ ID NO: 10.
3. Fremgangsmåde ifølge krav 1, hvor kationbytningsmaterialet omfatter tværbundne poly(styren-divinylbenzen)-gennemstrømningspartikler coated med en polyhydroxyleret polymer, der er funktionaliseret med sulfopropyl-grupper.
4. Fremgangsmåde ifølge krav 1, hvor kontaminanten er udvalgt fra gruppen bestående af ovarieproteiner fra kinesisk hamster (CHOP), udvasket protein A, DNA, aggregeret antistof, cellekulturmediumkomponent, garamycin og viral kontaminant.
5. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, hvor antistoffet er rituximab.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98382507P | 2007-10-30 | 2007-10-30 | |
EP08844379.1A EP2215117B2 (en) | 2007-10-30 | 2008-10-29 | Antibody purification by cation exchange chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2565206T3 true DK2565206T3 (da) | 2016-06-06 |
Family
ID=40262967
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14189095.4T DK2840090T3 (da) | 2007-10-30 | 2008-10-29 | Antistofrensning ved kationbytningskromatografi |
DK12189190.7T DK2565206T3 (da) | 2007-10-30 | 2008-10-29 | Antistofrensning ved kationbytningskromatografi |
DK08844379.1T DK2215117T4 (da) | 2007-10-30 | 2008-10-29 | Antistofrensning ved kationbytningschromatografi |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14189095.4T DK2840090T3 (da) | 2007-10-30 | 2008-10-29 | Antistofrensning ved kationbytningskromatografi |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08844379.1T DK2215117T4 (da) | 2007-10-30 | 2008-10-29 | Antistofrensning ved kationbytningschromatografi |
Country Status (32)
Country | Link |
---|---|
US (3) | US20090148435A1 (da) |
EP (4) | EP3441402A1 (da) |
JP (5) | JP5237382B2 (da) |
KR (3) | KR20140015166A (da) |
CN (3) | CN103554215B (da) |
AR (2) | AR069097A1 (da) |
AU (1) | AU2008318865B2 (da) |
BR (1) | BRPI0817182A2 (da) |
CA (1) | CA2703279C (da) |
CL (1) | CL2008003218A1 (da) |
CO (1) | CO6280422A2 (da) |
CY (1) | CY1116129T1 (da) |
DK (3) | DK2840090T3 (da) |
ES (3) | ES2572958T3 (da) |
HK (4) | HK1182401A1 (da) |
HR (2) | HRP20150282T4 (da) |
HU (3) | HUE027668T2 (da) |
IL (4) | IL205310A0 (da) |
ME (1) | ME02101B (da) |
MX (1) | MX2010004740A (da) |
NZ (1) | NZ584839A (da) |
PE (1) | PE20091434A1 (da) |
PH (1) | PH12013501128A1 (da) |
PL (3) | PL2215117T5 (da) |
PT (1) | PT2215117E (da) |
RS (1) | RS53850B2 (da) |
RU (1) | RU2498991C2 (da) |
SG (2) | SG10201401690XA (da) |
SI (3) | SI2565206T1 (da) |
TW (2) | TWI448330B (da) |
WO (1) | WO2009058812A1 (da) |
ZA (2) | ZA201002850B (da) |
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