IT1264101B1 - Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 - Google Patents

Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Info

Publication number
IT1264101B1
IT1264101B1 IT93BO000125A ITBO930125A IT1264101B1 IT 1264101 B1 IT1264101 B1 IT 1264101B1 IT 93BO000125 A IT93BO000125 A IT 93BO000125A IT BO930125 A ITBO930125 A IT BO930125A IT 1264101 B1 IT1264101 B1 IT 1264101B1
Authority
IT
Italy
Prior art keywords
synthesis
modified
glycosaminoglicans
semi
synthetic heparin
Prior art date
Application number
IT93BO000125A
Other languages
English (en)
Inventor
Fabrizio Ungarelli
Silvano Piani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of ITBO930125A0 publication Critical patent/ITBO930125A0/it
Priority to IT93BO000125A priority Critical patent/IT1264101B1/it
Priority to CA002114862A priority patent/CA2114862C/en
Priority to NZ250815A priority patent/NZ250815A/en
Priority to AU55085/94A priority patent/AU664939B2/en
Priority to ZA94970A priority patent/ZA94970B/xx
Priority to IL108689A priority patent/IL108689A/en
Priority to TW083101327A priority patent/TW266215B/zh
Priority to US08/206,980 priority patent/US5405949A/en
Priority to DK94104306.9T priority patent/DK0618234T3/da
Priority to ES94104306T priority patent/ES2102087T3/es
Priority to EP94104306A priority patent/EP0618234B1/en
Priority to AT94104306T priority patent/ATE154039T1/de
Priority to DE69403537T priority patent/DE69403537T2/de
Priority to KR1019940006018A priority patent/KR100194122B1/ko
Priority to FI941431A priority patent/FI105101B/fi
Priority to NO941128A priority patent/NO305994B1/no
Priority to JP6059447A priority patent/JP2731721B2/ja
Publication of ITBO930125A1 publication Critical patent/ITBO930125A1/it
Application granted granted Critical
Publication of IT1264101B1 publication Critical patent/IT1264101B1/it
Priority to GR970402059T priority patent/GR3024416T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Viene descritto un processo per la sintesi di glicosaminoglicani semisintetici di formula generale III (FORMULA III) a struttura eparinica od eparanica modificati nella posizione 2 dell'acido ?-L-iduronico-2-O-solfato in cui il gruppo solfato viene sostituito, parzialmente o totalmente, con un radicale nucleofilo. Detto processo viene effettuato trattando con un agente nucleofilo in ambiente alcalino glicosaminoglicani a struttura eparinica od eparanica.
IT93BO000125A 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 IT1264101B1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
CA002114862A CA2114862C (en) 1993-03-29 1994-02-03 Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the .alpha.-l-iduronic-2-0-sulfate acid
NZ250815A NZ250815A (en) 1993-03-29 1994-02-03 Synthesis of semi-synthetic glycosaminoglycans
AU55085/94A AU664939B2 (en) 1993-03-29 1994-02-10 Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-O-sulfate acid
ZA94970A ZA94970B (en) 1993-03-29 1994-02-11 Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the a-L-iduronic-2-O-sulfate acid
IL108689A IL108689A (en) 1993-03-29 1994-02-17 Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid
TW083101327A TW266215B (it) 1993-03-29 1994-02-18
US08/206,980 US5405949A (en) 1993-03-29 1994-03-07 Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid
DK94104306.9T DK0618234T3 (da) 1993-03-29 1994-03-18 Fremgangsmåde til fremstilling af semisyntetiske glycosaminoglycaner med heparin- eller heparanstruktur som er modificeret i 2-stillingen af alfa-L-iduron-2-O-sulfatsyren
ES94104306T ES2102087T3 (es) 1993-03-29 1994-03-18 Procedimiento para la sintesis de glucosaminoglucanos semisinteticos con estructura de heparina o heparano modificada en la posicion 2 del acido alfa-l-iduronico-2-o-sulfato.
EP94104306A EP0618234B1 (en) 1993-03-29 1994-03-18 Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid
AT94104306T ATE154039T1 (de) 1993-03-29 1994-03-18 Verfahren zur synthese von halbsynthetischen glykosaminoglykanen mit heparin- oder heparanstruktur, die in 2-position modifiziertes alpha-l-iduronsäure-2-o-sulfat enthalten
DE69403537T DE69403537T2 (de) 1993-03-29 1994-03-18 Verfahren zur Synthese von halbsynthetischen Glykosaminoglykanen mit Heparin- oder Heparanstruktur, die in 2-Position modifiziertes Alpha-L-Iduronsäure-2-O-Sulfat enthalten
KR1019940006018A KR100194122B1 (ko) 1993-03-29 1994-03-25 2위치가 변형된 α-L-이두로닉-2-0-셀페이트산을 가진 헤파린 또는 헤파란 구조를 갖는 글리코스아미노글리칸의 제조방법
FI941431A FI105101B (fi) 1993-03-29 1994-03-28 Menetelmä hepariini- tai heparaanirakenteen omaavien puolisynteettisten glykoaminoglykaanien valmistamiseksi
NO941128A NO305994B1 (no) 1993-03-29 1994-03-28 Fremgangsmåte til syntese av semisyntetiske glukosaminoglykaner med heparin- eller en heparanstruktur modifisert i 2-posisjonen av <alfa>-L-iduron-2-O-sulfatsyre
JP6059447A JP2731721B2 (ja) 1993-03-29 1994-03-29 α−Ｌ−イズロン酸−２−Ｏ−硫酸の２位が修飾されたヘパリンまたはヘパラン構造を有する半合成グリコサミノグリカンの合成方法
GR970402059T GR3024416T3 (en) 1993-03-29 1997-08-13 Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (3)

Publication Number Publication Date
ITBO930125A0 ITBO930125A0 (it) 1993-03-29
ITBO930125A1 ITBO930125A1 (it) 1994-09-29
IT1264101B1 true IT1264101B1 (it) 1996-09-10

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Country Status (18)

Country Link
US (1) US5405949A (it)
EP (1) EP0618234B1 (it)
JP (1) JP2731721B2 (it)
KR (1) KR100194122B1 (it)
AT (1) ATE154039T1 (it)
AU (1) AU664939B2 (it)
CA (1) CA2114862C (it)
DE (1) DE69403537T2 (it)
DK (1) DK0618234T3 (it)
ES (1) ES2102087T3 (it)
FI (1) FI105101B (it)
GR (1) GR3024416T3 (it)
IL (1) IL108689A (it)
IT (1) IT1264101B1 (it)
NO (1) NO305994B1 (it)
NZ (1) NZ250815A (it)
TW (1) TW266215B (it)
ZA (1) ZA94970B (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2435637A1 (en) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
KR100855331B1 (ko) 2001-09-12 2008-09-04 시그마타우 리서치 스위츠랜드 에스.에이 혈관형성 억제 활성을 가지며 응고억제 효과는 없는,헤파라나제 억제제로서 부분적으로 탈황산화된글리코스아미노글리칸의 유도체
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
WO2017154938A1 (ja) * 2016-03-09 2017-09-14 株式会社糖鎖工学研究所 硫酸基および／またはリン酸基を有する糖の製造方法
CN114901702B (zh) * 2019-12-27 2024-01-09 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
FI105101B (fi) 2000-06-15
GR3024416T3 (en) 1997-11-28
ITBO930125A1 (it) 1994-09-29
CA2114862C (en) 1999-05-25
NO305994B1 (no) 1999-08-30
EP0618234B1 (en) 1997-06-04
TW266215B (it) 1995-12-21
EP0618234A1 (en) 1994-10-05
NZ250815A (en) 1996-02-27
ES2102087T3 (es) 1997-07-16
AU664939B2 (en) 1995-12-07
AU5508594A (en) 1994-10-06
KR100194122B1 (ko) 1999-06-15
IL108689A (en) 1998-03-10
KR940021582A (ko) 1994-10-19
ATE154039T1 (de) 1997-06-15
JPH06298805A (ja) 1994-10-25
ZA94970B (en) 1994-08-24
ITBO930125A0 (it) 1993-03-29
FI941431A0 (fi) 1994-03-28
JP2731721B2 (ja) 1998-03-25
FI941431A (fi) 1994-09-30
NO941128D0 (no) 1994-03-28
CA2114862A1 (en) 1994-09-30
US5405949A (en) 1995-04-11
IL108689A0 (en) 1994-05-30
DE69403537D1 (de) 1997-07-10
NO941128L (no) 1994-09-30
DE69403537T2 (de) 1997-09-18
DK0618234T3 (da) 1997-08-25

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