DK173818B1 - Heparinderivat - Google Patents

Heparinderivat Download PDF

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Publication number
DK173818B1
DK173818B1 DK198902850A DK285089A DK173818B1 DK 173818 B1 DK173818 B1 DK 173818B1 DK 198902850 A DK198902850 A DK 198902850A DK 285089 A DK285089 A DK 285089A DK 173818 B1 DK173818 B1 DK 173818B1
Authority
DK
Denmark
Prior art keywords
heparin
sodium
ppm
heparins
heparin derivative
Prior art date
Application number
DK198902850A
Other languages
Danish (da)
English (en)
Other versions
DK285089A (da
DK285089D0 (da
Inventor
Silvano Piani
Gianfranco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Marinella Fantuz
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of DK285089D0 publication Critical patent/DK285089D0/da
Publication of DK285089A publication Critical patent/DK285089A/da
Application granted granted Critical
Publication of DK173818B1 publication Critical patent/DK173818B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
DK198902850A 1988-06-10 1989-06-09 Heparinderivat DK173818B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT350488 1988-06-10
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione

Publications (3)

Publication Number Publication Date
DK285089D0 DK285089D0 (da) 1989-06-09
DK285089A DK285089A (da) 1989-12-11
DK173818B1 true DK173818B1 (da) 2001-11-19

Family

ID=11108618

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198902850A DK173818B1 (da) 1988-06-10 1989-06-09 Heparinderivat

Country Status (18)

Country Link
US (1) US5010063A (fr)
EP (1) EP0347588B1 (fr)
JP (1) JPH0739442B2 (fr)
KR (1) KR960015110B1 (fr)
AT (1) ATE109164T1 (fr)
CA (1) CA1309402C (fr)
DE (2) DE68917040T2 (fr)
DK (1) DK173818B1 (fr)
ES (1) ES2012748T3 (fr)
FI (1) FI94534C (fr)
GR (1) GR900300018T1 (fr)
IE (1) IE64830B1 (fr)
IL (1) IL90411A (fr)
IT (1) IT1234508B (fr)
NO (1) NO174259C (fr)
NZ (1) NZ229212A (fr)
PT (1) PT90817B (fr)
ZA (1) ZA893882B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5232040A (en) * 1990-07-12 1993-08-03 Lanxide Technology Company, Lp Method for reducing metal content of self-supporting composite bodies and articles formed thereby
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
CA2235223A1 (fr) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Lyases de polysaccharides designees rationnellement derivees de l'heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU754936B2 (en) * 1996-11-27 2002-11-28 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
WO2000012726A2 (fr) * 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Heparinases a conception rationnelle derivees de l'heparinase i et ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
CA2643162C (fr) 1999-04-23 2018-01-02 Massachusetts Institute Of Technology Systeme et procede d'identification et de sequencage de polymeres, et d'analyse de leur composition par comparaison des proprietes
CA2377734A1 (fr) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Compositions d'heparine qui inhibent des facteurs de coagulation associes aux caillots
AU4351201A (en) * 2000-03-08 2001-09-17 Massachusetts Inst Technology Heparinase iii and uses thereof
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
PT1319183E (pt) * 2000-09-12 2009-06-29 Massachusetts Inst Technology Métodos e produtos relacionados a heparina de baixo peso molecular
US7709461B2 (en) * 2000-10-18 2010-05-04 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (fr) 2004-03-24 2005-10-05 Aventis Pharma S.A. Procédé d'oxydation d'héparines non-fractionnées et la détection de la présence ou de l'absence de glycosérine dans l'héparine et les produits dérivés de l'héparine.
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2011090948A1 (fr) * 2010-01-19 2011-07-28 Momenta Pharmaceuticals, Inc. Évaluation de préparations d'héparine
EP3144325B1 (fr) * 2010-09-14 2020-11-04 University Of Miyazaki Héparine de haute pureté et son procédé de production
WO2012115952A1 (fr) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Évaluation de préparations d'héparine
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина
WO2022015794A1 (fr) 2020-07-14 2022-01-20 Optimvia, Llc Procédés de synthèse de sulfate d'héparane non anticoagulant
EP3997238A1 (fr) 2019-07-09 2022-05-18 Optimvia, LLC Procédés de synthèse de polysaccharides anticoagulants

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065140A (en) * 1958-07-05 1962-11-20 Roussel Uclaf Heparin derivatives and methods of preparing same
US3016331A (en) * 1960-01-28 1962-01-09 Ormonoterapia Richter Spa Purification of heparin
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
DK285089A (da) 1989-12-11
IT8803504A0 (it) 1988-06-10
IL90411A0 (en) 1990-01-18
KR960015110B1 (ko) 1996-10-28
FI892850A0 (fi) 1989-06-09
NO892366D0 (no) 1989-06-09
PT90817B (pt) 1994-11-30
ZA893882B (en) 1990-02-28
KR910000771A (ko) 1991-01-30
PT90817A (pt) 1989-12-29
ES2012748T3 (es) 1994-10-16
EP0347588A1 (fr) 1989-12-27
NZ229212A (en) 1991-02-26
CA1309402C (fr) 1992-10-27
AU3512889A (en) 1989-12-14
ATE109164T1 (de) 1994-08-15
ES2012748A4 (es) 1990-04-16
FI94534B (fi) 1995-06-15
DK285089D0 (da) 1989-06-09
JPH0264102A (ja) 1990-03-05
AU611028B2 (en) 1991-05-30
EP0347588B1 (fr) 1994-07-27
IL90411A (en) 1993-05-13
DE68917040D1 (de) 1994-09-01
FI94534C (fi) 1995-09-25
NO174259B (no) 1993-12-27
IT1234508B (it) 1992-05-19
IE891762L (en) 1989-12-10
US5010063A (en) 1991-04-23
DE347588T1 (de) 1990-05-23
NO892366L (no) 1989-12-11
DE68917040T2 (de) 1995-01-12
FI892850A (fi) 1989-12-11
JPH0739442B2 (ja) 1995-05-01
IE64830B1 (en) 1995-09-06
NO174259C (no) 1994-04-06
GR900300018T1 (en) 1991-06-07

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B1 Patent granted (law 1993)
PBP Patent lapsed

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