DK174236B1 - Fremgangsmåde til fremstilling af et protein som har human vævsplasminogenaktivatorfunktion, fremgangsmåde til fremstilling af et farmaceutisk præparat indeholdende proteinet, DNA-isolat, som koder for proteinet, rekombinante klonings- og ...... - Google Patents

Fremgangsmåde til fremstilling af et protein som har human vævsplasminogenaktivatorfunktion, fremgangsmåde til fremstilling af et farmaceutisk præparat indeholdende proteinet, DNA-isolat, som koder for proteinet, rekombinante klonings- og ...... Download PDF

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Publication number
DK174236B1
DK174236B1 DK198301988A DK198883A DK174236B1 DK 174236 B1 DK174236 B1 DK 174236B1 DK 198301988 A DK198301988 A DK 198301988A DK 198883 A DK198883 A DK 198883A DK 174236 B1 DK174236 B1 DK 174236B1
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protein
plasminogen activator
tissue plasminogen
dna
sequence
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DK198301988A
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DK198883D0 (da
DK198883A (da
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Gordon Allen Vehar
David Vannorman Goeddel
William Jack Kohr
Diane Pennica
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Genentech Inc
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Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK198883D0 publication Critical patent/DK198883D0/da
Publication of DK198883A publication Critical patent/DK198883A/da
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK198301988A 1982-05-05 1983-05-04 Fremgangsmåde til fremstilling af et protein som har human vævsplasminogenaktivatorfunktion, fremgangsmåde til fremstilling af et farmaceutisk præparat indeholdende proteinet, DNA-isolat, som koder for proteinet, rekombinante klonings- og ...... DK174236B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US37486082 1982-05-05
US39800382A 1982-07-14 1982-07-14
US39800382 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator
US48305283 1983-04-07

Publications (3)

Publication Number Publication Date
DK198883D0 DK198883D0 (da) 1983-05-04
DK198883A DK198883A (da) 1983-12-20
DK174236B1 true DK174236B1 (da) 2002-10-07

Family

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Family Applications (1)

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DK198301988A DK174236B1 (da) 1982-05-05 1983-05-04 Fremgangsmåde til fremstilling af et protein som har human vævsplasminogenaktivatorfunktion, fremgangsmåde til fremstilling af et farmaceutisk præparat indeholdende proteinet, DNA-isolat, som koder for proteinet, rekombinante klonings- og ......

Country Status (26)

Country Link
EP (1) EP0093619B2 (ja)
JP (2) JPH0216981A (ja)
AR (1) AR241654A1 (ja)
BG (1) BG60253B2 (ja)
BR (1) BR8302318A (ja)
CA (1) CA1293211C (ja)
CS (1) CS248705B2 (ja)
CY (1) CY1341A (ja)
DD (1) DD210303A5 (ja)
DE (3) DE3380567D1 (ja)
DK (1) DK174236B1 (ja)
ES (1) ES522085A0 (ja)
FR (1) FR2526443B1 (ja)
GB (1) GB2119804B (ja)
GR (1) GR79202B (ja)
HK (1) HK88586A (ja)
IE (1) IE54975B1 (ja)
IL (1) IL68561A (ja)
KE (1) KE3647A (ja)
MY (1) MY8700119A (ja)
NO (2) NO831575L (ja)
OA (1) OA07419A (ja)
PL (1) PL152438B1 (ja)
PT (1) PT76636B (ja)
RO (1) RO90639B (ja)
ZW (1) ZW10483A1 (ja)

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ES8501629A1 (es) 1984-12-16
CA1293211C (en) 1991-12-17
AU563031B2 (en) 1987-06-25
AU1414283A (en) 1983-11-10
JPH05137583A (ja) 1993-06-01
IL68561A (en) 1991-01-31
DK198883D0 (da) 1983-05-04
JPH0448440B2 (ja) 1992-08-06
GB2119804B (en) 1986-02-26
PT76636B (en) 1986-01-10
HK88586A (en) 1986-11-28
NO852065L (no) 1983-11-07
JP2564444B2 (ja) 1996-12-18
CY1341A (en) 1987-01-16
PT76636A (en) 1983-06-01
DE3316297C2 (ja) 1989-09-21
DE93619T1 (de) 1987-08-13
KE3647A (en) 1986-07-25
ZW10483A1 (en) 1983-09-21
PL152438B1 (en) 1990-12-31
OA07419A (fr) 1984-11-30
BG60253B1 (bg) 1994-03-24
JPH0216981A (ja) 1990-01-19
MY8700119A (en) 1987-12-31
FR2526443B1 (fr) 1985-12-06
GB8312221D0 (en) 1983-06-08
DK198883A (da) 1983-12-20
BR8302318A (pt) 1984-01-10
EP0093619A1 (en) 1983-11-09
IL68561A0 (en) 1983-09-30
RO90639B (ro) 1987-01-31
ES522085A0 (es) 1984-12-16
IE54975B1 (en) 1990-04-11
IE831024L (en) 1983-11-05
PL241805A1 (en) 1984-07-30
DD210303A5 (de) 1984-06-06
EP0093619B2 (en) 1996-09-18
FR2526443A1 (fr) 1983-11-10
GR79202B (ja) 1984-10-22
DE3316297A1 (de) 1983-11-17
DE3380567D1 (en) 1989-10-19
BG60253B2 (bg) 1994-03-24
NO831575L (no) 1983-11-07
GB2119804A (en) 1983-11-23
RO90639A (ro) 1987-01-30
AR241654A1 (es) 1992-10-30
CS248705B2 (en) 1987-02-12
EP0093619B1 (en) 1989-09-13

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