DK175091B1 - Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbro-holdige eukaryotiske proteiner efter ekspression i prokaryotiske celler - Google Patents
Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbro-holdige eukaryotiske proteiner efter ekspression i prokaryotiske celler Download PDFInfo
- Publication number
- DK175091B1 DK175091B1 DK198703203A DK320387A DK175091B1 DK 175091 B1 DK175091 B1 DK 175091B1 DK 198703203 A DK198703203 A DK 198703203A DK 320387 A DK320387 A DK 320387A DK 175091 B1 DK175091 B1 DK 175091B1
- Authority
- DK
- Denmark
- Prior art keywords
- process according
- mol
- mmol
- concentration
- reactivation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Lubricants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK200001897A DK175109B1 (da) | 1985-10-23 | 2000-12-18 | Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbroer indeholdende eukaryotiske proteiner efter ekspression i prokaryotiske celler |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3537708 | 1985-10-23 | ||
DE19853537708 DE3537708A1 (de) | 1985-10-23 | 1985-10-23 | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
PCT/EP1986/000610 WO1987002673A2 (en) | 1985-10-23 | 1986-10-23 | Process for activating heterologous, eucaryotic proteins genetically engineered and presenting disulphide bridges after their expression in procaryotic cells |
EP8600610 | 1986-10-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK320387D0 DK320387D0 (da) | 1987-06-23 |
DK320387A DK320387A (da) | 1987-06-23 |
DK175091B1 true DK175091B1 (da) | 2004-05-24 |
Family
ID=6284269
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198703203A DK175091B1 (da) | 1985-10-23 | 1987-06-23 | Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbro-holdige eukaryotiske proteiner efter ekspression i prokaryotiske celler |
DK200001897A DK175109B1 (da) | 1985-10-23 | 2000-12-18 | Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbroer indeholdende eukaryotiske proteiner efter ekspression i prokaryotiske celler |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK200001897A DK175109B1 (da) | 1985-10-23 | 2000-12-18 | Fremgangsmåde til aktivering af genteknologisk fremstillede, heterologe, disulfidbroer indeholdende eukaryotiske proteiner efter ekspression i prokaryotiske celler |
Country Status (26)
Country | Link |
---|---|
EP (3) | EP0393725B1 (ja) |
JP (2) | JPH0728745B2 (ja) |
KR (1) | KR900009139B1 (ja) |
AT (2) | ATE98648T1 (ja) |
AU (2) | AU590029B2 (ja) |
CA (1) | CA1329157C (ja) |
CZ (1) | CZ280727B6 (ja) |
DD (1) | DD260517A5 (ja) |
DE (3) | DE3537708A1 (ja) |
DK (2) | DK175091B1 (ja) |
ES (2) | ES2020498T3 (ja) |
FI (2) | FI94050C (ja) |
GR (2) | GR920300062T1 (ja) |
HK (2) | HK153496A (ja) |
HR (1) | HRP921075B1 (ja) |
HU (2) | HU204855B (ja) |
IE (1) | IE62634B1 (ja) |
IL (1) | IL80325A (ja) |
PT (1) | PT83609B (ja) |
SI (1) | SI8611796B (ja) |
SK (1) | SK278317B6 (ja) |
SU (1) | SU1607689A3 (ja) |
UA (1) | UA6023A1 (ja) |
WO (1) | WO1987002673A2 (ja) |
YU (1) | YU47185B (ja) |
ZA (1) | ZA868012B (ja) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
JP2581668B2 (ja) * | 1985-11-27 | 1997-02-12 | 三井東圧化学株式会社 | ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいdna配列とそれを含むベクタ−及び細胞 |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
AU621051B2 (en) | 1987-04-28 | 1992-03-05 | Amgen, Inc. | Method for purifying granulocyte-macrophage colony stimulating factor |
DE3722082A1 (de) * | 1987-07-03 | 1989-01-12 | Behringwerke Ag | Verfahren zur bestimmung der aktivitaet von serinproteasen oder serinproteaseinhibitoren |
CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
DE3832898A1 (de) * | 1988-09-28 | 1990-04-12 | Boehringer Mannheim Gmbh | Praeparat von in prokaryonten exprimiertem plasminogenaktivator |
DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
DE3942143A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa pro stabilisierung |
AU8417091A (en) * | 1990-08-20 | 1992-03-17 | Novo Nordisk A/S | Biologically active compound, a process for the preparation thereof and use of the same |
DE69129747T2 (de) * | 1990-09-05 | 1998-11-12 | Southern Cross Biotech Pty. Ltd., Toorak, Victoria | In lösung bringen von proteinen in aktiver form |
DE4037196A1 (de) * | 1990-11-22 | 1992-05-27 | Boehringer Mannheim Gmbh | Verfahren zur reaktivierung von denaturiertem protein |
DE4113750A1 (de) * | 1991-04-26 | 1992-10-29 | Boehringer Mannheim Gmbh | Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen |
DE4139000A1 (de) | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
US5212091A (en) * | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
CA2109820A1 (en) * | 1992-03-24 | 1993-09-30 | George N. Cox | Refolding and purification of insulin-like growth factor i |
EP0600372B1 (de) | 1992-12-02 | 1997-02-05 | Hoechst Aktiengesellschaft | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
FR2729972B1 (fr) * | 1995-01-31 | 1997-04-18 | Sanofi Sa | Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine |
US5714371A (en) * | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
US5728804A (en) * | 1995-06-02 | 1998-03-17 | Research Corporation Technologies, Inc. | Use of cyclodextrins for protein renaturation |
KR100305341B1 (ko) * | 1996-06-11 | 2002-03-02 | 로셰 디아그노스틱스 게엠베하 | 변성된단백질의활성화방법 |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US6653098B1 (en) * | 1998-02-23 | 2003-11-25 | G. D. Searle & Co. | Method of producing mouse and human endostatin |
DE19850429A1 (de) * | 1998-10-27 | 2000-05-04 | Andre Schrattenholz | Fragmente |
EP1048732A1 (de) * | 1999-04-26 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen |
EP1077263A1 (de) * | 1999-07-29 | 2001-02-21 | F.Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen |
JP4873818B2 (ja) | 2000-05-16 | 2012-02-08 | ボルダー バイオテクノロジー, インコーポレイテッド | 遊離システイン残基を含有するタンパク質をリフォールディングする方法 |
DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
DE10105911A1 (de) | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Expression der rekombinanten Proteinase K aus Tritirachium album in Hefe |
DE102005033250A1 (de) | 2005-07-15 | 2007-01-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von G-CSF |
DE102006009437A1 (de) | 2006-03-01 | 2007-09-13 | Bioceuticals Arzneimittel Ag | G-CSF-Flüssigformulierung |
SG162834A1 (en) | 2006-07-14 | 2010-07-29 | Genentech Inc | Refolding of recombinant proteins |
EP2102355B1 (en) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
JP5964757B2 (ja) | 2010-03-17 | 2016-08-03 | ラチオファーマ ゲーエムベーハー | 生物学的活性型組換えヒトg−csfを得るための方法 |
AU2011317021B2 (en) * | 2010-10-20 | 2015-07-09 | Medimmune, Llc | Methods for processing inclusion bodies |
HUP1200171A1 (hu) | 2012-03-19 | 2013-09-30 | Richter Gedeon Nyrt | Módszerek polipeptidek elõállítására |
HUP1200172A2 (en) | 2012-03-19 | 2013-10-28 | Richter Gedeon Nyrt | Methods for refolding g-csf from inclusion bodies |
CN103852527B (zh) * | 2012-12-05 | 2015-05-13 | 中国科学院大连化学物理研究所 | 一种高通量蛋白质样品预处理装置 |
US10457716B2 (en) | 2014-08-06 | 2019-10-29 | University Of Notre Dame Du Lac | Protein folding and methods of using same |
WO2018121703A1 (en) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides, compositions, and methods thereof |
CA3200462A1 (en) | 2020-12-18 | 2022-06-23 | Sebastian Damerow | Methods for the purification of refolded fc-peptide fusion protein |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5135481A (ja) * | 1974-09-18 | 1976-03-25 | Fujiwa Kako Kk | Kojundohitorokinaaze no seiho |
US4468633A (en) | 1982-04-28 | 1984-08-28 | The Bendix Corporation | Adjustable microwave power combiner for a plurality of coaxially mounted impatt diodes |
GR79202B (ja) | 1982-05-05 | 1984-10-22 | Genentech Inc | |
US4432895A (en) * | 1982-11-24 | 1984-02-21 | Hoffmann-La Roche Inc. | Monomeric interferons |
GR79124B (ja) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
ATE107356T1 (de) * | 1983-03-25 | 1994-07-15 | Celltech Ltd | Verfahren zur herstellung eines proteins. |
JPS6051119A (ja) * | 1983-08-30 | 1985-03-22 | Green Cross Corp:The | ウロキナ−ゼ乾燥製剤 |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
FR2596360B1 (fr) * | 1986-04-01 | 1989-02-17 | Sotralentz Sa | Conteneur sur palette avec dispositif de protection en treillis plie et renforce |
JPH0651119A (ja) * | 1992-07-28 | 1994-02-25 | Sekisui Chem Co Ltd | 位相差板の製造方法 |
-
1985
- 1985-10-23 DE DE19853537708 patent/DE3537708A1/de active Granted
-
1986
- 1986-10-10 IE IE268386A patent/IE62634B1/en not_active IP Right Cessation
- 1986-10-15 IL IL80325A patent/IL80325A/xx not_active IP Right Cessation
- 1986-10-17 CZ CS867526A patent/CZ280727B6/cs not_active IP Right Cessation
- 1986-10-17 SK SK7526-86A patent/SK278317B6/sk unknown
- 1986-10-21 SI SI8611796A patent/SI8611796B/sl unknown
- 1986-10-21 YU YU179686A patent/YU47185B/sh unknown
- 1986-10-22 DD DD29546886A patent/DD260517A5/de not_active IP Right Cessation
- 1986-10-22 ZA ZA868012A patent/ZA868012B/xx unknown
- 1986-10-22 CA CA000521121A patent/CA1329157C/en not_active Expired - Lifetime
- 1986-10-23 PT PT83609A patent/PT83609B/pt not_active IP Right Cessation
- 1986-10-23 DE DE3650449T patent/DE3650449D1/de not_active Expired - Lifetime
- 1986-10-23 EP EP90109721A patent/EP0393725B1/de not_active Expired - Lifetime
- 1986-10-23 AT AT86114731T patent/ATE98648T1/de not_active IP Right Cessation
- 1986-10-23 EP EP86114731A patent/EP0219874B1/de not_active Expired - Lifetime
- 1986-10-23 ES ES90109721T patent/ES2020498T3/es not_active Expired - Lifetime
- 1986-10-23 DE DE86114731T patent/DE3689404D1/de not_active Expired - Lifetime
- 1986-10-23 HU HU865290A patent/HU204855B/hu unknown
- 1986-10-23 ES ES86114731T patent/ES2061434T3/es not_active Expired - Lifetime
- 1986-10-23 AT AT90109721T patent/ATE131489T1/de not_active IP Right Cessation
- 1986-10-23 KR KR1019870700536A patent/KR900009139B1/ko not_active IP Right Cessation
- 1986-10-23 UA UA4202987A patent/UA6023A1/uk unknown
- 1986-10-23 HU HU865290A patent/HUT43643A/hu unknown
- 1986-10-23 JP JP61505882A patent/JPH0728745B2/ja not_active Expired - Lifetime
- 1986-10-23 EP EP86906320A patent/EP0253823A1/de active Pending
- 1986-10-23 AU AU65993/86A patent/AU590029B2/en not_active Ceased
- 1986-10-23 WO PCT/EP1986/000610 patent/WO1987002673A2/de active IP Right Grant
-
1987
- 1987-06-22 SU SU874202987Q patent/SU1607689A3/ru active
- 1987-06-22 FI FI872753A patent/FI94050C/fi not_active IP Right Cessation
- 1987-06-23 DK DK198703203A patent/DK175091B1/da not_active IP Right Cessation
-
1989
- 1989-09-13 AU AU41321/89A patent/AU607083B2/en not_active Expired
-
1991
- 1991-04-12 JP JP3079762A patent/JPH0824594B2/ja not_active Expired - Lifetime
-
1992
- 1992-08-31 GR GR92300062T patent/GR920300062T1/el unknown
- 1992-10-16 HR HRP-1796/86A patent/HRP921075B1/xx not_active IP Right Cessation
-
1993
- 1993-09-03 FI FI933868A patent/FI95578C/fi not_active IP Right Cessation
-
1995
- 1995-12-14 GR GR950403376T patent/GR3018410T3/el unknown
-
1996
- 1996-08-08 HK HK153496A patent/HK153496A/xx not_active IP Right Cessation
- 1996-08-08 HK HK153596A patent/HK153596A/xx not_active IP Right Cessation
-
2000
- 2000-12-18 DK DK200001897A patent/DK175109B1/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |